• Asian Pacific Journal of Cancer Prevention
• /
• 제14권10호
• /
• pp.5883-5890
• /
• 2013

Previously, we demonstrated overexpression of semaphorin4D (SEMA4D, CD100) to be closely related to tumor angiogenesis in epithelial ovarian cancers (EOCs). However, the function and expression of SEMA4D in the EOC microenvironment has yet to be clarified in detail. In this study, we confirmed that overexpression of SEMA4D in primary tumors and ascites was related to low differentiation, platinum resistance and a refractory status (P<0.05), while high M2 macrophage count and percentage were evident in EOC patients with advanced FIGO stage and platinum resistance (P<0.05), using immunohistochemistry, enzyme-linked immunosorbent assay (ELISA), and fluorescence-activated cell sorting (FACS), respectively. The data showed correlations of SEMA4D expression and M2 macrophage counts in primary tumors and M2 macrophage percentage in ascites (r=0.281 and 0.355, each P<0.05). In the Cox proportional hazard mode, SEMA4D expression was an independent indicator of overall survival (OS) and progression-free survival (PFS) for EOC patients. Furthermore, higher expression of SEMA4D in ovarian cancer cell lines (SKOV3, A2780, and SW626) and their supernatants were found than that in a human primary cultured ovarian cell and its supernatant by reversed transcript PCR (RT-PCR), Western blotting and ELISA, respectively. Interestingly, peripheral blood monocytes (MOs) tended towards the M2-polarized macrophage phenotype ($CD163^{high}$) in vitro after human recombined soluble SEMA4D protein stimulation. These findings suggest that SEMA4D might possibly serve as a reliable tool for early and accurate prediction of EOC poor prognosis and could playan important role in promoting tumor dissemination and metastasis in the EOC microenvironment. Thus SEMA4D and its role in macrophage polarization in EOC warrants further study.

• 대한토목학회논문집
• /
• 제8권2호
• /
• pp.135-145
• /
• 1988

본(本) 연구(硏究)는 재료(材料)의 배합(配合)이 단순한 mortar를 제작 그 균열발생을 관찰, 측정하여 정적하중(靜的荷重)에 의한 균열 및 일정진폭을 갖는 동적하중(動的荷重)에 의한 균열성장영역 예측을 시도한 것이다. 사용시편은 mortar의 배합비(配合比)와 물-시멘트비(比)를 달리하여 ASTM E 561-80에서 제안한 CLWL-DCB(crack-line-loaded-double-cantilever-beam)의 제1방법인 벽개형(劈開型)모드(opening mode)에 의거 균열성장거동을 측정하였다. 본(本) 실험(實驗)에서는 X-Y recorder에 나타난 하중(荷重)(P)-균열개구변위($2V_1$), 균열개구변위($2V_1$)-균열선단개구변위($2V_2$)의 diagram을 해석하여 정적하중(靜的荷重)에 의한 균열선단의 비선형적인 미소균열을 포함하는 유효균열길이(effective crack length; $a_e$)와 균열선단의 미소균열을 제외한 물리적균열길이(physical crack length; $a_m$) 및 replica 필름으로 구한 균열길이(replica crack length; $a_t$)의 상관관계와 일정진폭을 갖는 반복하중에 의한 $a_e$, $a_m$, $a_t$를 구하여 정적하중(靜的荷重)에 의한 균열특성과 동적하중(動的荷重)에 의한 균열특성을 조사한 것이다.

• 대한기계학회논문집A
• /
• 제37권3호
• /
• pp.405-412
• /
• 2013

본 논문은 크리프 파단 수명평가에 주요인자인 정상상태 크리프 응력을 직관 용접부에 대해 정량화한다. 모재와 용접부의 크리프 특성 불균일이 응력에 미치는 영향을 체계적으로 분석하기 위해, 다양한 용접부 불균일에 대해 이차원 유한요소 크리프 탄성해석을 수행하였다. 용접부는 열영향부를 고려하였으며 각각의 재료는 이상화된 탄성-멱 크리프 법칙을 따른다고 가정하였다. 하중에 따른 영향을 보기 위해 내압과 인장하중에 대해 연구를 수행하였다. 용접부 크리프 응력의 정량화를 위해 크리프 불균일 지수를 도입하였으며, 무차원화된 단면평균응력과 선형적인 관계를 확인하였다. 불균일 지수로 정량화한 응력과 Type IV 영역을 모사한 용접부의 유한요소해석 결과 및 영국전력의 R5 문헌값의 비교를 통해 연구결과의 유효성을 검증하였다.

• 비파괴검사학회지
• /
• 제30권4호
• /
• pp.359-366
• /
• 2010

램파를 구조물 안전진단(structural health monitoring, 이하 SMH) 기법에 효과적으로 적용하기 위해서 구조물의 손상과 램파간의 물리적 특성 및 상호관계를 정확히 이해하는 것이 중요하다. 본 연구에서는 modal decomposition 방법을 이용하여 비대칭 불연속면에서 램파의 투과와 반사, 모드 변이를 모사하고, 그 진폭 비율을 불연속면의 깊이에 따라 예측하였다. 또한 이론적으로 예측된 결과를 압전센서(PZT)를 모사한 유한요소법(FEM) 모델과 실험을 통해 검증하였다. 그 결과, modal decomposition 방법을 이용한 이론적 예측이 압전센서를 이용한 유한요소 해석 및 실험 결과와 근접한 것을 확인하였으며, 불연속면의 깊이에 따른 램파의 반사와 투과, 모드 변이의 양을 이용하여 손상의 크기를 정량적으로 측정할 수 있는 방법을 제안하였다.

• 한국수자원학회논문집
• /
• 제33권3호
• /
• pp.375-382
• /
• 2000

대유역의 지표면 수문현상은 추계학적 변동에 의해 야기되는 안정된 상태의 변이와 함께 몇 개의 발생빈도가 높은 안정된 상태의 영향을 받기가 쉬운데 그 이유는 지표면과 대기 상호관계의 밀접한 조합과도 관계가 있다. 따라서 각 안정상태에서의 체류기간 즉, 가뭄기나 홍수기의 지속기간이 중요한 연구 과제라 할 수 있으며 본 연구에서는 한강유역에 대하여 안정상태의 평균 변이기간을 분석하였다. 비선형 물수지모형을 한강 유역에 대하여 과거의 자료를 바탕으로 검정하였고 모형을 통한 물리과정의 추계학적 표현과 산정된 모형변수들로부터 안정상태사이의 평균 변이기간이 계산되었다. 본 연구는 안정상태 사이의 변이기간 혹은 거주기간, 즉 시스템이 주어진 안정상태에 머무는 기간(가뭄이나 홍수상태의 지속기간)의 예측과 밀접한 관계가 있다.

• 한국의류학회지
• /
• 제38권5호
• /
• pp.611-626
• /
• 2014

Reading and foreseeing fashion trends is crucial and difficult in the fashion industry due to accelerated and diversified changes in fashion trends. We use network analysis to investigate fashion trends from 2004 to 2013 in order to find the inter-relevance among fashion trends. We extracted words from fashion trend info for women's wear provided by Samsung Design Net, created a 2-mode network of seasons and trend languages, and visualized this network using NodeXl program. Fashion trends repeated a unique pattern during the period. In the first half (2004-2008), retro modern, feminine modern, and ecological modern were dominant trends in consecutive order. The years 2009-2013 witnessed distinctive fashion trends in S/S seasons and in F/W seasons. 11F/W, 12F/W and 13F/W seasons were characterized by artistic creative style. From 2010, natural style dominated S/S seasons. 10S/S and 12S/S seasons were distinguished as a calm natural style that reflected a peaceful and simple life. In 11S/S and 13S/S seasons, soft natural style emerged as a sign of increased importance of inner spirit and natural energy. A seasonal reappearance of trends was observed every two years in S/S seasons that enabled the prediction that 14S/S will see another version of natural style. A macroscopic trend for the last 10 years was represented by the keywords 'modern' and 'natural'. 'Modern' involved the past styles such as 60's, Baroque and the origin of human life. 'Natural' was connected with design elements such as material, silhouette and color. Managerial implications and future study directions are discussed based on the results.

• 한국방송∙미디어공학회:학술대회논문집
• /
• 한국방송공학회 2006년도 학술대회
• /
• pp.127-132
• /
• 2006

Quantization in video coding plays an important role in controlling the bit-rate of compressed video bit-streams. It has been used as an important control means to adjust the amount of bit-streams to at]owed bandwidth of delivery networks and storage. Due to the dependent nature of video coding, dependent quantization has been proposed and applied for MPEG-2 video coding to better maintain the quality of reconstructed frame for given constraints of target bit-rate. Since Scalable Video Coding (SVC) being currently standardized exhibits highly dependent coding nature not only between frames but also lower and higher scalability layers where the dependent quantization can be effectively applied, in this paper, we propose a dependent quantization scheme for SVC and compare its performance in visual qualities and bit-rates with the current JSVM reference software for SVC. The proposed technique exploits the frame dependences within each GOP of SVC scalability layers to formulate dependent quantization. We utilize Lagrange optimization, which is widely accepted in R-D (rate-distortion) based optimization, and construct trellis graph to find the optimal cost path in the trellis by minimizing the R-D cost. The optimal cost path in the trellis graph is the optimal set of quantization parameters (QP) for frames within a GOP. In order to reduce the complexity, we employ pruning procedure using monotonicity property in the trellis optimization and cut the frame dependency into one GOP to decrease dependency depth. The optimal Lagrange multiplier that is used for SVC is equal to H.264/AVC which is also used in the mode prediction of the JSVM reference software. The experimental result shows that the dependent quantization outperforms the current JSVM reference software encoder which actually takes a linear increasing QP in temporal scalability layers. The superiority of the dependent quantization is achieved up to 1.25 dB increment in PSNR values and 20% bits saving for the enhancement layer of SVC.

• Nuclear Engineering and Technology
• /
• 제40권7호
• /
• pp.615-624
• /
• 2008

In this paper, the contribution of task types and error types involved in the human-related unplanned reactor trip events that have occurred between 1986 and 2006 in Korean nuclear power plants are analysed in order to establish a strategy for reducing the human-related unplanned reactor trips. Classification systems for the task types, error modes, and cognitive functions are developed or adopted from the currently available taxonomies, and the relevant information is extracted from the event reports or judged on the basis of an event description. According to the analyses from this study, the contributions of the task types are as follows: corrective maintenance (25.7%), planned maintenance (22.8%), planned operation (19.8%), periodic preventive maintenance (14.9%), response to a transient (9.9%), and design/manufacturing/installation (6.9%). According to the analysis of the error modes, error modes such as control failure (22.2%), wrong object (18.5%), omission (14.8%), wrong action (11.1 %), and inadequate (8.3%) take up about 75% of the total unplanned trip events. The analysis of the cognitive functions involved in the events indicated that the planning function had the highest contribution (46.7%) to the human actions leading to unplanned reactor trips. This analysis concludes that in order to significantly reduce human-induced or human-related unplanned reactor trips, an aide system (in support of maintenance personnel) for evaluating possible (negative) impacts of planned actions or erroneous actions as well as an appropriate human error prediction technique, should be developed.

• 대한조선학회지
• /
• 제13권1호
• /
• pp.1-9
• /
• 1976

Using the computer programs for calculation of natural vibrations of ship's hull developed by the authors et al., an investigation into influences of various parameters on the accuracy of calculation was done through example calculations of a 30,000 DWT petroleum products carrier M/S Sweet Brier built by Korea Shipbuilding and Engineering Corporation. The methodical principles employed for the computer program development are as follows; (a) the ship system is reduced to an equivalent discrete elements system conforming to Myklestad-Prohl model, (b) the problem formulation is of transfer matrix method, and (c) to obtain solutions an extended $G\ddot{u}mbel's$ initial value method is introduced. The scope of the investigation is influences of number of discrete elements, choice of significant system parameters such as rotary inertia, bending stiffness and shear stiffness, and simplification of distributions of added mass and stiffness as trapezoidal ones referred to those of midship section on the calculation accuracy. From the investigation the followings are found out; (1) To obtain good results for the modes up to the seven-noded thirty or more divisions of the hull is desirable. For fundamental mode fifteen divisions may give fairly good results. (2) The influence of rotary inertia is negligibly small at least for the modes up to the 5- or 6- noded. (3) In the case of assuming either bending modes or shear modes the calculation results in considerably higher frequencies as compared with those based on Timoshenko beam theory. However, the calculation base on the slender beam theory surprisingly gives frequencies within 10% error for fundamental modes. (4) It is proved that to simplify distributions of added mass and stiffness as trapezoidal ones referred to those of midship section is a promising approach for the prediction of natural frequencies at preliminary design stage; provided good accumulation of data from similar type ships, we may expect to obtain natural frequencies within 5% error.

• JSTS:Journal of Semiconductor Technology and Science
• /
• 제11권4호
• /
• pp.262-271
• /
• 2011

In this work, we present a unified analytical surface potential model, valid for both PD and FD SOI MOSFETs. Our model is based on a simplified one dimensional and purely analytical approach, and builds upon an existing model, proposed by Yu et al. [4], which is one of the most recent compact analytical surface potential models for SOI MOSFETs available in the literature, to improve its accuracy and remove its inconsistencies, thereby adding to its robustness. The model given by Yu et al. [4] fails entirely in modeling the variation of the front surface potential with respect to the changes in the substrate voltage, which has been corrected in our modified model. Also, [4] produces self-inconsistent results due to misinterpretation of the operating mode of an SOI device. The source of this error has been traced in our work and a criterion has been postulated so as to avoid any such error in future. Additionally, a completely new expression relating the front and back surface potentials of an FD SOI film has been proposed in our model, which unlike other models in the literature, takes into account for the first time in analytical one dimensional modeling of SOI MOSFETs, the contribution of the increasing inversion charge concentration in the silicon film, with increasing gate voltage, in the strong inversion region. With this refinement, the maximum percent error of our model in the prediction of the back surface potential of the SOI film amounts to only 3.8% as compared to an error of about 10% produced by the model of Yu et al. [4], both with respect to MEDICI simulation results.