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Evaluation of Cytotoxic Potential of Indonesian Medicinal Plants in Cultured Human Cancer Cells  

Park, Go-Woo-Ni (College of Pharmacy, Ewha Womans University)
Lee, Eun-Jin (College of Pharmacy, Ewha Womans University)
Min, Hye-Young (College of Pharmacy, Ewha Womans University)
Choi, Hye-Young (College of Pharmacy, Ewha Womans University)
Han, Ah-Reum (College of Pharmacy, Ewha Womans University)
Lee, Sang-Kook (College of Pharmacy, Ewha Womans University)
Seo, Eun-Kyoung (College of Pharmacy, Ewha Womans University)
Publication Information
Natural Product Sciences / v.8, no.4, 2002 , pp. 165-169 More about this Journal
Abstract
One-hundred and twenty plant extracts were prepared from 29 Indonesian plants and were primarily tested in vitro cytotoxicity in cultured human lung (A549), colon (Col2), and stomach (SNU-638) cancer cells. As a result, the 23 extracts were found to be active in the criteria of $ED_{50}$<$20\;{\mu}g/ml$. Remarkable cytotoxicity was observed for chloroform and n-butanol extracts of Calotropis gigantea, with $ED_{50}$ values ranging from 0.25 to $0.46\;{\mu}g/ml$. Five extracts derived from Eclipta alba and Excoecaria cochinchinensis displayed potent cell-line selective cytotoxicity, while the rest of 15 extracts showed modest cytotoxic activity against all of three cancer cells. In addition, the cytotoxic potential of subfractions of Zingiber cassumunar against a panel of human cancer cell lines is presented.
Keywords
Cytotoxicity; Indonesian plants; Plant extracts; Zingiber cassumunar;
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