• Clinical and Experimental Pediatrics
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• 제52권6호
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• pp.649-654
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• 2009

The immune system is comprised of cells and molecules whose collective and coordinated response to the introduction of foreign substance is referred to as the immune response. Defense against microbes is mediated by the early reaction (innate immunity) and the late response (adaptive immunity). Innate immunity consists of the epithelial barrier, phagocytes, complement and natural killer cells. Adaptive immunity, a more complex defense reaction, consists of activation of later-developed lymphocytes that, when stimulated by exposure to infectious agents, increase in magnitude and defensive capabilities with each successive exposure. In this review we discuss recent advances in important primary immune deficiency disorders of innate immunity (chronic granulomatous disease, leukocyte adhesion deficiency) and adaptive immunity (severe combined immune deficiency, Wiskott- Aldrich syndrome).

• Radiation Oncology Journal
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• 제30권4호
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• pp.182-188
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• 2012

Purpose: For recurrent esophageal cancer after primary definitive radiotherapy, no general treatment guidelines are available. We evaluated the toxicities and clinical outcomes of re-irradiation (re-RT) for recurrent esophageal cancer. Materials and Methods: We analyzed 10 patients with recurrent esophageal cancer treated with re-RT after primary definitive radiotherapy. The median time interval between primary radiotherapy and re-RT was 15.6 months (range, 4.8 to 36.4 months). The total dose of primary radiotherapy was a median of 50.4 Gy (range, 50.4 to 63.0 Gy). The total dose of re-RT was a median of 46.5 Gy (range, 44.0 to 50.4 Gy). Results: The median follow-up period was 4.9 months (range, 2.6 to 11.4 months). The tumor response at 3 months after the end of re-RT was complete response (n = 2), partial response (n = 1), stable disease (n = 2), and progressive disease (n = 5). Grade 5 tracheoesophageal fistula developed in three patients. The time interval between primary radiotherapy and re-RT was less than 12 months in two of these three patients. Late toxicities included grade 1 dysphagia (n = 1). Conclusion: Re-RT of recurrent esophageal cancer after primary radiotherapy can cause severe toxicity.

• 한국임상약학회지
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• 제25권3호
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• pp.166-170
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• 2015

Background: Primary warm autoimmune hemolytic anemia (AIHA) is a relatively rare hematologic disorder resulting from autoantibody production against red blood cells. There has been very few studies about primary warm AIHA in South Korea because of its low incidence. We retrospectively analyzed the treatment outcome of primary warm AIHA. Method: We reviewed retrospectively the medical records of 9 primary warm AIHA patients from December 2002 to January 2015. We analyzed the causes and clinical characteristics of primary warm AIHA patients. We retrospectively analyzed the clinical data in electronic medical records for 9 Korean patients with AIHA patients who were diagnosed during the period from December 2002 to January 2015 at the Regional University Hospital in Korea. The study protocol was approved by the Institutional Review Board (IRB #2015-08-007, Chosun University Hospital IRB). Results: The mean age was 52 years (range 27~78), the mean hemoglobin level was 5.0 g/dL (range 2.5~6.4 g/dL). All patients received steroids at therapeutic dosages (corticosteroid 1 mg/Kg) as first line treatment. Eight of them showed complete response (5/8, 62.5%) and partial response (3/8, 37.5%), one patient required second-line treatment with rituximab. Two patients who responded first line treatment were relapsed at 86 weeks and 24 weeks after response, respectively. Only one patient of them was retreated with corticosteroid because of anemic symptoms. Conclusion: This study indicates that oral corticosteroid is an effective therapy for primary warm AIHA.

• Earthquakes and Structures
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• 제10권5호
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• pp.1213-1232
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• 2016

This paper investigates the response of nonstructural components in the presence of nonlinear behavior of the primary structure considering the near-fault pulse-like ground motions. A database of 81 near-fault pulse-like ground motions is used to examine the effect of these ground motions on the response of nonstructural components. For comparison, a database of 573 non-pulse-like ground motions selected from the PEER database is also employed. The effects of peak ground velocity (PGV), maximum incremental velocity (MIV), primary structural degrading behavior and damping of nonstructural components are evaluated and discussed statistically. Results are presented in terms of amplification factor which quantifies the effect of inelastic deformations of the primary structure on subsystem responses. The results indicate that the near-fault pulse-like ground motions can significantly increase the amplification factors of nonstructural components with primary structural period and the magnitude of increase can reach 17%. The effect of PGV and MIV on amplification factors tends to increase with the increase of primary structural ductility. The near-fault pulse-like ground motions are more dangerous to components supported by structures with strength and stiffness degrading behavior than ordinary ground motions. A new simplified formulation is proposed for the application of amplification factors for design of nonstructural components for near-fault pulse-like ground motions.

• 한국지진공학회논문집
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• 제24권2호
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• pp.87-93
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• 2020

Seismic responses due to the dynamic coupling between a primary structure and secondary system connected to a structure are analyzed in this study. The seismic responses are compared based on dynamic coupling criteria and according to the error level in the natural frequency, with the recent criteria being reliant on the error level in the spectral displacement response. The acceleration responses and relative displacement responses of a primary structure and a secondary system for a coupled model and two different decoupled models of two degrees-of-freedom system are calculated by means of the time integration method. Errors in seismic responses of the uncoupled models are reduced with the recent criteria. As the natural frequency of the secondary system increases, error in the natural frequency decreases, but seismic responses of uncoupled models can be underestimated compared to that of coupled model. Results in this paper can help determine dynamic coupling and predict uncoupled models' response conservatism.

• Geomechanics and Engineering
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• 제22권6호
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• pp.509-518
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• 2020

Multi-layered primary linings have been proved to be highly effective for tunneling in severe squeezing grounds. But there still has not existed well-established design method for it. Basically, there are two main critical problems in this method, including determinations of allowable deformation and distribution of support stiffness. In order to address such problems, an attempt to investigate the mechanical response of a circular tunnel with double primary linings is performed in this paper. Analytical solutions in closed form for stresses and displacements around tunnels are derived. In addition, the effectiveness and reliability of theoretical formulas provided are well validated by using the numerical method. Finally, based on the analytical solutions, a parametric investigation on the effects of allowable deformation and distribution of support stiffness on tunnel performance is conducted. Results show that the rock pressure and displacement are significantly affected by these two design parameters. It can be found that rock pressure decreases as either allowable deformation increases or stiffness of the first primary lining decreases, but rock displacement shows an opposite trend. This paper can provide a useful guidance for the design of multi-layered primary linings.

• Nuclear Engineering and Technology
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• 제31권6호
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• pp.586-594
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• 1999

To limit both the large displacement and acceleration response of the structure efficiently, the relationships between acceleration and displacement responses of the structure under several earthquakes are investigated for various horizontal stiffness of the base isolation system to determine the effective stiffness of the base isolation system in this paper. An example structure is a five-storey steel frame building as the primary structure and the secondary structures are assumed to be located on the fifth floor of the primary structure. Input motions used in the structural analysis are El Centre 1940, Taft 1952, Mexico 1985, San Fernando 1971 Pacoima Dam, and artificially generated earthquakes. The relationships of the absolute peak acceleration and the displacement at the top of the structure are calculated for various natural periods of base isolators under various earthquakes. The peak acceleration response of the fifth floor in the base isolated structure is significantly reduced by a factor of 2.1 through 6.25. Also, the relative displacement response of the floor to the base of the superstructure is very small. The results of this study can be utilized to determine the effective stiffness of the base isolation system.

• 한국소음진동공학회:학술대회논문집
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• 한국소음진동공학회 2011년도 추계학술대회 논문집
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• pp.130-135
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• 2011

A study of the bending-extension-transverse shear coupled random response of the composite beams with thin-walled open sections subjected to various types of concentrated and distributed random excitations is dealt with in this paper. First of all, equations of motion of thin-walled composite H-type cross-section beams incorporating a number of nonclassical effects of transverse shear and primary and secondary warping, and anisotropy of constituent materials are derived. On the basis of derived equations of motion, analytical expressions for the displacement response of the composite beams are derived by using normal mode method combined with frequency response function method.

• 복식
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• 제54권8호
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• pp.59-74
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• 2004

The Purposes of this study are to investigate consumers' causes of clothing preference and dispreference separately, and to get 'real' descriptions about that causes using an open-ended response questionnaire. The sample was composed of 81 undergraduate students. Subjects were asked to select their preferred clothing and disprefered clothing respectively among wardrobes they have and to describe the causes of that preference/dispreference. The data was collected through an open-ended response questionnaire and analyzed using content analysis. The system for content analysis was divided into the view Point of image, clothing itself, wearer's physical characteristics, wearing situation, others' response, wearer's values, wearer's consciousness, and purchase process. Image was the primary cause that raised clothing preference, and clothing itself, wearer's physical characteristic, wearing situation, others' response, wearer's consciousness, wearer's values, and purchase process followed. In audition. wearer's physical characteristic was the primary cause that raised clothing dispreference. and image, clothing itself. wearer's consciousness, wearer's values. wearing situation, purchase process, and others' response followed. Finally, the framework for the causes of clothing preference/dispreference was developed.

• 한국농촌간호학회지
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• 제18권1호
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• pp.40-48
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• 2023

Purpose: This study is a descriptive research that analyzes the current status of education for COVID-19 response tasks and factors affecting work fatigue of primary health care practitioners who have experience in dispatching to respond to COVID-19. Methods: This study collected data through an online survey from September 21 to 29, 2022, targeting 193 primary health care practitioners. The data were analyzed by frequency, percentage, mean, standard deviation, and logistic regression analysis using the SPSS 25.0 program. Results: 74.1% of the study subjects were dispatched without receiving disaster medical training to respond to COVID-19. 59.6% of the study subjects' work fatigue was above the level of being very tired. The factors that affect the work fatigue of the subjects were disaster participation experience, work intensity, compensation regulations, compensation satisfaction, and understanding of COVID-19 guidelines. Conclusion: Based on the results of this study, an educational program for systematic disaster response and preparation for primary health care practitioners in charge of public health care should be developed to efficiently cope with the occurrence of new infectious diseases in the future.