• Journal of the Institute of Electronics Engineers of Korea SD
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• v.45 no.12
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• pp.1-7
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• 2008

Magnetic Tunneling Junction (MTJ) has been used as a nonvolatile universal storage element mainly in memory technology. However, according to several recent studies, magneto-logic using MTJ elements show much potential in substitution for the transistor-based logic device. Magneto-logic based on MTJ can maintain the data during the power-off mode, since an MTJ element can store the result data in itself. Moreover, just by changing input signals, the full logic functions can be realized. Because of its programmability, it can embody the reconfigurable magneto-logic circuit in the rigid physical architecture. In this paper, we propose a novel 3-bit arbitrary magneto-logic circuit beyond the simple combinational logic or the short sequential one. We design the 3-bit magneto-logic which has the most complexity using MTJ elements and verify its functionality. The simulation results are presented with the HSPICE macro-model of MTJ that we have developed in our previous work. This novel magneto-logic based on MTJ can realize the most complex logic function. What is more, 3-bit arbitrary logic operations can be implemented by changing gate signals of the current drivel circuit.

• Journal of the Korean Geographical Society
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• v.43 no.4
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• pp.561-579
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• 2008

The population concentration in Seoul has caused the chronic housing shortage. Accordingly the new towns in the Capital region were developed to alleviate overcrowding conditions in Seoul. The purpose of this study is to analyze changes of migration and commuting patterns according to new town development in the Capital region for the period of $1995{\sim}2005$. Further this study examines the changes of self-sufficiency level for new towns using jobs to housing ratio. During the last 10 years, the migration pattern in the Capital region has been pretty much followed the new town development. Such a migration pattern has influenced the commuting patterns, expanding the Seoul Metropolitan Area into northeastern par of the Capital region. The result reveals that self-sufficiency levels of new towns have become higher over the period of $1995{\sim}2005$, indicating that new towns are gradually strengthening their economic functions and have potential to become new business centers in the future. Therefore, the policy focusing on the increase of the job-housing balance ratio and self-sufficient level in new towns will be a desirable policy alternative to solve the transportation problems in the Capital region.

• Journal of Korean Society of Forest Science
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• v.104 no.3
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• pp.503-511
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• 2015

The purpose of this study is to suggest the introduction plans of forest land bank system for effective forestry management as well as the livelihood stability support of aged forest landowners. It is expected that forest land bank system can contribute to solve forestry management problems caused by small and scattered forest lands, aging forest landowners, and the increase of absentee forest landowners. This study examined an existing related case of Farmland Bank system, and suggested basic directions, main functions, priority, and agency for forest land bank system. The goals of forest land bank system include activating private forest land management, improving forest management scale, and supporting stable forestry income. Based on the examination of this study, main projects of forest land bank involve forest land sale and lease consignment, forest land reverse mortgage, forest land scale improvement project, and forest business recovery support program. In addition, this study discussed potential problems and their solutions in introducing and operating the forest land bank system. This study can play a key role to determine a basic direction and to establish policies of the forest land management.

• Journal of the Korean Geographical Society
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• v.29 no.3
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• pp.281-296
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• 1994

It is generally accepted that there is always a potential for crisis in the capitalist society because of the internal contradiction of capitalism. The contradiction is explicitly and implicitly expressed in space. The fundamental contradiction in capitalism, however, is controlled and mediated by the state (i.e., the capitalist state). We thus could argue that the state plays an important role in the capitalist society and in the capitalist spatial formation. It is necessary to note how and why spatial structure has developed unevenly in capitalist societies, particularly in the U.S., The general concept of uneven geographical development is understood in the context of the capitalist economic system and the role of the state. But the problem is that the capitalist state itself has a contradiction between the productive function (i.e., accumulation function) and the reproductive function (i.e., legitimation function). The compromise of the two functions is always the dilemma of the state and the state becomes the object of class struggle (e.g., political class struggle) . The research questions are as follows. First, what is the role of the state in the economic structure and what is the internal problem of the state\ulcorner Second, what is the role of the state in space economy (or in spatial structure)\ulcorner And last, what is the relation between the federal state and the local state in the U.S. and how does the relation form the urban policies and thus the urban and regional development\ulcorner The paper will be looking at how the political economy in the U.S. explains unevenly developed geographical phenomenon.

• Asian-Australasian Journal of Animal Sciences
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• v.22 no.4
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• pp.576-583
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• 2009

G protein-coupled receptor 43 (GPR43) is a newly-discovered short-chain free fatty acid receptor and its functions remain to be defined. The objective of this study was to investigate the function of GPR43 on lipolysis. We successfully cloned the GPR43 gene from the pig (EU122439), and measured the level of GPR43 mRNA in different tissues and primary pig adipocytes. The expression level of GPR43 mRNA was higher in adipose tissue and increased gradually with adipocyte differentiation. Then we examined GPR43 mRNA level in different types, growth-stages and various regions of adipose tissue of pigs. The results showed that the expression level of GPR43 mRNA was significantly higher in adipose tissue of obese pigs than in lean pigs, and the expression level also gradually increased as age increased. We further found that the abundance of GPR43 mRNA level increased more in subcutaneous fat than visceral fat. Thereafter, we studied the correlation between GPR43 and lipid metabolism-related genes in adipose tissue and primary pig adipocytes. GPR43 gene had significant negative correlation with hormone-sensitive lipase gene (HSL, r = -0.881, p<0.01) and triacylglycerol hydrolase gene (TGH, r = -0.848, p<0.01) in adipose tissue, and had positive correlation with peroxisome proliferator-activated receptor $\gamma$ gene ($PPAR_{\gamma}$, r = 0.809, p<0.01) and lipoprotein lipase gene (LPL, r = 0.847, p<0.01) in adipocytes. In addition, we fed different concentrations of docosahexaenoic acid (DHA) to mice, and analyzed expression level changes of GPR43, HSL and TGH in adipose. The results showed that DHA down-regulated GPR43 and up-regulated HSL and TGH mRNA levels; GPR43 also had significant negative correlation with HSL (low: r = -0.762, p<0.01; high: r = -0.838, p<0.01) and TGH (low: r = -0.736, p<0.01; high: r = -0.586, p<0.01). Our results suggested that GPR43 is a potential factor which regulates lipolysis in adipose tissue, and DHA as a receptor of GPR43 might promote lipolysis through down-regulating the expression of GPR43 mRNA.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.7
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• pp.3311-3317
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• 2014

Background: The consequence of Rho GDP dissociation inhibitor alpha (RhoGDI${\alpha}$) activity on migration and invasion of estrogen receptor positive ($ER^+$) and negative ($ER^-$) breast cancer cells has not been studied using the proteomic approach. Changes in expression of RhoGDI${\alpha}$ and other proteins interacting directly or indirectly with RhoGDI${\alpha}$ in MCF7 and MDA-MB-231, with different metastatic potentials is of particular interest. Materials and Methods: $ER^+$ MCF7 and ER- MDA-MB-231 cell lines were subjected to two-dimensional electrophoresis (2-DE) and spots of interest were identified by matrix-assisted laser desorption/ionization time of- flight/time-of-flight (MALDI-TOF/TOF) mass spectrometry (MS) analysis after downregulation of RhoGDI${\alpha}$ using short interfering RNA (siRNA) and upregulated using GFP-tagged ORF clone of RhoGDI${\alpha}$. Results: The results showed a total of 35 proteins that were either up- or down-regulated in these cells. Here we identifed 9 and 15 proteins differentially expressed with silencing of RhoGDI${\alpha}$ in MCF-7 and the MDA-MB-231 cells, respectively. In addition, 10 proteins were differentially expressed in the upregulation of RhoGDI${\alpha}$ in MCF7, while only one protein was identified in the upregulation of RhoGDI${\alpha}$ in MDA-MB-231. Based on the biological functions of these proteins, the results revealed that proteins involved in cell migration are more strongly altered with RhoGDI-${\alpha}$ activity. Although several of these proteins have been previously indicated in tumorigenesis and invasiveness of breast cancer cells, some ohave not been previously reported to be involved in breast cancer migration. Hence, these proteins may serve as useful candidate biomarkers for tumorigenesis and invasiveness of breast cancer cells. Conclusions: Future studies are needed to determine the mechanisms by which these proteins regulate cell migration. The combination of RhoGDI${\alpha}$ with other potential biomarkers may be a more promising approach in the inhibition of breast cancer cell migration.

• BMB Reports
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• v.49 no.10
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• pp.548-553
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• 2016

Mesenchymal stem cells (MSCs) are widely used in cartilage tissue engineering to repair articular cartilage defects. However, hypertrophy of chondrocytes derived from MSCs might hinder the stabilization of hyaline cartilage. Thus, it is very important to find a suitable way to maintain the chondrogenic phenotype of chondrocytes. It has been reported that cordycepin has anti-inflammatory and anti-tumor functions. However, the role of cordycepin in chondrocyte hypertrophy remains unclear. Therefore, the objective of this study was to determine the effect of cordycepin on chondrogenesis and chondrocyte hypertrophy in MSCs and ATDC5 cells. Cordycepin upregulated chondrogenic markers including Sox9 and collagen type II while down-regulated hypertrophic markers including Runx2 and collagen type X. Further exploration showed that cordycepin promoted chondrogenesis through inhibiting Nrf2 while activating BMP signaling. Besides, cordycepin suppressed chondrocyte hypertrophy through PI3K/Bapx1 pathway and Notch signaling. Our results indicated cordycepin had the potential to maintain chondrocyte phenotype and reconstruct engineered cartilage.

• Composites Research
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• v.30 no.1
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• pp.46-51
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• 2017

Structural battery has been researched extensively to combine the functions of the battery and structure without gravimetric or volumetric increments compared to their individual components. The main idea is to employ carbon fabric as the reinforcement and electrode, glass fabric as the separator, and solid-state electrolyte which can transfer load. However, state-of-the-art solid-state electrolytes do not have sufficient load carrying functionality and exhibiting appropriate ion conductivity simultaneously. Therefore, in this research, a system which has both battery and load carrying capabilities using glass fabric separator and liquid electrolyte was devised and tested to investigate the potential and feasibility of this structural battery system and observe electric properties. It was observed that elongating separator decreased electrical behavior stability. A possible cause of this phenomenon was the elongated glass fabric separator inadequately preventing the penetration of small particles of the cathode material into the anode. This problem was verified additionally by using a commercial separator. The characteristic of the glass fabric and the interface between the electrode and glass fabric needed to be further studied for the realization of such a load carrying structural battery system.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.19 no.6
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• pp.176-187
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• 2018

The Korean government has been encouraging 'continuous' post-pump priming project management through relevant local personnel planning, action, and management, upon the selection of 68 sites for urban regeneration as part of the New Deal Project. This study assessed the utilization characteristics of containers, the socio-experimental temporary occupation facilities, as a tool for 'sustainable' urban regeneration. This is to identify the potential limitations of urban regeneration by the utilization of containers as public sector temporary occupation facilities and to provide adequate directions based on its efficacy. By comparing three Korean cases with the Japanese WaiWai project, in terms of 10 elements, the preoccupations with the social trend and scenery, and undifferentiated functions of the facilities focusing on the commercial or working aspects have been identified as limitations of Korean cases. Based on the analyses, the following are suggested as plausible approaches to utilize socio-experimental containers for sustainable urban regeneration: 1. Planning and management should be done by the same organization because the absence of the planning party's participation in the management likely leads to the pursuit of only profits. 2. Diversification and combinations of different utilization purposes of a single site and numerous planning of experimental container uses are in need. 3. Accommodations of heavy commercial uses lead to a decline in the continuity of follow-up projects and a change in the urban regeneration directions. Therefore, it is important to include a public socio-experimental program rather than a simple commercial or promotion program for the following urban renewal project.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.24
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• pp.10949-10955
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• 2015

Liver cancer is one of leading digestive malignancies with high morbidity and mortality. There is an urgent need for the development of novel therapies for this deadly disease. It has been proven that asparagus polysaccharide, one of the most active derivates from the traditional medicine asparagus, possesses notable antitumor properties. However, little is known about the efficacy of asparagus polysaccharide as an adjuvant for liver cancer chemotherapy. Herein, we reported that asparagus polysaccharide and its embolic agent form, asparagus gum, significantly inhibited liver tumor growth with transcatheter arterial chemoembolization (TACE) therapy in an orthotopic hepatocellular carcinoma (HCC) tumor model, while significantly inhibiting angiogenesis and promoting tumor cell apoptosis. Moreover, asparagine gelatinous possessed immunomodulatory functions and showed little toxicity to the host. These results highlight the chemotherapeutic potential of asparagus polysaccharide and warrant a future focus on development as novel chemotherapeutic agent for liver cancer TACE therapy.