• Title/Summary/Keyword: Polyethylene glycol

Search Result 687, Processing Time 0.027 seconds

Controlled Release of Drugs from Silicone Rubber Matrices-Effects of Physical Properties of Drugs and Release Controlling Agents on Drug Release Mechanisms- (실리콘 마트릭스로부터의 약물조절 방출-약물 및 방출조절제의 물성이 방출기전에 미치는 영향-)

  • Jeon, So-Young;Lee, Seung-Jin
    • Journal of Pharmaceutical Investigation
    • /
    • v.21 no.4
    • /
    • pp.237-245
    • /
    • 1991
  • Matrix type silicone rubber devices were designed for long-term implantable drug delivery system. Release controlling agents (RCA), i.e., polypropylene glycol, polyethylene glycol, were employed to control drug release from the devices. The release rate of drug from RCA dispersed silicone matrices was mainly dependent on hydrophilicity-hydrophobicity of drug and RCA. In the case of hydrophilic drug, the release from the RCA dispersed matrix was regulated by swelling kinetics. Especially when the relatively hydrophobic polypropylene glycol was used, swelling control mechanism induced zero-order release kinetics. Whereas, the release of hydrophobic drug was resulted from partition mechanism. The effect of RCA was to increase drug diffusivity.

  • PDF

An Approach to Improve Thermal Insulation Properties and Fabric Hand of Wool and Wool-like Fabrics under High Molecular Polyethylene Glycol Treatment (고분자량 Polyethylene Glycol 처리에 따른 모직물과 유사모직물의 보온성과 태의 향상 방안 모색)

  • 조길수;이은주
    • Journal of the Korean Society of Clothing and Textiles
    • /
    • v.21 no.6
    • /
    • pp.1041-1050
    • /
    • 1997
  • This study was carried out to improve the thermal insulation properties of wool and wool- like fabrics by treating the fabrics with polyethylene glycol, to evaluate the fabric hand of PEG treated wool and wool-like fabrics and to grade up the fabric hand of the treated fabrics by treating with softening agents. Wool and wool-like fabrics were treated with high molecular PEG-8,000 by PDC. The thermal release/storage properties were measured on a DSC. Hand of specimens were evaluated by KES-FB system. The results were as follows; 1. PEG-treated fabrics showed thermal storage and thermal release properties by DSC and the heat contents were generally proportional to the add-ons. 2. PEG-treated fabrics showed higher Koshi and lower Numeri and Sofutosa values due to lower tensile energy and recovery and higher bending rigidity and shear stiffness as the add- ons increased. 3. PEG-treated fabrics showed much lower bending rigidity after softening agents treatment.

  • PDF

A Versatile and Practical Synthesis of 1, 8-Dioxo-octahydroxanthene Derivatives Catalyzed by Polyethylene Glycol (PEG) in Water (수용액에서 폴리에틸렌 글리콜 촉매에 의한 1, 8-Dioxo-octahydroxanthene 유도체의 다용도적이며 실용적인 합성)

  • Chavan, Abhijit P.
    • Journal of the Korean Chemical Society
    • /
    • v.53 no.4
    • /
    • pp.415-421
    • /
    • 2009
  • A convenient and practical synthesis of 1, 8-dioxo-octahydroxanthene derivatives using various aldehydes, 5, 5-dimethyl-1, 3-cyclohexanedione in water was successfully carried out in the presence of polyethylene glycol (PEG) as a catalyst. Simple work-up, clean products, high yields and water as a green solvent are the attractive features of this methodology.

Chemical Modification of Sheep Hemoglobin with Methoxy-Polyethylene Glycol

  • Jeong, Seong-Tae;Byun, Si-Myung
    • BMB Reports
    • /
    • v.29 no.3
    • /
    • pp.261-265
    • /
    • 1996
  • Sheep hemoglobin (SHb) was modified with methoxy-polyethylene glycol (mPEG) to develop a potential blood substitute. mPEG has been used to decrease antigenicity and immunogenicity of foreign proteins. When the mPEG was attached to SHb, the modified hemoglobins showed decreased electrophoretic mobility on SDS-PAGE and decreased free amino groups. When the remaining free amino groups of mPEG modified SHb were determined by TNBS free amino group titration methods. about 34% of total free amino groups were modified with mPEG. This mPEG-SHb conjugate of 34% amino groups modified showed no precipitation by double immunodiffusion with polyclonal antibodies against SHb. This modified hemoglobin still has oxygen transport activity. So this antigenicity decreased hemoglobin may be used in humans as a potential blood substitute.

  • PDF

Controlled Drug Release from Polyacrylic Acid-Polyethylene Glycol Interpenetrating Networks (폴리아크릴산-폴리에칠렌글리콜 IPN공중합체 마트릭스의 팽윤 및 약물방출)

  • Kim, Youn-Jung;Kim, Kil-Soo;Lee, Seung-Jin
    • Journal of Pharmaceutical Investigation
    • /
    • v.24 no.4
    • /
    • pp.257-263
    • /
    • 1994
  • The interpenetrating polymer networks (IPNs) of polyacrylic acid (PAA)-polyethylene glycol (PEG) were synthesized via crosslinking of PEG and simultaneous free radical polymerization of PAA. The equilibrium swelling of the IPNs matrices, ranged from 40% to 95%, was varied to a great extent as compared with PAA homopolymer due to the interpolymer interaction between PAA and PEG. The drug release kinetics of drug loaded matrices was significantly affected by the charge of drugs as well as interpolymer complexation.

  • PDF

Fabrication and characterization of polysulfone ultrafiltration membrane using polyethylene glycol and tartaric acid: morphology and performance in protein separation

  • Sharma, N.;Purkait, M.K.
    • Membrane and Water Treatment
    • /
    • v.8 no.6
    • /
    • pp.591-612
    • /
    • 2017
  • Increase in the hydrophilicity (HPCT) of polysulfone (PS) membrane and subsequently decrease in fouling can be achieved by surface modification of PS based membranes. Therefore, in this work, ultrafiltration membranes with increased HPCT were prepared using the enantiomeric tartaric acid (D-TA) and racemic tartaric acid (DL-TA). Phase inversion technique was used for the preparation of polyethylene glycol and TA blended PS membrane. Morphological analysis of the fabricated membranes was done by scanning electron microscope and atomic force microscopy. Bovine serum albumin (BSA) solution was taken for finding the permeation and rejection behavior of prepared membranes. Maximum BSA rejection was increased by 70.5% for the modified membrane.

Estimation of dimensional stability of woods with time by Polyethylene glycol treatment (Polyethylene glycol처리과정 중 목재 치수안정성의 경시적 평가)

  • 권구중;김남훈
    • Journal of the Korea Furniture Society
    • /
    • v.13 no.1
    • /
    • pp.2-8
    • /
    • 2002
  • This study was carried out to investigate the reasonable condition for better dimensional stability in woods by polyethylene glycol(PEG) treatment. Eight species grown in Kangwon-do were used for this study. Three species of softwoods(Pinus densiflora, Pinus koraiensis, Larix kaempferi) and two species of hardwoods(Prunus sargentii, Populus tomentiglandulosa) treated with 30% aqueous solution of PEG 1000 showed good dimensional stability under the treatment for 1 day. The dimensional stability of Betula davurica, Quercus mongolica and Quercus variabilis woods increased with increasing treatment time. From the above results, it was concluded that PEG penetration and dimensional stability were affected by characteristics of wood species such as density and structure.

  • PDF

The Effect of Human Recombinant Superoxide Dismutase Conjugated with Polyethylene Glycol on the Hepatic Toxicity of Acetaminophen (HrSOD-폴리에칠렌 접합체의 아세트아미노펜 간독성에 미치는 영향)

  • Yong, Chul-Soon;Park, Kyong-Ah;Oh, Doo-Man
    • Journal of Pharmaceutical Investigation
    • /
    • v.25 no.4
    • /
    • pp.313-322
    • /
    • 1995
  • The covalent conjugation of human recombinant superoxide dismutase (hrSOD) with trichloros-triazine activated polyethylene glycol (PEG) 5000 formed soluble conjugates with molecular weight of 92KD, which retained $90{\sim}98%$ of original activity with a markedly prolonged plasma half-life of enzyme activity. The effect of hrSOD-PEG conjugates on acetaminophen (ACP)-induced hepatotoxicity was tested in male rats which were pretreated with 3-methylcholanthrene. HrSOD-PEG conjugates inhibited the hepatotoxicity produced by ACP, on the other hand, native hrSOD had no protective effect. The above results indicated that oxygen radicals might participate in the mechanism of the ACP-induced hepatotoxicity and that polymer conjugated-protein drugs with prolonged half-lives could be employed as an effective therapeutic agent.

  • PDF

Determination of Polyol Concentration Affecting to the Transparent Bar Soap Using Design of Experiment Method (실험 계획법을 이용한 투명비누에 영향을 미치는 폴리올 농도 결정)

  • Cho, Wan-Goo
    • Journal of the Korean Applied Science and Technology
    • /
    • v.29 no.1
    • /
    • pp.54-62
    • /
    • 2012
  • In this experiment, the optimum concentration of polyols which were used for making transparent soaps was determined using design of experiment (DOE) method. Dipropylene glycol and 1,3 butylene glycol with short chains enhanced the transparency of soap, however, polyethylene glycol 400, glycerin and diglycerin made the soap opaque. The hardness of soap was increased as increasing the concentration of propylene glycol, diglycerin, dipropylene glycol and polyethylene glycol 400. The hardness, transparency, absorbance of water, and friction solubility could be optimized by controlling the concentration of dipropylene glycol, polyetylene glycol, sugar, and triethanolamine.

Effect of Polyethylene Glycol Molecular Weight and NCO Index on Properties of the Hydrophilic Reactive Hotmelt Polyurethane Adhesives (Polyethylene Glycol의 분자량 및 NCO index의 변화에 따른 Hydrophilic Reactive Hotmelt Polyurethane의 물성 변화)

  • Han, Young Chul;Kim, Dack Han;Oh, Kyung Seok;Shin, Hyeon Jeong;Yang, Jeong Han;Jeong, Han Mo
    • Textile Coloration and Finishing
    • /
    • v.30 no.2
    • /
    • pp.90-97
    • /
    • 2018
  • Hydrophilic reactive hot-melt polyurethane adhesive(HRHA) using a hydrophilic polyol having different molecular weight and NCO index was synthesized. This HRHA was synthesized using Polyethylene glycol(PEG) as a hydrophilic polyol, Polypropylene glycol(PPG) and Polycaprolactone diol(PCL) as hydrophobic polyols, and Methylene diphenyl diisocyanate(MDI) as an isocyanate. The changes in IR spectrum, viscosity and thermal properties of HRHA with different PEG molecular weights and NCO index were investigated, and the tensile strength and elongation of the HRHA casting film and the peel strength, moisture permeability and water pressure of the HRHA coated fabric were confirmed. In this experiment, as the molecular weight of PEG and NCO index increased, the adhesive strength, tensile strength, elongation and moisture permeability was increased but viscosity and Tg was decreased.