• The Korean Journal of Pharmacology
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• v.23 no.2
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• pp.57-75
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• 1987

Two modalities of gonadotropin secretion, pulsatile gonadotropin and preovulatory gonadotropin surge, have been identified in the mammals. Pulsatile gonadotropin secretion is modulated by the pulsatile pattern of GnRH release and complex ovarian steroid feedback actions. The neural mechansim that regulates the pulsatile release of GnRH in the hypothalamus is called "GnRH pulse generator". Ovarian steroids, estradiol and progesterone, appear to exert thier feedback effects both directly on the pituitary to modulate gonadotropin release and on a hypothalamic site to modulate GnRH release; estradiol primarily affects the amplitude while progesterone decreases the frequency of the pulsatile GnRH. Steroid hormones are known to affect catecholamine transmission in brain. MBH-POA is richly innervated by NE systems and close apposition of NE terminals and GnRH cell bodies occurs in the MBH as well as in the POA. NE normally facilitates pulsatile LH release by acting through ${\alpha}-receptor$ mechanism. However, precise nature of facilitative role of NE transmission in maintaining pulsatile LH has not been clearly understood. Close apposition of DA and GnRH terminals in ME might permit DA to influence GnRH release. Action of DA transmission probably is mediated by axo-axonic contacts between GnRH and DA fibers in the ME. Dopamine transmission does not normally regulate pulsatile LH release, but under certain conditions, increased DA transmission inhibit LH pulse. Endogenous opioid acts to suppress the secretion of GnRH into hypophysial portal circulation, thereby inhibiting gonadotropin secretion. However, an interaction between endogenenous opioid peptides and gonadotropin release is a complex one which involves ovarian hormones as well. LH secretion appears to be most suppressed by endogenenous opioids during the luteal phase, at a time of elevated progesterone secretion. The arcuate nucleus contains not only cell bodies for GnRH and ${\beta}-endorphin$ but also a dense aborization of fibers suggesting that GnRH release is changed by the interactions between GnRH and ${\beta}-endorphin$ cell bodies within the arcuate nucleus. The frequency and amplitude of pulsatile LH release seem to be increased during the preovulatory gonadotropin surge. Estradiol exerts positive feedback action on the hypothalamo-pituitary axis to trigger preovulatory LH surge. GnRH is also crucial hormonal stimulus for preovulatory LH surge. It is unlikely, however, that increased secretion of GnRH during the preovulatory gonadotropin surge represents an obligatory neural signal for generation of the LH discharge in primates including human. Modulation of preovulatory LH surge by catecholamines has been studied almost exclusively in rats. NE and E may be involved in distinct way to accumulate GnRH in the MBH and its release into the hypophysial portal system during the critical period for LH surge on proestrus in rats. However, the mechanisms whereby augmented adrenergic transmission may facilitate the formation and accumulation of GnRH in the ME-ARC nerve terminals before the LH surge have not been clearly understood.

• Journal of the Korean BIBLIA Society for library and Information Science
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• v.33 no.4
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• pp.73-92
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• 2022

This study intends to design a model that can effectively service policy data necessary for the implementation of new national agenda in order to provide high-quality policy information services that go beyond those of the existing Policy Information Portal (POINT) of National Sejong Library. To this end, it was determined that providing an integrated search environment, in lieu of data search through individual access, was necessary. Subsequently, four possible models for a national agenda service model were presented. First, designing a computerized system for both interface and electronic information source aspects was proposed for the national agenda service system operation. Second, designing the Linked Open Data system and the time-series service system for national policy information, providing the translation service of overseas original data, and securing the researcher's desired data were presented for the national agenda service information source operation. Third, strengthening public relations for policy users, building and promoting the site brand, operating SNS channels, and reinforcing the activation of auxiliary materials and the accessibility of external services were proposed for public relations of national agenda service. Fourth, expanding the information network with Open API, cloud service, and overseas libraries was proposed for collaborating and cooperating with the agenda service.

• The Journal of the Convergence on Culture Technology
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• v.9 no.3
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• pp.415-423
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• 2023

The purpose of this study was to prepare basic data for improving school library information service by investigating the information usage behavior of specialized high school students. Preferred information sources for each situation requiring information and the level of solving information problems using information sources were investigated, and difference analysis was conducted by department and grade. As a result of the survey, the percentage of students who preferred Internet portal services, personal information sources (teachers, friends, parents), and social media was high, while the percentage of students who preferred traditional print information sources and mass media was very low. The average score of the information problem solving level was 3.55, and the problem solving level in the areas of employment and career/admission was relatively low. Preferred sources of information were similar regardless of grade and department, and the difference between departments in information problem solving level was not statistically significant, but the difference between grades was statistically significant. In addition, there is an academic contribution in this field that specific examples of youth information use behavior have been added. Based on the results of the study, librarians should make efforts to verify the reliability of Internet portal site information, improve and promote library information sources, and expand library use education. In future studies, it was suggested to develop customized information services.

• The Journal of Korean Society for Radiation Therapy
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• v.21 no.2
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• pp.83-88
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• 2009

Purpose: Cone beam computed tomography (CBCT) using an on board imager (OBI) can check the movement and setup error in patient position and target volume by comparing with the image of computer simulation treatment in real.time during patient treatment. Thus, this study purposed to check the change and movement of patient position and target volume using CBCT in IMRT and calculate difference from the treatment plan, and then to correct the position using an automated match system and to test the accuracy of position correction using an electronic portal imaging device (EPID) and examine the usefulness of CBCT in IMRT and the accuracy of the automatic match system. Materials and Methods: The subjects of this study were 3 head and neck patients and 1 pelvis patient sampled from IMRT patients treated in our hospital. In order to investigate the movement of treatment position and resultant displacement of irradiated volume, we took CBCT using OBI mounted on the linear accelerator. Before each IMRT treatment, we took CBCT and checked difference from the treatment plan by coordinate by comparing it with the image of CT simulation. Then, we made correction through the automatic match system of 3D/3D match to match the treatment plan, and verified and evaluated using electronic portal imaging device. Results: When CBCT was compared with the image of CT simulation before treatment, the average difference by coordinate in the head and neck was 0.99 mm vertically, 1.14 mm longitudinally, 4.91 mm laterally, and 1.07o in the rotational direction, showing somewhat insignificant differences by part. In testing after correction, when the image from the electronic portal imaging device was compared with DRR image, it was found that correction had been made accurately with error less than 0.5 mm. Conclusion: By comparing a CBCT image before treatment with a 3D image reconstructed into a volume instead of a 2D image for the patient's setup error and change in the position of the organs and the target, we could measure and correct the change of position and target volume and treat more accurately, and could calculate and compare the errors. The results of this study show that CBCT was useful to deliver accurate treatment according to the treatment plan and to increase the reproducibility of repeated treatment, and satisfactory results were obtained. Accuracy enhanced through CBCT is highly required in IMRT, in which the shape of the target volume is complex and the change of dose distribution is radical. In addition, further research is required on the criteria for match focus by treatment site and treatment purpose.

• Journal of the Korean GEO-environmental Society
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• v.13 no.11
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• pp.69-79
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• 2012

This pre-supported nail method is able to decrease ground displacements more than NATM because this method reinforces ground with grouted steels before tunnel excavation. Therefore this method has advantage of being able to increase the stability and workability. This study presents applicability of pre-supported nail method with case of site measurement for shallow tunnel composed with high groundwater level and unconsolidated soil, performs this research the mechanism of new supporting system is compared with the conventional existing supporting system in terms of soil reinforcement. NATM has characteristics that construction stage displacement of the apparent height difference is observed in the step of divided excavation processing. Otherwise it is analyzed that pre-supported nail method is not sensitive in the displacement problem of excavation processing in comparison to NATM. It is found that this method is very applicable in shallow depth tunnel such as portal area, tunnel in soil and weak zone without arching effect.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.15 no.4
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• pp.1946-1952
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• 2014

The purpose of this study is to suggest some improvements of information service on the Internet through a comparative analysis of information use patterns of science and technology researchers in universities, research institutes and business enterprises. We classify information use patterns into information use purpose, information use types, a frequently used/referenced portal site, the initial method of internet search, information service selection factors and the channels of off-line information acquisition. The results of this study are as follows: First, according to frequency analysis, there are some information use patterns among S & T research groups. Second, according to ${\chi}^2$ analysis, there are some significant differences in ratio of information use patterns among them.

• Journal of The Korean Society of Agricultural Engineers
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• v.57 no.4
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• pp.39-49
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• 2015

Since most medical facilities and medical personnel are concentrated in urban areas in South Korea, an imbalance of access to medical facilities causes a gap in medical resource availability between urban and rural areas. Accessibility to medical facilities is a means of assessment that evaluates a measure of inequality in utilization of medical resources. The evaluation of accessibility uses Euclidean distance, in general; however, this method has its limits in that Euclidean distance cannot reflect actual distance. This study aims to estimate real road distance from village halls to medical facilities in rural areas using Open Application Programming Interface (Open API) of an internet portal site. Using real road distance, we evaluated medical accessibility and compared it with Euclidean distance. The accessibility to primary medical institutions was valued relatively well, but secondary and tertiary medical institutions were vulnerable in Pyeonchang-gun. Comparing Euclidean distance with real road distance from village halls to medical facilities, real road distance appeared to be approximately 1.4 times that of Euclidean distance. This calculation is similar to the circuity factor of Gangwon-do in Korea that estimated to fix the limits of Euclidean distance and assumed real road distance.

• Proceedings of the Korea Contents Association Conference
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• 2006.11a
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• pp.547-550
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• 2006

The criterion which judges an information retrieval system performance is to how many accurately retrieve an information that the user wants. The search result which uses only homograph has been appears the various documents that relates to each meaning of the word or intensively appears the documents that relates to specific meaning of it. So in this paper, we suggest semantic information retrieval technique using relation within User-Word Intelligent Network(U-WIN) to solve a disambiguation of query In our experiment, queries divide into two classes, the homograph used in terminology and the general homograph, and it sets the expansion query forms at "query + hypemym". Thus we found that only web document search's precision is average 73.5% and integrated search's precision is average 70% in two portal site. It means that U-WIN-Based semantic information retrieval technique can be used efficiently for a IR system.

• 대한예방의학회:학술대회논문집
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• 2001.04a
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• pp.39-49
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• 2001

전염병 정보화사업은 1995년 콜레라의 집단 발병을 계기로 1996년부터 추진되었다. 교통의 발달과 국제교류의 증가는 전염병의 전파와 확산속도가 빨라져 국민건강을 위협하고 있으며 기존의 수작업만으로 정보수집 및 효율적인 전염병관리가 어려워 체계적이고 효율적인 전염병관리를 위하여 국가적 D/B 구축, 전염병관리의 의사결정지원자료 축적의 필요성 제기되었으나 독자적인 망 구축에는 막대한 예산이 들고 망의 운영과 유지관리를 위한 예산과 조직의 한계가 있는 상황에서 콜레라 발생을 계기로 보건복지부 방역과, 국립보건원, 국립서울 검역소, 경기도 6개 보건소 및 경기 및 인천 보건환경연구원을 실험적으로 연계하여 전염병 관리에 필요한 정보의 내용과 흐름, 자료 관리를 위한 기관별, 자치단체별 역할과 기능 등에 관한 개념 정립 둥 전산개발과 함께 제도정비 방안 등이 동시에 수행되었다. 이러한 실험과 연구 결과를 토대로 1998년부터 인터넷을 활용한 전염병의 신고 보고, 전염병관련 자료의 D/B를 통한 전염병의 발생 예측, GIS 등 전염병에 관한 모든 정보를 제공할 수 있는 portal site 구축을 위한 2단계 정보화사업이 정보통신부 지원 하에 시도되었다. 약 2년간의 작업 결과 전염병관리의 전산화 가능성이 확인된 후 전염병예방법을 개정하여 전산 보고의 제도적 틀을 만들고 2000년 8월부터 법정전염병은 전산 보고가 이루어 지고 있다. 일방적이 보고이외 전염병관리의 쌍방화를 위하여 각종 지령/정보의 전파, 각종 통계, 지침, 교육자료, 전염병관련 논문 등을 제공하고 있으며, 상담, 민원접수는 전염병 관련 정보의 전문화와 함께 국민과 호흡할 수 있는 시스템으로 운영될 수 있도록 설계하였다. 그러나 현재 사용하고 있는 WEB EDI가 가진 속도 문제, 응용프로그램의 문제로 신고 보고를 C/S 버전으로 전환하여 사용자의 편리성을 증진하고 있다. 또한 예방접종자료의 전산화를 통한 이상반응 관리, 접종주기 관리, 예방접종으로 관리할 수. 있는 전염병관리(Vaccine preventable disease), 학교에서 발생하는 전염병의 감시 등 전염병 포탈 사이트에 걸맞게 정보 내용을 한층 확대하고 있고 일선의료기관도 활용할 수 있는 시스템으로 발전시키고 있다. 이를 위하여 정보관리과도 신설하였다. 그러나 전염병관리의 전산화는 궁극적으로 전염병 자료의 지역화와 그를 통한 전염병관리의 분권화 및 지방자치화를 이루고자 하는 것이다. 기술적인 측면에서 전산망은 쉽게 만들 수 있으나 전염병관리의 개선과 그 정착은 1-2년간의 전산프로그램개발 작업만으로 달성되기는 어려우며 범국가적인 노력과 더불어 일선보건요원의 교육과 훈련 및 보건소장 등 보건관리자의 전산마인드 개발 등의 작업도 매우 중요할 것으로 사료된다.

• Journal of the Korean Home Economics Association
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• v.45 no.10
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• pp.21-31
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• 2007

The purpose of this study was to clarify the factors that characterize the fashion brand online communities that have a high participation rate among high school students, and to determine the impact of those factors on the high school students' commitment to the community, especially in relation to their demographics. The study was implemented through a descriptive survey method using an online questionnaire. The sample consisted of 301 members of online fashion brand communities operated on the Daum portal site. The data were analyzed by frequency, factor analysis, and regression analysis. The results are as follows: (1) Factor analysis revealed that the characteristics of a fashion brand online community are associated with three factors ; compensation/interest, interactivity, and information. (2) Regression analysis showed that the more compensation/interest, opportunity for interaction, and information the community provides, the more likely high school student members are to show a higher level of commitment to the community. (3) There was no difference in the effect of community attribute factors on the high school student members' commitment to the community according to gender. The group of students majoring in human and liberal education was the most influenced by the attributes of fashion brand online communities. The interactivity factor had a greater impact on the group of students majoring in art and physical education than on the other groups. The greater the use of the Internet, the greater the impact of community attributes on commitment. (4) In the process of developing an online community, marketers should fully consider the fact that information factors have the biggest impact on high school students' commitment to the community. Therefore, greater effort should be made to differentiate between community attributes based on high school students' majors and their amount of Internet use in order to motivate commitment to the community and brand loyalty as well.