• Asian Pacific Journal of Cancer Prevention
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• 제13권2호
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• pp.607-611
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• 2012

Non-toxic stimulation of dendritic cells (DCs), which are central immunomodulators, may aid the prevention of cancer. Furthermore, induction of apoptosis in cancer cells by anticancer agents contributes to the induction of DC maturation. We previously reported that extracts from $Pinus$ $parviflora$ Sieb. et Zucc pine cone and $Mucuna$ seed induce differentiation of mouse bone marrow cells into mature dendritic cells and also induce apoptosis in various human cancer cell lines. In the present study, we screened 31 kinds of edible beans with biological activity similar to that of extracts from pine cone and $Mucuna$ and found that the heat-stable extract from azuki bean ($Vigna$ $angula$) stimulated differentiation of bone marrow cells into immature DCs with the greatest efficacy. The level of IL-6 produced by sequential treatment of DCs with azuki extract and lipopolysaccharide was the highest among the examined beans. Azuki extract also inhibited the growth of human leukemia U937 cells, leading to induction of apoptosis. These results suggest that azuki bean and its extract are immunopotentiating foods that can be used as a dietary supplement for cancer prevention and immunotherapy.

• 대한인간공학회지
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• 제36권3호
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• pp.221-230
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• 2017

Objective: The purpose of this study is to draw the accident prevention model using the signal detection theory, and to implement accident prevention program, based on a health promotion and support activities in a shipbuilding company. Background: Workers' health management is perceived important from the human resource management perspective, as well as from the personal perspective. Method: This study developed an accident prevention model by analyzing the correlation between 704 workers' health examination variables, and reviewed the verification of the model through a follow-up survey on the control variables and status of hazards targeting 650 workers for four years from 2007 to 2010. Also, a health promotion program was implemented targeting a production division to improve alcohol habits, smoking, musculoskeletal pain complaints and hearing control indices, which are the control variables of the model. Results: As a result of four years' implementation, the following effects were obtained: the days away from work fell 87.5%, and accident rate dropped 71.5% in 2010, respectively, compared to 2006, before the activity was implemented. Conclusion: This study shows that the accident prevention activities based on workers' health promotion activities are effective to prevent industrial accidents and injuries. Application: The research findings will serve as a practical guideline for establishing preventive measures in the shipbuilding company.

• Child Health Nursing Research
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• 제18권4호
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• pp.192-200
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• 2012

Purpose: This study was done to develop and test the effectiveness in late school-aged children of a healthy lifestyle education program for cancer prevention. Methods: Participants were 26 students in the sixth grade of N elementary school in J City (experimental group) and 25 students in the sixth grade of D elementary school with same educational conditions (control group). The research design was a nonequivalent control group pretest-posttest design. Data collection and execution of the study were carried out from March 10 to May 19, 2011. For the experimental treatment, 7 weekly sessions of the healthy lifestyle education program for cancer prevention were given by the researcher. Posttest was done immediately following the conclusion of the program and 4 weeks later. Frequencies, percentages, ${\chi}^2$-test, t-test, repeated measures ANOVA and paired t-test with SPSS WIN 18.0 were used to analyze the data. Results: Perceived barriers, perceived self-efficacy, activity related effect and family support significantly influenced cancer prevention knowledge and increases in healthy life styles. Conclusion: Results indicate that, as this program for cancer prevention was effective in increasing healthy lifestyle practices in these children, there is a need to further develop, test and implement programs in all schools.

• 한국컴퓨터정보학회논문지
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• 제13권5호
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• pp.273-278
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• 2008

도시범죄 관리에 대한 새로운 전략으로써 사전예방적 범죄 통제전략 중의 하나로 추진하고 있는 것이 환경설계를 통한 범죄예방이다. 이에 본 연구에서는 도시범죄와 관련하여 현실적으로 범죄문제에 대응할 수 있는 범죄예방 전략을 모색하고자 하는데 연구의 목적을 두었다. 이를 위해 광주광역시에서 2004년도에 발생한 도시범죄 중 동구의 주거지역에서 발생한 범죄를 대상으로 범죄분포가 어떻게 이루어지고 있는지를 현지조사를 통하여 분석함으로써 CPTED의 입장에서 범죄예방전략을 모색하고자 하였다.

• 대한의생명과학회지
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• 제15권4호
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• pp.355-362
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• 2009

I evaluated the protective effect of N-methyl-D-aspartate (NMDA)/glycine receptor antagonist, 7-chlorokinurenic acid (CKA) on cultured mouse astrocytes damaged by ischemia-like condition (ILC). The protective effect of CKA was assessed by cell viability, lactate dehydrogenase (LDH) activity, superoxide dismutase (SOD)-like activity and lipid peroxidation. To examine the effect of CKA on the cell apoptosis, the expression and the activity of caspase 3 were assessed by Western blotting. CKA increased the cell viability decreased by ILC. CKA also decreased the LDH activity and antioxidative effects such as SOD-like activity and inhibitory activity of lipid peroxidation. In addition, CKA suppressed the expression of caspase 3 associated with apoptosis, and increased the cell viability by the decrease of caspase 3 activity as like the caspase 3 inhibitor, Av-DVED-MED. From these results, these results suggest that ILS induces cell cytotoxicity in cultured astrocytes and CKA, NMDA/glycine receptor antagonist, is effective on the prevention of the cytotoxicity due to ILS by the antioxidative effect and the inhibition of apoptosis.

• Asian Pacific Journal of Cancer Prevention
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• 제14권4호
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• pp.2213-2216
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• 2013

Recently, use of natural products available from marine sources, and especially algae products, are receiving more attention. Scientific evidence for claimed nutraceutical and therapeutical effects of one such marine algae product, fucoxanthin, is discussed in this paper with a summary of the currently available literature regarding its antioxidant, anti-obesity and anticancer activities. It is safe for use in humans, but as it has poor solubility a nano-suspension mode of delivery may be adopted to improve efficacy of supplments. We conclude from ourliterature review that the marine algae product fucoxanthin has significant antioxidant, anti-obesity and anticancer activity with established mechanisms of action.

• Asian Pacific Journal of Cancer Prevention
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• 제16권16호
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• pp.6831-6839
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• 2015

Multidrug resistance is a principal mechanism by which tumors become resistant to structurally and functionally unrelated anticancer drugs. Resistance to chemotherapy has been correlated with overexpression of p-glycoprotein (p-gp), a member of the ATP-binding cassette (ABC) superfamily of membrane transporters. P-gp mediates resistance to a broad-spectrum of anticancer drugs including doxorubicin, taxol, and vinca alkaloids by actively expelling the drugs from cells. Use of specific inhibitors/blocker of p-gp in combination with clinically important anticancer drugs has emerged as a new paradigm for overcoming multidrug resistance. The aim of this paper is to review p-gp regulation by dietary nutraceuticals and to correlate this dietary nutraceutical induced-modulation of p-gp with activity of anticancer drugs.

• Journal of Dairy Science and Biotechnology
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• 제29권1호
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• pp.55-58
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• 2011

Certain lactic acid bacteria have anti-tumor activity, especially colon cancer. The fermented milk products containing that kind of lactic acid bacteria have to be recommended for human health as excellent health functional foods. This paper have been classified by 5 regions on the functions of lactic acid bacteria related to prevention of colon cancer. 1) Enhancing of host's immune response; Production of cytokines. 2) Binding and degradation of potential carcinogens; Binding and degradation of mutagenicity. 3) The changes of intestinal microflora and production of antitumorigenic or antimutagenic compounds; Production of azoxymethane. 4) Alteration of the metabolic activity of intestinal microflora; Decrease of harmful enzymes in intestinal tract. 5) Alteration of physicochemical conditions in the colon; Decrease of pH and bile acids contents.

• Asian Pacific Journal of Cancer Prevention
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• 제16권13호
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• pp.5137-5141
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• 2015

Prostate cancer is the most common malignancy among males worldwide, and is the second leading cause of cancer death among men in United States. According to GLOBOCAN (2012), an estimated 1.1 million new cases and 307,000 deaths were reported in 2012. The reasons for the increase of this disease are not known, but increasing life expectancy and modified diagnostic techniques have been suggested as causes. The established risk factors for this disease are advancing age, race, positive family history of prostate cancer and western diet (use of fat items). Several other risk factors, such as obesity, physical activity, sexual activity, smoking and occupation have been also associated with prostate cancer risk, but their roles in prostate cancer etiology remain uncertain. This mini-review aims to provide risk factors, disease knowledge, prevalence and awareness about prostate cancer.

• Asian Pacific Journal of Cancer Prevention
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• 제14권2호
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• pp.891-894
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• 2013

The present study was performed to assess the activity of the botulinum toxin A on breast cancer cells. The T47D cell line was exposed to diverse concentrations of the botulinum toxin A and cell viability and apoptosis were estimated using MTT and propidium iodine/annexin V methods, respectively. Botulinum toxin A exerted greater cytotoxic activity in T47D cells in comparison with MCF10A normal cells; this appeared to be via apoptotic processes caspase-3 and -7. In conclusion, botulinum toxin A induces caspase-3 and -7 dependent apoptotic processes in the T47D breast cancer cell line.