• The KSFM Journal of Fluid Machinery
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• v.7 no.2 s.23
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• pp.7-13
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• 2004

In an attempt to solve multiobjective optimization problems, weighted sum method is most widely used for the advantage that a designer can consider the relative significance of each object functions by weight values but it can be highly sensitive to weight vector and occasionally yield a deviated optimum from the relative weighting values designer designated because the multiobjective function has the form of simple sum of the product of the weighting values and the object functions in traditional approach. To search the design solution agree well to the designer's weighting values, we proposed new multiobjective function which was the functional of each normalized objective functions and considered to find the design solution comparing the distance between the characteristic line and the ideal optimum. In this study, proposed multiobjective function was applied to design high efficiency and low noise axial flow fan and the result shows this approach is effective for the case that the quality of the design can be highly affected by the designer's subjectiveness represented as weighting values in multiobjective design optimization process.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.11 no.12
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• pp.4691-4696
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• 2010

The This research paper deals with research on the 3D strip layout design of HEV UV terminal by utilizing the Cimatron Die Design, an automation module. To ensure smooth stamping of the product, strip layout was corrected for 33.5 degrees of slope, and blank layout of the double-width, 1-line, 1-pull out inner carrier was then optimized as a single arrangement. To mass-produce two different terminals from one common die, 3D strip layout design and die design were completed in 29 different processes.

• Journal of the Korean Society of Clothing and Textiles
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• v.34 no.10
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• pp.1754-1766
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• 2010

Excessive consumption, pollution, and am expanding global population are seen as very important issues that must be solved through reusable materials and the reduction of energy consumption. This study examines the values and design elements such as line, color, and textures in eco-friendly fashion that could contribute to the product development of an eco-friendly brand. The following methods of analysis were used in this study. An in-depth interview (where the interviewer records the response of interviewers to questions) was used to grasp the diverse design properties of products that customers need or want and the recorded interviews were documented by computer using open coding. The results show that the personal, economic, and social value of eco-friendly fashion has increased, in addition to the environmental value. The needs and preference of customers for eco-friendly fashion design were diversified and the consumer consciousness was more advanced than the consciousness of experts. This shows that it is not enough to consider the effect on the environment. In conclusion, understanding the personal, environmental, economic, and social value from the viewpoint of customers, finding the optimal design factors, and reflecting them in the development of products are necessary for advanced eco-friendly fashion.

• Journal of Korean Institute of Industrial Engineers
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• v.12 no.1
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• pp.119-131
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• 1986

Described in this paper is a modelling methodology for mass production system simulation. The mass production system under consideration consists of various types of flow lines, special purpose production facilities, conveyor lines, palletized carts, and storage facilities. This type of production system is typical in home appliance industry, automobile industry, footwear industry, etc. where a variety of product mix are mass-produced. The modelling methodology is based on the "discrete-event formalism", and an "activity-oriented world view" is adopted to formalize the system description. A distinctive feature of the modelling methodology is that only the static structure (ie, system components) is included in the fixed model. The dynamic structure of the system is specified through a "data-driven" mechanism, which is an extension of the "experimental frame" concept. Each type of system components (ie, flow line, conveyors, carts, etc.) is formally modeled by using Activity Cycle Diagrams. The issue of "model structuring" is also addressed. The modeling methodology has been successfully applied in a real simulation study of a mass production system.

• THE INTERNATIONAL COMMERCE & LAW REVIEW
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• v.22
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• pp.107-135
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• 2004

The International Standard Banking Practice for the Examination of Documents under Documentary Letters of Credit (ISBP) is the product by the ICC Banking Commission, October 2002. The ISBP is a practical complement to UCP 500, ICC's universally used rules on documentary credits. It explains, in explicit detail, how the rules are to be applied on a day-to-day basis. It fills a needed gap between the general principles announced in the rules and the daily work of the documentary credit practitioner. By using the ISBP, document checkers can bring their practices in line with those followed by their colleagues worldwide. The result should be a significant reduction in the number of documents refused for discrepancies on first presentation. We are convinced that the benefits of the ISBP will not only be of high importance for users of UCP 500, but also that the practices in the ISBP will survive a UCP revision, or will even be included in the next version of the rule (so call "UCP 600"). Though the above-mentioned benefits of the ISBP, there are several troublesome topics that will probably have to wait for a new UCP revision. It will be a challenge for the drafters of a future UCP to find solutions that will further clarify these points.

• BMB Reports
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• v.34 no.3
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• pp.230-236
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• 2001

dTDP-rhamnose is synthesized from dTTP and glucose-1-phosphate by four enzymatic steps in the gram-negative bacteria. By using a homologous PCR product, a gene cluster encoding four genes (rfbA, rfbB, rfbC, rfbD) involved in L-rhamnose biosynthesis by Acinetobacter calcoaceticus was isolated and sequenced. The four genes were clustered on the biosynthetic operon in the order of rfbB, D, A, C. A gene, rfbA, encoding glucose-l-phosphate thymidylyltransferase (RfbA), was cloned from A. calcoaceticus pathogenic and encapsulated in the gram-negative bacterium. This enzyme catalyzes the formation of dTDP-D-glucose From $\alpha$-D-glucose-1-phosphate and dTTP.RfbA was amplified by PCR and inserted into the $T_7$ expression system. The activity of RfbA was determined by the capillary electrophoresis. The $K_m$ values for dTTP and $\alpha$-D-glucose-1-phosphate were calculated to be 1.27 mM and 0.80 mM, respectively by using the Line-Weaver Burk plot. RfbA is inactivated by diethylpyrocarbonate.

• BMB Reports
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• v.49 no.3
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• pp.149-158
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• 2016

Plants have evolved a vast chemical cornucopia to support their sessile lifestyles. Man has exploited this natural resource since Neolithic times and currently plant-derived chemicals are exploited for a myriad of applications. However, plant sources of most high-value natural products (NPs) are not domesticated and therefore their production cannot be undertaken on an agricultural scale. Further, these plant species are often slow growing, their populations limiting, the concentration of the target molecule highly variable and routinely present at extremely low concentrations. Plant cell and organ culture constitutes a sustainable, controllable and environmentally friendly tool for the industrial production of plant NPs. Further, advances in cell line selection, biotransformation, product secretion, cell permeabilisation, extraction and scale-up, among others, are driving increases in plant NP yields. However, there remain significant obstacles to the commercial synthesis of high-value chemicals from these sources. The relatively recent isolation, culturing and characterisation of cambial meristematic cells (CMCs), provides an emerging platform to circumvent many of these potential difficulties.

• International Journal of Precision Engineering and Manufacturing
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• v.4 no.2
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• pp.49-56
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• 2003

As semi-solid forging (SSF) is compared with conventional casting such as gravity die-casting and squeeze casting, the product without inner defects can be obtained from semi-solid forming and globular microstructure as well. Generally, SSF consists of reheating, forging, and ejecting processes. In the reheating process, the materials are heated up to the temperature between the solidus and liquidus line at which the materials exists in the form of liquid-solid mixture. The process variables such as reheating time, reheating temperature, reheating holding time, and induction heating power has large effect on the quality of the reheated billets. It is difficult to consider all the variables at the same time for predicting the quality. In this paper, Taguchi method, regression analysis and neural network were applied to analyze the relationship between processing conditions and solid fraction. A356 alloy was used for the present study, and the learning data were extracted from the reheating experiments. Results by neural network were in good agreement with those by experiment. Polynominal regression analysis was formulated using the test data from neural network. Optimum processing condition was calculated to minimize the grain size and solid fraction standard deviation or to maximize the specimen temperature average. Discussion is given about reheating process of row material and results are presented with regard to accurate process variables fur proper solid fraction, specimen temperature and grain size.

• Natural Product Sciences
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• v.15 no.4
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• pp.185-191
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• 2009

Intestinal epithelial cells (IEC) play an important role in the mucosal immune system. IEC-derived mediators of inflammatory cascades play a principal role in the development of colon inflammation. The aim of this study was to investigate the inhibitory effect of aqueous extracts of Schizandra chinensis fruits (SC-Ex) on the production of inflammatory mediators by the human colonic epithelial cells. HT-29 cells were stimulated with dextran sulfate sodium in the presence or absence of SC-Ex to examine the cytoprotection and production of IL-8 and reactive oxygen species (ROS). It was shown that dextran sulfate sodium (DSS) caused the reduction of cell viability and production of IL-8 and ROS in DSS-treated HT-29 cells. We observed that the treatment of SC-Ex protected significantly cell proliferation from DSS-induced damage in dose-dependent manner. SC-Ex (10 and 100 ${\mu}g$/ml) also suppressed DSS-induced production of IL-8 mRNA and protein. Moreover, DSS-induced ROS production was inhibited markedly by the treatment of 100 ${\mu}g$/ml SC-Ex. These results suggest that SC-Ex has the protective effects on DSS-induced cell damage and the release of inflammatory mediators in the intestinal epithelial cells.

• Natural Product Sciences
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• v.20 no.1
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• pp.7-12
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• 2014

Twelve triterpenoids (1 - 12) were isolated from $CHCl_3$-soluble fraction of fruiting bodies of Ganoderma lucidum. Extensive spectroscopic and chemical studies established the structures of these compounds as butyl lucidenate P (1), butyl lucidenate $E_2$ (2), butyl lucidenate $D_2$ (3), butyl lucidenate Q (4), ganoderiol F (5), methyl ganoderate H (6), methyl ganoderate J (7), lucidumol B (8), ganodermanondiol (9), methyl lucidenate N (10), methyl lucidenate A (11) and butyl lucidenate N (12). All of the compounds were examined for their cytotoxic activity against HL-60, HeLa, and MCF-7 cancer cell lines. Among them, compounds 4 and 8 showed cytotoxic activity with $IC_{50}$ values of 6.6 and 1.6 ${\mu}M$ against HL-60, respectively. In addition, compound 8 also showed cytotoxic activity with $IC_{50}$ values of 2.0 ${\mu}M$ against HeLa cancer cell line, other compounds were moderate or inactive.