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http://dx.doi.org/10.7841/ksbbj.2014.29.6.405

Preparation of Gemcitabine-Loaded PLLA/Gemcitabine-PLLA Microparticles Using Supercritical Fluid and Their Release Characteristics  

Hong, Jin-Hee (Department of Chemical Engineering, The University of Suwon)
Lim, Giobin (Department of Chemical Engineering, The University of Suwon)
Ryu, Jong-Hoon (Department of Chemical Engineering, The University of Suwon)
Publication Information
KSBB Journal / v.29, no.6, 2014 , pp. 405-413 More about this Journal
Abstract
In this study, gemcitabine (Gem)-Poly(L-lactic acid) (PLLA) conjugates were synthesized through an amide linkage reaction. Then, the microparticles of Gem-PLLA/PLLA blends containing gemcitabine were prepared using a supercritical fluid process, called aerosol solvent extraction system (ASES). Gemcitabine-loaded Gem-PLLA/PLLA microparticles obtained from the ASES process showed a spherical shape. The amount of gemcitabine released after 30 day incubation in a phosphate buffer solution of pH 7.4 was about 90% of the total amount of gemcitabine present in the product.
Keywords
Drug-polymer conjugate; Gemcitabine; Poly(L-lactic acid); Supercritical carbon dioxide; Aerosol solvent; extraction system;
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