• 대한두경부종양학회지
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• 제35권2호
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• pp.11-17
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• 2019

Background/Objectives: Papillary thyroid carcinoma (PTC) has generally an indolent character with a good prognosis. However, recurrence remains a major concern for the patients during their lifetime. Despite the slowly progressing character of PTC, recurrence can occur within a short period after initial surgery. This study aimed to determine the clinical findings and cause of recurrence in patients who underwent re-operative surgery due to neck node recurrence by reviewing the CT (computed tomographic) scan imaging of the recurrence of PTC retrospectively. Materials & Methods: We reviewed the medical records of patients referred to Ajou University Hospital from January 2002 to January 2018. All patients had re-operative surgery due to neck node recurrence and CT scan results of preoperative evaluation and postoperative follow up. Over this period, 110 patients who underwent re-operation due to neck node recurrence with a CT scan were included in our cohort, resulting in a total of 220 re-operations. Results: The time from initial operation to first re-operation was examined in 110 patients. The median time to re-operation was 28 months, with a range of 4 months to 186 months. Most re-operations (82.7%) occurred within the first five years, 43.6% were in the first two years from the initial surgery. The result of the retrospective CT review showed newly developed cases (21,19.1%), missed diagnosis cases (42,38.2%), real recur cases after surgery (33,30.0%), and remnant lymph nodes (LNs) cases (14,12.7%). We further sub-analyzed 14 cases with remnant LNs. Reasons for remnant LNs included insufficient operation (N=5) and beyond general surgical extent. (N=9). Conclusion: Re-operation due to cervical lymph node recurrence is mostly a persistent disease. They included a missed diagnosis and incomplete operation. These finding may reduce the reoperation of cervical lymph node recurrence by accurate preoperative evaluation and complete surgical resection at the initial surgery.

• 한국임상수의학회지
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• 제31권5호
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• pp.371-375
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• 2014

다섯 마리의 개에서 복강경 보조 방광경을 이용하여 요로결석을 제거하였다. 모든 개에서 요로결석으로 인한 배뇨 장애를 보였으며, 수술 방법은 동일하다. 수술 전에 요도를 통해 도뇨관을 방광까지 장착한다. 배꼽 1-2 cm 위 정중선에 5 mm 캐뉼라를 장착하고, 복강경 카메라를 도입한다. 방광 선단 바로 위쪽의 복벽에 10 mm 캐뉼라를 장착하고, Babcock 포셉을 이용하여 방광 일부를 복강 밖으로 노출시킨다. 방광에 찌름절개하고 방광의 절개면과 복벽 절개면을 $360^{\circ}$ 단순 연속 봉합하여 일시적으로 고정시킨다. 2.7 mm 직경의 카메라를 sheath에 연결하여 방광 내부를 탐색하고 지속적인 세척 하에 요로결석을 제거한다. 술 후 주요한 합병증은 나타나지 않았으며, 7-21 개월 간의 추적검사 결과 배뇨장애나 어떠한 재발의 증거도 관찰되지 않았다.

• 한국임상수의학회지
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• 제26권3호
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• pp.273-275
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• 2009

사지마비를 보이는 6년령 시쮸 숫컷이 내원하였다. 신경검사소견 및 영상진단소견에서 경추 4번과 5번 사이, 경추 5번과 6번 사이 및 경추 6번과 7번 사이의 디스크가 탈출되어 척수를 압박하고 있는 것으로 나타났다. 오존가스를 경추 4번과 5번 사이 디스크 및 경추 6번과 7번 사이 디스크에 주입하고 경추 5번과 6번 사이는 복측 감압술로 탈출된 디스크를 제거하였다. 환축은 수술후 목 통증이 사라지고 수술후 3주경 정상보행을 나타냈다. 수술후 2개월째 자기공명영상에서 경추 5번과 6번 사이 디스크와 경추 6번과 7번 사이 디스크의 탈출된 소견이 사라졌고 경추 4번과 5번 사이의 디스크는 탈출된 정도가 현저히 줄어든 소견을 보였다.

• 한국임상수의학회지
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• 제32권4호
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• pp.363-365
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• 2015

반달가슴곰 (Ursus thibetanus)은 국제적 멸종위기종으로, 국립공원관리공단에서 종복원 프로그램을 진행 중이다. 하지만 자연방사가 어려운 개체들은 제한된 사육 시설로 인해 곰 개체수 관리가 필요하여 수컷에서 고환절제술을 시행하였다. Tiletamine-zolazepam 2 mg/kg과 medetomidine $40{\mu}g/kg$ 합제를 이용하여 곰을 포획하고, 기관 삽관을 통해 isoflurane으로 전신마취를 유지하였다. 고환절제술은 전음낭 절개를 통해 closed method로 시행되었으며, LigaSure를 사용하여 정삭을 소락 절단였다. 절개면 피하조직은 흡수성 봉합사로 연속봉합 하였으며, 피부는 조직접착제로 봉합하였다. 별다른 부작용 없이 전신마취에서 회복되었으며, 총 마취 시간은 58분(곰 A)과 53분(곰 B)이었다. 수술시간은 26분(곰 A)과 24분(곰 B)이었으며, 술 후 부종이나 합병증은 관찰되지 않았다. 본 연구는 반달가슴곰에서 LigaSure를 이용한 최초의 고환절제술 증례이다.

• Journal of Korean Neurosurgical Society
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• 제30권7호
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• pp.907-915
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• 2001

Objective : Percutaneous vertebroplasty is often complicated by the presence of multiple fractures or non-localizing pain in the patients with osteoporotic vertebral fractures. The purpose of this study is to estimate the value of preoperative radiologic studies in the localization of symptomatic vertebrae and to determine the factors which can influence on the clinical results. Materials and Methods : We retrospectively reviewed the clinical and radiologic data of 57 vertebrae in 30 patients underwent percutaneous vertebroplasty for osteoporotic vertebral compression fractures. Inclusion criteria was severe pain(McGill-Melzack score 3, 4 or 5) associated with the acute vertebral fractures and absence of spinal nerve root or cord compression sign. Acute symptomatic vertebral fracture was determined by the presence of signal change on MR images or increased uptake on whole body bone scan. Results : Pain improvement was obtained immediately in all patients and favorable result was sustained in 26 patients(86.7%) during the mean follow-up duration of 4.7 months(5 complete pain relief, 21 marked pain relief). Those who underwent vertebroplasty for all acute symptomatic vertebrae had significantly better clinical result than those who did not. Further vertebral collapse and eventual bursting fracture occurred in 1 vertebra which showed intradiskal leakage of bone cement and disruption of cortical endplate on postoperative CT scan. Conclusion : Preoperative MR imaging and whole body bone scan are very useful in determining the symptomatic vertebrae, especially in the patients with multiple osteoporotic vertebral fractures. To obtain favorable clinical result, the careful radiologic evaluation as well as clinical assessment is required. Control of PMMA volume seems to be the most critical point for avoiding complications.

• 대한척추외과학회지
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• 제25권4호
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• pp.169-174
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• 2018

연구계획: 증례 보고 목적: 신경인성 종양과 유사한 흉요추부의 경막외 해면상 혈관종 환자를 보고하고자 한다. 선행 연구문헌의 요약: 뼈에 침습이 없는 경막외 해면상 혈관종은 매우 드문 질환으로 제한된 문헌 보고만이 존재한다. 대상 및 방법: 53세 여자 환자가 내원 한달여 전부터 시작된 좌측 하지의 감각저하를 동반한 저린 느낌을 주소로 내원하였다. 내원시 시행한 신경학적 검진에서 기타 다른 신경학적 이상 소견은 관찰되지 않았다. 자기공명영상에서는 흉추 11-12번간 좌측 추간공에 $2{\times}0.5cm$ 크기의 종괴가 관찰되었다. 수술을 시행하여 이를 완전 적출하였다. 결과: 병리 검사에서 해면상 혈관종이 확진되었다. 수술 부위의 약한 통증을 제외하고, 추적 관찰 2년동안 추가적인 신경학적인 증상 발생 없이 좋은 결과를 보였다. 수술 후 2년째에 촬영한 MRI에서 종양의 재발 소견은 관찰되지 않았다. 결론: 척추의 경막외 해면상 혈관종은 매우 드문 질환이며, 다른 경막외 병변들과 감별하기는 쉽지 않다. 그러나, 수술적 치료의 좋은 예후를 보이는 점을 감안하면, 경막외 병변의 감별진단시 이를 반드시 고려해야 할 것으로 생각한다.

• 한국방사선학회논문지
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• 제16권5호
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• pp.559-565
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• 2022

대체적으로는 전임상 평가로써 소·대동물을 통한 의료기기 개발 평가를 이루고 있으며 본 연구에서는 소화기계 위 날문부 협착 치료 평가모델 개발을 위해 스텐트 삽입 후 발생하는 조직 과증식 형성 모델을 개발하고자 한다. 파일럿실험으로 백서 3마리에서 날문부에 조영제를 주입하고 정상의 날문부 사이즈를 확인하였으며, 그에 맞는 사이즈의 스텐트를 삽입하였다. 1주일 내에 모든 백서에서 스텐트의 이동이 확인되었으며 본 실험에서는 스텐트를 투시 가이드 하에 gastrostomy 후 스텐트 삽입 시 날문부를 suture 하여 고정하여 조직 과증식이 형성이 가능하도록 하였다. 20마리의 백서를 Healthy Group / Gastrostomy Group으로 나누었다. Stent Group 백서를 마취 후 복부 절개 후 투시 가이드하에 gastrostomy를 실시하여 위 날문부에 스텐트를 삽입하였다. 또한, 연동운동에 의한 스텐트의 이동을 방지하기 위하여 위의 스텐트와 스텐트가 삽입된 위의 날문부를 suture 하여 고정하였다. 수술 후 행동 및 체중 변화를 매주 모니터링 하였다. 수술 후 4주 뒤 위장조영술을 시행 후 희생하였다. 위의 날문부 과증식 정도 평가를 위해 희생 후 적출한 위의 날문부 병리학적 분석을 실시하였다. 조직병리 및 면역 염색 평가에서 Gastrostomy Group이 통계적으로 유의하게 더 높았다(all p<.001). 결론적으로 Gastrostomy를 통한 위 날문부 수술 모델은 위 날문부 스텐트 삽입술 전임상 평가를 위한 조직 과증식의 형성 정도가 연구평가 툴로써 적정한 것으로 사료된다.

• Journal of Korean Neurosurgical Society
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• 제66권1호
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• pp.72-81
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• 2023

Objective : Ischemia and hemorrhage of pituitary adenomas (PA) caused important clinical syndrome. However, the differences on clinical characteristics and surgical outcomes between these two kinds apoplexy were less reported. Methods : A retrospective analysis was made of patients with pituitary apoplexy between January 2013 and June 2018. Baseline and clinical characteristics before surgery were reviewed. All patients underwent transsphenoidal surgery and were followed up at least 1 year. Results : Total 67 cases (5.8%) among 1147 pituitary tumor patients were enrolled, which consisted of 28 (~2.4%) ischemic PA and 39 (~3.4%) hemorrhagic PA. There were more male patients in the ischemic group compared with hemorrhagic group (78.6% vs 53.8%, p=0.043). However, the mean age, tumor size and functional tumor ratio were significant higher in the hemorrhagic group. Headache was more common in ischemic PA (82.1%) than that of hemorrhagic PA (51.3%, p=0.011). Magnetic resonance imaging findings found that mucosal thickening and enhancement of the sphenoid sinus was observed in 15 ischemic PA patients (n=27, 55.6%), but none in patients with hemorrhagic PA (n=38, p<0.0001). It was worth noting that the rate of pre-surgical hypopituitarism in ischemic PA patients were seemed higher than that in hemorrhagic PA patients, but not significant. The two groups got a total tumor resection rate at 94.1% and 92.9%, independently. No significant difference on the operative time, blood loss in operation and complications in perioperative period was observed in two groups. After operation, cranial nerve symptoms recovered to normal at 81.8% of ischemic PA patients and 82.6% of hemorrhagic PA patients. Importantly, the incidence of postoperative hypopituitarism partially decreased in both groups, among which the rate of hypothyroidism in ischemic PA patients significantly decreased from 46.4% to 18.5% (p=0.044). Conclusion : Patients with ischemic PA presented different clinical characteristics to the hemorrhagic ones. Transsphenoidal surgery should be considered for the patients with neuro-ophthalmic deficits and might benefit for pituitary function recovery of the apoplectic adenoma patients, especially pituitary thyroid axis in ischemic PA patients.

• Journal of Korean Neurosurgical Society
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• 제66권4호
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• pp.446-455
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• 2023

Objective : Chronic subdural hematoma (CSDH) is a common neurosurgical disease and generally treated with burr-hole surgery alone. Tranexamic acid (TXA) is an antifibrinolytic agent that potentially reduces recurrence rates and the residual hematoma volume. However, the role of postoperative TXA medication remains unclear to date. This study aimed to verify the effectiveness of adjunctive TXA in the view of early hematoma resolution. Methods : Between January 2018 and September 2021, patients with CSDH who underwent burr-hole trephination in a single tertiary institute were reviewed. The study population was divided into three groups, TXA, non-TXA, and antithrombotics (AT) groups, according to the medical history of cardio-cerebrovascular disease and TXA administration. The primary endpoint was CSDH recurrence, defined as re-appearance or re-accumulation of CSDH requiring neurosurgical interventions. The secondary outcome was CSDH resolution, defined as complete or near-complete resorption of the CSDH. The CSDH resolution time and serial changes of hematoma thickness were also investigated. Results : A total of 240 patients was included in the analysis consisting of 185 male and 55 female, with a median age of 74 years. During the median imaging follow-up period of 75 days, 222 patients were reached to the primary or secondary endpoint. TXA was administered as an adjunctive therapy in 41 patients (TXA group, 16.9%) while 114 patients were included in the non-TXA group (47.9%) and 85 were in the AT group. The recurrence rate was the lowest in the TXA group (2.4%), followed by non-TXA (7.0%) and AT (8.2%) groups. However, there was no statistical significance due to the small number of patients with recurrence. CSDH resolution was achieved in 206 patients, and the median estimated time to resolution was significantly faster in the TXA group (p<0.001). Adjunctive TXA administration was a significant positive factor for achieving CSDH resolution (p<0.001). The hematoma thickness was comparable among the three groups at the initial time and after surgery. However, CSDH thickness in the TXA group decreased abruptly in a month and showed a significant difference from that in the other groups (p<0.001). There was no TXA-related adverse event. Conclusion : The adjunctive use of TXA after CSDH surgery significantly facilitated the resorption of residual CSDH and resulted in the early CSDH resolution. Adjunctive TXA may be an effective treatment option to reduce recurrence by enhancing CSDH resolution in the selective patients.

• Korean Journal of Radiology
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• 제23권10호
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• pp.1019-1027
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• 2022

Objective: Thyroidectomy bed lesions frequently show suspicious ultrasound (US) features after thyroid surgery. Fine-needle aspiration (FNA) may not provide definitive pathological information about the lesions. Although core-needle biopsy (CNB) has excellent diagnostic performance in characterizing suspicious thyroid nodules, no published studies have evaluated the performance of CNB specifically for thyroidectomy bed lesions. Therefore, we aimed to evaluate the diagnostic performance and safety of CNB for characterizing thyroidectomy bed lesions. Materials and Methods: A total of 124 thyroidectomy bed lesions in 113 patients (79 female and 34 male; age, 23-85 years) who underwent US-guided CNB between December 2008 and December 2020 were included. We reviewed the US imaging features of the target lesions and the histories of previous biopsies. The pathologic results, diagnostic performance for malignancy, and complications of CNB were analyzed. Results: All samples (100%) obtained by CNB were adequate for pathological analysis. Pathological analysis revealed inconclusive results in two lesions (1.6%). According to the reference standard, 50 lesions were ultimately malignant (40.3%), and 72 were benign (58.1%), excluding the two inconclusive lesions. The performance of CNB for diagnosing malignant thyroidectomy bed lesions in the 122 lesions had a sensitivity of 98.0% (49/50), a specificity of 100% (72/72), positive predictive value of 100% (49/49), and negative predictive value of 98.6% (72/73). Eleven lesions were referred for CNB after prior inconclusive FNA results in thyroidectomy bed lesions, for all of which CNB yielded correct conclusive pathologic diagnoses. According to the pathological analysis of CNB, there were various benign lesions (58.9%, 73/124) besides recurrence, including benign postoperative lesions other than suture granuloma (32.3%, 40/124), suture granuloma (15.3%, 19/124), remnant thyroid tissue (5.6%, 7/124), parathyroid lesions (4%, 5/124), and abscesses (1.6%, 2/124). No major or minor complications were associated with the CNB procedure. Conclusion: US-guided CNB is accurate and safe for characterizing thyroidectomy bed lesions.