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http://dx.doi.org/10.7314/APJCP.2016.17.9.4433

Diagnostic Power of Blood Parameters as Screening Markers in Gastric Cancer Patients  

Pietrzyk, Lukasz (Department of Didactics and Medical Simulation, Chair of Human Anatomy, Medical University of Lublin)
Plewa, Zbigniew (Department of General, Oncological and Minimally Invasive Surgery, 1st Military Clinical Hospital)
Denisow-Pietrzyk, Marta (Department of Didactics and Medical Simulation, Chair of Human Anatomy, Medical University of Lublin)
Zebrowski, Remigiusz (Department of General, Oncological and Minimally Invasive Surgery, 1st Military Clinical Hospital)
Torres, Kamil (Department of Didactics and Medical Simulation, Chair of Human Anatomy, Medical University of Lublin)
Publication Information
Asian Pacific Journal of Cancer Prevention / v.17, no.9, 2016 , pp. 4433-4437 More about this Journal
Abstract
Background: Gastric cancer (GC) is the fifth most common cancer worldwide. Since development is usually asymptomatic, it is generally diagnosed at an advanced stage. The value of screening in patients with nonspecific symptoms for GC is controversial. Aim: The study aimed to evaluate whether hematological parameters (platelet count (PC), mean platelet volume (MPV), MPV/PC ratio, red blood cell distribution width (RDW), neutrophil to lymphocyte ratio (NLR), and platelet to lymphocyte ratio (PLR)) are useful markers to differentiate between gastric cancer patients and healthy individuals. Materials and Methods: Sixty-one patients with gastric cancer and sixty-one healthy individuals were enrolled to the survey and retrospective analysis of selected blood parameters were performed. Results: The mean values of PC, MPV, RDW, NLR, and PLR were significantly higher in GC patients compared to the control group. No statistical differences were observed in MPV/PC ratios. Likewise, no significant statistical differences were revealed in values of blood parameters among TNM stage groups. The RDW showed the highest diagnostic specificity and sensitivity. Conclusions: Hematological parameters: PC, MPV, RDW, NLR, PLR have diagnostic power and can discriminate patients with gastric cancer from patients without cancer. Blood parameters compared with clinical symptoms might alert physicians and patients and lead to performancce of upper gastrointestinal endoscopy, the gold standard in gastric cancer screening and therebly increase the early detection of cancer.
Keywords
Gastric cancer; platelet; mean platelet volume; red blood cell distribution width; neutrophil; lymphocyte;
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