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http://dx.doi.org/10.7314/APJCP.2015.16.13.5397

Platelet Indices May be Useful in Discrimination of Benign and Malign Endometrial Lesions, and Early and Advanced Stage Endometrial Cancer  

Kurtoglu, Emel (Department of Gynecology and Obstetrics, School of Medicine, Ondokuz Mayis University)
Kokcu, Arif (Department of Gynecology and Obstetrics, School of Medicine, Ondokuz Mayis University)
Celik, Handan (Department of Gynecology and Obstetrics, School of Medicine, Ondokuz Mayis University)
Sari, Seher (Department of Gynecology and Obstetrics, School of Medicine, Ondokuz Mayis University)
Tosun, Migraci (Department of Gynecology and Obstetrics, School of Medicine, Ondokuz Mayis University)
Publication Information
Asian Pacific Journal of Cancer Prevention / v.16, no.13, 2015 , pp. 5397-5400 More about this Journal
Abstract
Background: The aim of this study was to investigate the predictive value of white blood cells (WBC), the neutrophil to lymphocyte ratio (NLR), platelet indices including mean platelet volume (MPV), platelet distribution width (PDW), platelet crit (PCT) and platelet to lymphocyte ratio (PLR) in discrimination between benign and malign endometrial lesions, and early and advanced stage endometrial adenocarcinomas. Materials and Methods: Data for 105 patients undergoing total abdominal or vaginal hysterectomy for benign uterine diseases and 114 patients surgically staged for endometrium adenocarcinoma at Ondokuz Mayis University, Department of Gynecology and Obstetrics, between 2008 and 2014, were collected. Parameters were preoperative and postoperative complete blood counts in the week prior to surgery with differentials including WBC, platelet count, platelet indices (MPV, PCT, PDW), NLR and PLR. Pathologic evaluations for both benign and malign endometrium lesions, grade of endometrium adenocarcinoma, tumor stage, presence of lymphovascular space invasion (LVI) were retrospectively analyzed. Results: Regarding definitive factors in discriminating patients with endometrium cancer from those with benign diseases, MPV was significantly increased in the malign group whereas there was a significant decrease in the PDW value compared to the benign group. The best cut-off value in differentiation of the benign and malign groups, malign cases were found to increase over the value of 7.54 for MPV, and under 37.8 for PDW. When definitive factors in discrimination of early stage endometrium cancer from advanced stage disease and LVI in the malign group were evaluated according to the ROC analysis, no significant relation was detected between blood parameters and the stage and the LVI of the disease. Conclusions: MPV and PDW may have predictive value in the discrimination of benign and malign endometrium diseases. Nevertheless, since there have been few reports on this topic, further large-scale prospective studies are necessary.
Keywords
Endometrium cancer; mean platelet volume; platelet distribution width; lymphovascular space invasion;
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1 Acmaz G, Aksoy H, Unal D, et al (2014). Are neutrophil/ lymphocyte and platelet/lymphocyte ratios associated with endometrial precancerous and cancerous lesions in patients with abnormal uterine bleeding? Asian Pac J Cancer Prev, 15, 1689-92.   DOI
2 Avci A, Alizade E, Fidan S, et al (2014). Neutrophil/lymphocyte ratio is related to the severity of idiopathic dilated cardiomyopathy. Scand Cardiovasc J, 48, 202-8.   DOI
3 Ayhan A, Bozdag G, Taskiran C, et al (2006). The value of preoperative platelet count in the prediction of cervical involvement and poor prognostic variables in patients with endometrial carcinoma. Gynecol Oncol, 103, 902-5.   DOI   ScienceOn
4 Bhatti I, Peacock O, Lloyd G, et al (2010). Preoperative hematologic markers as independent predictors of prognosis in resected pancreatic ductal adenocarcinoma: neutrophillymphocyte versus platelet-lymphocyte ratio. Am J Surg, 200, 197-203.   DOI
5 Cho H, Hur HW, Kim SW, et al (2009). Pre-treatment neutrophil to lymphocyte ratio is elevated in epithelial ovarian cancer and predicts survival after treatment. Cancer Immunol Immunother, 58, 15-23.   DOI
6 Cho MS, Bottsford-Miller J, Vasquez HG, et al (2012). Platelets increase the proliferation of ovarian cancer cells. Blood, 120, 4869-72.   DOI   ScienceOn
7 den Ouden M, Ubachs JM, Stoot JE, et al (1997). Whole blood cell counts and leucocyte differentials in patients with benign or malignant ovarian tumours. Eur J Obstet Gynecol Reprod Biol, 72, 73-7.   DOI
8 Doll A, Abal M, Rigau M, et al (2008). Novel molecular profiles of endometrial cancer-new light through old windows. J Steroid Biochem Mol Biol, 108, 221-9.   DOI   ScienceOn
9 Feng JF, Huang Y, Chen QX (2014). Preoperative platelet lymphocyte ratio (PLR) is superior to neutrophil lymphocyte ratio (NLR) as a predictive factor in patients with esophageal squamous cell carcinoma. World J Surg Oncol, 12, 58.   DOI
10 Karpatkin S, Pearlstein E (1981). Role of platelets in tumor cell metastases. Ann Intern Med, 95, 636-41.   DOI
11 Kaya V, Yildirim M, Demirpence O, et al (2013). Prognostic significance of basic laboratory methods in non-small-celllung cancer. Asian Pac J Cancer Prev, 14, 5473-6.   DOI   ScienceOn
12 Kwon HC, Kim SH, Oh SY, et al (2012). Clinical significance of preoperative neutrophil-lymphocyte versus plateletlymphocyte ratio in patients with operable colorectal cancer. Biomarkers, 17, 216-22.   DOI   ScienceOn
13 Kayadibi H, Sertoglu E, Uyanik M, et al (2014). Neutrophillymphocyte ratio is useful for the prognosis of patients with hepatocellular carcinoma. World J Gastroenterol, 20, 9631-2.
14 Kokcu A, Kurtoglu E, Celik H, Tosun M, Malatyalioglu E, Ozdemir AZ (2014). May the platelet to lymphocyte ratio be a prognostic factor for epithelial ovarian cancer? Asian Pac J Cancer Prev, 15, 9781-4.   DOI
15 Kurtoglu E, Kokcu A, Celik H, Tosun M, Malatyalioglu E (2015). May ratio of neutrophil to lymphocyte be useful in predicting the risk of developing preeclampsia? A pilot study. J Matern Fetal Neonatal Med, 28, 97-9.   DOI
16 McMillan DC, Canna K, McArdle CS (2003). Systemic inflammatory response predicts survival following curative resection of colorectal cancer. Br J Surg, 90, 215-9.   DOI
17 O'Keefe SC, Marshall FF, Issa MM, et al (2002). Thrombocytosis is associated with a significant increase in the cancer specific death rate after radical nephrectomy. J Urol, 168, 1378-80.   DOI
18 Pecorelli S (2009). Revised FIGO staging for carcinoma of the vulva, cervix, and endometrium. Int J Gynaecol Obstet, 105, 103-4.   DOI
19 Suh DH, Kim HS, Chung HH, et al (2012). Pre-operative systemic inflammatory response markers in predicting lymph node metastasis in endometrioid endometrial adenocarcinoma. Eur J Obstet Gynecol Reprod Biol, 162, 206-10.   DOI
20 Tavares-Murta BM, Mendonca MA, Duarte NL, et al (2010). Systemic leukocyte alterations are associated with invasive uterine cervical cancer. Int J Gynecol Cancer, 20, 1154-9.   DOI   ScienceOn
21 Williams KA, Labidi-Galy SI, Terry KL, et al (2014). Prognostic significance and predictors of the neutrophil-to-lymphocyte ratio in ovarian cancer. Gynecol Oncol, 132, 542-50.   DOI
22 Wang D, Yang JX, Cao DY, et al (2013). Preoperative neutrophillymphocyte and platelet-lymphocyte ratios as independent predictors of cervical stromal involvement in surgically treated endometrioid adenocarcinoma. Onco Targets Ther, 6, 211-6.