DOI QR코드

DOI QR Code

May the Platelet to Lymphocyte Ratio be a Prognostic Factor for Epithelial Ovarian Cancer?

  • Kokcu, Arif (Department of Obstetrics and Gynecology, Faculty of Medicine, University of Ondokuz Mayis) ;
  • Kurtoglu, Emel (Department of Obstetrics and Gynecology, Faculty of Medicine, University of Ondokuz Mayis) ;
  • Celik, Handan (Department of Obstetrics and Gynecology, Faculty of Medicine, University of Ondokuz Mayis) ;
  • Tosun, Migraci (Department of Obstetrics and Gynecology, Faculty of Medicine, University of Ondokuz Mayis) ;
  • Malatyalıoglu, Erdal (Department of Obstetrics and Gynecology, Faculty of Medicine, University of Ondokuz Mayis) ;
  • Ozdemir, Ayse Zehra (Department of Obstetrics and Gynecology, Faculty of Medicine, University of Ondokuz Mayis)
  • 발행 : 2014.12.18

초록

Background: The study aimed to evaluate changes in hematologic parameters, including white blood cell, platelet count, platelet indices, the platelet to lymphocyte and neutrophil to lymphocyte ratios in patients with early and advanced stages of epithelial ovarian cancers. Materials and Methods: The study included 100 patients with epithelial ovarian cancer who underwent primary staging exploratory laparotomy. Preoperative hematologic parameters, tumor histopathologic type, grade, stage and serum CA-125 levels were retrospectively analyzed. These parameters were compared between the patients with early (stage I-II) and advanced (stage III-IV) ovarian cancer. Results: White blood cell count and platelet indices, including mean platelet volume, platelet distribution width and platelet crit did not show a statistically significant difference between groups with early and advanced ovarian cancer. However, the neutrophil to lymphocyte ratio, platelet count, the platelet to lymphocyte ratio and CA-125 level showed a statistically significant difference between the two groups (p<0.05, p<0.01, p<0.001, p<0.01 respectively). Conclusions: It was found that the neutrophil to lymphocyte ratio, platelet count and the platelet to lymphocyte ratio increased with the increasing stage of ovarian cancer. Furthermore, it was seen that the platelet to lymphocyte ratio is an independent prognostic factor related to the stage of epithelial ovarian cancer.

키워드

참고문헌

  1. Acmaz G, Aksoy H, Unal D, et al (2014). Are neutrophil/ lymphocyte and platelet/lymphocyte ratios associated with endometrial precancerous and cancerous lesions in patients with abnormal uterine bleeding? Asian Pac J Cancer Prev, 15, 1689-92. https://doi.org/10.7314/APJCP.2014.15.4.1689
  2. Asher V, Lee J, Innamaa A, Bali A (2011). Preoperative platelet lymphocyte ratio as an independent prognostic marker in ovarian cancer. Clin Transl Oncol, 13, 499-503. https://doi.org/10.1007/s12094-011-0687-9
  3. Balkwill F, Mantovani A (2001). Inflammation and cancer: back to Virchow? Lancet, 357, 539-45. https://doi.org/10.1016/S0140-6736(00)04046-0
  4. Cho H, Hur HW, Kim SW, et al (2009). Pre-treatment neutrophil to lymphocyte ratio is elevated in epithelial ovarian cancer and predicts survival after treatment. Cancer Immunol Immunother, 58, 15-23. https://doi.org/10.1007/s00262-008-0516-3
  5. Cho MS, Bottsford-Miller J, Vasquez HG, et al (2012). Platelets increase the proliferation of ovarian cancer cells. Blood, 120, 4869-72. https://doi.org/10.1182/blood-2012-06-438598
  6. Crasta JA, Premlatha TS, Krishnan SM, Vallikad E, Rameshkumar K (2010). Significance of preoperative thrombocytosis in epithelial ovarian cancer. Indian J Pathol Microbiol, 53, 54-6. https://doi.org/10.4103/0377-4929.59184
  7. Dirican A, Kucukzeybek Y, Erten C, et al (2013). Prognostic and predictive value of hematologic parameters in patients with metastatic renal cell carcinoma: second line sunitinib treatment following IFN-alpha. Asian Pac J Cancer Prev, 14, 2101-5. https://doi.org/10.7314/APJCP.2013.14.3.2101
  8. Feng JF, Huang Y, Chen QX (2014). Preoperative platelet lymphocyte ratio (PLR) is superior to neutrophil lymphocyte ratio (NLR) as a predictive factor in patients with esophageal squamous cell carcinoma. World J Surg Oncol, 12, 58. https://doi.org/10.1186/1477-7819-12-58
  9. Ikeda M, Furukawa H, Imamura H, et al (2002). Poor prognosis associated with thrombocytosis in patients with gastric cancer. Ann Surg Oncol, 9, 287-91. https://doi.org/10.1007/BF02573067
  10. Karpatkin S, Pearlstein E (1981). Role of platelets in tumor cell metastases. Ann Intern Med, 95, 636-41. https://doi.org/10.7326/0003-4819-95-5-636
  11. Kemal Y, Yucel I, Ekiz K, et al (2014). Elevated serum neutrophil to lymphocyte and platelet to lymphocyte ratios could be useful in lung cancer diagnosis. Asian Pac J Cancer Prev, 15, 2651-4. https://doi.org/10.7314/APJCP.2014.15.6.2651
  12. Lee M, Kim SW, Nam EJ, et al (2011). The impact of pretreatment thrombocytosis and persistent thrombocytosis after adjuvant chemotherapy in patients with advanced epithelial ovarian cancer. Gynecol Oncol, 122, 238-41. https://doi.org/10.1016/j.ygyno.2011.04.012
  13. Li AJ, Madden AC, Cass I, et al (2004). The prognostic significance of thrombocytosis in epithelial ovarian carcinoma. Gynecol Oncol, 92, 211-4. https://doi.org/10.1016/j.ygyno.2003.09.002
  14. Ma X, Wang Y, Sheng H, et al (2014). Prognostic significance of thrombocytosis, platelet parameters and aggregation rates in epithelial ovarian cancer. J Obstet Gynaecol Res, 40, 178-83. https://doi.org/10.1111/jog.12151
  15. Mallappa S, Sinha A, Gupta S, Chadwick SJ (2013). Preoperative neutrophil to lymphocyte ratio >5 is a prognostic factor for recurrent colorectal cancer. Colorectal Dis, 15, 323-8. https://doi.org/10.1111/codi.12008
  16. Miglani RK, Bhateja N, Bhat RS, Kumar KV (2013). Diagnostic Role of Platelet Lymphocyte Ratio(PLR) in pancreatic head masses. Indian J Surg, 75, 4-9. https://doi.org/10.1007/s12262-012-0443-6
  17. O'Keefe SC, Marshall FF, Issa MM, Harmon MP, Petros JA (2002). Thrombocytosis is associated with a significant increase in the cancer specific death rate after radical nephrectomy. J Urol, 168, 1378-80. https://doi.org/10.1016/S0022-5347(05)64453-9
  18. Raungkaewmanee S, Tangjitgamol S, Manusirivithaya S, Srijaipracharoen S, Thavaramara T (2012). Platelet to lymphocyte ratio as a prognostic factor for epithelial ovarian cancer. J Gynecol Oncol, 23, 265-73. https://doi.org/10.3802/jgo.2012.23.4.265
  19. Roxburgh CS, McMillan DC (2010). Role of systemic inflammatory response in predicting survival in patients with primary operable cancer. Future Oncol, 6, 149-63. https://doi.org/10.2217/fon.09.136
  20. Stone RL, Nick AM, McNeish IA, et al (2012). Paraneoplastic thrombocytosis in ovarian cancer. N Engl J Med, 366, 610-8. https://doi.org/10.1056/NEJMoa1110352
  21. Suh DH, Kim HS, Chung HH, et al (2012). Pre-operative systemic inflammatory response markers in predicting lymph node metastasis in endometrioid endometrial adenocarcinoma. Eur J Obstet Gynecol Reprod Biol, 162, 206-10. https://doi.org/10.1016/j.ejogrb.2012.02.028
  22. Tamussino KF, Gucer F, Reich O, et al (2001). Pretreatment hemoglobin, platelet count, and prognosis in endometrial carcinoma. Int J Gynecol Cancer, 11, 236-40. https://doi.org/10.1046/j.1525-1438.2001.01024.x
  23. Tanoglu A, Yiyit N, Berber U, Karagoz E (2014). Is the combination of neutrophil to lymphocyte and platelet to lymphocyte ratios a useful predictor of treatment response and prognosis in patients with non-small cell lung cancer? Asian Pac J Cancer Prev, 15, 4373. https://doi.org/10.7314/APJCP.2014.15.10.4373
  24. Thavaramara T, Phaloprakarn C, Tangjitgamol S, Manusirivithaya S (2011). Role of neutrophil to lymphocyte ratio as a prognostic indicator for epithelial ovarian cancer. J Med Assoc Thai, 94, 871-7.
  25. Topcu HO, Guzel AI, Ozer I, et al (2014). Comparison of neutrophil/lymphocyte and platelet/ lymphocyte ratios for predicting malignant potential of suspicious ovarian masses in gynecology practice. Asian Pac J Cancer Prev, 15, 6239-41. https://doi.org/10.7314/APJCP.2014.15.15.6239
  26. Tuszynski GP, Nicosia RF (1996). The role of thrombospondin-1 in tumor progression and angiogenesis. Bioessays, 18, 71-6. https://doi.org/10.1002/bies.950180113
  27. Unal D, Eroglu C, Kurtul N, Oguz A, Tasdemir A (2013). Are neutrophil/lymphocyte and platelet/lymphocyte rates in patients with non-small cell lung cancer associated with treatment response and prognosis? Asian Pac J Cancer Prev, 14, 5237-42. https://doi.org/10.7314/APJCP.2013.14.9.5237
  28. Vergote IB, Kaern J, Abeler VM, et al (1993). Analysis of prognostic factors in stage I epithelial ovarian carcinoma: importance of degree of differentiation and deoxyribonucleic acid ploidy in predicting relapse. Am J Obstet Gynecol, 169, 40-52. https://doi.org/10.1016/0002-9378(93)90129-7
  29. Williams KA, Labidi-Galy SI, Terry KL, et al (2014). Prognostic significance and predictors of the neutrophil-to-lymphocyte ratio in ovarian cancer. Gynecol Oncol, 132, 542-50. https://doi.org/10.1016/j.ygyno.2014.01.026
  30. Zeimet AG, Marth C, Muller-Holzner E, Daxenbichler G, Dapunt O (1994). Significance of thrombocytosis in patients with epithelial ovarian cancer. Am J Obstet Gynecol, 170, 549-54. https://doi.org/10.1016/S0002-9378(94)70225-X

피인용 문헌

  1. Relations of Platelet Indices with Endometrial Hyperplasia and Endometrial Cancer vol.16, pp.12, 2015, https://doi.org/10.7314/APJCP.2015.16.12.4905
  2. Platelet Indices May be Useful in Discrimination of Benign and Malign Endometrial Lesions, and Early and Advanced Stage Endometrial Cancer vol.16, pp.13, 2015, https://doi.org/10.7314/APJCP.2015.16.13.5397
  3. Value of the Platelet to Lymphocyte Ratio in the Diagnosis of Ovarian Neoplasms in Adolescents vol.16, pp.5, 2015, https://doi.org/10.7314/APJCP.2015.16.5.2037
  4. Investigating Preoperative Hematologic Markers for Prediction of Ovarian Cancer Surgical Outcome vol.17, pp.3, 2016, https://doi.org/10.7314/APJCP.2016.17.3.1445
  5. Diagnostic and prognostic roles of the mean platelet volume in malignant tumors: a systematic review and meta-analysis vol.27, pp.8, 2016, https://doi.org/10.3109/09537104.2016.1169265
  6. The Prognostic Significance of Neutrophil-to-Lymphocyte and Platelet-to-Lymphocyte Ratios in Patients With Multiple Myeloma vol.30, pp.6, 2016, https://doi.org/10.1002/jcla.22004
  7. The platelet-to-lymphocyte ratio as a predictor of patient outcomes in ovarian cancer: a meta-analysis vol.20, pp.5, 2017, https://doi.org/10.1080/13697137.2017.1326894
  8. Platelet to lymphocyte ratio (PLR) retains independent prognostic significance in advanced stage marginal zone lymphoma patients treated with rituximab, cyclophosphamide, vincristine, and prednisone combination chemotherapy (R-CVP): Consortium for Improving Survival of Lymphoma trial vol.52, pp.3, 2017, https://doi.org/10.5045/br.2017.52.3.200
  9. The diagnostic efficacy of platelet-to-lymphocyte ratio and neutrophil-to-lymphocyte ratio in ovarian cancer vol.66, pp.6, 2017, https://doi.org/10.1007/s00011-017-1026-6
  10. Preoperative red cell distribution width and neutrophil-to-lymphocyte ratio predict survival in patients with epithelial ovarian cancer vol.7, pp.1, 2017, https://doi.org/10.1038/srep43001
  11. Monoclonal gammopathies regardless of subtypes are associated with poor prognosis of diffuse large B-cell lymphoma vol.97, pp.30, 2018, https://doi.org/10.1097/MD.0000000000011719
  12. Analysis of preoperative blood platelet parameters in terms of diversity of epithelial ovarian cancer vol.97, pp.12, 2018, https://doi.org/10.1097/MD.0000000000010180
  13. Diabetes control could through platelet-to-lymphocyte ratio in hemograms vol.65, pp.1, 2019, https://doi.org/10.1590/1806-9282.65.1.38