• Title/Summary/Keyword: Principle of maximum

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Mouse Single Oral Dose Toxicity Test and Bone Marrow Micronucleus Test of Mahwangbujaseshin-tang Extracts (마황부자세신탕(麻黃附子細辛湯)의 마우스 단회 경구투여 독성 및 골수세포를 이용한 유전독성 평가)

  • Sung, Ik-Jae;Park, Mee-Yeon;Kim, Jong-Dae
    • Journal of Physiology & Pathology in Korean Medicine
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    • v.24 no.1
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    • pp.124-133
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    • 2010
  • The object of this study was to obtain acute information single oral dose toxicity of Mahwangbujaseshin-tang extracts, with mouse bone marrow cell micronucleus test for detecting possible genotoxicity. In order to observe the 50% lethal dose, approximate lethal dosage, maximum tolerance dosage and target organs, test articles were once orally administered to ICR mice at dose levels of 2000, 1000, 50 mg/kg according to the recommendation of KFDA Guidelines. The mortality and changes on body weight, clinical signs and gross observation were monitored during 14 days after dosing according to KFDA Guidelines with organ weights of 12 types of principle organs. In addition, after twice oral treatment of Mahwangbujaseshin-tang extracts 2000, 1000 and 500 mg/kg, we checked the changes on the number of MNPCE. We could not find any mortality, clinical signs, changes in the body weight and gross findings upto 2000 mg/kg treated group. The limited dosages in rodents except for increases of lymphoid organ weights and hypertrophy encounted as results from pharmacological effects of Mahwangbujaseshin-tang extracts, immune modulator effects with some sporadic accidental findings not toxicological signs. No evidence of increases of MNPCE numbers were also detected in all three different dosages of Mahwangbujaseshin-tang extracts treated mice. The results obtained in this study suggest that the LD50 and ALD of Mahwangbujaseshin-tang extracts in mice were considered as over 2000 mg/kg because no mortalities were detected upto 2000 mg/kg that was the highest dose recommended by KFDA and OECD. And the results of mouse bone marrow micronucleus test of Mahwangbujaseshin-tang extracts is negative results.

Study on the Separation Performance of a Tray-type Paddy Separator (트레이형 현립분리기의 분리성능에 관한 연구)

  • 정창주
    • Journal of Biosystems Engineering
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    • v.5 no.1
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    • pp.43-50
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    • 1980
  • The milling plants in Korea have been generally used the paddy-separator that operated in accordance with the principle of sieving action. This type of paddy separator was considered as inefficient, especially in relation to the new high-yielding varieties which have different size characteristics within their varieties and also as compared to traditional varieties. With the installation of modern paddy separator it may be possible to increase the overall milling system efficiency and to reduce the grain loss. This study was intended to identify and define important parameters required for assessing the separation performance of a tray-type paddy separator and to determine the optimum conditions of the inclination of separator-table. The results of the study were summarized as follows : (1) Separation performance can be given by use of many parameters found from the measurement of separator outputs. such as upper-tail recovery $(\varepsilon)$, purity of upper-tail $(\gamma)$ , separation recovery of brown rice $(\alpha)$, separation recovery paddy $(\beta)$, and efficiency of separator $(\epsilon)$, Among these para-meters , $\varepsilon$, $\gamma$, $\alpha$ and $\beta$, were designated , respectively, their independent properties of the paddy separator. In addition, their modes of variation due to a varied inclination of the separation table did not indicated in the same direction . However, the efficiency of separator had an advantage to indicate the overall characteristics of the separator performance with a clear optimum inclination condition of the separator table. (2) The optimum feed rate and maximum efficiency of the separator did not occur at the identical inclination of the separator table. Thus, for its practical operation it is necessary to compromise between the qualitative and quantitative performances of the separator. (3) The optimum setting of the separator table tested in the study showed to occur at its inclination of approximately $26^\circ<$/TEX> for the front and $8^\circ<$/TEX> for lateral.

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Mathematical modeling of concrete beams containing GO nanoparticles for vibration analysis and measuring their compressive strength using an experimental method

  • Kasiri, Reza;Massah, Saeed Reza
    • Advances in nano research
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    • v.12 no.1
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    • pp.73-79
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    • 2022
  • Due to the extensive use of concrete structures in various applications, the improvement of their strength and quality has become of great importance. A new way of achieving this purpose is to add different types of nanoparticles to concrete admixtures. In this work, a mathematical model has been employed to analyze the vibration of concrete beams reinforced by graphene oxide (GO) nanoparticles. To verify the accuracy of the presented model, an experimental study has been conducted to compare the compressive strengths of these beams. Since GO nanoparticles are not readily dissolved in water, before producing the concrete samples, the GO nanoparticles are dispersed in the mixture by using a shaker, magnetic striker, ultrasonic devices, and finally, by means of a mechanical mixer. The sinusoidal shear deformation beam theory (SSDBT) is employed to model the concrete beams. The Mori-Tanaka model is used to determine the effective properties of the structure, including the agglomeration influences. The motion equations are calculated by applying the energy method and Hamilton's principle. The vibration frequencies of the concrete beam samples are obtained by an analytical method. Three samples containing 0.02% GO nanoparticles are made and their compressive strengths are measured and compared. There is a good agreement between our results and those of the mathematical model and other papers, with a maximum difference of 1.29% between them. The aim of this work is to investigate the effects of nanoparticle volume fraction and agglomeration and the influences of beam length and thickness on the vibration frequency of concrete structures. The results show that by adding the GO nanoparticles, the vibration frequency of the beams is increased.

Study to Select a Strategic Fisheries for the Encouragement of a Long Term Planning Project in the Korean Fishing Industry. (한국어업의 장기적 진흥계획을 위한 전략 업종 선정에 관한 연구)

  • 장수호
    • The Journal of Fisheries Business Administration
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    • v.1 no.1
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    • pp.19-68
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    • 1970
  • This is a study of a long term project to encourage the Korean fishing industry. It seeks to supply a sound theoretical background in an attempt to liberalize the capital investment of the industry. However, the discussions developed in this thesis are based on, the existing world's fisheries resources, the possibility of their prospective cultivation, and the analysis of the evolution of Korean fisheries and fisheries organization. According to the reasults of the analysis ; out of the prospective world fisheries resources which are estimated at about 200 millions m/t the total yield per year is only about 70 millions m/t (1969), and Korea occupies only 850 thousands m/t. This therefore means that the Korean fishing industry allows much room for further growth. But the purpose of Korea's existing fishing industry organizations is entirely directed toword coastal fisheries and their functions never reache beyond the limit of off-shore fisheries. Thus almost 99% of the fisheries population engage in small scale fisheries along the coast line. The result is that the resource are almost exhausted by such over-exploitation. Being faced by this fact, it is of urgent necessity to modernize the management of fisheries as well as to encourage larger scale management of fisheries industries. This should be accompanied by the liberalization of capital investment. For this purpose this study also recommends the unification or annexation of small organizations to establish larger ones that will function for a larger scale industry. and further this study recommends that, in order to reorganize the existing fisheries organizations, a principle of selection should be applied in the areas of (1) maximum sustainable yields, (2) the possibility of forming an enterprise and (3) the maintenance of organization stability.

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Improvement of Power Unbalance Problem due to Distributed Design of Isolated Bidirectional DC-DC Converter for High Voltage (고전압용 절연형 양방향 DC-DC 컨버터의 분산 설계로 인한 전력 불균형 문제의 개선방안)

  • Oh, Seong-Taek;Kwon, Hyuk-Jin;Park, Jeong-Uk;Choi, Seing-Won;Lee, Il-Oun;Lee, Jun-Young
    • The Transactions of the Korean Institute of Power Electronics
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    • v.26 no.2
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    • pp.82-89
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    • 2021
  • This study proposes a DAB two-stage series structure with insulated bidirectional DC-DC converter for two-way power transfer between the renewable energy of high voltages (1 kV and above). The proposed circuit transforms the existing DAB converter into a two-stage series structure to reduce the pressure in the switch. The problem of power imbalance occurring in the design of the DAB converter second-stage series is improved by applying the cell balancing method circuit and the common mode coupled inductor using an external flying capacitor instead of reflecting the existing improvement measures, voltage balance control, and inductor current control. In addition, a no-load supercharging sequence is proposed in high voltages and high-speed switching by using the fixed duty output method. This study presents the analysis results through the structure of the proposed circuit, the principle of improving the power imbalance problem, and simulations. Prototypes were manufactured to meet the specifications of input/output voltage of 1700 V, maximum load of 65 kW, and switching frequency of 51kHz, and the validity of the topology was verified using the experimental results and efficiency data.

Response of Mulberry Brown Leaf Spot Fungus Myrothecium roridum to Different Plant Extracts

  • Chattopadhyay, S.;Institute, Traning;Majil, M.D.;Pratheesshkumar;Das, K.K.;Saratchandra, B.
    • International Journal of Industrial Entomology and Biomaterials
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    • v.5 no.2
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    • pp.183-188
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    • 2002
  • Anti-fungal potential of 5 plant extracts viz., Eucalyptus citriodora, Allium sativum, Cassia sophera, Chromolaena odorata and Datura metel on the growth of mulberry brown leaf spot pathogen Myrothecium roridum were examined. Except fur the aqueous extract of Allium bulb, ethanolic leaf extract of all other plants more efficiently reduced the colony growth of the fungus on potato-dextrose-agar, Of which, Allium and Eucalyptus extracts were more effective. Initiation of radial growth of M. roridum on solid media was deferred maximum 6 days by ethanolic Eucalyptus extract and 4 days by aqueous Allium extract at $0.4 mg.ml^{-1}$. In the liquid media amended with Eucalyptus extract ($0.4 mg.ml^{-1}$) complete inhibition of sporulation was noticed upto 8 days, and initial inhibition of mycelial bio-mass generation was considerably diminished with time and reduction was 1.3 fold 14 days after application. While, complete inhibition of mycelial growth for 6-14 days was recorded with $\geq$0.1 mg.ml$^{-1}$ commercial eucalyptus oil. However, rejuvenation of growth appeared when fungus was re-inoculated in fresh media. Post-inoculate application of different doses Of Eucalyptus and Allium extracts significantly (p < 0.05) reduced the disease severity in pot-ted mulberry. However, persistence of the effect up to 28 days was apparent at $\geq$ 1.0 mg.ml$^{-1}$ and effectively was on par with carbendazim (1 mg.ml$^{-1}$ ). Almost equal control ability of 1.0 mg.ml$^{-1}$ Eucalyptus extracts can be achieved by ca. 10 times lowered dose of commercial eucalyptus oil. It seems, the toxic principle of E. citrodora to M. roridum is fungistatic in nature and may have essential oil based origin.

Low Speed Design of Rear Rotor in Contra-Rotating Axial Flow Pump

  • Cao, Linlin;Watanabe, Satoshi;Momosaki, Simpei;Imanishi, Toshiki;Furukawa, Akinori
    • International Journal of Fluid Machinery and Systems
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    • v.6 no.2
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    • pp.105-112
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    • 2013
  • The application of contra-rotating rotors for higher specific speed pump has been proposed in our studies, which is in principle effective for reducing the rotational speed and/or the pump size under the same specification of conventional axial flow pump. In the previous experiments of our prototype, the cavitation inception at the tip region of the rear rotor rather than that of the front rotor and the strong potential interaction from the suction surface of the rear rotor blade to the pressure surface of the front one were observed, indicating the possibility to further improve the pump performance by optimizing rotational speed combination between the two rotors. The present research aims at the design of rear rotor with lower rotational speed. Considering the fact that the incoming flow velocity defects at the tip region of the rear rotor, an integrated inflow model of 'forced vortex' and 'free vortex' is employed. The variation of maximum camber location from hub to tip as well as other related considerations are also taken into account for further performance improvement. The ideas cited above are separately or comprehensively applied in the design of three types of rear rotor, which are subsequently simulated in ANSYS CFX to evaluate the related pump performance and therefore the whole low speed design idea. Finally, the experimental validation is carried out on one type to offer further proofs for the availability of the whole design method.

Step-up Switched Capacitor Multilevel Inverter with a Cascaded Structure in Asymmetric DC Source Configuration

  • Roy, Tapas;Bhattacharjee, Bidrohi;Sadhu, Pradip Kumar;Dasgupta, Abhijit;Mohapatra, Srikanta
    • Journal of Power Electronics
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    • v.18 no.4
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    • pp.1051-1066
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    • 2018
  • This study presents a novel step-up switched capacitor multilevel inverter (SCMLI) structure. The proposed structure comprises 2 unequal DC voltage sources, 4 capacitors, and 14 unidirectional power switches. It can synthesize 21 output voltage levels. The important features of the proposed topology are its self-voltage boosting and inherent capacitor voltage balancing capabilities. Furthermore, a cascaded structure of the proposed SCMLI with an asymmetric DC voltage source configuration is presented. The proposed topology and its cascaded structure are compared with conventional and other recently developed topologies in terms of different aspects, such as the required components to produce a specific number of output voltage levels, the total standing voltage (TSV) and peak inverse voltage of the structure, and the maximum number of switches in the conducting path. Furthermore, a cost function is developed to verify the cost-effectiveness of the proposed topology with respect to other topologies. The TSV of the proposed topology is significantly lower than those of other topologies. Moreover, the developed topology is cost-effective compared with other topologies. A detailed operating principle, power loss analysis, and selection procedure for switched capacitors are presented for the proposed SCMLI structure. Extensive simulation and experimental studies of a 21-level inverter structure prove the effectiveness and merits of the proposed SCMLI.

The Characteristics of Efficiency and Torque in $L_1-B_8$ mode USM Having Linear Movement (선형 운동하는 $L_1-B_8$ 모드 초음파 전동기의 효율과 토크 특성)

  • U, Sang-Ho;Shin, Soon-In;Kim, Jin-Soo
    • Proceedings of the Korean Institute of Electrical and Electronic Material Engineers Conference
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    • 2002.07b
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    • pp.585-588
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    • 2002
  • The USM uses friction between a mobile part (rotor) and a vibration part(stator), which is different from the principle of the conventional motor based on the interaction of electric and magnetic fields. In this thesis, a flat-type $L_1-B_8$ mode USM was designed and fabricated the characteristics of an ultrasonic vibration. The results of fabricated USM are as follows: (1) In case of ultrasonic motor with elastic-body of stainless, when applied voltage, frequency, pressing force of rotor were 50 [V], 27.9 [kHz], 1.5 [N], 5.0[mN m] respectively, the speed of revolution could be presented up to 0 [cm/s]. (2) In case of ultrasonic motor with elastic-body of brass, when applied voltage, frequency, pressing force of rotor were 50 [V], 21.4 [kHz], 1.5 [N], 1.4[mN m]respectively, the speed of rotor revolution was presented up to 0 [cm/s]. (3) The USM of elastic-body of stainless showing 1.17[%], somewhat low, in the maximum efficiency according to torque was superior to the USM of elastic-body of brass showing 0.34 [%]. The Flat-type $L_1-B_8$ mode USM had characteristics of typical drooping torque-speed, large torque and high speed, and operating in both directions by phase reversal.

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An experimental study on tailings deposition characteristics and variation of tailings dam saturation line

  • Wang, Guangjin;Tian, Sen;Hu, Bin;Kong, Xiangyun;Chen, Jie
    • Geomechanics and Engineering
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    • v.23 no.1
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    • pp.85-92
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    • 2020
  • This study adopted soil test and laboratory physical model experiments to simulate the tailings impoundment accumulation process according to the principle of similarity. Relying on the practical engineering, it analyzed the tailings deposition characteristics on dry beach surface during the damming process, as well as the variation rules of dam saturation line. Results suggested that, the tailings particles gradually became finer along the dry beach surface to inside the impoundment. The particle size suddenly changed at the junction between the deposited beach and the water surface, which displayed an obvious coarsening phenomenon. Besides, the deposited beach exhibited the vertical feature of coarse upward and fine downward on the whole. Additionally, in the physical model, the saturation line elevated with the increase in dam height, and its amplitude was relatively obvious within the range of 1.0-4.5 m away from the initial dam. Under flood condition, the saturation line height was higher than that under normal condition on the whole, with the maximum height difference of 4 cm. This study could provide an important theoretical basis for further studies on dam failure experiments and the evolution rules of leaked tailings flow.