Journal of the Korean Society of Manufacturing Technology Engineers (한국생산제조학회지)

The Korean Society of Manufacturing Technology Engineers (한국생산제조학회)
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Disposable Microfluidic Infusion Pump using Elastomeric Blister Actuator

탄성 블리스터 액츄에이터를 이용한 일회용 미세유체 주입펌프

  • 장웅기 (강원대학교 기계메카트로닉스공학과 대학원) ;
  • 김형진 (강원대학교 기계메카트로닉스공학과 대학원) ;
  • 김병희 (강원대학교 기계메카트로닉스공학과) ;
  • 서영호 (강원대학교 기계메카트로닉스공학과 대학원)
  • Received : 2012.04.17
  • Accepted : 2012.11.13
  • Published : 2013.04.15
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Abstract

This paper presents a disposable microfluidic infusion pump using the restoring force of elastomeric membrane of Polydimethylsiloxane. Microfluidic infusion pump consists of hydraulic resistance control part, elastomeric blister actuator part, drug inlet and outlet. Expanded elastomeric blister actuator continuously pushes liquid in the chamber to outlet. At same time, microchannel diameter near the outlet was controlled by thin elastomeric membrane in hydraulic resistance control part. Eventually flow rate of infused liquid is controlled by air pressure. In experimental study, the amount of the filled liquid in the blister is precisely controlled by the height of the blister. Flow rate of infused liquid could be controlled, that is, controlled release of the drug over time was possible by adjusting hydraulic resistance and restoring pressure with the blister actuator.

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References

  1. Nir. Y., Paz, A., Sabo, A., and Potasman, I., 2003, "Fear of injections in young adults,", Am. J. Trop. Med. Hyg, Vol. 68, pp. 341-344.
  2. Kermode, M., 2004, "Unsafe injections in low-income country health settings : need for injection safety promotion to prevent the spread of blood-borne viruses," healthPromot. Int, Vol. 19, pp. 95-103.
  3. Mitragotri, S., 2004, "Current status and future potential of transdermal grug delivery," Nat. Rev. Grug Discov, Vol. 3, pp. 124-125.
  4. Hoffman, P. N., Abuknesha, R.a., Andrews, N.J., Samuel, D., and Lioyd, J.S., 2001, "Amodel to assess the infection potential of jet injectiors used in mass immunisation," Vaccine, Vol. 19, pp. 4020-4027. https://doi.org/10.1016/S0264-410X(01)00106-2
  5. Theintz, G. E., and Sizonenko,P. C., 2009, "Risks of jet injection of insulin in children," Eur. J. Pediatr., Vol. 150, pp. 554-556.
  6. You, J. I., Han, Y. H., and Hah, J. M, 2011, "Painless microjet injector using laser pulse energy," The Korean Society of Mechanical Engineers, Vol. 36, No. 6, pp. 587-593.
  7. Prausnitz, M. R., 2004, "Microneedles for transdermal drug delivery," Advanced Drug Delivery Reviews, Vol. 56, pp. 581-587. https://doi.org/10.1016/j.addr.2003.10.023
  8. Skryabian, E. A., and Dunn, T. S., 2006, "Disposable infusion pumps," Am J Health-Syst Pharm, Vol. 63, pp. 1260-1268. https://doi.org/10.2146/ajhp050408
  9. Touitou, T., 2002, "Drug delivery across the skin, expert opin," Biol.Ther., Vol. 2, pp. 723-733.
  10. Hilt, J. Z., and Peppas, N. A., 2005, "Microfabricated drug delivery devices," International Journal of Pharmaceutics, Vol. 306, pp. 15-23. https://doi.org/10.1016/j.ijpharm.2005.09.022
  11. Gerstel, M .S., and Place, V. A., 1976, Drug delivery device, US Patent No. 3,964,482.
  12. Recasens, B. S., and Papaceit, J., 2002, "Use of elastomeric pumps for continuous intravenous analgesia administration in ambulatory surgery pain management," Ambul Surg, Vol. 10, pp. 3-7. https://doi.org/10.1016/S0966-6532(02)00019-7
  13. Mizuuchi, M., Yamakage, M., and Iwasaki, S., 2003, "The infusion rate of most disposable, nonelectric infusion pumps decreases under hypobaric conditions," Can J An-aesth, Vol. 50, pp. 657-62. https://doi.org/10.1007/BF03018707
  14. LeBlanc, K. A., Bellanger, D., and Rhynes, V. K., 2005, "Evaluation of continuous infusion of 0.5% bupivacaine by elastomeric pump for postoperative pain management after open inguinal hernia repair," J Am Coll Surg, Vol. 200, pp. 198-202. https://doi.org/10.1016/j.jamcollsurg.2004.10.011
  15. Capdevila, X., Macaire, P., and Aknin, P., 2003, "Patient-controlled perineural analgesia after ambulatory orthopedic surgery: a comparison of electronic versus elastomeric pumps," Anesth Analg, Vol. 96, pp. 414-417.
  16. Ganapathy, S., Amendola, A., and Lichfield, R., 2000, "Elastomeric pumps for ambulatory patient controlled regional analgesia," Can J Anaesth, Vol. 47, pp. 897-902. https://doi.org/10.1007/BF03019672
  17. Maillefer, D., Gamper, S., Frehner, B., Balmer, P., van Lintel H., and Renaud P., 2001, "A high-performance silicon micropump for disposable drug delivery systems," Technical Digest, Vol. 14, pp. 413-417.
  18. Kim, H. J., Seo, Y. H., and Kim, B. H., 2010, "Flow rate control in microchannels baesd on contact angle and fluidic resistance," Korean society of manufacturing technology engineers, Vol. 10, pp. 495-498.
  19. Yoon, S. H., Vimalier, R. O., Kim, K. H., Seo, Y. H., and Mofrad, M. R. K., 2010, "Analysis of circular PDMS microballoons with ultralarge deflection for MEMS design," Journal of Microelectro mechanical Systems, Vol. 19, No. 4, pp. 854-864. https://doi.org/10.1109/JMEMS.2010.2049984
  20. Chien W. Z., 1947 "Large deflection of a circular clamped plate under uniform pressure," Chinese Journal of Physics, Vol. 7, pp. 102-113.
  21. Liu, M., Sun, J., Sun, Y., Bock, C., and Chen, Q., 2009, "Thickness-dependent mechanical properties of polydimethylsiloxane membranes," J. Micromech. Microeng. Vol. 19, pp. 035028. https://doi.org/10.1088/0960-1317/19/3/035028
  22. Gupta, J., Park, S. S., Bondy, B., Felner, E. I., and Prausnitz, M. R., 2011, "Infusion pressure and pain during microneedle injection into skin of human subjects," Biomaterials, Vol. 32, pp. 6823-6831. https://doi.org/10.1016/j.biomaterials.2011.05.061
  23. Sawano, S., Naka, S., Werber, A., Zappe, H., and Konishi, S., 2008, "Sealing method of PDMS as elastic material for MEMS," Proc. IEEE 21st Int. Conf. MEMS, pp. 419-422.
  24. Doh, I., and Cho, Y. H., 2009, "A passive flow-rate regulator using pressure-dependent autonomous deflection of parallel membrane valves," Transactions of the KSME A, Vol. 33, No 6, pp. 573-576. https://doi.org/10.3795/KSME-A.2009.33.6.573

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