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Anti-allergic Effects of Artemisia iwayomogi on Animal Models of Allergic Reactions  

Shin, Tae-Yong (College of Pharmacy, Woosuk University)
Shin, Hye-Young (College of Pharmacy, Wonkwang University)
Kim, Hyung-Min (College of Oriental Medicine, Kyung Hee University)
Publication Information
Natural Product Sciences / v.10, no.1, 2004 , pp. 24-28 More about this Journal
Abstract
The effects of aqueous extract of Artemisia iwayomogi (Compositae) (AIAE) on the mast cell-dependent allergic and inflammatory reactions were investigated. AIAE (0.05 to 1 g/kg) dose-dependently inhibited systemic allergic reaction induced by compound 48/80 in mice. AIAE (0.1 and 1 g/kg) also significantly inhibited local allergic reaction activated by anti-DNP IgE. AIAE (0.001 to 1 mg/ml) dose-dependently inhibited the histamine release from rat peritoneal mast cells (RPMC) activated by compound 48/80. Moreover, AIAE inhibited the secretion of interleukin (IL)-6 in phorbol 12-myristate 13-acetate (PMA) plus calcium ionophore A23187-stimulated human mast cell line (HMC-1) cells. These results provide evidence that AIAE may be beneficial in the treatment of allergic diseases.
Keywords
Artemisia iwayomogi; allergic reaction; compound 48/80; anti-DNP IgE; IL-6;
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1 Alber, G., Miller, L., Jelsema, C., Varm-Blank, N., and Metzger, H., Stmcture/function relationships in the mast cell high-aSinity receptor for IgE (FceRI): Role of cytoplasmic domains. J. Biol. Chem. 266, 22613-22620 (1991)
2 Allansmith, M. R., Baird, R. S., Ross, R. N., Bamey, N. R, and Bloch, K. J., Ocular anaphylaxis induced in the rat by topical application of compound 48/80. Dose response and time course study. Acta Ohpthatmol. 67, 145-153 (1989)
3 Bueb, J. L., Mousli, M. C., Bronner, C., Rouot, B., and Landry, Y, Activation of Gi-like proteins, a receptor-independent effect of kinins in mast cells. Mot. Pharmacol. 38, 816-822 (1990)
4 Kang, C. K., Yook, C. S., and Han, D. R., Studies on the consdtuents of herbs, roots and flowers in Artemisia iwayomogi Kitamura. Bull. K.H. Pharma. Sci. 21, 39-43 (1993)
5 Kim, H. M., and Lee, Y. M., Role of TGF-beta 1 on the IgE-dependent anaphylaxis reaction. J. Immunol. 162, 4960-4965 (1999)
6 Lagunoff, D., Martin, T.W., and Read, G., Agents that release histamine from mast cells. Annu. Rev. Pharmacol. Toxicol. 23, 331-351 (1983)   DOI   ScienceOn
7 Petersen, L. J., Mosbech, H., and Skov, R, Allergen-induced histamine release in intact human skin in vivo assessed by skin microdialysis technique: Characterizadon of factors influencing histamine releasability. J. AUergy Clin. Immunol. 97, 672-679 (1996)   DOI   ScienceOn
8 Shin, H. Y, Jeong, H. J., Na, H. J., Hong, S. H., Lee, S. K., Lee, K. N., Song, Y. S., Kim, H. M., and Shin, T. Y, Daeganghwal- tang inhibits the stem cell factor-induced migration and inflammatory cytokines secretion in mast cells. J. Ethfwpharmacol. 85, 157-161 (2003)   DOI   ScienceOn
9 Shin, T. Y, Inhibition of immunologic and nonimmunologic stimulation-mediated anaphylactic reactions by the aqueous extract of Mentha arvensis. Immunophannacol. Immurwtoxicol. 25, 273-283 (2003)
10 Gordon, J. R., Burd, P. R., and Galli, S. J., Mast cells as a source of multifunctional cytokines. Immunol. Today, 11, 458-464 (1990)   DOI   ScienceOn
11 Metzger, H., Alcaraz, G., Hohman, R., Kinet, J. P, Pribluda, V., and Quarto, R., The receptor with high affinity for immunoglobulin E. Annu. Rev. Immunol. 4, 419-470 (1986)   DOI   ScienceOn
12 Yurt, R. W., Leid, R. W., and Austen, K. F, Native heparin from rat peritoneal mast cells. J. BioI. Chem. 252, 518-521 (1977)
13 Lee, K. R., Zee, O. R, Kwak, J. H., Kim, Y. S., Park, H. K., Koo, K. A., and Youn, H. J., The polysaccharide fracdons of Artemisiae species (1). Kor. J. Pharmacogn., 24, 289-295 (1993)
14 Galli, S. J., New concepts about the mast cell. N. Engt. J. Med. 328, 257-265 (1993)   DOI   ScienceOn
15 Mousli, M. C., Bronner, C., Landry, Y, Bockaert, J., and Rouot, B., Direct activation of GTP-binding regulatory proteins (G proteins) by substance P and compound 48/80. FEBS Lett. 259, 260-262 (1990b)   DOI   ScienceOn
16 Gordon, J. R., and Galli, S. J., Mast cells as a source of both preformed and immunologically inducible TNF-alpha/cachectin. Nature, 364, 274-276 (1990)
17 Beaven, M. A., and Metzger, H., Signal transduction by Fc receptors: The Fc epsilon RI case. J. Immunol. 14, 222-226 (1993)
18 Segal, D. M., Taurog, J., and Metzger, H., Dimeric iinmunoglobulin E serves as a unit signal for mast cell degranulation. Proc. Natt. Acad. Sci. 74, 2993-2997 (1977)   DOI   ScienceOn
19 Mousli, M.C., Broinner, C., Bockaert, J., Rouot, B., and Landry, Y, Interaction of substance P, compound 48/80 and mastoparan with $\alpha$-subunit C-terminal of G protein. Immunol. Lett. 25, 355-358 (1990a)   DOI   ScienceOn
20 Katayama, S., Shionoya, H., and Ohtake, S., A new method for extraction of extravasated dye in the skin and the influence of fasting stress on passive cutaneous anaphylaxis m guinea pigs and rats. MicrobioL Immunol. 22, 89-101 (1978)   DOI
21 Shore, P. A., Burkhalter, A., and Cohn, V. H., A method for fluoromethc assay of histamine in tissues. J. Phannacol. Exp. Ther. 127, 182-186 (1959)
22 Kanemoto, T. J., Kasugai, T, Yamatodani, A., Ushio, H., Mochizuki, T., Tohya, K., Kimura, M., Nishimura, M., and Kitamura, Y, Supemormal histamine release and normal cytotoxic activity of Biege rat mast cells with giant granules. Int. Arch. AItergy Immuniol. 100, 99-106 (1993)   DOI   ScienceOn
23 Tasaka, K., Mio, M., and Okamoto, M., Intracellular calcium release induced by histamine releasers and its inhibition by some antiallergic drugs. Ann. Attergy, 56, 464-469 (1986)
24 Ennis, M., Pearce, F. L., and Weston, P. M., Some studies on the release of histamine from mast cells stimulated with polylysine. Br. J. Pharmacol. 70, 329-334 (1980)   DOI   ScienceOn