• Journal of the Korean Chemical Society
• /
• v.54 no.5
• /
• pp.621-632
• /
• 2010

In this study, we examined the characteristics of analogies generated by science-gifted students depending on the consideration of attributes and relationships in the processes of generating analogies and investigated the applicability of analogy-generating activities in science-gifted education programs. The analyses of the results revealed that the analogy-generating processes of science-gifted students were categorized into three kinds of patterns depending on the consideration of attributes and relationships of the target concept and the source analog. There are also some differences in the types of analogies generated and selected to be good, and in the proper mapping numbers by the patterns depending on the consideration of attributes and relationships. Most science-gifted students used the analogy-generating activities to other target concept, and recognized them to be useful. However, they had difficulties in selecting source analogs at the processes of generating analogy. These obtained in this study will help to explore a potential use of the analogy-generating activities in an effective education program for fostering the creativity of science-gifted students.

• Journal of Microbiology
• /
• v.41 no.4
• /
• pp.340-344
• /
• 2003

The group I intron from Tetrahymena thermophila has been demonstrated to employ splicing reactions with its substrate RNA in the trans configuration. Moreover, we have recently shown that the transsplicing group I ribozyme can replace HCV-specific transcripts with a new RNA that exerts anti-viral activity. In this study, we explored the potential use of RNA replacement for cancer treatment by developing trans-splicing group I ribozymes, which could replace tumor-associated RNAs with the RNA sequence attached to the 3' end of the ribozymes. Thymidine phosphorylase (TP) RNA was chosen as a target RNA because it is known as a valid cancer prognostic factor. By performing an RNA mapping strategy that is based on a trans-splicing ribozyme library, we first determined which regions of the TP RNA are accessible to ribozymes, and found that the leader sequences upstream of the AUG start codon appeared to be particularly accessible. Next, we assessed the ribozyme activities by comparing trans-splicing activities of several ribozymes that targeted different regions of the TP RNA. This assessment was performed to verify if the target site predicted to be accessible is truly the most accessible. The ribozyme that could target the most accessible site, identified by mapping studies, was the most active with high fidelity in vitro. Moreover, the specific trans-splicing ribozyme reacted with and altered the TP transcripts by transferring an intended 3' exon tag sequence onto the targeted TP RNA in mammalian cells with high fidelity. These results suggest that the Tetrahymena ribozyme can be utilized to replace TP RNAs in tumors with a new RNA harboring anti-cancer activity, which would revert the malignant phenotype.

• Korean Journal of Geomatics
• /
• v.2 no.1
• /
• pp.57-64
• /
• 2002

Measuring the depth of water is very important in ensuring the protection and safety of seaside. There are many difficulties in making the contour bathymetric map, and contour line due to the limitation of continuous measurement of water depth and collimation with the conventional measuring and positioning methods. But the real-time kinematic GPS (RTK GPS) positioning using a carrier phase enables us to decide a precise position without breaking a signal even under the condition of a moving environment. It is also possible to obtain an accurate depth of water in real time with a fathometer through the measuring of time delay between sending and receiving epochs. This research aims at investigation of accuracy potential of RTK GPS in combination with Echo Sounder(E/S) for the coastal mapping. Apart from this purpose, the accuracy of ambiguity resolution with the OTF(On the Fly) method was tested with respect to the initialization time. The result shows that the accuracy is better than 1cm with 5-minute initialization in the distance of 10km baseline. The seaside topography was measured by the RTK GPS only, on the other hand the seafloor topography was surveyed in combination of RTK GPS and E/S. Comparing to the volume of seaside measured by RTK GPS and digital topographical map, the difference of only 2 % was achieved. This indicates that the coastal mapping with RTK GPS is successfully conducted. In addition it is also demonstrated that the 3-dimensional perspective model resulted from the undersea topography measured by RTK GPS and E/S is very close to that from the digital map. Through this study, it was verified that RTK GPS is to be very useful method in the analysis of coastal morphology owing to its capability of getting the precise DTM for the using of harbor reclamation, dredging, and the estimation of soil movement in a river.

• Korean Journal of Remote Sensing
• /
• v.18 no.1
• /
• pp.1-12
• /
• 2002

Landslide prediction modeling has been regarded as one of the important environmental applications in GIS. While, landslide stability in a certain area as collateral process for prediction modeling can be characterized by DEM-based hydrological features such as flow-direction, flow-accumulation, flow-length, wetness index, and so forth. In this study, Slope-Area plot methodology followed by stability index mapping with these hydrological variables is firstly performed for stability analysis with actual landslide occurrences at Boeun area, Korea, and then Landslide prediction modeling based on likelihood ratio model for landslide potential mapping is carried out; in addition, KOMPSAT EOC imagery is used to detect the locations and scalped scale of Landslide occurrences. These two tasks are independently processed for preparation of unbiased criteria, and then results of those are qualitatively compared. As results of this case study, land stability analysis based on DEM-based hydrological variables directly reflects terrain characteristics; however, the results in the form of land stability map by landslide prediction model are not fully matched with those of hydrologic landslide analysis due to the heuristic scheme based on location of existed landslide occurrences within prediction approach, especially zones of not-investigated occurrences. Therefore, it is expected that the resets on the space-robustness of landslide prediction models in conjunction with DEM-based landslide stability analysis can be effectively utilized to search out unrevealed or hidden landslide occurrences.

• Korean Journal of Remote Sensing
• /
• v.21 no.6
• /
• pp.493-503
• /
• 2005

In this study, the weight of evidence(WofE) technique based on GIS was applied to spatially estimate the groundwater yield characteristics at the Pocheon area In Gyunggi-do. The groundwater preservation depends on many hydro-geologic factors that include hydrologic data, land-use data, topographic data, geological map and other natural materials collected at the site, even with man-made things. All these data can be digitally processed and managed by GIS database. In the applied technique of WofE, the prior probabilities were estimated as the factors that affect the yield on lineament, geology, drainage pattern or river system density, landuse and soil. We calculated the value of the weight values, W+ and W-, of each factor and estimated the contrast value of it. Results by the groundwater yield characteristic computation using this scheme were presented feasibility map in the form of the posterior probability to the consideration of in-situ samples. It is concluded that this technique is regarded as one of the effective techniques for the feasibility mapping related to the estimation of groundwater-bearing potential zones and its spatial pattern.

• Asian-Australasian Journal of Animal Sciences
• /
• v.32 no.12
• /
• pp.1826-1835
• /
• 2019

Objective: Testicular growth and development are strongly influenced by androgen. Although both testis weight and plasma testosterone level are inherited traits, the interrelationship between them is not fully established. Males of DDD/Sgn (DDD) mice are known to have extremely heavy testes and very high plasma testosterone level among inbred mouse strains. We dissected the genetic basis of testis weight and analyzed the potential influence of plasma testosterone level in DDD mice. Methods: Quantitative trait loci (QTL) mapping of testis weight was performed with or without considering the influence of plasma testosterone level in reciprocal $F_2$ intercross populations between DDD and C57BL/6J (B6) mice, thereby assessing the influence of testosterone on the effect of testis weight QTL. Candidate genes for testis weight QTL were investigated by next-generation sequencing analysis. Results: Four significant QTL were identified on chromosomes 1, 8, 14, and 17. The DDDderived allele was associated with increased testis weight. The $F_2$ mice were then divided into two groups according to the plasma testosterone level ($F_2$ mice with relatively "low" and "high" testosterone levels), and QTL scans were again performed. Although QTL on chromosome 1 was shared in both $F_2$ mice, QTL on chromosomes 8 and 17 were identified specifically in $F_2$ mice with relatively high testosterone levels. By whole-exome sequencing analysis, we identified one DDD-specific missense mutation Pro29Ser in alpha tubulin acetyltransferase 1 (Atat1). Conclusion: Most of the testis weight QTL expressed stronger phenotypic effect when they were placed on circumstance with high testosterone level. High testosterone influenced the QTL by enhancing the effect of DDD-derived allele and diminishing the effects of B6-derived allele. Since Pro29Ser was not identified in other inbred mouse strains, and since Pro29 in Atat1 has been strongly conserved among mammalian species, Atat1 is a plausible candidate for testis weight QTL on chromosome 17.

• Journal of the Architectural Institute of Korea Planning & Design
• /
• v.35 no.4
• /
• pp.3-14
• /
• 2019

The purpose of this study is to analyze the distribution characteristics of the agency-managed shared housings in Seoul and draw the possible implications from it. The needed data for the study was obtained from an on-line shared housing portal service which provides housing information from various shared housing management agencies. By mapping out the locations and other related data into a GIS(Geographic Information System) program, this study shows that shared housings in Seoul can be sorted into four large clusters. Each cluster has a different ratio of housing types and room capacities reflecting each regional circumstance and common causes. Women-only shared housing takes up 79% of the overall shared housing ratio and, while multi-family housing type has the most count, the apartment type has a noticeably high ratio in women-only housing compared to the apartment type ratio among the other gender-specific housings. Given the high crime rate against the single-person household of young adult women, the reason for the popularity of shared-apartment housing among young women can be deduced. However, the potential tenants' practical choices and their concern for safety are not the only causes that drive the current shared housing market. The young adults in their 20's and 30's choose to live in popular places where they can engage social activities. A new tier of shared housing market has also appeared in places where young adults could not have afforded if they lived alone. Choosing where we live is no longer about just meeting the requirements for a house based on what she/he needs but also about satisfying the preferences for a living based on what she/he desires. This paper indicates that although there is an undeniable premise that 'sharing a house' revolves around the realm of housing welfare and is not a typical topic for the upper-income households, the way we live and how we choose our place to live is shifting.

• Nuclear Engineering and Technology
• /
• v.55 no.9
• /
• pp.3268-3276
• /
• 2023

The practice of identifying the potential zones for mineral exploration in a speedy and low-cost method includes the use of satellite imagery analysis as a part of remote sensing techniques. It is challenging to explore the iron mineralization of a region through conventional methods which are a time-consuming process. The current study utilizes the Hyperion satellite imagery for mapping the iron mineralization and associated geological features in the Irikkur region, Kannur, Kerala. Along with the remote sensing results, the field study and laboratory-based analysis were conducted to retrieve the ground truth point and geochemical proportion to verify the iron ore mineralization. The MC simulation showed for shielding properties indicate an increase in the linear attenuation coefficient with raising the Fe₂O₃+SiO₂ concentrations in the investigated rocks where it is varied at 0.662 MeV in the range 0.190 cm^-1 - 0.222 cm^-1 with rising the Fe₂O₃+SiO₂ content from 57.86 wt% to 71.15 wt%. The analysis also revealed that when the γ-ray energy increased from 0.221 MeV to 2.506 MeV, sample 1 had the largest linear attenuation coefficient, ranging from 9.33 cm1 to 0.12 cm^-1. Charnockite rocks were found to have exceptional shielding qualities, making them an excellent natural choice for radiation shielding applications.

• Journal of the Korean GEO-environmental Society
• /
• v.16 no.1
• /
• pp.17-27
• /
• 2015

Recently, Korean government has tried out to set up earthquake hazards prevention system. In the system, several geotechnical hazard maps including liquefaction hazard map and landslide hazard map for the whole country have drawn to consider the domestic seismic characteristics. To draw the macro liquefaction hazard map, big data of site investigations in metropolitan areas and provincial areas has to be verified for its application. In this research, we carried out site response analyses using 522 borehole site investigation data in S city during a desirable earthquake. The soil classification was separately compared to shear wave velocity considering the uncertainty of site investigation data. Probability distribution and statistical analysis for the results of site response analyses was applied to the feasibility study. Finally, we suggest a new site amplification coefficient, hereby presented with the similar results of liquefaction hazard mapping using the calculated liquefaction potential index by the site response analyses. Above-mentioned study will be expected to help to follow research and draw liquefaction hazard map in moderate seismic region.

• Journal of the Korean Geographical Society
• /
• v.43 no.2
• /
• pp.235-252
• /
• 2008

Many cartographers have for many years searched for a way to construct cartograms in which the sizes of geographic areas such as states, counties or census tracts are reseated in proportion to their population or some other socio-economic properties. While many techniques and algorithms for creating cartograms have been proposed, some of them are still extremely complex to generate in a proper manner, and many of them suffer either from this lack of readability or from seamless integration with GIS software. This paper, therefore, presents a simple population cartogam technique based on the Circular Cartogram Algorithm(CCA) by Dorling(1996) to tackle these drawbacks by drawing the areas as simple circles for use as a base map and linking the construction with GIS mapping processes. For an automated approach in the cartogram generation, this paper proposes a close coupling method of ArcView GIS 3.3. package in order for users to access to the cartopam algorithm. Then, they will be available through an interface that the ArcView GIS system allows user-written routines to be accessed easily. The CCA and its coupling architecture ensure to improve the potential applicability of the use of cartograms to census mapping at practical levels. As the cartogram examples, cartograms of population and property types in 2005 Korea census data sets are illustrated in the end, by which viewers can easily identify the residential concentration and their relative ratio in Seoul metropolitan area.