• Asian Pacific Journal of Cancer Prevention
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• 제16권17호
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• pp.7599-7602
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• 2015

Background: In this study, we aimed to determine platelet indices such as platelet count (PLT), mean platelet volume (MPV), platelet distribution width (PDW), Plateletcrit (PCT) platelet count (PLT) in lung cancer cases, and evaluate any relationships between these parameters and stage or histologic types. Materials and Methods: This retrospective study covered 44 lung cancer patients and 47 healthy subjects. Platelet indices including PLT, PCT, MPV, PDW were estimated and compared with normal subjects. The results were evaluated statistically. Results: The PDW value was significantly higher in the cancer group compared to the control group; however, the values for PCT and MPV were lower. Conclusions: We suggest potential use of platelet indices in diagnosis of lung cancer.

• Asian Pacific Journal of Cancer Prevention
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• 제16권13호
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• pp.5397-5400
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• 2015

Background: The aim of this study was to investigate the predictive value of white blood cells (WBC), the neutrophil to lymphocyte ratio (NLR), platelet indices including mean platelet volume (MPV), platelet distribution width (PDW), platelet crit (PCT) and platelet to lymphocyte ratio (PLR) in discrimination between benign and malign endometrial lesions, and early and advanced stage endometrial adenocarcinomas. Materials and Methods: Data for 105 patients undergoing total abdominal or vaginal hysterectomy for benign uterine diseases and 114 patients surgically staged for endometrium adenocarcinoma at Ondokuz Mayis University, Department of Gynecology and Obstetrics, between 2008 and 2014, were collected. Parameters were preoperative and postoperative complete blood counts in the week prior to surgery with differentials including WBC, platelet count, platelet indices (MPV, PCT, PDW), NLR and PLR. Pathologic evaluations for both benign and malign endometrium lesions, grade of endometrium adenocarcinoma, tumor stage, presence of lymphovascular space invasion (LVI) were retrospectively analyzed. Results: Regarding definitive factors in discriminating patients with endometrium cancer from those with benign diseases, MPV was significantly increased in the malign group whereas there was a significant decrease in the PDW value compared to the benign group. The best cut-off value in differentiation of the benign and malign groups, malign cases were found to increase over the value of 7.54 for MPV, and under 37.8 for PDW. When definitive factors in discrimination of early stage endometrium cancer from advanced stage disease and LVI in the malign group were evaluated according to the ROC analysis, no significant relation was detected between blood parameters and the stage and the LVI of the disease. Conclusions: MPV and PDW may have predictive value in the discrimination of benign and malign endometrium diseases. Nevertheless, since there have been few reports on this topic, further large-scale prospective studies are necessary.

• Asian Pacific Journal of Cancer Prevention
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• 제17권9호
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• pp.4433-4437
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• 2016

Background: Gastric cancer (GC) is the fifth most common cancer worldwide. Since development is usually asymptomatic, it is generally diagnosed at an advanced stage. The value of screening in patients with nonspecific symptoms for GC is controversial. Aim: The study aimed to evaluate whether hematological parameters (platelet count (PC), mean platelet volume (MPV), MPV/PC ratio, red blood cell distribution width (RDW), neutrophil to lymphocyte ratio (NLR), and platelet to lymphocyte ratio (PLR)) are useful markers to differentiate between gastric cancer patients and healthy individuals. Materials and Methods: Sixty-one patients with gastric cancer and sixty-one healthy individuals were enrolled to the survey and retrospective analysis of selected blood parameters were performed. Results: The mean values of PC, MPV, RDW, NLR, and PLR were significantly higher in GC patients compared to the control group. No statistical differences were observed in MPV/PC ratios. Likewise, no significant statistical differences were revealed in values of blood parameters among TNM stage groups. The RDW showed the highest diagnostic specificity and sensitivity. Conclusions: Hematological parameters: PC, MPV, RDW, NLR, PLR have diagnostic power and can discriminate patients with gastric cancer from patients without cancer. Blood parameters compared with clinical symptoms might alert physicians and patients and lead to performancce of upper gastrointestinal endoscopy, the gold standard in gastric cancer screening and therebly increase the early detection of cancer.

• Asian Pacific Journal of Cancer Prevention
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• 제16권6호
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• pp.2409-2412
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• 2015

Purpose: We aimed to study the inflammatory parameters of complete blood count in breast cancer cases. Materials and Methods: This retrospective study covered 178 breast cancer patients and 107 age and body mass index matched healthy women. Complete blood count parameters, neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR) and MPV/platelet were analyzed. Results: The leukocyte, neutrophil and neutrophil/lymphocyte ratio were higher in the patient group (p values 0.001, 0.0001 and 0.0001, respectively) while haemoglobin and hematocrit were higher in the control group (p=0.0001 for both). Logistic regression analysis showed that elevated neutrophils and platelet distribution width (PDW) (OR: 0.627, 95%CI: 0.508-0.774, p=0.001 and OR: 1.191 95%CI: 1.057-1.342 p=0.003) were independent variables for predicting breast cancer. The cut-off value for the neutrophil/lymphocyte ratio was 2.56. Conclusions: According to our study results, neutrophil levels as part of complete blood count may be used as an independent predictor of breast cancer risk.

• Asian Pacific Journal of Cancer Prevention
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• 제17권4호
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• pp.2321-2323
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• 2016

Background: Inflammatory hematological parameters like the neutrophil/lymphocyte (N/L) ratio have been investigated in many cancer types and significant relationships found with prognosis, for example. The aim of this present study was to investigate the impact of hematological parameters notably on N/L ratio and mean platelet volume (MPV) in papillary thyroid cancer cases. Materials and Methods: A total of 79 patients who underwent a thyroidectomy operation in Findikli, Goiter Research and Treatment Center during 2011-2015 period were enrolled in the study, 41 with papillary thyroid cancer and 38 with benign goiter confirmed by pathological examination. We collected clinical and laboratory data for the patients from hospital records retrospectively. Blood samples taken at admission were assessed for parameters compared between the groups. Results: No significant differences between papillary thyroid cancer and benign goiter groups were apparent in terms of age, the N/L ratio, MPV, white blood cell count (WBC), red blood cell count (RBC), hemoglobin, hematocrit, platelet, neutrophil, lymphocyte, red blood cell distribution width (RDW) and platelet crit (PCT) levels (p>0.05). Only the level of platelet distribution width (PDW) significantly differed, being lower in the papillary cancer group (p<0.05). Conclusions: No significant relationship between papillary thyroid cancer and inflammatory hematological parameters including in particular the N/L ratio and MPV. The relevance of the PDW values remains unclear.

• Asian Pacific Journal of Cancer Prevention
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• 제15권22호
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• pp.9781-9784
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• 2014

Background: The study aimed to evaluate changes in hematologic parameters, including white blood cell, platelet count, platelet indices, the platelet to lymphocyte and neutrophil to lymphocyte ratios in patients with early and advanced stages of epithelial ovarian cancers. Materials and Methods: The study included 100 patients with epithelial ovarian cancer who underwent primary staging exploratory laparotomy. Preoperative hematologic parameters, tumor histopathologic type, grade, stage and serum CA-125 levels were retrospectively analyzed. These parameters were compared between the patients with early (stage I-II) and advanced (stage III-IV) ovarian cancer. Results: White blood cell count and platelet indices, including mean platelet volume, platelet distribution width and platelet crit did not show a statistically significant difference between groups with early and advanced ovarian cancer. However, the neutrophil to lymphocyte ratio, platelet count, the platelet to lymphocyte ratio and CA-125 level showed a statistically significant difference between the two groups (p<0.05, p<0.01, p<0.001, p<0.01 respectively). Conclusions: It was found that the neutrophil to lymphocyte ratio, platelet count and the platelet to lymphocyte ratio increased with the increasing stage of ovarian cancer. Furthermore, it was seen that the platelet to lymphocyte ratio is an independent prognostic factor related to the stage of epithelial ovarian cancer.

• 대한의생명과학회지
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• 제13권1호
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• pp.11-15
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• 2007

We examined the effects of pregnancy and pregnancy-induced hypertension (PIH) on platelet activation. Thirty-six women with PIH (blood pressure > 140/90 mm Hg after two consecutive measurements after the $24^{th}$ weeks of gestation) without proteinuria, fifty-six normotensive pregnant women, and fifty non-pregnant women were studied. WBC, RBC, platelet related variables, including mean platelet component (MPC), mean platelet volume (MPV) and platelet component distribution width (PCDW) were determined for this study. MPC levels were significantly lower in women with PIH compared with normotensive pregnant women and non-pregnant women (P<0.05). MPC levels were inversely con-elated with PIH (r=-0.49, P<0.001), systolic BP (r=-0.22, P<0.01), diastolic BP (r=-0.17, P<0.005), WBC (r=-0.30, P<0.001), MPV (r=-0.41, P<0.001), and PCDW (r=-0.68, P<0.001), and positively con-elated with RBC (r=0.32, P<0.001), platelet count (r=0.21, P<0.05), and mean platelet mass (MPM) (r=0.18, P<0.05). MPC levels were found to be an independent factor associated with PIH and PCDW (P<0.01) after adjustments were made for potential confounding factors such as gestational age, systolic blood pressure, diastolic blood pressure, WBC, RBC, Platelet count, and PCDW. In conclusion, MPC levels were significantly lower in women with PIH, and MPC levels were found to be an independent factor associated with PIH and PCDW. Therefore, platelet activation is suggested as a useful predictor for patients with PIH.

• 대한의생명과학회지
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• 제12권4호
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• pp.337-341
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• 2006

Platelets clearly play an important role in inflammatory responses. In this study, we aimed to evaluate the relationship between aging and platelet activation. A total number of 799 persons (383 males and 416 females), who were apparently healthy and aged more than 20 years were recruited by a health promotion center in a community-based hospital in Seoul, Korea. We collected material data about their medical history and health behavior. Platelet parameters including mean platelet component (MPC), mean platelet volume (MPV), and platelet component distribution width (PCDW) were determined within 1 hour after blood collection using the ADVIA 120 automated hematology analyzer. The MPC of the women ($27.2{\pm}1.2$) was significantly love. than that of the men ($27.5{\pm}1.3$). The MPC of all participants was found to decrease with increasing age (P<0.01). Study participants in their twenties had the highest MPC ($27.7{\pm}1.1$), followed by those in their thirties ($27.6{\pm}1.1$), forties ($27.4{\pm}1.3$), fifties ($27.2{\pm}1.3$), sixties ($27.2{\pm}1.2$) and seventies ($27.1{\pm}1.2$). Multiple regression analysis showed that aging and gender were related with MPC after adjusting for confounding factors, including age, gender, smoking habit, hypertension, diabetes, body mass index and total cholesterol level. The this study shows that aging is related to platelet activation. Future research will need to determine the implications of increased platelet activation with aging, especially regarding the increased incidence of cardiovascular diseases and related mortalities that occur in older age groups.

• Clinical and Experimental Pediatrics
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• 제45권4호
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• pp.505-511
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• 2002

목 적 : 소아 ITP 환아에서 진단 및 IVIg 치료시의 MPV 및 PDW의 변동을 관찰하여 정상아과 비교하고자 하였고 진단 및 초기 치료시의 MPV와 PDW값 분석을 통하여 급성과 만성 ITP의 구분이 예측 가능한지와 면역글로불린에 대한 초기반응이 예측 가능한지를 알아보고자 하였다. 방 법 : 1995년 12월부터 2001년 5월까지 아주대학교병원 소아과에서 ITP로 진단 받고 치료 중이거나 치료 후 추적 관찰 중인 환아 71명을 대상으로 하였다. 치료는 IVIg를 하루에 400 mg/kg 용량으로 5일간 투여하였고 Coulter Counter STKS를 사용하여 매일 말초혈액검사를 시행하여 혈소판, MPV, PDW 를 확인하였고 치료 후 주기적으로 추적검사 하였다. 정상 대조군으로 38명의 정상 환아의 MPV와 PDW를 측정하였다. 급성 ITP는 치료 후 혈소판수가 $100,000/{\mu}L$ 이상으로 증가되어 유지된 경우로, 만성 ITP는 혈소판수가 발병 6개월내에 일시적인 증가가 있을 지라도 발병 후 6개월 이상 경과 중에 $100,000/{\mu}L$ 이상으로 유지되지 않는 경우로 정의하였다. 또한 혈소판 수치가 치료 5일째 $100,000/{\mu}L$ 이상 증가된 환아들을 A군, $100,000/{\mu}L$ 이하인 환아들을 B군으로 정의하여 위와 같은 MPV, PDW를 분석하였다. 동기간 중 ITP로 내원 하였으나 IVIg 투여 없이 호전된 환아의 MPV, PDW 수치를 IVIg 치료군과 비교하였다. 결 과: 급성 ITP는 53례, 만성 ITP는 18례로 총 71례였으며 진단시 혈소판수는 $20,000/{\mu}L$ 이하가 65례(91.5%)로 대다수를 차지하였다. ITP 환아의 진단 당시 MPV와 PDW의 평균값은 6.77 fL, 15.16%로 정상 대조군의 7.29 fL, 15.96% 보다 의의 있게 낮았고(P<0.05), 만성보다는 급성에서, A군보다는 B군에서 MPV와 PDW값이 낮았으나 통계적으로 유의한 차이는 없었다. 전체 환아에 대해서 치료 후 1일째 MPV가 의의 있게 증가하고 그 이후 유지되었고 급성과 만성으로 나눠서 봤을 때 두 군간에 의의 있는 차이는 없었다. 하지만 IVIg 치료의 반응에 따라 구분하여 보면 A군에서 치료 후 1일째 MPV가 급격히 증가 후 감소하는 경향을 보였으나 B군은 치료 후 4일째까지 천천히 증가하는 양상을 보였다(P<0.05). 전체환아에서 PDW는 치료 후 2일에 걸쳐 의의 있게 증가한 후 유지되는 경향을 보였다. 정상 대조군에서는 혈소판과 MPV간에 의의 있게 반비례 관계를 보였으나(r=-0.415, P<0.05) ITP 환아의 진단시에는 혈소판과 MPV간에 의의 있게 비례 관계를 나타내었다(r=0.646, P<0.05). 동기간에 자연 회복된 9례의 ITP 환아와 IVIg로 치료한 대상 환아를 비교해 봤을 때 자연 회복된 환아들은 진단시 MPV가 증가되어 있었고 혈소판이 증가되면서 점차로 감소되는 양상을 보였다. 결 론 : 소아 ITP 환아에서 IVIg 치료 후에 혈소판 증가와 함께 MPV와 PDW는 증가하였다. IVIg 치료후 MPV와 PDW를 관찰하는 것이 치료 초기에 급성과 만성을 예측하는 데는 유용하지 않으나 MPV는 초기 치료 반응의 예측인자로서 유용한 것으로 사료된다. 본 연구결과에서 관찰된 소아 ITP 환아에서 진단시 MPV와 PDW가 정상 대조군에 비해 낮은 것과 IVIg 투여 후의 MPV 및 PDW의 증가에 대해서는 향후 더욱 광범위한 연구를 통해 더 많은 논의를 거쳐야 할 것이다.

• Clinical and Experimental Reproductive Medicine
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• 제41권2호
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• pp.92-95
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• 2014

Objective: This study sought to evaluate platelet volume indices (mean platelet volume [MPV], platelet distribution width [PDW], and platelet large cell ratio [P-LCR]) in varicocele patients, and compare it with platelet volume parameters in healthy controls. Methods: This cross-sectional study involved 2 groups: group 1 included 51 varicocele subjects and group 2 consisted of 50 healthy control subjects of similar ages. Peripheral venous blood samples were collected with ethylenediaminetetraacetic acid-K2 anticoagulant between 8:30 AM and 10 AM following an overnight fast. Platelet volume parameters (MPV, PDW, and P-LCR) were measured in both groups within 2 hours of sampling. Results: The mean PDW, MPV, and P-LCR were $13.9{\pm}2.5%$, $10.1{\pm}1.3fL$, and $27.3{\pm}7.8%$ in varicocele patients, respectively, and were $12.6{\pm}2.4%$, $9.3{\pm}1.1fL$, and $21.9{\pm}6.4%$ in the control group, respectively. The mean PDW, MPV, and P-LCR were significantly higher in the varicocele group than the control group. Conclusion: The results of the present study suggest that vascular components may play an important role in the pathophysiology of varicocele; therefore, there is a great need for prospective studies to confirm this relationship.