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Dietary spray-dried plasma improves intestinal morphology of mated female mice under stress condition

  • Liu, Yanhong;Choe, Jeehwan;Kim, Sheena;Kim, Byeonghyeon;Campbell, Joy M.;Polo, Javier;Crenshaw, Joe D.;Pettigrew, James E.;Song, Minho
    • Journal of Animal Science and Technology
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    • v.60 no.6
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    • pp.10.1-10.6
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    • 2018
  • Background: Stress causes inflammation that impairs intestinal barrier function. Dietary spray-dried plasma (SDP) has recognized anti-inflammatory effects and improvement of gut barrier function. Therefore, the purpose of this study was to investigate the effects of dietary SDP on intestinal morphology of mated female mice under stress condition. Results: Villus height, width, and area of small intestines were low on gestation day (GD) 3 or 4 under stress conditions, and higher later (Time, P < 0.05). Crypt depth of colon was low on GD 4 and higher later (Time, P < 0.05). Meanwhile, the SDP treatments improved (P < 0.05) intestinal morphology, indicated by increased villus height, villus width, villus area, and ratio between villus height and crypt depth of small intestines and crypt depth of colon, and by decreased crypt depth of small intestines, compared with the control diet. The SDP treatments also increased (P < 0.05) the number of goblet cells in intestines compared with the control diet. There were no differences between different levels of SDP. Conclusion: Dietary SDP improves intestinal morphology of mated female mice under stress condition.

Study of a measure to improve the fit of U.S. apparel products directly imported to Korea - With a focus on female casual pants -

  • Choi, Sunyoon;Chun, Jongsuk
    • The Research Journal of the Costume Culture
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    • v.23 no.2
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    • pp.284-293
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    • 2015
  • This study intends to analyze the fit of directly-imported American casual pants for Korean female college students in terms of appearance and comfortableness. The authors carried out a wearing test with sample pants from 3 brands (DKNY: A, Gap: B, Polo: C) that had the most market share and that were mostly preferred by Korean female college students. Results showed that pants A had insufficient ease in the crotch, as the depth of the crotch was short. The hip girth received a low assessment in terms of appearance. Moreover, the hem widths were wide while the pants length was long. Pants B were expected to be most appropriate for Korean women's bodies, as they had the longest crotch depth among the three brands. However, the pants appeared to pull downward due to the narrow thigh and the knee girth and hem width. Moreover, the crotch girth and hip girth received a poor appearance assessment. Pants C were rated as satisfactory for their thigh girth, knee girth, and hem width. However, the crotch was uncomfortable, as it had a short crotch depth. The hip girth received a low appearance assessment. This study suggests that a pattern adjustment is required for directly-imported American pants to provide a better fit for the bodies of Korean women. The crotch depths should be approximately 17.5 cm. The hem widths should be approximately 20 cm. We also suggest a leg length of 75 cm, a waist girth of 86 cm, and a hip girth of 97 cm.

Inhibition of DNMT3B and PI3K/AKT/mTOR and ERK Pathways as a Novel Mechanism of Volasertib on Hypomethylating Agent-Resistant Cells

  • Eun-Ji Choi;Bon-Kwan Koo;Eun-Hye Hur;Ju Hyun Moon;Ji Yun Kim;Han-Seung Park;Yunsuk Choi;Kyoo-Hyung Lee;Jung-Hee Lee;Eun Kyung Choi;Je-Hwan Lee
    • Biomolecules & Therapeutics
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    • v.31 no.3
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    • pp.319-329
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    • 2023
  • Resistance to hypomethylating agents (HMAs) in myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML) is a concerning problem. Polo-like kinase 1 (PLK1) is a key cell cycle modulator and is known to be associated with an activation of the PI3K pathway, which is related to the stabilization of DNA methyltransferase 1 (DNMT1), a target of HMAs. We investigated the effects of volasertib on HMA-resistant cell lines (MOLM/AZA-1 and MOLM/DEC-5) derived from MOLM-13, and bone marrow (BM) samples obtained from patients with MDS (BM blasts >5%) or AML evolved from MDS (MDS/AML). Volasertib effectively inhibited the proliferation of HMA-resistant cells with suppression of DNMTs and PI3K/AKT/mTOR and ERK pathways. Volasertib also showed significant inhibitory effects against primary BM cells from patients with MDS or MDS/AML, and the effects of volasertib inversely correlated with DNMT3B expression. The DNMT3B-overexpressed AML cells showed primary resistance to volasertib treatment. Our data suggest that volasertib has a potential role in overcoming HMA resistance in patients with MDS and MDS/AML by suppressing the expression of DNMT3 enzymes and PI3K/AKT/mTOR and ERK pathways. We also found that DNMT3B overexpression might be associated with resistance to volasertib.

A Bicentric Propensity Matched Analysis of 158 Patients Comparing Porcine Versus Bovine Stented Bioprosthetic Valves in Pulmonary Position

  • Bunty Ramchandani;Raul Sanchez;Juvenal Rey;Luz Polo;Alvaro Gonzalez;Maria-Jesus Lamas;Tomasa Centella;Jesus Diez;Angel Aroca
    • Korean Circulation Journal
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    • v.52 no.8
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    • pp.623-631
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    • 2022
  • Background and Objectives: Pulmonary valve replacement (PVR) is the most common operation in adults with congenital heart disease (CHD). There is controversy regarding the best bioprosthesis. We compare the performance of stented bioprosthetic valves (the Mosaic [MedtronicTM] porcine pericardial against Carpentier Perimount Magna Ease [EdwardsTM] bovine) in pulmonary position in patients with CHD. Methods: Between January 1999 and December 2019, all the PVRs were identified from hospital databases in 2 congenital heart centres in Spain. Valve performance was evaluated using clinical and echocardiographic criteria. Propensity score matching was used to balance the 2 treatment groups. Results: Three hundred nineteen patients were retrospectively identified. After statistical adjustment, 79 propensity-matched pairs were available for comparison Freedom from reintervention for the porcine cohort was 98.3%, 96.1%, and 91.9% at 3, 5, and 10 years and 100%, 98%, and 90.8% for the bovine cohort (p=0.88). Freedom from structural valve degeneration (SVD) for the porcine cohort was 96.9%, 92.8% and 88.7% at 3, 5, and 10 years and 100%, 98%, and 79.1% for the bovine cohort (p=0.38). Bovine prosthesis was associated with a reintervention hazard ratio (HR), 1.12; 95% confidence intervals (CIs), 0.24-5.26; p=0.89 and SVD HR, 1.69 (0.52-5.58); p=0.38. In the first 5 years, there was no difference in outcomes. After 5 years, the recipients of the bovine bioprosthesis were at higher risk for SVD (reintervention HR, 2.08 [0.27-16.0]; p=0.49; SVD HR, 6.99 [1.23-39.8]; p=0.03). Conclusions: Both bioprosthesis have similar outcomes up to 5 years, afterwards, porcine bioprosthesis seem to have less SVD.

A STUDY ON THE CHILD PATIENT'S PREFERENCE TOWARD DENTIST'S ATTIRE (소아환자의 치과의사 복장에 대한 선호도 연구)

  • Wee, You-Min;Lee, Chang-Seop;Lee, Sang-Ho
    • Journal of the korean academy of Pediatric Dentistry
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    • v.29 no.2
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    • pp.168-179
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    • 2002
  • The purpose of this study was to find a method for improving the children's behavior during dental treatment in relation with dentist's attire. For this study 150 children, visiting a dental clinic, were asked to participate in a survey on the attire of the dentist. The results of the survey were as follows: 1. In the survey for the preference between gown and ordinary clothes according to sex(P<0.05), age(P<0.05), residence (P<0.05) and number of visits(P<0.05), there was more preference for gown(65.3%). 2. The preference for the type of gown and attire under the gown was a long gown and white shirt (30.7%), followed by a suit-like gown (18.7%) and white shirt, and long gown and polo shirt(17.3%). 3. The preference for the color of gown was white(34.7%), followed by pink (18.7%), green(18.0%), blue(15.3%) and yellow(13.3%). 4. The preference for the pattern on the gown was cartoon characters(49.3%), followed by hospital logo(28.7%) and no pattern(14.7%). 5. The preference for ordinary clothes of female dentists was polo shirt(37.3%), followed by striped shirt(28.7%), round T-shirt(18.7%), and everyday Korean traditional dress(15.3%). 6. The preference for ordinary clothes of male dentists was pattern necktie and no pattern Y-shirt(28.0%), followed by no pattern necktie and Y-shirt(21.3%) or pattern shirt with no necktie, and no pattern Y-shirt with no necktie(14.7%). 7. The preference on the protective equipment worn was mask and glove(28.7%), followed by no protective equipment(26.7%), mask, glove and protective glasses(22.7%) at)d only mask(22.0%). Based on the above results, it seems that parting with the traditional white gown and wearing multi-color and pattern attire will provide psychological stability and help improve children's behavior during treatment.

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Analysis of Knit Item Trend Appeared in Foreign Fashion Collections - Analysis for the Proposal of Knit Item Category List and Practical Use - (해외 패션 컬렉션에 나타난 니트 아이템 경향 분석 - 니트 아이템 분류목록의 제안과 실용화를 위한 탐색적 분석 -)

  • Kim, Hye-Young;Lee, Shin-Young
    • The Research Journal of the Costume Culture
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    • v.14 no.5
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    • pp.813-827
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    • 2006
  • In this investigation, the following study was carried out for an experimental proposal of the knit item lists which were not actualized due to lack of studies. First of all, we have put the knit item titles that have been used through the document investigation, into the lists in order to clarify the original item list. Furthermore, we have pointed out the problems and the areas to be developed in the original item lists, and proposed twenty new knit item lists. By defining the design traits of each item, we have established item list which could be classified more systematically. As a result, the knit item titles of twenty newly proposed item titles are knit pull over, knit pull over top, knit top, knit t shirt, knit shirt, knit polo shirt, knit blouse, knit vest, knit hood, knit jumper, knit jacket, knit coat, knit cardigan, knit ensemble, knit cape, knit shawl, knit bikini, knit one-piece, knit pants, and knit skirt. Secondly, in order to investigate the possibility of practical use of twenty knit item lists proposed by this study, we have applied anova with repeated measurement for foreign fashion collection knit item trends of the past 10 years based on the proposed item lists. As a result, four items classified as top, shirt, cardigan, and pants had similar changes in the trend for last 10 years in S/S season while eleven items classified as pull over, pull over top, blouse, vest, jacket, coat, cardigan, ensemble, cape, shawl, and one-piece had similar trend changes for F/W season. The first significance of this study is on the experimental proposal of knit item list which could be used in the actual clothing industry and academic field. Furthermore, by defining the design traits of each knit item, it sublated the confusions brought by vocabularies in design of knit products and distribution in the industry perspective, and it made it possible to categorize the knit items correctly in knit design analysis and knit design education in academic field. The second significance shows that this study brought about positive results in the possibility of industrial academic practical use of proposed list by indicating that most of the knit designs appeared in the foreign collections in the past ten years could be correctly classified through investigational analysis.

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Analysis on Rainwater Harvesting System as a Source of Non-Potable Water for Flood Mitigation in Metro Manila (마닐라의 홍수저감을 위한 잡용수 대체자원으로서의 가정용우수저류시설 분석)

  • Necesito, Imee V.;Felix, Micah Lourdes A.;Kim, Lee-Hyung;Cheong, Tae Sung;Jeong, Sangman
    • Journal of Wetlands Research
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    • v.15 no.2
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    • pp.223-231
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    • 2013
  • Excessive precipitation, drought, heat waves, strong typhoons and rising sea levels are just some of the common indicators of climate change. In the Philippines, excessive precipitation never failed to devastate and drown the streets of Metro Manila, a highly urbanized and flood-prone area; such problems are expected to occur frequently. Moreover, the water supply of Metro Manila is dependent only to Angat Reservoir. Rainwater harvesting can serve as an alternative source of raw water and it can mitigate the effects of flooding. The harvested rainwater can be used for: potable consumption if filtered and disinfected; and non-potable consumptions (e.g., irrigation, flushing toilets, carwash, gardening, etc.) if used untreated. The rainfall data were gathered from all 5 rainfall stations located in Metro Manila namely: Science Garden, Port Area, Polo, Nangka and Napindan rain gauge stations. To be able to determine the potential volume of rainwater harvested and the potentiality of rainwater harvesting system as an alternate source of raw water; in this study, three different climatic conditions were considered, the dry, median and wet rainfall years. The frequent occurrence of cyclonic events in the Philippines brought significant amount of rainwater that causes flooding in the highly urbanized region of Metro Manila. Based from the results of this study, the utilization of rainwater harvesting system can serve as an alternative source of non-potable water for the community; and could also reduce the amount of surface runoff that could result to extreme flooding.

State-of-the-art Node of Freeform Structure (프리폼 구조의 노드 기술 현황 분석)

  • Lee, Kyoung Ju;Oh, Jin Tak;Kim, Sang Dae;Ju, Young Kyu
    • 한국방재학회:학술대회논문집
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    • 2011.02a
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    • pp.153-153
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    • 2011
  • 현대 건축은 기능적이고 합리적이었지만 획일적이었던 박스형 건축에서 탈피해 형태와 공간에 있어서 다양한 변화를 시도하고 있다. 특별한 건축물의 실현을 위해 각 나라의 기술력은 급속한 발전을 이루었고, 보다 더 독특한 건축물에 대한 관심은 비정형 건축물에 대한 관심의 증대로 이어지고 있다. 이러한 비정형 건축물에 적합한 구조로써 프리폼(Free-Form) 구조가 있다. 프리폼 구조로 입체골조(Double Layered Structure)를 많이 사용하였으나, 최근 유리로 되어 투명하고 기하학적 모양의 건축물을 추구함에 따라 평면골조(Single Layered Structure)가 증가하고 있는 추세이다. 평면골조는 축력 지배형과 모멘트 지배형으로 분류할 수 있고 프리폼 구조의 구성 요소 중 가장 취약하고 중요한 부분은 노드이다. 본 연구에서는 프리폼 구조 중 가장 큰 관심이 고조되고 있는 평면골조 모멘트 지배형의 노드에 대한 국내외 기술 분석을 통해 향후 연구 방향성을 제시하고자 한다. 입체골조는 하나의 노드에 여러개의 부재가 3차원으로 결합되어야 하기 때문에 다른 골조 시스템에 비해 노드부가 복잡하지만, 건축물의 외관을 유리로 하여 투명하게 하고 비틀리고 구부러진 구조물에 대한 건축적 요구가 많아짐에 따라 평면골조의 인기가 높아지고 있다. 이러한 시대의 흐름에 발맞추어 건물의 구조적, 기하학적 요구를 충족시키기 위해 다양한 노드 시스템이 개발 중이며, 가해지는 하중의 특성에 따라 축력 지배형과 모멘트 지배형으로 구분하여 노드의 양상을 분류할 수 있다. 축력 지배형의 대표적인 시스템은 다이아그리드(Diagrid)이다. 축력 지배형 프리폼 구조의 노드는 전체 구조물의 하중을 축력으로 받아 모두 전달해야 하기 때문에 크기가 크고 가새가 2~4개층에 걸쳐서 설치되기 때문에 중량이다. 모멘트 지배형 노드를 갖는 프리폼 구조의 형태는 대부분 지붕 구조로써 지붕 자체의 하중만을 견디도록 설계된다. 따라서 노드부와 노드에 붙는 부재들이 가볍기 때문에 사람이 들 수 있고 노드의 크기가 작아 시공성이 좋으며 대량 생산이 가능하다는 장점이 있다. 노드의 형태는 힘의 흐름과 쓰임에 따라 다양하다. 평면골조 모멘트 지배형의 노드는 접합방식에 따라 Splice node connection과 End-Face node connection 두 가지로 분류할 수 있다. Splice node connection은 각 부재의 종축으로 노드와 구조부재 사이에 이음재를 두어 연결하고, 연결 형태에 따라 전단력을 전달할 수 있는 1~2개의 접촉면이 생긴다. 전단응력을 받는 볼트로 이음재를 이어 조립하거나 용접으로 접합할 수 있다. 대표 노드로, SBP-1, SBP-2와 POLO-1 등이 있다. End-Face node connection은 각 연결된 부재의 단부와 노드 사이의 연결면은 종축방향의 수직이고, 인장응력을 받는 볼트를 사용하거나 용접에 의해 접합할 수 있다. 대표 노드로 SBP-4, WABI-1, MERO-1(Cylinder), MERO-2(Block), MERO-4(Double Dish) 등이 있다. 본 기술 현황 분석을 통해 현재 개발된 노드를 분류하고 가장 관심이 높은 Single Layer 모멘트 지배형 노드를 비교, 분석하였다. 최근 건물의 경향을 반영한 프리폼 구조를 실현하기 위해서 필수적인 노드의 개발은 국외에서 활발히 연구되고 있지만 그 기술이 개방되어 있지 않다. 국내에서는 동대문 디자인 플라자에 새로운 노드를 적용하고 고려대학교에서 모멘트 지배형 노드를 개발하는 등 발전 가능성을 보이고 있지만 국외 사례들에 비하면 아직 초기 단계라 할 수 있다. 따라서 현장 용접을 지양하고 공장 제작하여 현장에서 조립하며, 프로젝트 별로 상이한 노드를 사용하는 것이 아닌 다양한 요구를 효과적으로 수용하는 구조 효율성을 향상시킨 노드 상세의 개발이 이루어져야 할 것이다.

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Representation Types of Gog and Magog in Old Western Maps (서양고지도에 나타난 곡과 마곡의 표현 유형)

  • Jung, In-Chul
    • Journal of the Korean Geographical Society
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    • v.45 no.1
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    • pp.165-183
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    • 2010
  • For the study of the development of Asia map made by european map makers, one should consider Gog and Magog which existed in the maps for more than 700 years. Gog and Magog are described as an apocalyptic people in the Bible and medieval literature, and they are important elements in medieval mappaemundi and early modem world maps. This study classified representation types of Gog and Magog in old western maps. Maps were classed in to six categories according to the location and ethnic groups which they represent, and they were discussed in cartographic context. The maps until the fourteenth century place Gog and Magog, shut up by Alexander, near Caspian Sea. In the fifteenth century, Gog and Magog were described as Closed Jews in maps. From the sixteenth century they appear in the far northeastern part of Asia and they are named as Amagog or Ung and Mongul. In the mid-seventeenth century, they are located in Eastern Siberia by French cartographers. But with the expansion of geographic knowledge, Gog and Magog disappeared completely in the eighteenth century. In general, God and Magog were represented on the basis of traditional lore rather than on the Bible, and they became one means of mapping others of European community.

Media Research in Global Brand Timelapse Advertisement (글로벌 브랜드 타임랩스 광고에 나타난 영상 연구)

  • Yu, Jung-Sun;Chung, Jean-Hun
    • Journal of Digital Convergence
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    • v.15 no.8
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    • pp.333-340
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    • 2017
  • Timelapse is an imaging technique that captures motion at regular intervals and then projects it at normal speed. We looked at Timelapse advertising images of global brands and presented a model for analyzing components and expression methods of Timelapse, a new image technique. In previous research, literature research, Internet data survey, and YouTube data were investigated. Continuous photography has been developed as an imaging technique, and we have examined the current production status applied to domestic and foreign documentary, domestic and foreign drama, film, and advertisement. In 2015-2016, I will analyze the techniques of iPhones (2016), Ralph Lauren Polo Ads (2015), and Canon EOS (2013) videos that use Timelapse techniques in their recent advertisements. The results show that the Timelapse component is a static element, the static motif is mainly an artificial structure, the place is outdoor, the color is taken at a time showing the characteristics of the place, and the layout is all centered. The dynamic motif is a moving object. The dynamic line consists of a story based on the object. The time is about 11-15 seconds, the longest is about 1 minute and 30 seconds, and the editing is mainly focused on the product with the brand logo emphasized. In conclusion, it is the role of the image to pay attention to the advertisement and catch the eye. In order to motivate the buyer's mind, it is necessary to direct and edit such as Timelapse, which stimulates the emotions inherent in the mind and stimulates the non-verbal symbols. Future research is likely to reveal various attempts at temporal editing of images.