• Genomics & Informatics
• /
• 제14권3호
• /
• pp.104-111
• /
• 2016

Zika virus (ZIKV) is a mosquito borne pathogen, belongs to Flaviviridae family having a positive-sense single-stranded RNA genome, currently known for causing large epidemics in Brazil. Its infection can cause microcephaly, a serious birth defect during pregnancy. The recent outbreak of ZIKV in February 2016 in Brazil realized it as a major health risk, demands an enhanced surveillance and a need to develop novel drugs against ZIKV. Amodiaquine, prochlorperazine, quinacrine, and berberine are few promising drugs approved by Food and Drug Administration against dengue virus which also belong to Flaviviridae family. In this study, we performed molecular docking analysis of these drugs against nonstructural 3 (NS3) protein of ZIKV. The protease activity of NS3 is necessary for viral replication and its prohibition could be considered as a strategy for treatment of ZIKV infection. Amongst these four drugs, berberine has shown highest binding affinity of -5.8 kcal/mol and it is binding around the active site region of the receptor. Based on the properties of berberine, more similar compounds were retrieved from ZINC database and a structure-based virtual screening was carried out by AutoDock Vina in PyRx 0.8. Best 10 novel drug-like compounds were identified and amongst them ZINC53047591 (2-(benzylsulfanyl)-3-cyclohexyl-3H-spiro[benzo[h]quinazoline-5,1'-cyclopentan]-4(6H)-one) was found to interact with NS3 protein with binding energy of -7.1 kcal/mol and formed H-bonds with Ser135 and Asn152 amino acid residues. Observations made in this study may extend an assuring platform for developing anti-viral competitive inhibitors against ZIKV infection.

• 디지털융복합연구
• /
• 제17권12호
• /
• pp.445-450
• /
• 2019

본 연구는 검색엔진으로 진화하고 있는 유튜브의 여행 Vlog에 대한 시청패턴과 콘텐츠 니즈를 파악하는 데 목적이 있다. 일차적으로 설문 지법을 사용하여 45명을 대상으로 사전 조사를 진행하였고, 이차적으로 이를 통해 얻은 결괏값을 바탕으로 Creating Pleasurable Interfaces 모형을 활용하여 심층 면담을 진행하였다. 그 결과, 첫 번째로 시청자는 여행 Vlog를 활용하여 단편적인 정보보다는 여행에 관련된 전반적인 정보를 얻고 있었다. 두 번째로 유튜브에 업로드된 여행 Vlog의 절대량이 부족하여 시청자가 원하는 정보를 얻는데 물리적인 어려움이 있었다. 세 번째로 여행 Vlog를 활용한 마케팅이 대중 매체의 광고 형식에서 벗어나지 못해 콘텐츠 전반에 서비스나 제품 노출에 일관성이 부족하다는 문제점이 도출되었다. 본 연구를 바탕으로 도출된 결과는 여행 관련 기업의 콘텐츠 마케팅 전략에 있어서 인사이트를 제공하고 크리에이터들에게 콘텐츠 제작에 실질적인 도움을 줄 수 있으리라 기대된다.

• 디지털융복합연구
• /
• 제18권7호
• /
• pp.223-228
• /
• 2020

주가는 사람들의 심리를 반영하고 있으며, 주식시장 전체에 영향을 미치는 요인으로는 경제성장률, 경제지료, 이자율, 무역수지, 환율, 통화량 등이 있다. 국내 주식시장은 전날 미국 및 주변 국가들의 주가지수에 영향을 많이 받고 있으며 대표적인 주가지수가 다우지수, 나스닥, S&P500이다. 최근 주가뉴스를 이용한 주가분석 연구가 활발히 진행되고 있으며, 인공지능 기반한 분석을 통하여 과거 시계열 데이터를 기반으로 미래를 예측하는 연구가 진행 중에 있다. 하지만, 주식시장은 예측시스템에 의해서 단기간 적중이 되더라도, 시장은 더 이상의 단기 전략대로 움직여지지 않고, 새롭게 변할 수밖에 없다. 따라서, 본 모델을 삼성전자 주식데이터와 뉴스 정보를 텍스트 마이닝으로 모니터링하여 분석한 결과를 나타내어 예측이 가능한 모델을 제시하였으며, 향후 종목별 예측을 통하여 실제 예측이 정확한지 확인하여 발전시켜 나갈 예정임.

• Journal of Ginseng Research
• /
• 제44권2호
• /
• pp.312-320
• /
• 2020

Background: Ginseng (Panax ginseng Meyer) is an essential source of pharmaceuticals and functional foods. Ginseng productivity has been compromised by high light (HL) stress, which is one of the major abiotic stresses during the ginseng cultivation period. The genetic improvement for HL tolerance in ginseng could be facilitated by analyzing its genetic and molecular characteristics associated with HL stress. Methods: Genome-wide analysis of gene expression was performed under HL and recovery conditions in 1-year-old Korean ginseng (P. ginseng cv. Chunpoong) using the Illumina HiSeq platform. After de novo assembly of transcripts, we performed expression profiling and identified differentially expressed genes (DEGs). Furthermore, putative functions of identified DEGs were explored using Gene Ontology terms and Kyoto Encyclopedia of Genes and Genome pathway enrichment analysis. Results: A total of 438 highly expressed DEGs in response to HL stress were identified and selected from 29,184 representative transcripts. Among the DEGs, 326 and 114 transcripts were upregulated and downregulated, respectively. Based on the functional analysis, most upregulated and a significant number of downregulated transcripts were related to stress responses and cellular metabolic processes, respectively. Conclusion: Transcriptome profiling could be a strategy to comprehensively elucidate the genetic and molecular mechanisms of HL tolerance and susceptibility. This study would provide a foundation for developing breeding and metabolic engineering strategies to improve the environmental stress tolerance of ginseng.

• 한국융합학회논문지
• /
• 제9권3호
• /
• pp.181-186
• /
• 2018

카셰어링(Car Sharing) 서비스는 대표적인 공유경제의 성공 모델 중 하나이다. 카셰어링 서비스는 스마트폰 어플리케이션으로 언제든 쉽게 예약, 반납이 가능하고 분 단위로 요금을 내는 차량 대여 서비스이다. 이것은 소비자들의 차량 구매 비용에 대한 부담을 감소시키고 차량으로 인해 발생하는 환경문제를 해결하는 등의 장점으로 향후 자동차 시장을 좌우할 것으로 전문가들은 전망하고 있다. 국내에서도 대표적인 여러 업체가 이미 주를 이루고 있고, 그 밖에 다른 업체들도 카셰어링 서비스에 진입하고 실정이다. 따라서 이러한 기업들 사이에서 경쟁력 있는 카셰어링 서비스로 자리 잡기 위해서는 보다 차별화된 서비스 전략이 필요하며, 본 연구에서는 국내 카셰어링 업체들을 비교분석하여 차별화 사례를 조사하고, 설문조사 기법을 통하여 고객특성과 상황에 맞춘 고객 맞춤형 서비스와 효과적인 차량형 인포테인먼트 등의 새로운 형태의 차별화 방안 제안하였다. 본 연구 결과로 제안된 서비스 방식의 변화, 고객 맞춤 서비스 제공, 새로운 플랫폼 적용 등이 구체적이며 심도있는 향후 연구를 기대한다.

• 기술경영경제학회:학술대회논문집
• /
• 기술경영경제학회 2002년도 제20회 동계학술발표회 논문집
• /
• pp.133-149
• /
• 2002

This study aims to investigate the impact of wide use of digital technology, in particular, the Internet, on innovation process and corporate strategy in electronics industry. The introduction of digital technology has changed innovation process, business model and organizational structure of the electronics companies. With the introduction of digital technology, the entire value chain of electronics industry from procurement, sales, and marketing to R&D and manufacturing has been restructured. E-commerce has been a major agenda for e-business. Recently, collaboration among electronics companies through e-marketplace has emerged as an important issue. A web-based e-commerce standard, so called RosettaNet, has been developed for facilitating e-transactions of electronics firms. The development of digital technology has dramatically increased the processing speed and sophisticated the virtual reality technology. As simulation becomes easier and more effective, the uncertainty and risk involved in R&D has decreased significantly. Another positive impact is closer cooperation between R&D and manufacturing functions. Taking advantage of automated and flexible production technology, has a new type of firm, so called, EMS (Electronics Manufacturing Services) emerged, whose strategic focus is on manufacturing only. The EMS can be seen as a kind of innovative organization, that is, a modular organization for production function. Digital technology has made convergence of computer and communication possible at early years but right now the convergence has been accelerated in extensive areas of communication, broadcasting, information appliances, software, contents, and services. Firms' effort for an innovative product and service has been intensified and the competition for a new standard product and service has become severe in electronics industry. Business activities are always realized in a specific organizational context. Accordingly building up innovation-friendly organization has emerged as a critical concern. Due to the striking decrease of transaction cost, a network type of organization has proliferated, and a business function turns into a modular organization. As a whole, digital technology has pushed electronics firms into developing their own business model, which takes consideration of standardization of business platform and their core competency.

• KSII Transactions on Internet and Information Systems (TIIS)
• /
• 제11권8호
• /
• pp.3862-3888
• /
• 2017

In high diversity node situation, single-channel MAC protocols suffer from many collisions. To solve this problem, the research of multichannel MAC protocol has become a hotspot. And the cyclic quorum-based multichannel (CQM) MAC protocol outperformed others owing to its high frequency utilization. In addition, it can avoid the bottleneck that others suffered from and can be easily realized with only one transceiver. To obtain the accurate performance of CQM MAC protocol, a Markov chain model, which combines the channel hopping strategy of CQM protocol and IEEE 802.11 distributed coordination function (DCF), is proposed. The metrics (throughput and average packet transmission delay) are calculated in performance analysis, with respect to node number, packet rate, channel slot length and channel number. The results of numerical analysis show that the optimal performance of CQM protocol can be obtained in saturation bound situation. And then we obtain the saturation bound of CQM system by bird swarm algorithm (BSA). Finally, the Markov chain model and saturation bound are verified by Qualnet platform. And the simulation results show that the analytic and simulation results match very well.

• 방사선산업학회지
• /
• 제7권1호
• /
• pp.45-49
• /
• 2013

In tissue engineering application, a fibrous structure of scaffolds has been issued as an alternative system to regulate cell survival and tissue regeneration, and electrospinning technique has been popularly used to generate fibrous meshes or sheets mimicking the structure of native extracellular matrix (ECM). However, recent strategy in the scaffold development is expanded to provide the structural property as well as a biological property of native ECM, a variety of surface modification techniques have been used to introduce biological property. In this study, we developed biomimetic poly(L-lactide-co-${\varepsilon}$-caprolactone) (PLCL) nano- and micro-fibrous scaffolds as a unique platform with structural and biological properties with native ECM using electrospinning method and gamma-ray irradiation. Surface morphology of the scaffolds was observed by scanning electron microscopy, and alteration of surface property was evaluated with toluidine blue O staining, water contact angle measurement and ATR-FTIR analysis.

• 산업융합연구
• /
• 제17권3호
• /
• pp.39-49
• /
• 2019

ICT의 발전에 따라 대학교육의 새로운 패러다임이 요구되고 있다. 이에 따른 스마트 캠퍼스 구축은 대학 교육의 패러다임을 바꾸는 학습과 지식 중심의 접근을 비롯하여 혁신적인 기술의 적용, 여러 이해관계자의 니즈를 반영하는 접근 등 다양한 관점에서 효율적인 시스템 구축을 시도해야 한다. 본 연구는 스마트 캠퍼스 생태계를 위한 플랫폼 구축에 관한 연구로서 스마트 캠퍼스의 다양한 이해관계자의 니즈를 반영하는 접근을 하였으며, 이 중에 가장 중요한 대학생 사용자들의 학습과 대학생활 및 사회연결을 축으로 하여 이들의 경쟁력 강화와 사회진출을 돕기 위한 기능에 초점을 맞추는 연구를 하였다. 먼저, 선행연구고찰을 통해 스마트 캠퍼스 구축관련 이론들을 살펴보았으며, 다음으로는 국내외 환경분석과 동향분석을 통하여 대학생 핵심역량개발과 취업지원을 중심으로 하는 e-포트폴리오와 산학협력 지원 시스템에 대해 목표모델을 설계하여 제시하였으며, 지속적인 스마트 캠퍼스 발전 모델을 위한 주안점을 제안하였다.

• Journal of Contemporary Eastern Asia
• /
• 제20권2호
• /
• pp.40-62
• /
• 2021

Are intentions important in deciding the outcome of an action such as sharing misinformation among social media users during the pandemic? What is their role and how far they are important for the very act of fake sharing news? The social media users' actions on the social platform are determined by what they plan to do themselves; however, their motivation has an immense role to play in the dissemination of fake news on social media. The study proposes a conceptual model for understanding how select factors affect fake news sharing motivation and intentions of social media users. The study scrutinizes the relationship between content and context, fear of missing out (FoMO), news verification and news sharing gratification on the motivation and intention of social media users of networked Asian society. Empirical Data were drawn from social media users (N = 243) from India, using an online questionnaire based on prior studies and structural equation modeling (SEM) approach was used to analyze the data collected. Results indicate that news content, news verification, and news sharing gratification have a direct and positive relationship with sharing motivation. On the other hand, news context and content, FoMO and news sharing gratification have a positive significant relationship with sharing intention. Likewise, it was discovered that news verification will decrease sharing intention of the social media users. However, news context, that is the pandemic in the case of the present study and FoMO were not identified as determinant variables for sharing motivation among social media users. The research limitations and further scope were discussed.