• Journal of the Korean Society of Manufacturing Technology Engineers
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• v.22 no.2
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• pp.235-240
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• 2013

This paper presents a disposable microfluidic infusion pump using the restoring force of elastomeric membrane of Polydimethylsiloxane. Microfluidic infusion pump consists of hydraulic resistance control part, elastomeric blister actuator part, drug inlet and outlet. Expanded elastomeric blister actuator continuously pushes liquid in the chamber to outlet. At same time, microchannel diameter near the outlet was controlled by thin elastomeric membrane in hydraulic resistance control part. Eventually flow rate of infused liquid is controlled by air pressure. In experimental study, the amount of the filled liquid in the blister is precisely controlled by the height of the blister. Flow rate of infused liquid could be controlled, that is, controlled release of the drug over time was possible by adjusting hydraulic resistance and restoring pressure with the blister actuator.

• Journal of the Society of Naval Architects of Korea
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• v.44 no.6
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• pp.627-634
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• 2007

A bonded plate or a coated part can be debonded by external impact or thermal expansion. To analyse adhesive strength, the blister test is generally adopted. In this paper, a blister test is modelled theoretically and then the stability and bifurcation of the blister are studied under several different cases. The blister is simplified to consist of a pure bending plate attached elastically to the rigid substrate. Expression of the energy release rate is obtained as a form of an explicit function for a circular-type blister or tunnel-type blister grown by controlling the internal pressure or internal volume. Stability and bifurcation are also studied in the frame of the quasi-static evolution. The study shows that the circular- type blister propagates with the first mode of bifurcation and that the tunnel-type blister propagates with a regular wave. It is proved that the waves have the same form on two side lines of the tunnel and that the wave length can be obtained. When the internal pressure is controlled, the blister is unstable, but when the internal volume is controlled, it is stable.

• Proceedings of the KSME Conference
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• 2003.11a
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• pp.1133-1138
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• 2003

The pressure tubes, which contain high temperature heavy water and fuel, are within the core of a CANDU nuclear reactor, and are thus subjected to high stresses, temperature gradient, and neutron flux. Further, it is well known that pressure tubes of cold-worked Zr-2.5Nb materials result in hydrogen diffusion, which create fully-hydrided regions (frequently called Blister). Thus a proper investigation of hydrogen diffusion within zirconium-alloy nuclear components, such as CANDU pressure tube and fuel channels is essential to predict the structural integrity of these components. In this respect, this paper presents numerical investigation of hydrogen diffusion to quantify the hydrogen concentration for blister growth of CANDU pressure tube. For this purpose, coupled temperature-hydrogen diffusion analyses are performed by means of two-dimensional finite element analysis. Comparison of predicted temperature field and blister with published test data shows good agreement.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.28 no.2
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• pp.189-195
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• 2004

The pressure tubes, which contain high temperature heavy water and fuel, are within the core of a CANDU nuclear reactor, and are thus subjected to high stresses, temperature gradient, and neutron flux. Further, it is well known that pressure tubes of cold-worked Zr-2.5Nb materials result in hydrogen diffusion, which create fully-hydrided regions (frequently called Blister). Thus a proper investigation of hydrogen diffusion within zirconium-alloy nuclear components, such as CANDU pressure tube and fuel channels is essential to predict the structural integrity of these components. In this respect, this paper presents numerical investigation of hydrogen diffusion to quantify the hydrogen concentration fur blister growth of CANDU pressure tube. For this purpose, coupled temperature-hydrogen diffusion analyses are performed by means of two-dimensional finite element analysis. Comparison of predicted temperature field and blister with published test data shows good agreement.

• Korean journal of dermatology
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• v.56 no.9
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• pp.577-578
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• 2018

• Journal of the Korean Society for Precision Engineering
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• v.19 no.11
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• pp.174-182
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• 2002

The integrity evaluation of pressure tube is essential for the safety of CANDU reactor, and integrity must be assured when flaws or contacts between pressure tube and surrounding calandria tube are found. In order to complete the integrity evaluation, not only complicated and iterative calculation procedures but also a lot of data and knowledge are required. For this reason, an integrity evaluation system, which provides an efficient way of the evaluation with the help of attached databases, was developed. The developed system was built on the basis of ASME Sec.？ and FFSG issued by the AECL, and applicable for the evaluation of blister, sharp flaw and blunt notch. Delayed hydride cracking and blister evaluation modules are included in the general flaw and notch evaluation module. In order to verify the developed system, several case studies have been performed and the results were compared with those from AECL. A good agreement was observed between those two results.

• Nuclear Engineering and Technology
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• v.33 no.2
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• pp.192-200
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• 2001

Hydride blisters were formed on the outer surface of Zr-2.5Nb pressure tube by a non- uniform steady thermal diffusion process. A thermal gradient was applied to the pressure tube with a heat bath kept at a temperature of 415$^{\circ}C$ and an aluminum cold finger cooled with flowing water of 15$^{\circ}C$. Optical microscopy and tree-dimensional laser profilometry were used to characterize the hydride blisters with different hydrogen concentrations and thermal diffusion time. Hydride blisters were expected to start at a hydrogen concentration of 30 - 70 ppm and a thermal diffusion time of 4 - 6$\times$10$^{5}$ sec. The hydride blister size increases with higher hydrogen concentrations and longer thermal diffusion time . Some of the samples revealed cracks on the hydride blisters. The ratio of hydride blister depth to height was estimated as approximately 8: 1.

• Korean Journal of Acupuncture
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• v.28 no.3
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• pp.141-150
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• 2011

Objectives : The aims of this study were to evaluate a blister caused by cupping. Methods : We searched relevant case reports, survey, and review articles using databases of online bibliography. Results : 1. The fluid in the blister caused by cupping therapy is normal substance by laboratory analysis. The fluid has no signs of infection in the culture, Gram stain, or tissue biopsy 2. In histological finding, the blister caused by cupping therapy is made by dermo-epidermal seperation at subcellular level. Suction blistering was neither inflammatory nor autolysis activation of lysosomal hydrolases. 3. Blistering times directly, related to suction pressure. Suction blister formation time is accelerated in older subjects compared with younger individuals and higher temperature was more susceptable to the blister compared with lower temperature. The flexor aspect of forearm is a easy site for suction blister formation compared with leg and abdominal site. 4. Blister caused by cupping therapy is treated by regular and judicious changes of sterile dressing over several weeks. The vesicles healed well and left no visible scar. Conclusions : Blister caused by cupping therapy is artificially controlled by doctor's therapeutic purpose. Blister is not histologically injurious to health and the blister is a natural concomitant after cupping therapy.

• Nuclear Engineering and Technology
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• v.35 no.5
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• pp.369-377
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• 2003

Since Zr-2.5Nb pressure tubes have a high risk for the formation of blisters during their operation in pressurized heavy water reactors, there has been a strong incentive to develop a method for the non-destructive detection of blisters grown on the tube surfaces. However, because there is little mismatch in acoustic impedance between the hydride blisters and zirconium matrix, it is not easy to distinguish the boundary between the blister and zirconium matrix with conventional ultrasonic methods. This study has focused on the development of a special ultrasonic method, so called ultrasonic velocity ratio method for a reliable detection of blisters formed on Zr-2.5Nb pressure tubes. Hydride blisters were grown on the outer surface of the Zr-2.5Nb pressure tube using a cold finger attached to a steady state thermal diffusion equipment. To maximize a difference in the ultrasonic velocity in hydride blisters and the zirconium matrix, the ultrasonic velocity ratio of longitudinal wave to shear wave, $V_L/V_S$, has been determined based on the flight time of the longitudinal echo and reflected shear echo from the outer surface of the tubes. The feasibility of the ultrasonic velocity ratio method is confirmed by comparing the contour plots reproduced by this method with those of the blisters grown on the Zr-2.5Nb pressure tubes.

• Journal of Mechanical Science and Technology
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• v.17 no.7
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• pp.947-957
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• 2003

The pressure tube is a major component of the CANDU reactor, which supports nuclear fuel bundle. In order to complete the integrity evaluation of pressure tube, expert knowledge, iterative calculation procedures and a lot of input data are required. More over, results of integrity assessment may be different according to the evaluation method. For this reason, an integrity evaluation system, which provides efficient way of evaluation with the help of attached database, was developed. The present system was built on the basis of 3D FEM results, ASME Sec. XI, and Fitness For Service Guidelines for CANDU pressure tubes issued by the AECL (Atomic Energy Canada Limited). The present system also covers the delayed hydride cracking and the blister evaluation, which are the characteristics of pressure tube integrity evaluation. In order to verify the present system, several case studies have been performed and the results were compared with those from AECL. A good agreement was observed between those two results.