• Molecules and Cells
• /
• v.44 no.9
• /
• pp.658-669
• /
• 2021

Enhancers have been conventionally perceived as cis-acting elements that provide binding sites for trans-acting factors. However, recent studies have shown that enhancers are transcribed and that these transcripts, called enhancer RNAs (eRNAs), have a regulatory function. Here, we identified putative eRNAs by profiling and determining the overlap between noncoding RNA expression loci and eRNA-associated histone marks such as H3K27ac and H3K4me1 in hepatocellular carcinoma (HCC) cell lines. Of the 132 HCC-derived noncoding RNAs, 74 overlapped with the eRNA loci defined by the FANTOM consortium, and 65 were located in the proximal regions of genes differentially expressed between normal and tumor tissues in TCGA dataset. Interestingly, knockdown of two selected putative eRNAs, THUMPD3-AS1 and LINC01572, led to downregulation of their target mRNAs and to a reduction in the proliferation and migration of HCC cells. Additionally, the expression of these two noncoding RNAs and target mRNAs was elevated in tumor samples in the TCGA dataset, and high expression was associated with poor survival of patients. Collectively, our study suggests that noncoding RNAs such as THUMPD3-AS1 and LINC01572 (i.e., putative eRNAs) can promote the transcription of genes involved in cell proliferation and differentiation and that the dysregulation of these noncoding RNAs can cause cancers such as HCC.

• Journal of the Korea institute for structural maintenance and inspection
• /
• v.25 no.6
• /
• pp.19-26
• /
• 2021

The seismic isolation system have been applied in order to protect the collapse of bridge by seismic load and the vertical load transmitted from the superstructure. However, the failure and damages of non-shrinkage mortar, isolator and wedge in total 12 bridge were reported by Pohang Earthquake. In this study, the damage mechanism and behavior characteristics of elastomeric bearing by an earthquake were evaluated to consider the seismic isolation system including non-shrinkage mortar and the seat concrete of pier. To discuss the effect of installed wedge and damage mode of elastomeric bearing, the compressive-shear tests were carried out. Also, the mechanical behaviors and damage mechanism for each component of elastomeric bearing were evaluated by using finite element analysis. From the test results, the cracks were created at boundary between non-shrinkage mortar and seismic isolator and the shear loads were rapidly increased after bump into wedge. The cause for damage mechanism of seismic isolation system was investigated by comparing stress distribution of anchor socket and non-shrinkage mortar depending on wedge during earthquake.

• Journal of the Korean GEO-environmental Society
• /
• v.20 no.5
• /
• pp.5-12
• /
• 2019

On November 15, 2017, a unpredictable liquefaction damage was occurred at the $M_L=5.4$ Pohang earthquake and after, many researches have been conducted in Korea. In Korea, where there were no cases of earthquake damage, it has been extremely neglectable in preparing earthquake risk maps and building earthquake systems that corresponded to prevention and preparation. Since it is almost impossible to observe signs and symptoms of drought, floods, and typhoons in advance, it is very effective to predict the impacts and magnitudes of seismic events. In this study, 14,040 borehole data were collected in the metropolitan area and liquefaction evaluation was performed using the amplification factor. Based on this data, liquefaction hazard maps were prepared for ground accelerations of 0.06 g, 0.14 g, 0.22 g, and 0.30 g, including 200years return period to 4,800years return period. Also, the correlation analysis between the earthquake acceleration and LPI was carried out to draw a real-time predictable liquefaction hazard map. As a result, 707 correlation equations in every cells in GIS map were proposed. Finally, the simulation for liquefaction risk mapping against artificial earthquake was performed in the metropolitan area using the proposed correlation equations.

• Journal of the Korean GEO-environmental Society
• /
• v.20 no.7
• /
• pp.5-10
• /
• 2019

In recent Gyeongju and Pohang earthquakes, motions that exceed the design ground motion were recorded. This has led to adjustments to the design earthquake intensity in selected design guidelines. An increment in the design intensity requires reevaluation of all associated facilities, requiring extensive time and cost. Firstly, the seismic factor of safety of built concrete retaining walls are calculated. Secondly, the seismic margin of concrete retaining walls is evaluated. The design sections of concrete walls built at power plants and available site investigation reports are utilized. Widely used pseudo-static analysis method is used to evaluate the seismic performance. It is shown that all concrete walls are safe against the adjusted design ground motion. To determine the seismic margin of concrete walls, the critical accelerations, which is defined as the acceleration that causes the seismic factor of safety to exceed the allowable value, are calculated. The critical acceleration is calculated as 0.36g~0.8g. The limit accelerations are significantly higher than the design intensity and are demonstrated to have sufficient seismic margin. Therefore, it is concluded that the concrete retaining walls do not need to be reevaluated even if the design demand is increased up to 0.3g.

• Korean Journal of Mineralogy and Petrology
• /
• v.35 no.1
• /
• pp.51-64
• /
• 2022

For effective preservation of the rocks, which bearing plant fossils at Gumkwangdong Formation, Pohang, the properties of rock and treatment of chemicals were examined in an artificial weathering test. The rocks are diatomaceous siliceous mudstone, which contain a small amount of smectite and has developed laminated layers. The rocks react with water, the d₀₀₁ spacing of smectite was increased. On the one hand, the physical properties of the rock samples, such as surface hardness, improved after the application of ethyl silicate-based stone strengthener. On the other hand, the spacing of interlayer of swelling clay minerals decreased and spacing of laminae layer increased. When the ethyl silicate-based stone strengthener was applied after pretreatment with a swelling inhibitor, interlayer and spacing of laminae changes were similar to those when only the stone strengthener was treated. The effect of the swelling inhibitor was almost negligible. When the rocks that have been conserved with chemicals react with water, spacing of laminae has widened much, whereas when the rocks was in contact with moisture only, there was little change. In addition, if it is placed in the outdoor after conservation treatment, although it occurs slightly slower than the untreated rock, the separation of the lamination layer and the pulverization of the rock occur within a very short time. Consolidation is required to improve the physical properties of fossil rock, but when exposed to rain and undergoing freeze-thaw process, the effect is lost very quickly. Therefore, regardless of the chemical treatment, it is a priority to prevent direct rainfall contact with the rock.

• Journal of the Korean Geotechnical Society
• /
• v.38 no.4
• /
• pp.59-70
• /
• 2022

There is a growing interest in evaluating earthquake damage and determining disaster prevention measures due to the magnitude 5.8 earthquake in Pohang, Korea. Since the liquefaction phenomena occurred extensively in the residential area as a result of the earthquake, there was a demand for research on liquefaction phenomenon evaluation and liquefaction disaster prediction. Liquefaction is defined as a phenomenon where the strength of the ground is completely lost due to a sudden increase in excess pore water pressure caused due to large dynamic stress, such as an earthquake, acting on loose sand particles in a short period of time. The liquefaction potential index, which can identify the occurrence of liquefaction and predict the risk of liquefaction in a targeted area, can be used to create a liquefaction hazard map. However, since liquefaction assessment using existing field testing is predicated on a single borehole liquefaction assessment, there has been a representative issue for the whole targeted area. Spatial interpolation and geographic information systems can help to solve this issue to some extent. Therefore, in order to solve the representative problem of geotechnical information, this research uses the kriging method, one of the geostatistical spatial interpolation techniques, and constructs a geotechnical information database for liquefaction and spatial interpolation. Additionally, the liquefaction hazard map was created for each return period using the constructed geotechnical information database. Cross validation was used to confirm the accuracy of this liquefaction hazard map.

• Proceedings of the Korea Water Resources Association Conference
• /
• 2020.06a
• /
• pp.401-401
• /
• 2020

최근 전 세계적으로 기후변화로 인한 자연재해가 빈번하게 발생하고 있으며, 우리나라 역시 해마다 가뭄과 홍수 등의 피해가 큰 실정이다. 특히 가뭄으로 인한 피해는 농업분야와 직결되어 있으며, 미래식량과 물안보에 영향을 미친다. 최근에는 국내 물관리일원화 정책에 따른 통합물관리 시행으로 수요관리에 의한 물이용 효율성이 물관리 기본원칙으로 포함되어 있어, 농업용수 분야의 물절약 필요성과 중요성은 더욱 증대되고 있는 실정이다. 농업농촌부문 가뭄대응 종합대책의 일환으로 2016년부터 농업용수 이용자 측면에서 물절약 실천을 유도하기 위한 물절약 교육 모델의 개발과 농업인 대상 시범교육이 실시되고 있으나 일부 지역에만 단발성 사업으로 제한적으로 추진되고 있는 실정이다. 따라서 물절약 교육 및 홍보사업을 보다 체계적이고 광법위하게 적용하여 농업 현장에서의 가시적인 물절약 성과를 도출하기 위한 노력이 요구된다. 이에 대한 일환으로 본 연구에서는 물절약 교육 콘텐트 개발 및 현장 교육에 반영하기 위하여 농업인 대상 물절약 의식과 행동실천 여부에 대해 조사를 실시해 보았다. 포항 및 영덕지역의 한국농어촌공사 관할지구 내 농업용수 이용자 중 수리시설감시원(이하 '수감원') 100여명을 대상으로 설문조사로 파악해 보았다. 설문에 참여한 수감원들은 대부분 65세 이상의 고령으로 농업에 오랜 기간 종사한 경험의 소유자로서 소규모 농업경영이 주를 이루었다. 대부분 농사기간동안 물부족 경험이 있었으며, 모내기 및 벼생육기 강우조건에 따라 물부족을 경험한 것으로 파악되었다. 이로 인해 설문 참여자들의 물절약 필요성에 대해서는 높은 공감대를 나타내었으며, 특히 농업인 대상 물절약 교육의 필요성에 대해서 매우 높은 공감대를 나타내었다. 농업인의 물과다 사용 및 물꼬관리 부실 등 필지단위 물관리 부실에 대해서도 상당히 인정하는 편이었으며, 이러한 농업인의 관행적인 물관리 행태에 대해서 변화를 유도할 수 있는 수리계조직 부활을 통한 농업인 물관리 직접 참여 등의 대안이 필요하다는 의견에 대해서도 긍정적이었다. 또한 농업인 용수이용에 대한 비용 부담에 대해서도 다소 긍정적인 의견도 제시되었다. 본 연구 결과로 농업인의 적극적인 물관리 및 물절약 참여를 이끌어 낼 수 있는 실현가능한 관련 제도 마련의 필요성과 체계적이고 지속적인 물절약 교육 및 홍보 정책 추진의 필요성이 제기된다.

• Journal of Korea Entertainment Industry Association
• /
• v.13 no.8
• /
• pp.391-400
• /
• 2019

In this study, we tried to find out the difference in confidence in performing Healthy Life on CPR before and after CPR education to middle school volunteers. Through the above statistical analysis process, the following findings were obtained: First, the general characteristics of the respondents who participated in this survey were higher than that of boys, followed by third, first and second graders. Second, junior high school volunteers were shown to have similar confidence (Chonbach's α=.80) and confidence (Chonbach's α=.76) before CPR education, and confidence in the degree of social contribution (Chonbach's α=7.77). Third, the Pearson Rates Correlation was performed to see the correlation between grade, gender, pre-education confidence, post-training confidence, confidence in the application of airway methods, confidence in the patient's breathing, confidence in chest compression, confidence in the use of defibrillators, and post-cardiopulmonary resuscitation education. As a result, it was confirmed that there was a significant correlation between all the spokesmen. In particular, post-training self-confidence was the highest correlation with coping confidence in case of cardiac arrest, followed by chest compressive confidence. Comparing and reviewing these findings and prior studies as shown above, we were able to establish that CPR education has an impact on the confidence performed by gender.

• Korean Journal of Social Welfare Studies
• /
• v.41 no.4
• /
• pp.81-105
• /
• 2010

This study is aimed to investigate the effects of stress on suicidal impulse, considering the mediating effects of existent spirituality, family support, and depression. The data, collected from 1,000 adults were examined by the statistics software SPSS 17.0 and AMOS 17.0, in which descriptive statistics, structural equation model analysis, and multi-group simultaneous analysis are utilized. The study shows that, from the structural equation modeling, the stress has positive effects on depression and suicidal impulses, but negative effects on existent spirituality. Existent spirituality acts as a protective factor, negatively affecting the suicidal impulse. Depression has positive effects on suicidal impulse. Therefore, existent spirituality and depression have mediational effects on the relationship between stress and suicidal impulse. The results of multi-group simultaneous analysis imply that there are no age and sex differences. In conclusion, social workers need to make great efforts to exterminate stress, and treat depression at the first priority, because the depression is a major sign of suicide. As a protective factor, strengthening existent spirituality is a very effective way to prevent a suicidal impulse.

• Journal of Navigation and Port Research
• /
• v.47 no.6
• /
• pp.350-357
• /
• 2023

Marine accidents frequently occur due to the unreasonable operation of ships excluded from ship departure control during marine special weather warnings within smooth water areas. Coastal wave buoys installed in smooth water areas are major reference indicators for ship departure control and can be seen as being directly connected to the safety of ships navigating smooth water areas and the coast. In this study, the location appropriateness of currently operating coastal wave buoys and additional installation in the smooth water areas were assessed by analyzing coastal marine accidents over the past 30 years (1991-2020), the main wind direction and wind speed of each major trading port, and the GICOMS ship track data in 2018. The study results showed that an additional coastal wave buoy should be installed at each of the major trading ports(Inchon Port, Pohang Port, Ulsan Port, and Busan Port) and that the location of the coastal wave buoy needs to be moved in the case of Busan Port. Based on various data analysis in this study, the suggestion for an additional installation and movement of the coastal wave buoy presented in this study is expected to contribute to improving the reliability of ship departure control and resolving safety blind spots.