• Proceedings of the Korean Society for Technology of Plasticity Conference
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• 2005.05a
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• pp.344-344
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• 2005

• BMB Reports
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• v.53 no.11
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• pp.551-564
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• 2020

Proper development of the nervous system is critical for its function, and deficits in neural development have been implicated in many brain disorders. A precise and predictable developmental schedule requires highly coordinated gene expression programs that orchestrate the dynamics of the developing brain. Especially, recent discoveries have been showing that various mRNA chemical modifications can affect RNA metabolism including decay, transport, splicing, and translation in cell type- and tissue-specific manner, leading to the emergence of the field of epitranscriptomics. Moreover, accumulating evidences showed that certain types of RNA modifications are predominantly found in the developing brain and their dysregulation disrupts not only the developmental processes, but also neuronal activities, suggesting that epitranscriptomic mechanisms play critical post-transcriptional regulatory roles in development of the brain and etiology of brain disorders. Here, we review recent advances in our understanding of molecular regulation on transcriptome plasticity by RNA modifications in neurodevelopment and how alterations in these RNA regulatory programs lead to human brain disorders.

• Proceedings of the Korean Society for Technology of Plasticity Conference
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• 2003.05a
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• pp.120-126
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• 2003

Finite element analysis model is suggested for analysis of milli-forming process, which forms milli-size products. Since the size of workpiece in a milli-forming process ranges from a few hundred micrometers to a few millimeters, microstructural changes such as the growth of micro-voids and the development of preferred orientation in a grain become crucial factors for the success of milli-forming. This analysis model incorporates anisotropy from deformation torture and deterioration of mechanical properties due to the growth of micro-voids. Applications of the proposed modeling to milli-forming are given and the results are carefully examined to understand the deformation characteristics such as texture development and damage evolution during extrusion/drawing of a milli-bar.

• Proceedings of the Korean Society for Technology of Plasticity Conference
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• 2001.10a
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• pp.309-312
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• 2001

FEM simulating system of the cross-rolling texture formation offers a systematic and efficient way of exploring the relationship between the process variables and the state of plastic anisotropy of sheet product. Cross-rolled sheets possess higher average plastic strain ratios and lower planer anisotropy than those of the straight-rolled sheets. The employed model is a finite-element polycrystal model which each element used in FEM is assumed to be a crystal having different orientation by Takahashi. Texture development, deformation textures due to cross-rolling are predicted for face-centered cubic sheet metal. Crystal orientations are assigned on the basis of the pole figures obtained by X-ray diffraction. Development of anisotropy during cross rolling of an fcc sheet material is predicted theoretically with respected to flow stress and R-value in tensile test.

• Proceedings of the Korean Society for Technology of Plasticity Conference
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• 2003.10b
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• pp.43-46
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• 2003

Prediction of final microstructures after high temperature forming of Ti-6Al-4V alloy was attempted in this study. Using two typical microstructures, i.e., equiaxed and $Widmanst\ddot{a}tten$ microstructures, compression test was carried out up to the strain level of 0.6 at various temperatures $(700\~1100^{\circ}C)$ and strain rates $(10^{-4}\~10^2/s)$. From the flow stress-strain data, parameters such as strain rate sensitivity (m) and activation energy (Q) were calculated and used to establish constitutive equations for both microstructures. Then, finite element analysis was performed to predict the final microstructure of the deformed body, which was well accorded with the experimental results.

• Proceedings of the Korean Society for Technology of Plasticity Conference
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• 2003.08a
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• pp.41-52
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• 2003

The tendency of current die manufacturing is focusing into development period shortening and panel quality improvement. This brings change of manufacturing process. In existing process, depended on experience, we were faced on a limit of sufficiency in this focus. Thus, we have attempted to make a conquest of that by constructing a process of CAE. Our attempt apply not only draw die formability but also trimming and flanging die formability with simulation of sheet metal. In this paper, we publish effects that were obtained by constructing a process.

• Proceedings of the Korean Society for Technology of Plasticity Conference
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• 2003.10b
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• pp.36-39
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• 2003

Due to the strength and biocompatibility requirement, the stainless steel SUS 316L is widely used for trauma internal fixation device. SUS 316L can be hardened and strengthened only by cold work. In this work, the material compression test is performed both in laboratory and computer simulation by a FEM analysis software DEFORM to correlate the hardness to strain. This data is then used for preform design and predict the hardness of the finish bone plate forging. Finally, we compared the hardness between the actual forging and computer analysis results. Although the predicted hardness from computer simulation. is 55HV higher than the final forging sample, we can get good compatibility on the hardening tendency of cold forging.

• Proceedings of the Korean Society of Crop Science Conference
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• 2017.06a
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• pp.321-321
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• 2017

Water availability in rainfed lowlands (RFL) is strongly affected by climate change. In RFL, rice plants are exposed to soil moisture fluctuations (SMF) but rarely to simple progressive drought as widely believed. Typical RFL field is characterized by a about 5-cm thick high bulk density hardpan layer underneath the cultivated layer at about 20 cm depth that impedes deep root development. Root system has the ability to develop in response to changes in SMF, known as phenotypic plasticity. We hypothesized that genotypes that can adapt to RFL have root plasticity. The roots can sharply respond to re-wetting after drought period and thus penetrate the hardpan layer when the hardpan is wet and so becomes relatively soft, and thus access water under the hardpan. This study aimed to identify CSSLs derived from a cross between Sasanishiki and Habataki which adapted to such RFL conditions. We used 39 CSSLs together with the parent Sasanishiki, which were grown in hydroponics and pot under transient soil moisture stresses (drought and then rewatering), and compared with continuously well-watered (WW) (control) up to 14 days after sowing (DAS), and 20 DAS, respectively. Based on the results of hydroponics and pot experiments, we selected a few lines, which were grown in the soil-filled rootbox with artificial hardpan layer and without artificial hardpan. For the rootbox without artificial hardpan, plants were grown under WW and transient soil moisture stresses for 49 DAS. While the rootbox with artificial hardpan, the plants were grown under WW (control) and SMF (WW up to 21 DAS, 1st drought (22-36 DAS), rewatering (37-44 DAS), and followed by 2nd drought (45-58 DAS)). Among the 39 CSSLs, only CSSL439 (SL39) consistently showed significantly higher shoot dry weight (SDW) than Sasanishiki under transient soil moisture stress conditions as well as SMF conditions in all the experiments. Furthermore, under WW, SL39 consistently showed no significant differences from Sasanishiki in shoot and root growth in most of traits examined. SL39 showed significantly greater total root length (TRL) than Sasanishiki under transient soil moisture stress, which is considered as phenotypic plasticity in response to rewatering after drought period. Such plastic root development was the key trait that effectively contributed to root elongation and branching during the rewatering period and consequently enhanced the root to penetrate hardpan layer when the soil penetration resistance at hardpan layer reduced. In addition, using the rootbox with artificial hardpan layer ($1.7g\;cm^{-3}$, heavily compacted), SL39 showed greater root system development than Sasanishiki under SMF, which was expressed in its significantly higher TRL, total nodal RL, and total lateral RL at hardpan layer as well as at below the hardpan layer. These results prove that SL39 has plasticity that enables its root systems to penetrate hardpan layer in response to rewatering. Under SMF, such root plasticity contributed to its higher gs and Pn.

• Proceedings of the Korean Society for Technology of Plasticity Conference
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• 2005.10a
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• pp.287-290
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• 2005

The shearing and punching processes are analyzed with the finite element method using an isotropic material model. The experimental result in the punching process shows that final radiuses of sheet metal according to the rolling direction and transverse direction are different because of the material anisotropy. The material anisotropy is induced by complicated large deformation in the polycrystalline aggregate. The contact region between the punch and sheet metal experiences severe deformation such as shear, compression and tension in the punching process. In this paper, the analysis of punching process for Al 1100 is performed with the ABAQUS Standard. The analysis of texture development and evolution is carried out based on the deformation history in the punching process. The deformation histories are extracted by UMAT in the ABAQUS Standard. The torture development is investigated with the pole figure and yield surface during the punching process.

• Proceedings of the Korean Society for Technology of Plasticity Conference
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• 2004.08a
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• pp.223-230
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• 2004

In order to improve the productivity and quality of the hot rolled products, many morden mills have continuously required advanced roll materials. The introduction of HSS rolls in early stands of the Hot Strip Mill brought the excellent performance in wear resistance and surface roughness. Ni-grain rolls used in the later stands was needed to improve the roll performance. Therefore, the carbide reinforced Ni-grain roll was developed. The present paper will describe the development of carbide reinforced rolls made by INI STEEL and the results of mill tests. The wear resistance was increased upto $40\%$ and the anti-accident ablility was remarkably improved compared to the normal Ni-rain roll.