• Clinical Nutrition Research
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• 제12권1호
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• pp.40-53
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• 2023

Differential bitterness perception associated with genetic polymorphism in the bitter taste receptor gene taste 2 receptor member 38 (TAS2R38) may influence an individual's food preferences, nutrition consumption, and eventually chronic nutrition-related disorders including cardiovascular disease. Therefore, the effect of genetic variations on nutritional intake and clinical markers needs to be elaborated for health and disease prevention. In this study, we conducted sex-stratified analysis to examine the association between genetic variant TAS2R38 rs10246939 A > G with daily nutritional intake, blood pressure, and lipid parameters in Korean adults (males = 1,311 and females = 2,191). We used the data from the Multi Rural Communities Cohort, Korean Genome and Epidemiology Study. Findings suggested that the genetic variant TAS2R38 rs10246939 was associated with dietary intake of micronutrients including calcium (adjusted p = 0.007), phosphorous (adjusted p = 0.016), potassium (adjusted p = 0.022), vitamin C (adjusted p = 0.009), and vitamin E (adjusted p = 0.005) in females. However, this genetic variant did not influence blood glucose, lipid profile parameters, and other blood pressure markers. These may suggest that this genetic variation is associated with nutritional intake, but its clinical effect was not found. More studies are needed to explore whether TAS2R38 genotype may be a potential predictive marker for the risk of metabolic diseases via modulation of dietary intake.

• 한국연소학회지
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• 제13권2호
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• pp.1-6
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• 2008

An experimental study of the flame response in a turbulent premixed combustor has been conducted with room temperature, atmospheric pressure inlet conditions using premixed natural gas. The fuel is premixed with the air upstream of a choked inlet to avoid equivalence ratio fluctuations. Therefore the observed flame response is only the result of the imposed velocity fluctuations, which are produced using a variable speed siren. Measurements are made of the velocity fluctuation in the nozzle using hot wire anemometry and of the heat release fluctuation in the combustor using chemiluminescence emission. The results are analyzed to determine the phase and gain of the flame transfer function as a function of the modulation frequency. Of particular interest is the effect of flame structure on the flame response predictions and measurements. The results show that both the gain and the phase of flame transfer function are closely associated with the flame length and structure, which is dependent upon the upstream flow perturbation as well as equivalence ratio in the current study.

• Biomolecules & Therapeutics
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• 제13권3호
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• pp.138-142
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• 2005

Adenosine and GABA are known to be major inhitory neurotransmitters in the central nervous system and its receptors mediate various neurophamacological effects including cardiovascular modulatory effects. Inhibitory cardiovascular effects induced by intrathecal (i.t.) administration of adenosine $A_1$ receptor agonist and its modulation by cyclic AMP was suggested by our previous report. In this experiment, we examined the modulation of cardiovascular effects of adenosine $A_1$ receptor and adenosine $A_2$ receptor by $GABA_B$ receptors antagonist in the spinal cord. I.t. administration of 10 nmol of $N^6$-cyclohexyladenosine (CHA, an adenosine $A_1$ receptor agonist), I.t. administration of 2 nmol of 5'-(N-cyclopropyl)-carboxamidoadenosine (CPCA, an adenosine $A_2$ receptor agonist), pretreatment with 5-aminovaleric acid (a $GABA_B$ receptor antagonist, 50 nmol, i.t.) prior to administration of CHA and pretreatment with 5-aminovaleric acid (a $GABA_B$ receptor antagonist, 50 nmol, i.t.) prior to administration of CPCA were performed in anesthetized, artificially ventilated Sprague-Dawley rats. I.t. administration of 50 nmol of 5-aminovaleric acid significantly attenuated the inhibitory cardiovascular effects of CHA but did not attenuated the inhibitory cardiovascular effects of CPCA. It is suggested that cardiovascular responses of adenosine $A_1$ receptor is modulated by $GABA_B$ receptor and adenosine $A_2$ receptor is not modulated by $GABA_B$ receptor in the spinal cord.

• 대한기계학회논문집B
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• 제29권8호
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• pp.963-970
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• 2005

The combustion instability of turbulent flames is the most important problem of the gas turbine combustor. Thus improved understanding of mechanisms of combustion instability is necessary for the design and operation of gas turbine combustors. In this study, the cause of the combustion instability in a rearward-step dump combustor was investigated with respect to the fuel flow modulation; choked fuel flow, unchoked fuel flow and fully premixed mixture flow. We observed various types of combustion instabilities with respect to the change of equivalence ratio, fuel flow conditions and fuel injection location. Particularly in the unchoked fuel flow condition, it was found that the oscillation time of combustion instability is strongly related to the convection time of the fuel and that the pressure fluctuation in a lab-scale combustor is highly related to the vortex and the equivalence ratio fluctuations due to fuel flow modulation and unmixedness of the fuel and air.

• 대한기계학회논문집A
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• 제21권10호
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• pp.1636-1647
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• 1997

As most of today's automatic transmissions in passenger car adopt a electro-hydraulic control system, the role of electronically controlled solenoid valves occupies an important position and it is essential to predict solenoid transient characteristics in order to design and evaluate the performance of the hydraulic control system. However, in general, both the magnetic and electrical parameters f the solenoid system are hardly known and it is not easy to model this section with moderate complexity although mechanical system could be developed using the classical second order system. This paper presents a dynamic modelling technique of a solenoid valve, that is controlled by pulse width modulation for an automatic transmission, in terms of system identification theory. In nonlinear computer simulation, it is shown that the identified systems which produce magnetic force to input duty cycle for various excitation signals predict the static and dynamic performance very well near the operating point and in experiment conducted to confirm the validity of identification theory for PWM solenoid valve, we find that there is a good agreement between the experimental data and simulation result. Hence, this model can be utilized in the development of pressure control system with PWM solenoid valve.

• 한국정보통신학회:학술대회논문집
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• 한국해양정보통신학회 2005년도 춘계종합학술대회
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• pp.947-950
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• 2005

본 논문에서는 전차 포탑의 선회, 고저를 담당하던 기존의 유압시스템을 모터를 사용하는 전기시스템으로 대체한 후 이 시스템에 벡터제어기법을 적용하였다. 모터의 각 상에 원하는 교류 전류를 공급하기 위한 전압원 인버터의 스위칭 방법으로는 주로 사용하는 공간벡터 PWM 변조방식 보다는 연산량이 적어서 빠른 연산을 수행할 수 있는 MIN-MAX PWM 변조방식을 사용하였으며 디지털 필터를 설계 적용하였다. 설계된 전류제어기는 전차의 환경시제에서 전류제어, 속도제어, 주파수응답 및 속도 궤적 추종 실험을 하였으며 그 성능을 입증하였다.

• 한국음향학회지
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• 제9권2호
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• pp.42-52
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• 1990

음향전파 측정에 상호상관법(직접법과 M계열 변조상관법)을 이용하므로서 임펄스 입력에 의한 경우와 같은 결과를 얻을 수 있다는 것과, 또 상호상관법의 특징인 외란노이즈의 영향을 줄일 수 있었던 것 등을 건축음향분야에서 측정계를 대상으로 하여 이론적으로 정리하였다. 또 이들 계측법을 응용하여 흡음재료의 사입사 흡음특성의 측정, 실의 단독 단음응답 및 잔향감쇄 과정의 측정, 음압레벨 분포, 차음성능 등을 측정하고 여러 건축음향측정에서 이들 방법이 유효하다는 것을 실험적으로 확인하였다.

• Nutrition Research and Practice
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• 제9권1호
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• pp.49-56
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• 2015

BACKGROUND/OBJECTIVES: Glutathione S-transferase (GST) forms a multigene family of phase II detoxification enzymes which are involved in the detoxification of reactive oxygen species. This study examines whether daily supplementation of kale juice can modulate blood pressure (BP), levels of lipid profiles, and blood glucose, and whether this modulation could be affected by the GSTM1 and GSTT1 polymorphisms. SUBJECTS/METHODS: 84 subclinical hypertensive patients showing systolic BP over 130 mmHg or diastolic BP over 85 mmHg received 300 ml/day of kale juice for 6 weeks, and blood samples were collected on 0-week and 6-week in order to evaluate plasma lipid profiles (total cholesterol, triglyceride, HDL-cholesterol, and LDL-cholesterol) and blood glucose. RESULTS: Systolic and diastolic blood pressure was significantly decreased in all patients regardless of their GSTM1 or GSTT1 polymorphisms after kale juice supplementation. Blood glucose level was decreased only in the GSTM1-present genotype, and plasma lipid profiles showed no difference in both the GSTM1-null and GSTM1-present genotypes. In the case of GSTT1, on the other hand, plasma HDL-C was increased and LDL-C was decreased only in the GSTT1-present type, while blood glucose was decreased only in the GSTT1-null genotype. CONCLUSIONS: These findings suggest that the supplementation of kale juice affected blood pressure, lipid profiles, and blood glucose in subclinical hypertensive patients depending on their GST genetic polymorphisms, and the improvement of lipid profiles was mainly greater in the GSTT1-present genotype and the decrease of blood glucose was greater in the GSTM1-present or GSTT1-null genotypes.

• 한국진공학회:학술대회논문집
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• 한국진공학회 2013년도 제45회 하계 정기학술대회 초록집
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• pp.220-220
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• 2013

Surface-normal transmission electro-absorption modulator (EAM) are attractive for high-definition (HD) three-dimensional (3D) imaging application due to its features such as small system volume and simple epitaxial structure [1,2]. However, EAM in order to be used for HD 3D imaging system requires uniform modulation performance over large area. To achieve highly uniform modulation performance of EAM at the operating wavelength of 850 nm, it is extremely important to remove the GaAs substrate over large area since GaAs material has high absorption coefficient below 870 nm which corresponds to band-edge energy of GaAs (1.424 eV). In this study, we propose and experimentally demonstrate a transmission EAM in which highly selective backside etching methods which include lapping, dry etching and wet etching is carried out to remove the GaAs substrate for achieving highly uniform modulation performance. First, lapping process on GaAs substrate was carried out for different lapping speeds (5 rpm, 7 rpm, 10 rpm) and the thickness was measured over different areas of surface. For a lapping speed of 5 rpm, a highly uniform surface over a large area ($2{\times}1\;mm^2$) was obtained. Second, optimization of inductive coupled plasma-reactive ion etching (ICP-RIE) was carried out to achieve anisotropy and high etch rate. The dry etching carried out using a gas mixture of SiCl4 and Ar, each having a flow rate of 10 sccm and 40 sccm, respectively with an RF power of 50 W, ICP power of 400 W and chamber pressure of 2 mTorr was the optimum etching condition. Last, the rest of GaAs substrate was successfully removed by highly selective backside wet etching with pH adjusted solution of citric acid and hydrogen peroxide. Citric acid/hydrogen peroxide etching solution having a volume ratio of 5:1 was the best etching condition which provides not only high selectivity of 235:1 between GaAs and AlAs but also good etching profile [3]. The fabricated transmission EAM array have an amplitude modulation of more than 50% at the bias voltage of -9 V and maintains high uniformity of >90% over large area ($2{\times}1\;mm^2$). These results show that the fabricated transmission EAM with substrate removed is an excellent candidate to be used as an optical shutter for HD 3D imaging application.

• 에너지공학
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• 제22권4호
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• pp.394-398
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• 2013

최근들어 자동차에어콘 콤프레셔의 전기마그네트식 콘트롤밸브는 내부형 스워시 프레이트형을 사용하고 있다. 이 시스템은 외부로부터 공급되는 전류량(신호)에 의하여 작동되며 동시에 스워시판 작동에 의한 압력은 냉매가 흐르는 비율에 의하여 결정된다. 본 논문에서는 압축기의 크랭크케이스 압력이 전기마그네트 콘트롤 밸브 전기 흐름량에 따른 유량의 값을 측정하여 엔진의 효율을 향상시키고자 한다.