• Journal of Korean Society of Coastal and Ocean Engineers
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• v.20 no.5
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• pp.498-509
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• 2008

Reliability analyses of Level I, II and III for bearing capacity, overturning and sliding of quaywall are carried out to investigate their safety levels depending upon its failure modes, and sensitivity analyses of each design variable are performed to find their effects on safety levels of quaywall. Reliability indices was 1.416 for both level II and III for case study I, and with 2.201 and 1.880, respectively, for the case study II at the critical loading conditions. Thus we were able to know that Level II (FORM) approach is good enough to use in practical design. Generally, it was found that probabilities of failure of quaywall were higher for sliding and bearing capacity failure modes and lower for overturning failure mode. From sensitivity analyses, the most influential design variables to reliability index of quaywall were coefficient of friction, residual water pressure and resistance moment for the sliding, overturning and bearing capacity failure modes, respectively. Especially, the sensitivity of reliability index due to inertial force and dynamic water pressures, which include a large COV when earthquake occurs, did not change greatly.

• BMB Reports
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• v.42 no.7
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• pp.401-410
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• 2009

We have developed a targeted lipidomics approach that makes it possible to directly analyze chiral eicosanoid lipids generated in cellular systems. The eicosanoids, including prostaglandins (PGs), thromboxanes (TXs), leukotrienes (LTs) and alcohols (HETEs), have been implicated as potent lipid mediators of various biological processes. Enzymatic formations of eicosanoids are regioselective and enantioselective, whereas reactive oxygen species (ROS)-mediated formation proceeds with no stereo-selectivity. To distinguish between enzymatic and non-enzymatic pathways of eicosanoid formation, it is necessary to resolve enantiomeric forms as well as regioisomers. High sensitivity is also required to analyze the eicosanoid lipids that are usually present as trace amounts (pM level) in biological fluids. A discovery of liquid chromatography-electron capture atmospheric pressure chemical ionization/mass spectrometry (LC-ECAPCI/MS) allows us to couple normal phase chiral chromatography without loss of sensitivity. Analytical specificity was obtained by the use of collision-induced dissociation (CID) and tandem MS (MS/MS). With combination of stable isotope dilution methodology, complex mixtures of regioisomeric and enantiomeric eicosanoids have been resolved and quantified in biological samples with high sensitivity and specificity. Targeted chiral lipidomics profiles of bioactive eicosanoid lipids obtained from various cell systems and their biological implications have been discussed.

• Geomechanics and Engineering
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• v.18 no.1
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• pp.1-9
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• 2019

In this study, both 2D and 3D failure shapes of rock mass above the water-filled cavity are put forward when the surrounding rock mass cannot bear the pressure caused by the water-filled cavity. Based on the analytical expressions derived by kinematic approach, the profiles of active and passive failure patterns are plotted. The sensitivity analysis is conducted to explore the influences of different rock parameters on the failure profiles. During the excavation of the deep tunnels above the karst cavity, the water table always changes because of progressive failure of cavity roof. Therefore, it is meaningful to discuss the effects of varying water level on the failure patterns of horizontal rock layers. The changing laws of the scope of the failure pattern obtained in this work show good consistency with the fact, which could be used to provide a guide in engineering.

• Journal of the East Asian Society of Dietary Life
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• v.9 no.3
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• pp.378-385
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• 1999

A reduced NaCl intake for the general population of the world has been recommended to reduce the overall blood pressure level and hence to reduce the overall incidence of cardiovascular disease. A high NaCl diet convincingly contributes to elevated arterial pressure in humans and animal models of hypertension. Among individuals there is considerable variability of blood pressure responsiveness to NaCl intake. In normotensive as well as hypertensive subjects, blood pressure can be judged to be salt sensitivity (SS) when observed to vary directly and substantially with the net intake of NaCl. The prevalence of SS in normotensive adults in the U.S. ranges from 15% to 42% and in hypertensive adults from 28% to 74%. SS is a risk factor for hypertension and may be an important marker in the identification of children for hypertension prevention programs. High NaCl intakes produce expansion of the extracellular fluid volume and thus increase blood pressure. Nonchloride salts of sodium does not expand the extracellular fluid volume and does not alter blood pressure. Blood pressure response to NaCl may be modified by other components of the diet. Low dietary intakes of potassium or calcium augment NaCl-induced increases of blood pressure. Conversely, high dietary intakes of potassium or calcium attenuate NaCl-induced hypertension. A greater intakes of potassium or calcium may prevent or delay the occurrence of hypertension. SS occurs when dietary potassium is even marginally deficient but is dose-dependently suppressed when dietary potassium is increased within its normal range. Orally administered KHCO$_3$, abundant in fruits and vegetates, but not KCl has a calcium-retaining effect which may contributed to its reversal of pressor effect of dietary NaCl. Since nutrients other than NaCl also affect blood pressure levels, a reduced NaCl intake should be only one component of a nutritional strategy to lower blood pressure.

• Journal of Energy Engineering
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• v.12 no.2
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• pp.93-100
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• 2003

An estimation methodology of the mass and energy (M/E) release due to the main steam line break (MSLB) has been developed with the RETRAN-3D code. In the case of equipment qualification (EQ), the over-estimated temperature would exceed the design limits of some cables or valves. In order to have a more flexible EQ profiles from the MSLB M/E release, the methodology with the best-estimated code was used. The major conditions affecting the MSLB M/E were found to be the initial SG level, heat transfer between primary and secondary sides, power level, operable protection system, main or auxiliary feedwater availability, and break conditions. The RETRAN-3D models were developed for the Kori unit 1 (KRN-1) which is typical two loop Westinghouse (WH) designed plant. Particularly, a detailed model of the steam generators was developed to estimate a more realistic two-phase heat transfer effect of the steam flow. After the modeling, the methodology has been developed through the sensitivity analyses. The M/E release data generated from the analyses have been used as the input to the inside containment pressure and temperature (P/T) analysis. According to the results at the point of view containment P/T, the Kori unit 1 can have more margin of 5∼15 ㎪ in pressure and 8∼15$^{\circ}C$ in temperature.

• JSTS:Journal of Semiconductor Technology and Science
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• v.14 no.6
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• pp.733-740
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• 2014

A resistive micro Pirani gauge using amorphous silicon (a-Si) thin membrane is proposed. The proposed Pirani gauge can be easily integrated with the other process-compatible membrane-type sensors, and can be applicable for in-situ vacuum monitoring inside the vacuum package without an additional process. The vacuum level is measured by the resistance changes of the membrane using the low noise correlated double sampling (CDS) capacitive trans-impedance amplifier (CTIA). The measured vacuum range of the Pirani gauge is 0.1 to 10 Torr. The sensitivity and non-linearity are measured to be 78 mV / Torr and 0.5% in the pressure range of 0.1 to 10 Torr. The output noise level is measured to be $268{\mu}V_{rms}$ in 0.5 Hz to 50 Hz, which is 41.2% smaller than conventional CTIA.

• Proceedings of the Korean Society for Noise and Vibration Engineering Conference
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• 2001.11b
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• pp.1235-1241
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• 2001

Pantograph design process must be considered in terms of stability of aerodynamics and reduction of aeroacoustics. Furthermore Pantograph needs to be insensible to severe circumstance condition like typhoon, tunnel, a change of season. In this paper, robust design of panhead sections is conducted based on the Taguchi's design of experiment method. In the aeroacoustic noise analysis, an acoustic analogy using the Ffowcs Williams and Hawkings (FW-H) equation is used to calculate the flow induced sound pressure level. From the near-field CFD analysis data, the far-field noise is predicted at the positions of 25m away from panhead contact strips. Based on aerodynamic (CFD) and aeroacoustic (FW-H) analysis data, the optimal sizing and positioning ofpanhead elements are determined using robust design optimization method. Design parameters such as thickness, length and radius are controllable factors, while outdoor air temperature and atmospheric pressure are considered as uncontrollable factors in the context of Taguchi's approach. A number of CFD simulation and aeroacoustic analysis are performed based on orthogonal arrays. Using a parameter design procedure associated with signal-to-noise (SIN) ratio and sensitivity analysis, an optimal level of design parameters are extracted to minimize the disconnection ratio between contact strips and catenary system, and reduce the far-field aeroacoustic noise.

• Transactions of the Korean Society of Mechanical Engineers B
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• v.34 no.4
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• pp.443-448
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• 2010

In this paper, the changes in performance parameters, e.g., the combustor pressure, turbine power, engine mixture ratio, temperature of gas generator, and product gas, of a liquid rocket engine employing gas generator cycle with the variations in propellant-supply pressure have been described. Engine performance is numerically calculated using the 13 major system-level variables of the rocket engine. The combustor pressure and turbine power increase with an increase in the oxidizer-supply pressure and decrease with an increase in fuel-supply pressure. The lower mixture ratio of gas generator for increased fuel mass flow rate decreases the gas generator gas temperature and deteriorates the gas material properties as the turbine working fluid. The turbine power decreases with an increase in fuel-supply pressure; this results in a decrease in the main-combustor pressure, which is directly proportional to engine thrust.

• Tuberculosis and Respiratory Diseases
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• v.44 no.3
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• pp.592-600
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• 1997

Background : The level of imposed work of breathing (WOB) is important for patient-ventilator synchrony and during weaning from mechanical ventilation. Triggering methods and the sensitivity of demand system are important determining factors of the imposed WOB. Flow triggering method is available on several modern ventilator and is believed to impose less work to a patient-triggered breath than pressure triggering method. We intended to compare the level of imposed WOB on two different methods of triggering and also at different levels of sensitivities on each triggering method (0.7 L/min vs 2.0 L/min on flow triggering ; $-1\;cmH_2O$ vs $-2cm\;H_2O$ on pressure triggering). Methods : The subjects were 12 patients ($64.8{\pm}4.2\;yrs$) on mechanical ventilation and were stable in respiratory pattern on CPAP $3\;cmH_2O$. Four different triggering sensitivities were applied at random order. For determination of imposed WOB, tracheal end pressure was measured through the monitoring lumen of Hi-Lo Jet tracheal tube (Mallincrodt, New York, USA) using pneumotachograph/pressure transducer (CP-100 pulmonary monitor, Bicore, Irvine, CA, USA). Other data of respiratory mechanics were also obtained by CP-100 pulmonary monitor. Results : The imposed WOB was decreased by 37.5% during 0.7 L/min on flow triggering compared to $-2\;cmH_2O$ on pressure triggering and also decreased by 14% during $-1\;cmH_2O$ compared to $-2\;cmH_2O$ on pressure triggering (p < 0.05 in each). The PTP(Pressure Time Product) was also decreased significantly during 0.7 L/min on flow triggering and $-1\;cmH_2O$ on pressure triggering compared to $-2\;cmH_2O$ on pressure triggering (p < 0.05 in each). The proportions of imposed WOB in total WOB were ranged from 37% to 85% and no significant changes among different methods and sensitivities. The physiologic WOB showed no significant changes among different triggering methods and sensitivities. Conclusion : To reduce the imposed WOB, flow triggering with sensitivity of 0.7 L/min would be better method than pressure triggering with sensitivity of $-2\;cm\;H_2O$.

• 한국연소학회:학술대회논문집
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• 2003.05a
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• pp.247-253
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• 2003

Burning velocities of conventional methane flame and oxygen-enriched methane flame were determined by experimentally and numerically at atmospheric pressure in order to examine the validity of various detailed reaction mechanisms in oxygen-enriched flame. The schlieren system was adopted to obtain the burning velocity of flame stabilized on a circular nozzle. Premix code was employed to compute the burning velocity. Three reaction mechnisms were tested at several oxygen enrichment level, whose names are GRI 3.0, MB(Miller and Bowman) and LKY(Lee Ki Yong) reaction mechanism. Sensitivity analysis was also performed to discriminate dominantly affecting reaction on burning velociy. The results showed that conventional reaction mechanisms originally based on methane-air flame were underpredict the burning velocity at high oxygen-enrichment level. The modified GRI 3.0 reaction mechanism based on our experimental results was suggested and shows a good agreement in estimating the burning velocity and the NO number density of oxygen-enriched flame.