• Natural Product Sciences
• /
• v.8 no.4
• /
• pp.165-169
• /
• 2002

One-hundred and twenty plant extracts were prepared from 29 Indonesian plants and were primarily tested in vitro cytotoxicity in cultured human lung (A549), colon (Col2), and stomach (SNU-638) cancer cells. As a result, the 23 extracts were found to be active in the criteria of $ED_{50}$<$20\;{\mu}g/ml$. Remarkable cytotoxicity was observed for chloroform and n-butanol extracts of Calotropis gigantea, with $ED_{50}$ values ranging from 0.25 to $0.46\;{\mu}g/ml$. Five extracts derived from Eclipta alba and Excoecaria cochinchinensis displayed potent cell-line selective cytotoxicity, while the rest of 15 extracts showed modest cytotoxic activity against all of three cancer cells. In addition, the cytotoxic potential of subfractions of Zingiber cassumunar against a panel of human cancer cell lines is presented.

• Food Science and Biotechnology
• /
• v.15 no.4
• /
• pp.534-542
• /
• 2006

The effects of ethanol fractions of three different rice grain extracts, Jakwangchalbyeo, Hwasunchalbyeo, and Ilpumbyeo, on apoptotic cell death in the rat hepatoma H4IIE cell line were investigated using the MTT [3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide] cell viability assay. One hundred mg/mL Jakwangchalbyeo extract significantly reduced cell viability to 69.5, 57.2, and 46.1% within 24, 48, and 72 hr, respectively. Fluorescence-activated cell sorting (FACS) analyses were also performed to characterize the cell death pattern caused by treatment with the rice grain extracts. Apoptotic cell death was clearly observed with time after treatment with the Jakwangchalbyeo extract. In Western blotting analysis, degradation of the 116 kDa poly-ADP-ribose polymerase (PARP) molecule was observed with concomitant formation of an 89 kDa product 24, 48, and 72 hr after treating cells with the Jakwangchalbyeo extract. This indicates that an apoptotic process caused cell death in these cells. In conclusion, red-pericarp Jakwangchalbyeo extract induced apoptotic cell death in H4IIE cells to a larger extent than the other rice extracts.

• Journal of Nutrition and Health
• /
• v.37 no.3
• /
• pp.236-250
• /
• 2004

The objective of this study was to investigate difference in the diet by the kind of meal and the economic status. Nutrient contents at each meals were compared and differences in food intake at different meal were analyzed by economic status. Data from the 1998 Korean National Health Examination Nutrition Survey were used. Using the poverty line based on the 1998 Korean minimum cost of living, the subjects (n = 10400) were classified into high class (36.1％), middle class (40.7％) and low class (23.1 ％). Most nutrient intakes were obtained for main meals regardless of economic status. For high class, breakfast, lunch, dinner and snacks bring about 21, 29, 30 and 19 ％ of total energy intake, for middle class 22, 29, 30 and 19％ and for low class 24, 30, 30 and 16％, respectively. The high-middle class people tend to get more food intakes and nutrients at dinner and snacks, while the low class at main meals. This result was associated with the consumption of a smaller number of meals and a greater number of snacks daily as the economic level was going up (p 〈 0.05). Meals contributed to energy, protein and fat intake, and snacks to water, retinol and vitamin C. The food intakes by food group were different at meals by economic class. Seaweed product were popular breakfast foods in both middle and low groups. Thus three meals such as breakfast, lunch and dinner still delivered most of the energy and most of the macro-nutrients regardless of economic status.

• International Journal of Costume and Fashion
• /
• v.18 no.2
• /
• pp.85-100
• /
• 2018

The purpose of this study is to research the level of emotional responses and corresponding behavioral responses of consumers who have experienced out-of-stock (OOS) shopping. Answers were gathered from 526 people in the 20-49 year age range, residing in a metropolitan area. SPSS 18.0 was used to perform factor analysis, reliability measures and regression analysis. The subordinate concept of emotional responses from consumers who experience an OOS event while at an on online shopping mall is the first subject of research for this study; this is tied in with three central factors; namely, anger/annoyance, anxiety and feeling regret. These can be further categorized into a positive emotional response and a negative emotional response. The experiment scrutinizes how emotional responses towards an OOS event experience affect behavioral responses. It then focuses on positive emotional responses as the second subject of this research: namely, how regret significantly affects the product substitution (S), and how anger/annoyance, anxiety and regret significantly influence a delayed purchase (D). Anger/annoyance, anxiety and regret significantly affect the incomplete store switch over (L1), and anger/annoyance and anxiety significantly influence the complete store switch over (L2).

• Microbiology and Biotechnology Letters
• /
• v.47 no.1
• /
• pp.34-42
• /
• 2019

Apigenin, a common natural product that is found in many plants and vegetables, has been reported to have many biological activities, including antioxidative, anti-inflammatory, and anticancer effects. The triple-negative breast carcinoma cell line MDA-MB-231 is known to be highly invasive and resistant to chemotherapy. In this study, we investigated the anticancer effect of apigenin on human MDA-MB-231 cells. First, the cytotoxicity of apigenin toward MDA-MB-231 cells was analyzed by MTT assay. Then, the cell cycle and apoptotic effects of apigenin were examined, and the molecular mechanism underlying its anticancer activity was explored. Apigenin inhibited the growth of the cells in a dose-dependent manner, correlating with the cell cycle arrest at the G2-M phase as well as an increase of early apoptosis. The cell-cycle inhibitory effect was highly associated with the increased expression of p21 and decreased expression of CDK6, cyclin D1, and cyclin B1. The induction of apoptosis by apigenin was associated with the upregulated expression of cleaved PARP and cleaved caspase-3, -7, and -9.

• Proceedings of the Korea Information Processing Society Conference
• /
• 2004.05a
• /
• pp.947-950
• /
• 2004

프로덕트 라인은 다양하고 빠르게 변화하는 시장의 요구사항과 특정 도메인 영역에 속하는 애플리케이션 간의 재사용 가능한 아키텍처 및 컴포넌트의 구성으로부터 연관된 시스템 구축 시 생산성과 품질의 향상을 제공함으로써 현재 많은 관심의 초점이 되고 있다. 컴포넌트의 가변성은 컴포넌트를 사용자의 요구사항에 알맞게 기능을 특화할 수 있다. 또한 프로덕트 라인에서 컴포넌트 내부에 공통으로 사용할 워크플로를 가지고 있어 컴포넌트 사용자는 순차 다이어그램 등을 통해 메시지 흐름을 직접 구현할 필요가 없고, 재사용 가능한 아키텍처는 많은 변화 계획들과 메카니즘을 포함하고 있다. 하지만, 아키텍처를 설계하기 위한 아키텍처에서의 변화성 관리와 컴포넌트의 변화성에 대한 명확한 방법이 미흡하다. 따라서 본 논문에서는 재사용 가능한 아키텍처를 설계하기 위해 변화성의 명확한 표현과 컴포넌트의 변화성을 설계하기 위해 다중 뷰의 모델링을 통하여 프로덕트 라인의 다양한 측면을 제시하고, 사례연구로 성적관리 컴포넌트 모델링에 적용해 보고자 한다.

• Journal of the Semiconductor & Display Technology
• /
• v.18 no.1
• /
• pp.5-9
• /
• 2019

Optical emission spectroscopy is used to identify chemical species and monitor the changes of process results during the plasma process. However, plasma process monitoring or fault detection by using emission signal variation monitoring is vulnerable to background signal fluctuations. IR heaters are used in semiconductor manufacturing chambers where high temperature uniformity and fast response are required. During the process, the IR lamp output fluctuates to maintain a stable process temperature. This IR signal fluctuation reacts as a background signal fluctuation to the spectrometer. In this research, we evaluate the effect of infrared background signal fluctuation on plasma process monitoring and improve the plasma process monitoring accuracy by using simple infrared background signal subtraction method. The effect of infrared background signal fluctuation on plasma process monitoring was evaluated on $SiO_2$ PECVD process. Comparing the $SiO_2$ film thickness and the measured emission line intensity from the by-product molecules, the effect of infrared background signal on plasma process monitoring and the necessity of background signal subtraction method were confirmed.

• Journal of Embryo Transfer
• /
• v.33 no.4
• /
• pp.337-342
• /
• 2018

Cryopreservation is mainly used for preservation of boar sperm. However, this method stresses the sperm by reactive oxygen species (ROS), and the conception rate and the litter size are not more efficient than the liquid preservation of spermatozoa. Therefore, we use chitosan which is a natural product derived antioxidant compound. We used GnHA (chitosan+hyaluronic acid) and GnHG (chitosan hydrogel) as chitosan complexes to cryopreserve boar sperm for improve sperm metabolism and function. Sperm parameter (sperm motility, progressive motility, path velocity, straight-line velocity, curvilinear velocity) is measured by computer-assisted sperm analysis (CASA) using frozen sperm with GnHA or GnHG (0, 0.25, 0.5, 1 mg/mL), respectively. Also, lipid peroxidation analysis using malondialdehyde (MDA) is performed to confirm the antioxidative effect of chitosan in frozen spermatozoa. CASA analysis showed GnHA and GnHG are effective against cryopreserved boar sperm. And antioxidant effect is measured by lipid peroxidation analysis. GnHA and GnHG, which is chitosan complex are effective for boar sperm cryopreservation by antioxidant effect.

• The Journal of Asian Finance, Economics and Business
• /
• v.8 no.1
• /
• pp.451-455
• /
• 2021

This research seeks to find out how to provide satisfaction to consumers. The aim is to analyze and test empirically the effect of price and sales promotion on customer satisfaction that is mediated by service quality. This study uses primary data; questionnaires are distributed to 100 consumers at the Jingga Project boutique. The sampling technique uses simple random sampling. The data were collected using a questionnaire measured by a Likert scale with analysis tools using Warp PLS 7.0. The results showed that the variables price and sales promotion have a positive effect on customer satisfaction. Furthermore, the mediating variable, namely, service quality, is proven to be able to indirectly mediate the effect of price and sales promotion on customer satisfaction. In line with the marketing theory, which states that customer satisfaction is the feeling of pleasure or disappointment of someone who appears after comparing the performance (results) of the product against the expected performance. From the results of this study, it is clear that the variables price and sales promotion significantly affect customer satisfaction, as well as service quality, which is the mediating variable in this study. Service quality indirectly or partially mediate the effect of price on customer satisfaction.

• Journal of IKEEE
• /
• v.25 no.2
• /
• pp.285-290
• /
• 2021

The existing aiming inspection use foreign-made aiming inspection equipment. However, the quantity is insufficient and the difficult to maintain. So it takes a lot of time to inspect the target. This system can reduces the time of aiming inspection and be maintained and distributed smoothly because it is a domestic product. In this paper, we develop a system that can detect targets and monitor shooting results through a target detection deep learning model. The system is capable of real-time detection of targets and has significantly increased the identification rate through several preprocessing of distant targets. In addition, a graphical user interface is configured to facilitate user camera manipulation and storage and management of training result data. Therefore the system can replace the currently used aiming inspection equipment and non-fire training.