• Nuclear Engineering and Technology
• /
• v.45 no.6
• /
• pp.721-730
• /
• 2013

Within the framework of the ASTRID project, core design studies are being conducted by the CEA with support from AREVA and EDF. The pre-conceptual design studies are being conducted in accordance with the GEN IV reactor objectives, particularly in terms of improving safety. This involves limiting the consequences of 1) a hypothetical control rod withdrawal accident (by minimizing the core reactivity loss during the irradiation cycle), and 2) an hypothetical loss-of-flow accident (by reducing the sodium void worth). Two types of cores are being studied for the ASTRID project. The first is based on a 'large pin/small spacing wire' concept derived from the SFR V2b, while the other is based on an innovative CFV design. A distinctive feature of the CFV core is its negative sodium void worth. In 2011, the evaluation of a preliminary version (v1) of this CFV core for ASTRID underlined its potential capacity to improve the prevention of severe accidents. An improved version of the ASTRID CFV core (v2) was proposed in 2012 to comply with all the control rod withdrawal criteria, while increasing safety margins for all unprotected-loss-of-flow (ULOF) transients and improving the general design. This paper describes the CFV v2 design options and reports on the progress of the studies at the end of pre-conceptual design phase 1 concerning: - Core performance, - Intrinsic behavior during unprotected transients, - Simulation of severe accident scenarios, - Qualification requirements. The paper also specifies the open options for the materials, sub-assemblies, absorbers, and core monitoring that will continue to be studied during the conceptual design phase.

• Advances in Traditional Medicine
• /
• v.10 no.4
• /
• pp.263-270
• /
• 2010

Scoparia dulcis L. is widely used in the traditional system of medicine for treating liver ailments. In the present study the terpenoids and terpenoid fractions isolated from 1:1:1 petroleum ether, diethyl ether and methanol (PDM) extract of Scoparia dulcis L. were tested for their in vitro 1, 1-Diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activity. Selected samples from the assay were further tested for their in vitro hepatoprotective activity against $CCl_4$ induced hepatotoxicity in freshly isolated rat hepatocytes. In the in vitro antioxidant study, fractions 7, 11, 13, 14, and 15 and PDM extract show the DPPH radical scavenging activity. The phytochemical screening of all these fractions show the presence of terpenoids. In the in vitro hepatoprotective study all these fractions and the PDM extract significantly prevent the $CCl_4$ induced changes in the aspartate aspartate amino transferase, alanine amino transferase and alkaline phosphatase levels (p < 0.05). The above results are comparable with the standard, silymarin. The results of the study indicate that, the PDM extract of Scoparia dulcis L. possesses potential hepatoprotective activity and this may be attributed to its free radical scavenging potential, which in turn may be attributed to the presence of terpenoids.

• Journal of Ginseng Research
• /
• v.43 no.3
• /
• pp.421-430
• /
• 2019

Background: The ginsenoside Rg3, one of active components of red ginseng, has chemopreventive and anticancer potential. Cancer stem cells retain self-renewal properties which account for cancer recurrence and resistance to anticancer therapy. In our present study, we investigated whether the standardized Korean Red Ginseng extract (RGE) and Rg3 could modulate the manifestation of breast cancer stem cell-like features through regulation of self-renewal activity. Methods: The effects of RGE and Rg3 on the proportion of $CD44^{high}/CD24^{low}$ cells, as representative characteristics of stem-like breast cancer cells, were determined by flow cytometry. The mammosphere formation assay was performed to assess self-renewal capacities of breast cancer cells. Aldehyde dehydrogenase activity of MCF-7 mammospheres was measured by the ALDEFLUOR assay. The expression levels of Sox-2, Bmi-1, and P-Akt and the nuclear localization of hypoxia inducible $factor-1{\alpha}$ in MCF-7 mammospheres were verified by immunoblot analysis. Results: Both RGE and Rg3 decreased the viability of breast cancer cells and significantly reduced the populations of $CD44^{high}/CD24^{low}$ in MDA-MB-231 cells. RGE and Rg3 treatment attenuated the expression of Sox-2 and Bmi-1 by inhibiting the nuclear localization of hypoxia inducible $factor-1{\alpha}$ in MCF-7 mammospheres. Suppression of the manifestation of breast cancer stem cell-like properties by Rg3 was mediated through the blockade of Akt-mediated self-renewal signaling. Conclusion: This study suggests that Rg3 has a therapeutic potential targeting breast cancer stem cells.

• Structural Engineering and Mechanics
• /
• v.44 no.1
• /
• pp.15-34
• /
• 2012

In the present paper, an improved high-order theory is used for bending analysis of soft-core sandwich plates. Third-order plate assumptions are used for face sheets and quadratic and cubic functions are assumed for transverse and in-plane displacements of the orthotropic soft core. Continuity conditions for transverse shear stresses at the interfaces as well as the conditions of zero transverse shear stresses on the upper and lower surfaces of the plate are satisfied. Also, transverse flexibility and transverse normal strain and stress of the orthotropic core are considered. The equations of motion and boundary conditions are derived by principle of minimum potential energy. Analytical solution for bending analysis of simply supported sandwich plates under various transverse loads are presented using Navier's solution. Comparison of the present results with those of the three-dimensional theory of elasticity and some plate theories in the literature confirms the accuracy of the proposed theory.

• Proceedings of the Korean Geotechical Society Conference
• /
• 2001.03a
• /
• pp.249-256
• /
• 2001

Optical Color Corescanner firstly developed by DMT-GeoTec, Germany and further upgraded through the Korea-Germany joint project is capable of duplicating the core surfaces. The tool uses a digital CCD line camera. As the core is rotated by an electric motor, the camera scans the uppermost line, everytime with a circumferential increment of up to 0.05mm(20pixels/mm) and hence a complete 360$^{\circ}$ unwrapped image(core image) is produced. This paper illustrated diverse research benefits of such core images from several test sites in our country. All scanned images could be stored as a data-base one and easily used with software facilities \circled1 to evaluate a percental distribution of mineral components or grain size etc. not only for the rock classification but also for e.g. the assessment of building stones, \circled2 to study potential reservoirs as a hydrocarbon indicator using ultraviolet fluorescence reflection from cores, \circled3 to facilitate the qualitative and quantitative analysis of fractures, \circled4 to evaluate the fractures and thin bedded reservoirs using spectral color responses. Based on abundant scanning experiments, it would seem that this imaging work should lead to reflecting the future trend in underground survey toward a more comprehensive understanding of the properties and behaviors of in situ rocks.

• Journal of the Korean Society for Precision Engineering
• /
• v.28 no.5
• /
• pp.623-631
• /
• 2011

Metallic sandwich panels based on a truss core structure have been developed for a wide range of potential applications with their lightweight and multi-functionality. Structural performance of sandwich panels can be predicted from the studies on mechanical behavior of a unit cell of truss core structures. Analytical investigations on the unit cell provide approximated guidelines for the design of overall core structures for a specific application in short time. In this study, the effects of geometrical parameters on mechanical behavior of a pyramidal shape of unit cell were investigated with analytical models. The unit cell with truss member angle of 45 degree was considered as reference model and other models were designed to have the same weight and projected area but different truss member angle. All truss members were assumed to be connected with pin joint in analytical models. Under the assumptions, the equivalent strength and stiffness of the unit cell under compressive and shear loads were predicted and compared. And finally, the optimum core member angle to have maximum mechanical property could be calculated and verified with FE analysis results.

• Journal of the Korean Society for Aeronautical & Space Sciences
• /
• v.32 no.8
• /
• pp.82-90
• /
• 2004

The mechanical characteristics of three types of core with two-dimensional isotropic patterns-triangular, hexagonal and starcell-were studied in applications to sandwich structures. The Young's modulus and shear modulus were calculated for the three core types in the direction normal to the faces. The compressive buckling strength and shear buckling strength were calculated by modeling each cell wall of the core as a plate under compressive or shear load. To verify this model, tests were conducted on scaled specimens to measure the compressive buckling strength of each core. The bending flexibilites of the three cores were also studied. Compliances for the three cores were measured using biaxial flexural tests. The three isotropic core patterns exhibited distinct characteristics. In the direction normal to the faces, all three cores had the same stiffness. However, the starcell core exhibited high flexibility compared to the other cores, indicating potential for application to curved sandwich structures.

• Proceedings of the Korea Concrete Institute Conference
• /
• 1995.04a
• /
• pp.195-200
• /
• 1995

This paper presents the practical use of high strength concrete on 28-story Samsung Shin-dacbang Housing-Commercial Combined Building with 8-story basements located in Seoul. 700 Kg/$\textrm{cm}^2$ compressive Strength concrete was placed for basement core-walls and 500 kg/$\textrm{cm}^2$ concrete was used for structural frames up to 10th floor. The thermal sensors were installed prior to concrete casting into the core walls to measure the heat of hydration during hardening process. The correlation of core strength to the standard cylinder test strength was also discussed. The successful utilization of 500 and 700 kg/$\textrm{cm}^2$ concrete shows that the practical application of high strength concrete has a great potential to the high-rise R.C building construction.

• Journal of Electrical Engineering and Technology
• /
• v.9 no.6
• /
• pp.1909-1913
• /
• 2014

In this study, a superconducting fault current limiter (SFCL) having two magnetic paths was proposed, and its current limiting characteristics were analyzed. For the SFCL to effectively perform the current limiting operation, it must be designed considering the magnetic saturation of the E-I core. Further, the influence of the magnetic flux on its peak current limiting characteristics was investigated. In addition, the magnetic flux curves of the SFCL obtained from the fault current limiting experiments were analyzed, and the subtractive polarity winding case was observed to not only further reduce the saturation potential of the core but also perform the peak current limiting functions well when compared with the additive polarity winding case.

• Computers and Concrete
• /
• v.13 no.3
• /
• pp.389-409
• /
• 2014

Precast hollow core slabs (HCS) are technically advanced products in the precast concrete industry, widely used in the last years due to their versatility, their multipurpose potential and their low cost. Using three dimensional FEM (Finite Element Method) elements, this study focuses on the stresses induced by the prestressing of steel. In particular the investigation of the spalling crack formation that takes place during prestressing is carried out, since it is important to assure the appropriate necessary margins concerning such stresses. In fact, spalling cracks may spread rapidly towards the web, leading to the detachment of the lower part of the slab. A parametric study takes place, capable of evaluating the influence of the tendon position and of the web width on the spalling stress. Consequently, after an extensive literature review on the topic of soft computing, an optimization of the HCS is performed by means of Genetic Algorithms coupled with 3-D FEM models.