Korean Circulation Journal

The Korean Society of Cardiology (대한심장학회)
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A Bicentric Propensity Matched Analysis of 158 Patients Comparing Porcine Versus Bovine Stented Bioprosthetic Valves in Pulmonary Position

  • Bunty Ramchandani (Congenital Cardiovascular Surgery, Hospital Universitario La Paz) ;
  • Raul Sanchez (Congenital Cardiovascular Surgery, Hospital Universitario La Paz) ;
  • Juvenal Rey (Congenital Cardiovascular Surgery, Hospital Universitario La Paz) ;
  • Luz Polo (Congenital Cardiovascular Surgery, Hospital Universitario La Paz) ;
  • Alvaro Gonzalez (Congenital Cardiovascular Surgery, Hospital Universitario La Paz) ;
  • Maria-Jesus Lamas (Congenital Cardiovascular Surgery, Hospital Universitario Ramon y Cajal) ;
  • Tomasa Centella (Congenital Cardiovascular Surgery, Hospital Universitario Ramon y Cajal) ;
  • Jesus Diez (Instituto de Investigacion, Hospital Universitario La Paz) ;
  • Angel Aroca (Congenital Cardiovascular Surgery, Hospital Universitario La Paz)
  • Received : 2021.09.30
  • Accepted : 2022.03.30
  • Published : 2022.08.01
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Abstract

Background and Objectives: Pulmonary valve replacement (PVR) is the most common operation in adults with congenital heart disease (CHD). There is controversy regarding the best bioprosthesis. We compare the performance of stented bioprosthetic valves (the Mosaic [MedtronicTM] porcine pericardial against Carpentier Perimount Magna Ease [EdwardsTM] bovine) in pulmonary position in patients with CHD. Methods: Between January 1999 and December 2019, all the PVRs were identified from hospital databases in 2 congenital heart centres in Spain. Valve performance was evaluated using clinical and echocardiographic criteria. Propensity score matching was used to balance the 2 treatment groups. Results: Three hundred nineteen patients were retrospectively identified. After statistical adjustment, 79 propensity-matched pairs were available for comparison Freedom from reintervention for the porcine cohort was 98.3%, 96.1%, and 91.9% at 3, 5, and 10 years and 100%, 98%, and 90.8% for the bovine cohort (p=0.88). Freedom from structural valve degeneration (SVD) for the porcine cohort was 96.9%, 92.8% and 88.7% at 3, 5, and 10 years and 100%, 98%, and 79.1% for the bovine cohort (p=0.38). Bovine prosthesis was associated with a reintervention hazard ratio (HR), 1.12; 95% confidence intervals (CIs), 0.24-5.26; p=0.89 and SVD HR, 1.69 (0.52-5.58); p=0.38. In the first 5 years, there was no difference in outcomes. After 5 years, the recipients of the bovine bioprosthesis were at higher risk for SVD (reintervention HR, 2.08 [0.27-16.0]; p=0.49; SVD HR, 6.99 [1.23-39.8]; p=0.03). Conclusions: Both bioprosthesis have similar outcomes up to 5 years, afterwards, porcine bioprosthesis seem to have less SVD.

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