• Journal of Preventive Medicine and Public Health
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• v.56 no.4
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• pp.384-387
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• 2023

The aim of this study was to present a framework for clinicians to use when discussing electronic cigarette (e-cigarette) use and its association with pre-diabetes. A communication tool was designed using evidence-based strategies from the academic literature. A four-step framework is presented, which includes: step (1) helping patients to understand the association between e-cigarette use and pre-diabetes; step (2) the synergistic health impacts of e-cigarette use and pre-diabetes; step (3) management of diabetes-related lifestyle factors; and step (4) stages of change assessment related to e-cigarette reduction. This communication tool provides support for clinicians to discuss the risk of pre-diabetes associated with e-cigarette use. Moving forward, implementation and evaluation of this model are needed.

• Animal cells and systems
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• v.15 no.3
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• pp.211-218
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• 2011

Fragmentation in human pre-implantation embryos has been suggested as the process of apoptosis. We have previously demonstrated a direct relationship between the increased reactive oxygen species (ROS) and apoptosis in human pre-implantation embryos. ROS is known to suppress the function of mitochondria in which steroidogenic acute regulatory protein (StAR) and peripheral-type benzodiazepine receptor (PBR) are presented. Therefore, the purpose of this study was to examine the expression of StAR and PBR in human pre-implantation embryos and to evaluate whether reduction of these proteins is associated with apoptosis. Apoptosis was detected by annexin V-fluorescein isothiocyanate (FITC) and mitochondrial membrane potential was measured by 5,5',6,6'-tetrachloro-1,1',3,3'-tetraethyl-benzimidazolyl-carbocyanine iodide (JC-1). Immunofluorescence staining and Western blotting were applied to examine the expression of StAR and PBR in the embryos. Lipid droplets in the embryos were stained with Oil Red O. The fragmented pre-implantation embryos were stained with annexin V-FITC, but not the normal ones. The mitochondria with active membrane potential were present less in the fragmented embryos compared with the non-fragmented embryos. We also confirmed that both StAR and PBR were expressed in the embryos and their expression levels were lower in the fragmented ones. In addition, the number and size of lipid droplets were increased in the fragmented embryos. The present study provides evidence that reduction of StAR and PBR in human pre-implantation embryos is associated with an increase in the lipid droplets leading to apoptosis.

• The Research Journal of the Costume Culture
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• v.28 no.5
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• pp.669-676
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• 2020

The purpose of this research was to revive the bathochromic effects of wool fabrics by using natural dyestuffs with minimum heavy metallic mordants. The natural dyestuffs used in this research were the indigo plant, Phellodendron amurense, and Caesalpinia sappan. Sample no. 1 was pre-dyed five times with indigo. Sample no. 2 was pre-dyed five times with indigo and then once dyed with Phellodendron amurense. Following the same method as sample no. 2 with an additional Phellodendron, Sample no. 3 consisted of a pre-dye five times with indigo and twice with Phellodendron amurense. Sample no. 4 was pre-dyed six times with indigo and then once dyed with Caesalpinia sappan. Sample no. 5 followed the same method as no. 4 with an additional dye of Caesalpinia sappan. Sample no. 6 was pre-dyed five times with indigo and then once dyed with Phellodendron amurense and once dyed with Caesalpinia sappan. The results were as follows: first, all samples showed deeper colors. Second, according to the results of the surface K/S measurement, the surface K/S of wool fabrics was >20. Third, the results of lightfastness measurement showed superiority over grade 4 in samples no. 1, 2, 3, 5, and 6. However, sample no. 4 was grade 3. In the colorfastness to washing measurement, sample no. 2 showed greater superiority than grade 3-4, while samples no. 1 and 3 were grade 3. In addition, the colorfastness to dry cleaning for all samples was satisfactory or excellent by more than grade 3.

• Korean Journal of Environmental Biology
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• v.39 no.4
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• pp.452-462
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• 2021

Pretilachlor (PRE) is a common acetanilide herbicide used worldwide. However, its effects on aquatic organisms, particularly marine photosynthetic life, are not sufficiently known. Herein, we evaluated the toxic effects of PRE by physiological and molecular parameters in the photosynthetic dinoflagellate Prorocentrum minimum. The cell density, pigment content, and photosynthetic parameters (F_v/F_m and PI_ABS) were considerably decreased with increased PRE exposure time and doses. In addition, photosynthesis-related genes, PmpsbA, PmpsaA, and PmatpB, were significantly upregulated when exposed to 1.0 mg L^-1 of PRE for 24 h (p<0.001). In 72 h treatment, the relative gene expression was significantly increased (0.1 and 0.5 mg L^-1; p<0.01). In contrast, PmrbcL was decreased or little changed compared to the controls. Reactive oxygen species (ROS) increased after 24 h exposure (p<0.001). However, the transcriptional fold-changes in glutathione S-transferase (GST) were significantly increased (0.5 and 1.0 mg L^-1; p<0.001) at 72 h. These findings suggested that the PmGST might be involved in PRE detoxification in P. minimum. In addition, PRE may affect the photosystem function in phytoplankton similar to other acetanilides, causing severe damage or cell death.

• Journal of Genetic Medicine
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• v.8 no.1
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• pp.17-27
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• 2011

Pre-eclampsia is a major cause of maternal and perinatal mortality and morbidity worldwide, but remains unclear about the underlying disease mechanisms. Pre-eclampsia is currently believed to be a two-stage disease. The first stage involves shallow cytotrophoblast invasion of maternal spiral arteriole, resulting in placental insufficiency. The hypoxic placenta release soluble factors, cytokines, and trophoblastic debris into maternal circulation, which induce systemic endothelial damage and dysfunction. This cause the second stage of the disease: maternal syndrome. Epidemiological research has consistently demonstrated a familial predisposition to pre-eclampsia. Intensive research efforts have been made to discover susceptibility genes that will inform our understanding of the pathophysiology of preeclampsia and that may provide direction for therapeutic or preventative strategies. In this review, we summarize the current understanding of the role of genetic factors in the pathophysiology of pre-eclampsia and explain the molecular approach to search for genetic clues in pre-eclampsia.

• Magazine of the Korean Society of Agricultural Engineers
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• v.17 no.4
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• pp.3921-3930
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• 1975

This research was carried out to investigate several mechanical characteristics of pre-stressed steel beams. The configuration of specimens used for this study were as follows; a cover plate having permissible fiber stress of 4,000 kg/$\textrm{cm}^2$ was welded at bottom having the allowable bending stress 2500 kg/$\textrm{cm}^2$ steel beam, the section ratios of pre-stressed steel beam and cover plate were 0.5 and 0.6. Adopted pre-stresses were 0%, 50%, and 100% of an allowable fiber stress of a steel beam. The results obtained from the study may be summarized as follows; 1. The elastic range of a beam was increased by the application of pre-stress to the beam, which leads to a lighter section. 2. The permissible moment capacity of a pre-stressed steel beam was greated than that of a steel beam without pre-stressing. 3. The equivalent allowable stress induced by adopting the different section ratio of pre-stressed beam to cover plate were figured out 4. The optimum value of section ratio of beam and cover plate was 0.3 to 0.4 in case of a 1.5m span composite beam, a combination of an allowable stress 2,500kg/$\textrm{cm}^2$ steel beam and a permissible fiber stress 4,000 kg/$\textrm{cm}^2$ steel cover plate, was used. 5. The magnitude of the pre-stress was desirable to be same as the allowable stress of a steel beam. 6. It was concluded that if the construction techniques in the field are developed and improved, the practicing of pre-stress to the steel structure has a promising future.

• The Mathematical Education
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• v.51 no.2
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• pp.131-144
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• 2012

The purpose of this study is to investigate the change of mathematics pre-service teachers' teaching behaviors in microteaching. This study is organized along the following lines: 1) mathematics pre-service teachers conduct twice microteachings, 2) the microteaching recordings and lesson observation reports written by pre-service teachers are analyzed. Through reviewing the first microteaching, pre-service teacher have reviewed and found out improvements of their teaching. In the second microteaching, pre-service teachers' teaching behaviors have been positively and effectively changed with respect to teaching methods, proposal of learning objectives, prior knowledge usage, presenting lesson's content, concise descriptions, brief language usages, multimedia, and appropriate questions. However, they frequently used inappropriate expressions from their unconscious habits. Therefore, the educational institutions should provide opportunities involved in well-structured microteaching training program with pre-service teachers, which in turn, help pre-service teachers to have more positive teaching competence.

• Journal of Korean Biological Nursing Science
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• v.13 no.2
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• pp.117-124
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• 2011

Purpose: Dyslipidemia is one of the most important cardiovascular risk factors. The purpose of this study was to compare serum lipid levels in college students and pre-graduates. Methods: Data were obtained from student health examination in one university located in Kyunggi-province. Participants were 440 college students and 1973 pre-graduates. The data were collected in May of 2010. T-test, Chi-square test, Fisher's exact test, and multiple regression with dummy variables using SAS version 9.1 were performed. Results: Pre-graduates showed significantly higher level of total cholesterol, triglyceride, and LDL than college students. There was no significant difference in alcohol drinking between college students and pre-graduates. However, smoking and diet behavior were significantly different; pre-graduates were more likely being current smoker and recommended to change diet behavior. When adjusting covariates including general and behavioral characteristic, pre-graduates had significantly higher total cholesterol (p<.001), triglyceride (p=.003), and LDL (p=.003). Among covariates, smoking was significantly related to triglyceride, particularly past smokers. Conclusion: There is a need to develop a lipid-reducing program targeting pre-graduates. This program should be considered behavioral factors, particularly smoking. In addition, given the fact that pre-graduates had unhealthy habits compared with college students, interventions for correcting health behaviors in this population are required.

• Journal of the Korean Society of Earth Science Education
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• v.10 no.2
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• pp.226-234
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• 2017

The purpose of this study is to investigate the effect of the application of storytelling on pre-service teachers of elementary school who take courses in 'earth's strata and rock' on science teaching concept and science teaching efficacy. The experiment was aimed at one class (32 students) enrolled in the 'earth's strata and rock' course at intensive course through 15 weeks from March to June. The experiment was taking lectures of "earth's strata and rock" for one semester, and the pre-service teachers of elementary school finished class demonstration with storytelling technique by group. The results and analysis of the study were analyzed by the corresponding sample test in before and after the group test. The conclusion of the study is as follows. First, the application of storytelling method on pre-service teachers of elementary school was effective in science concept. teaching efficacy. Second, the application of storytelling method on pre-service teachers of elementary school was effective in science teaching efficacy. Third, the application of storytelling method on pre-service teachers of elementary school responded positively.

• Textile Coloration and Finishing
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• v.28 no.3
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• pp.208-218
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• 2016

This study investigated the effects of the working mechanisms of proteins, mordants, and dyes, as well as the mordanting order, on dye uptake by silk fabric pre-treated with proteins and dyed with freeze-dried sappan wood water extract. Soybean protein and sodium caseinate were used as the proteins. 1. When Al mordants were not used, the dyeability of the fabrics increased upon protein pre-treatment as compared to the case without treatment. 2. Dyeing with protein pre-treatment, followed by mordanting, led to the highest dye uptake, and the optimal protein concentration was 5%. 3. The K/S values slightly decreased with an increase in the dyeing temperature, and the fabric turned dark red in color when dyeing was carried out at increasing temperature. Fabrics showed the highest dye uptake at $40^{\circ}C$. 4. Regarding the effect of time, the K/S values of the fabrics with and without protein treatment showed almost no increase after the initial dyeing time of 10min; further, there was hardly any difference in the cases with and without protein pre-treatment. 5. In case of protein pre-treatment fabrics, the washing fastness was level 2. The dry cleaning fastness showed very excellent result with level 4-5. The rubbing fastness was better in dry rubbing than in wet rubbing of the fabrics. For the light fastness, all dyed fabrics showed low fastness.