• Biomolecules & Therapeutics
• /
• 제6권3호
• /
• pp.225-231
• /
• 1998

This studies were performed for investigation of mechanism on central antidiuretic action of L$_{G}$-Nitro-L-arginine (L-NOARG), nitic oxide systhase inhibitor, in dog. Antidiuretic action of L-NOARG infused into the carotid artery was not affected by renal denervation but inhibited by pretreatment with arginine, NO Precusor. Furthermore, L-NOARG inhibited the diuretic action of dopamine induced by hemodynamic development. Above results suggest that antidiuretic actions of L-NOARG mediated by endogenous substances not associated with renal nerve. Therefore, it is demonstrated that those endogenous substances might be associated with NO which mediate the diuretic action of dopamine.e.

• Biomolecules & Therapeutics
• /
• 제14권2호
• /
• pp.96-101
• /
• 2006

Amyloid$\beta(A{\beta})$ has been reported have an effect on the induction of oxidative stress that involves the functional and structural abnormalities in Alzheimer's disease. As a role of a radical scavenger, a green tea treatment was found have some inhibitory effect on the neurodegenerative process. The aim of this study was to determine if green tea catechin (GTC) reduces in transgenic model. To test this, transgenic mice carrying neuronspecific enolase (NSE) controlled C-terminus (105) of APP (APP-C105) were created and treated them with a low ana high dose of GTC for 6 months. Herein, we conclude that transgenic mice expressing NSE/APP-C105 were successfully created and the GTC-treated group exhibited significant reduction in body weight. Thus, GTC might be a good prevention of obesity or good treatment for AD patient.

• 미생물학회지
• /
• 제28권4호
• /
• pp.297-303
• /
• 1990

Secretion of Serratia marcescens nuclease by E. coli harboring pNUC4 was investigated. 29.2, 54.2 and 16.6% of total nuclease were observed in culture medium, periplasm, and cytoplasm of E. coli, respectively. To investigate the secretion mechanism of Serratia nuclease by E. coli, secretion kinetics of nuclease was examined in the presences of sodium azide, and energy metabolism inhibitor; procaine, an exoprotein processing inhibitor; and chloramphenicol, a protein synthesis inhibitor. In the presence of sodium azide, periplasmic unclease was gradually decreased and the extracellular nyclease was linearly increased according to the incubation time. Similar results were obtained in presences of procaine and chloramphenicol. From these results, we concluded that two transport processes are involved in nuclease secretion: secretion of nuclease through the inner membrane is occurred by an energy-dependent process and probably requiring precusor processing: secretion of nuclease through outer membrane does not require energy, de novo protein synthesis, and precursor processing.

• 대한전기학회:학술대회논문집
• /
• 대한전기학회 2006년도 제37회 하계학술대회 논문집 B
• /
• pp.1245-1246
• /
• 2006

Ferroelectric PZT (70/30) thick films were fabricated by the screen printing method. And the PZT (30/70) precusor solution were infiltrated by the spin-coating method on the PZT thick films to obtain a densification. All PZT thick films were sintered at $1050^{\circ}C$ for 10 min. Structural properties, such as crystalline structure, microstructures and compositional ratio, of PZT thick films were investigated with the variation of the number of sol coatings using XRD, SEM and EDS, respectively. All PZT thick films exhibited a perovskite polycrystalline structure without a pyrochloer phase. The thickness of PZT thick films, 4-times screen-printed, was approximately $60{\mu}m$. And the densification of the PZT thick films increased with increasing the number of sol coatings.

• 마이크로전자및패키징학회지
• /
• 제9권3호
• /
• pp.1-6
• /
• 2002

A low temperature process technology of copper thin films has been developed by a chemical vapor deposition technology for multi-level metallzations in ULSI fabrication. The copper films were deposited on TiN/Si substrates in helium atmosphere with the substrate temperature between $130^{\circ}C$ and $250^{\circ}C$. In order to get more reliable metallizations, effects on the post-annealing treatment to the electrical properties of the copper films have been investigated. The Cu films were annealed at the $5 \times10^{-6}$ Torr vacuum condition and the electrical resistivity and the nano-structures were measured for the Cu films. The electrical resistivity of Cu films shown to be reduced by the post-annealing. The electrical resistivity of 2.0 $\mu \Omega \cdot \textrm{cm}$ was obtained for the sample deposited at the substrate temperature of $180^{\circ}C$ after vacuum annealed at $300^{\circ}C$. The resistivity variations of the films was not exactly matched with the size of the nano-structures of the copper grains, but more depended on the contamination of the copper films.

• 대한전기학회:학술대회논문집
• /
• 대한전기학회 2006년도 제37회 하계학술대회 논문집 C
• /
• pp.1705-1706
• /
• 2006

Ferroelectric PZT (70/30) thick films were fabricated by the screen printing method. And the PZT (30/70) precusor solution were infiltrated by the spin-coating method on the PZT thick films to obtain a densification. All PZT thick films were sintered at $1050^{\circ}C$ for 10 min. Structural properties, such as crystalline structure, microstructures and compositional ratio, of PZT thick films were investigated with the variation of the number of sol coatings using XRD, SEM and EDS, respectively. All PZT thick films exhibited a perovskite polycrystalline structure without a pyrochloer phase. The thickness of PZT thick films, 4-times screen-printed, was approximately $60{\mu}m$. And the densification of the PZT thick films increased with increasing the number of sol coatings.

• 생명과학회지
• /
• 제7권4호
• /
• pp.309-315
• /
• 1997

The fermented black tea with tea fungus (FBTF) was prepared by culturing tea fungus biomass in black tea with 10% sucrose (BT) at 30$\circ$ for 14 days. The flavor quality of FBTF was investigated by sensory and chemical analysis, and the results were compared with BT. The data of sensory analysis indicated that fruity, wine-like, sharp-pungent, and vinegar-like flavor notes were increase, while earthy note was reduced during fermentation. GC-MS analysis of volatile compounds collected from FBTF and BT by Tenax trap showed that linalool, liinalool oxide other flavor compounds known as black tea flavor compounds were disappeared. Some major flavor compounds produced during fermentation were acetic acid, ethanol, limonene, $\alpha$-terpineol, and these volatiles may be attributed to the flavor of characteristic FBTF. Biosynthetic pathway for the formation of limonene and $\alpha$-terpineol are proposed through mevalonic acid pathway using acetic acid as precusor and/or through transformation of linalool and linalool oxide.

• 통합자연과학논문집
• /
• 제2권4호
• /
• pp.285-288
• /
• 2009

A synthetic route for 12 metal thiocarboxylate complex, $Cd(SOCCH_3)_2Lut_2$ [Lut = 3,5-dimethylpyridine (lutidine)], were investigated for their potential to act as precursors for the formation of cadmium sulfide nanoparticles. $Cd(SOCCH_3)_2Lut_2$ were characterized by 1H-NMR spectroscopy. Thermal decomposition of $Cd(SOCCH_3)_2Lut_2$ is expected to undergo thiocarboxylic anhydride elimination to give stoichiometric cadmium sulfide nanoparticles and removes the organic supporting ligands cleanly. Prepared cadmium sulfide nanoparticles were characterized by fluorescence and UV-vis absorption spectroscopy and displayed an emission band at 500 nm with an excitation wavelength of 360 nm.

• 한국자기학회지
• /
• 제24권1호
• /
• pp.1-10
• /
• 2014

$Co_2Z$-type hexaferrite 시편을 다양한 합성법을 이용하여 제조하였다. 수열합성법을 이용하여 M-type, $Co_2Y$-type, $Co_2Z$-type을 제조하였으며, 제조된 M-type과 $Co_2Y$-type을 출발물질로 하여 고상반응법(ball milling)과 수열합성법(hydrothermal)으로 $Co_2Z$-type을 제조하였다. 제조된 시편의 결정구조와 미세구조 자기적 성질은 XRD, FESEM, VSM, impedance analyzer를 이용하여 조사하였다. M-type과 $Co_2Y$-type은 단일상의 결정구조를 얻을 수 있었다. 여러 합성법 중에 M+Y ball milling, M+Y hydrothermal에서 제조한 시편이 $Co_2Z$-type hexaferrite의 단일상과 대체로 일치하는 것을 알 수 있었으며, $Co_2Z$-type의 모든 시편들은 이론적인 포화 자화값(50 emu/g)과 비슷한 값을 나타내었다. 소결한 시편들의 투자율은 시약을 precusor로 하여 제조한 $Co_2Z$-type의 투자율이 가장 높았으며, 열처리 온도가 증가함에 따라 투자율은 낮아졌다. 다른 합성법에서는 열처리 온도에 따른 변화가 거의 나타나지 않는 것을 확인할 수 있었다.

• IMMUNE NETWORK
• /
• 제4권4호
• /
• pp.205-215
• /
• 2004

In the early host defense system, effector function of natural killer (NK) cells results in natural killing against target cells such as microbe-infected, malignant, and certain allogenic cells without prior stimulation. NK cell cytotoxicity is selectively regulated by homeostatic prevalence between a repertoire of both activating and inhibitory receptors, and the discrimination of untransformed cells is achieved by recognition of major histocompatibility complex (MHC) class I alleles through inhibitory signals. Although it is well known that the bipotential T/NK progenitors are derived from the common precusor, functional mechanisms in terms of the development of NK cells remain to be further investigated. NK cells are mainly involved in innate immunity, but recent studies have been reported that they also play a critical role in adaptive immune responses through interaction with dendritic cells (DC). This interaction will provide effector functions and development of NK cells, and elucidation of its precise mechanism may lead to therapeutic strategies for effective treatment of several immune diseases.