• Preventive Nutrition and Food Science
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• 제21권1호
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• pp.38-43
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• 2016

Matrix metalloproteinases (MMPs) are crucial extracellular matrices degrading enzymes that take important roles in metastasis of cancer progression as well as other significant conditions such as oxidative stress and hepatic fibrosis. Natural products are on the rise for their potential to provide remarkable health benefits. In this context, halophytes have been of interest in the nutraceutical field with reported instances of isolation of bioactive compounds. In this study, Limonium tetragonum, an edible halophyte, was studied for its ability to inhibit MMP-2 and -9 using HT1080 fibrosarcoma cells. Results showed that L. tetragonum extract was able to inhibit the enzymatic activity and mRNA expression of MMP-2 and -9 according to gelatin zymography and RT-PCR assays, respectively, but it was not able to significantly change the MMP pathway related factors such as tissue inhibitors of metalloproteinases. Also, Mitogen-activated protein kinases pathway-related protein levels and their phosphorylation were assayed. While the phosphorylated p38 levels were decreased, extracellular signal-regulated kinase and c-Jun N-terminal kinase were not affected by L. tetragonum treatment. In conclusion, it was suggested that L. tetragonum contains substances acting as MMP inhibitors on enzymatic activity rather than intracellular pathway intervention, which could be useful for further utilization of L. tetragonum as a source for anti-MMP agents.

• 한국환경복원기술학회지
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• 제9권1호
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• pp.1-13
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• 2006

The recent environmental protection issue has diminished the supply of sand for soft ground improvements so much that the prices of sand have shown a sudden rise. Plastic material is one of substitutes for sand material, but plastic is nonperishable and doubtable if it has potential environmental hormone disrupting substances. Moderate-priced natural fiber drain board made with coconut coir and jute filter are in the spotlight recently as an alternative material for sand and plastic drain board etc. Natural fiber drain has not only competitive price but also a characteristic of assimilation into the soils after finishing of its own function. Discharge capacity of the fiber drain board evaluated by triaxial type discharge capacity test was relatively lower than that of plastic drain board. Nevertheless, settlement and pore pressure dissipation behaviors of the fiber drain board and the plastic drain board which were installed in the clayey soil during the composite discharge capacity test were almost similar. It was also found that biodegradation of the fiber drain board was in progress until 18 month after installation in the clayey soil, but they had still enough engineering properties to use at field.

• 한국산학기술학회논문지
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• 제13권11호
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• pp.5525-5533
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• 2012

최근의 건축물은 초고층화 또는 지하 공간의 심층화되어감에 따라 과도한 수직 거리 이동으로 인하여 체력이 부족한 사람들이 피난층 비상구에 이르기 전에 지쳐서 쓰러질 가능성이 있다. 화재 발생 인접 구역으로부터의 초기 피난에는 계단을 사용한 후에 나머지 거리는 승강기를 이용하여 안전한 공지나 도로로 탈출하는 방법을 요구하고 있다. 이에 따라 서울특별시 초고층 건축물 가이드 라인에서 피난용승강기에 대해 제정되었다. 최근 층수는 지하 7층 지상53층, 바닥면적 $6,800m^2$ 연면적 $127,050m^2$, 용도는 문화 및 집회시설 판매시설 업무시설 숙박시설(호텔) 공동주택(아파트)의 건축물을 설계하면서 피난용승강기를 별도로 설치하기에는 효율적이지 못하다는 판단하에 승용승강기의 설치기준에 따라 설계된 승강기를 피난용으로 사용하기로 결정하였다. 그러나 이에 대한 세부 설계지침내용이 아직까지 마련되어 있지 않아 국내법과 해외 설치기준을 근거로 승용승강기를 피난용으로 이용하기 위한 설계방법을 정리하였으며, 실제 설계된 도면으로 ELVAC+와 PathFinder의 피난프로그램으로 승강기수와 승강기를 이용한 피난자수의 적정성에 대해 연구하였다.

• 한국화재소방학회논문지
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• 제33권6호
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• pp.53-62
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• 2019

최근 건축물은 대지 이용의 효율성을 높이기 위해 주상 복합화·고층화되는 추세이며, 이에 따른 화재의 발생빈도 및 잠재적인 위험요소도 증가하고 있다. 특히, 고층 공동주택의 경우 비상용승강기와 별도로 승용승강기 중 1대 이상을 피난용승강기로 설치하게 되어 특별피난계단 부속실, 비상용승강기 승강장 겸용의 경우 피난용승강기 승강장과 직렬형태의 구조가 되어 새로운 형태의 제연구역 이 발생한다. 따라서 비상용승강기 승강장과 피난용승강기 승강장의 직렬형태 구조에 대한 제연구역 선정의 제시가 필요하며, 새로운 형태에서 제연성능을 달성하는 것에 대한 문제가 대두되고 있다. 따라서 본 논문에서는 이러한 문제를 해결하기 위해 CONTAM을 이용하여 각 제연구역 형식(비상용승강기 승강장 단독제연, 피난용승강기 승강장 단독제연, 비상용승강기 승강장과 피난용승강기 승강장 동시제연 누설틈새 적용·미적용)의 방연풍속, 차압을 확인하고, 직렬형태 구조에 대해 제연성능을 확보하기 위한 방안을 제시하고자 한다.

• 청정기술
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• 제7권3호
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• pp.215-223
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• 2001

A present semiconductor cleaning technology is based upon RCA cleaning technology which consumes vast amounts of chemicals and ultra pure water(UPW) and is the high temperature process. Therefore, this technology gives rise to the many environmental issues, and some alternatives such as electrolyzed water(EW) are being studied. In this work, intentionally contaminated Si wafers were cleaned using the electrolyzed water. The electrolyzed water was generated by an electrolysis system which consists of three anode, cathode, and middle chambers. Oxidative water and reductive water were obtained in anode and cathode chambers, respectively. In case of NH4Cl electrolyte, the oxidation-reduction potential and pH for anode water(AW) and cathode water(CW) were measured to be +1050mV and 4.8, and -750mV and 10.0, respectively. AW and CW were deteriorated after electrolyzed, but maintained their characteristics for more than 40 minutes sufficiently enough for cleaning. Their deterioration was correlated with CO2 concentration changes dissolved from air. Contact angles of UPW, AW, and CW on DHF treated Si wafer surfaces were measured to be $65.9^{\circ}$, $66.5^{\circ}$ and $56.8^{\circ}$, respectively, which characterizes clearly the eletrolyzed water. To analyze the amount of metallic impurities on Si wafer surface, ICP-MS was introduced. It was known that AW was effective for Cu removal, while CW was more effective for Fe removal. To analyze the number of particles on Si wafer surfaces, Tencor 6220 were introduced. The particle distributions after various particle removal processes maintained the same pattern. In this work, RCA consumed about $9{\ell}$ chemicals, while EW did only $400m{\ell}$ HCl electrolyte or $600m{\ell}$ NH4Cl electrolyte. It was hence concluded that EW cleaning technology would be very effective for promoting environment, safety, and health(ESH) issues in the next generation semiconductor manufacturing.

• 분석과학
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• 제30권3호
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• pp.113-121
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• 2017

Now a day's rise of new antibiotic resistant bacterial strains is a global threat. Ethnic people of India have been employing Aphanamixis polystachya (Wall.) R. Parker wood extract in healing cancerous wounds. The aim of this study was to evaluate the antimicrobial activity and to identify the medicinally potent chemicals in the essential oil extract of A. polystachya. The antibacterial properties of various organic extracts were evaluated against a range of bacteria (gram-positive and gram-negative bacteria) based on the disc diffusion method and GC-MS based analysis for finding active oil extract components. All extracts of A. polystachya leaves showed potential antibacterial activity, notably ethyl acetate, while petroleum ether extracts revealed highly sensitive activity against all tested bacteria (zones of inhibition ranging from 8.83 to 11.23 mm). In addition, the petroleum ether extract had the lowest MIC value (32 to $256{\mu}g/mL$) against E. coli, S. lutea, X. campestris, and B. subtilis bacteria. The major compounds detected in oil [${\beta}$-elemene (16.04 %), ${\beta}$-eudesmol (12.78 %), ${\beta}$-caryophyllene (19.37 %), ${\beta}$-selinene (11.32 %), elemol (5.76 %), and ${\alpha}$-humulene (5.68 %)] are expected to be responsible for the potent antimicrobial activity. The results of this study offer valuable insights into the potent role of A. polystachya essential oil extract in pharmaceutical and antibiotic research.

• 한국진공학회:학술대회논문집
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• 한국진공학회 2016년도 제50회 동계 정기학술대회 초록집
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• pp.139.1-139.1
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• 2016

Multiferroic materials are of great interest because of its potential applications in the design of devices combining magnetic, electronic and optical functionalities. Among various multiferroic materials, $BiFeO_3$(BFO) is known to be one of the intensively focused mainly due to the possibility of multiferroism at device working temperature (> $200^{\circ}C$). However, leakage current and weak polarization resulting from oxygen deficiency and crystalline defect should be resolved. Furthermore the magnetic ordering of pure BFO mainly prefers to have antiferromagnetic coupling. Up to now many attempts have been performed to improve the ferromagnetic and the ferroelectric properties of BFO by doping. In this work, we investigated the effects of Ni substitution on the multiferroism of bulk BFO. Four BFO samples (a pure BFO and three Ni-doped BFO's; $BiFe_{0.99}Ni_{0.01}O_3$, $BiFe_{0.98}Ni_{0.02}O_3$ and $BiFe_{0.97}Ni_{0.03}O_3$) were synthesized by the standard solid-state reaction and rapid sintering technique. The XRD results reveal that Ni atoms are substituted into Fe-sites and give rise to phase transition of cubic to rhombohedal. By using vibrating sample magnetometer and standard ferroelectric tester, the multiferroic properties at room temperature were characterized. We found that the magnetic moment of Ni-doped BFO turned out to be maximized for 3% of Ni dopant.

• 국제초고층학회논문집
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• 제6권3호
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• pp.249-259
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• 2017

The use of high-strength steels in construction of highrise and mega building structures can bring about many technological advantages from fabrication to erection. However, key design criteria such as local and lateral stability in current steel design specifications were developed based on tests of ordinary steels which have stress-strain characteristics very different from that of high strength steels. A series of tests on 800 MPa tensile strength steel (HSA800) members are summarized in this paper which were conducted to investigate the appropriateness of extrapolating current ordinary-steel based design criteria to high strength steels. 800 MPa I-shape beam specimens designed according to flange local buckling (FLB) criteria of the AISC Specification developed a sufficient strength for elastic design and a marginal rotation capacity for plastic design. It is shown that, without introducing distinct and significant yield plateau to the stress-strain property of high-strength steel, it is inherently difficult to achieve a high rotation capacity even if all the current stability limits are met. 800 MPa I-shape beam specimens with both low and high warping rigidity exhibited sufficient lateral torsional buckling (LTB) strength. HSA800 short-column specimens with various edge restraint exhibited sufficient local buckling strength under uniform compression and generally outperformed ordinary steel specimens. The experimental P-M strength was much higher than the AISC nominal P-M strength. The measured residual stresses indicated that the impact of residual stress on inelastic buckling of high-strength steel is less. Cyclic seismic test results showed that HSA800 members have the potential to be used as non-ductile members or members with limited ductility demand in seismic load resisting systems. Finally, recent applications of 800 MPa high strength steel to highrise and mega building structures in Korea are briefly presented.

• 한국지구과학회지
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• 제24권1호
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• pp.46-60
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• 2003

In Namyang Bay of western Korea, macrotidal-flat deposits are divisible into three late Quaternary units: Unit M1 of upper marine mud, Unit T1 of middle siderite-bearing terrestrial clay, and Unit M2 of lower marine mud. Unit M1 represents typical Holocene intertidal mudflat deposits, showing a coarsening-upward textural trend. It probably resulted from the continual retrogradation of tidal flat during the mid-to-late Holocene sea-level rise. Reddish brown-color Unit T1 consists of homogeneous clay with abundant freshwater siderite grains and plant remains. Unit T1 is clearly separated from the overlying Unit M1 by a sharp lithologic boundary. Radiocarbon age, siderite grains and lithologic features indicate that Unit T1 is originated from freshwater bog or swamp deposition infilling the localized topographic lows during the early Holocene age. Overlain unconformably by early Holocene swamp clay, Unit M2 is orange to yellow in color and mottled, suggesting significant degree of weathering during the sea-level lowstand. Such subaerial oxidation is confirmed in the vertical profiles of geotechnical properties, clay mineral assemblages and magnetic susceptibility. Unit M2 appears to be correlated with the upper part of the late Pleistocene tidal deposits developed along the western Korean coast. The sedimentary succession of the Namyang-Bay tidal-flat deposit provides stratigraphic information for the Holocene-late Pleistocene unconformity and also permits an assessment of the preservation potential of the late Pleistocene marginal marine deposit along the western coast of Korea.

• BMB Reports
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• 제51권9호
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• pp.462-467
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• 2018

A previous study of ours indicated that Drosophila flightless-1 controls lipid metabolism, and that there is an accumulation of triglycerides in flightless-1 (fliI)-mutant flies, where this mutation triggers metabolic stress and an obesity phenotype. Here, with the aim of characterizing the function of FliI in metabolism, we analyzed the levels of gene expression and metabolites in fliI-mutant flies. The levels of enzymes related to glycolysis, lipogenesis, and the pentose phosphate pathway increased in fliI mutants; this result is consistent with the levels of metabolites corresponding to a metabolic pathway. Moreover, high-throughput RNA sequencing revealed that Drosophila FliI regulates the expression of genes related to biological processes such as chromosome organization, carbohydrate metabolism, and immune reactions. These results showed that Drosophila FliI regulates the expression of metabolic genes, and that dysregulation of the transcription controlled by FliI gives rise to metabolic stress and problems in the development and physiology of Drosophila.