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Polyphenol-rich Sargassum horneri alleviates atopic dermatitis-like skin lesions in NC/Nga mice by suppressing Th2-mediated cytokine IL-13

  • Suyama Prasansali, Mihindukulasooriya;Hyo Jin, Kim;Jinhee, Cho;Kalahe Hewage Iresha Nadeeka Madushani, Herath;Jiwon, Yang;Duong Thi Thuy, Dinh;Mi-Ok, Ko;You-Jin, Jeon;Ginnae, Ahn;Youngheun, Jee
    • ALGAE
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    • v.37 no.4
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    • pp.331-347
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    • 2022
  • Atopic dermatitis (AD) is one of major skin inflammatory diseases characterized by excessive Th2-mediated immune responses. Recent evidence provides that interlukin-13 (IL-13) plays the role of a key Th2 cytokine that drives the inflammation underlining AD. Due to adverse effects of commercially available synthetic drugs, the need for treatments based on natural products is gaining much attention. Sargassum horneri is an edible brown algae known for beneficial bioactivities including anti-inflammation. We investigated if polyphenol-rich S. horneri extracts (SHE) could suppress AD-like skin lesions in NC/Nga mice and if that involved inhibition of the infiltration of Th2-mediated cytokine IL-13. We observed markedly increased infiltration of IL-13 positive cells in AD-like skin lesions of mice but SHE treatments decreased it. Also, the dermal expression of IL-13 was sufficient to cause inflammatory responses in mice skin resembling human AD. SHE suppressed the dermal infiltration of inflammatory cells where IL-13 plays a crucial role in skin tissues and in the recruitment of inflammatory cells. Furthermore, it was confirmed that SHE reduced T cell, dendritic cell, and macrophage populations in spleen. Moreover, SHE decreased the collagen deposition in skin and ear dermis resulting in reduced fibrosis that occurs in AD due to excessive collagen. Taken together, our results reveal that SHE suppressed the infiltration of inflammatory cells into skin dermis by decreasing the infiltration of IL-13 positive cells. Therefore, SHE could be taken as a useful therapeutic agent to alleviate AD.

A Study on the Economic Analysis of Chestnut Prices and Production Forecasting (밤 가격(價格)의 경제분석(經濟分析) 및 생산예측(生産豫測)에 관(關)한 연구(硏究))

  • Song, Hyung Sop;Cho, Eung Hyouk
    • Korean Journal of Agricultural Science
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    • v.14 no.2
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    • pp.263-271
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    • 1987
  • The cyclical trend and seasonal variations of chestnut prices have been analyzed to find out the chestnut price fluctuation in Korea during 1966-1985. The optimum prices, production, and plantation area for the next twenty five years (1986-2010) have been forcasted by the derived equation models. The results of study can be summarized as follows: 1. The chestnut prices were increased by 14.67 percent per annum during 1966-1972, an d decreased by 9.24 percent during 1973-1985, due to the excessive production of chestnut. 2. The chestnut prices showed the lowest price during the harvesting season, especially in October (89.1), and highest in July (109.1). Seasonal fluctuation of chestnut prices were 0.0837 (C.V value) during 1966-1975, and 0.0706 during 1976-1985. Such a seasonal fluctuation of chestnut prices tends to be even with the passage of time. 3. The equation model of predicted chestnut prices was derived as follows : PR=117788.088 - 7.60 TC/Pop + 6.585 GNP/Pop The chestnut prices will be the lowest in 1988, but increased rapidly thereafter. 4. The equation model of optimum chestnut production was derived as follows : $${\ell}n\;PD/Pop=-8.5147-0.8267{\ell}n\;PR+3.3063{\ell}n\;GNP/Pop$$ To maintain optimum chestnut prices according to this model, chestnut production should be 133,000 ton for 1988, and 1,899,000 ton for 2010. 5. Optimum chestnut plantation area will be 4,000 ha in 1988, and thereafter total plantation area will be up to 57,400 ha in 2010.

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Water Physiology of Panax ginseng. 1. Habitat observation. cultural experience, weather factors and characteristics of root and leaf (인삼의 수분생리 1. 자생지관찰.재배 경험.기상요인과 근 및 엽의 특성)

  • Park, Hoon
    • Journal of Ginseng Research
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    • v.4 no.2
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    • pp.197-221
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    • 1980
  • Habitat observation, cultural experience of old and present plantation, weather factors in relation to crop stand and water physiology of root and leaf were reviewed. According to habitat observation ginseng plants love water but plate wit talus well grow at drained place with high moisture content in air and soil while ginseng plants were not found in dry or wet place. According to cultivation experience ginseng plants require abundant water in nursery and main field but most old planters believe that ginseng plaints are draught-loving thus require little water. The experience that rain especially in summer i.e unfavorable might be due to mechanical damage of leaves arid leaf disease infection, or severe leaf fall which is caused by high air temperature and coinsided with rain. According to crop stand observation in relation to weather factors abunsant water increased each root weight but decreased total yield indicating tile increase of missing root rate. Rain in summer was unfavorable too. Though rain in June was favorable for high yield general experience that cloudy day and rain were unfavorable might be due to low light intensity under shade. Present leading planters also do loot consider the importance of water in main field. Water content is higher in top than in root and highest in central portion of root and in stem of top. For seedling the heavier the weight of root is tile higher the water content while it reveries from two years old. Water potential of intact root appeared to be -2.89 bar suggesting high sensitivity to water environment. Under water stress water content severly decreased only in leaf. Water content of leaf appeared to be 78% for optimum, below 72% for functional damage and 68% for perm anent wilting. Transpiration or curs Principally through stomata in lower side of leaf thus contribution of upper side transpiration decreased with the increase of intensity. Transpiration is greater in the leaves grown under high light intensity. Thus water content is lower with high light inte nsity under field condition indicating that light is probable cause of water stress in field. Transpiration reached maximum at 10K1ut The decrease of transpiration at higher temperature seems to be due to the decrease of stomata aperture caused by water stress. Severe decrease of photosynthesis under water stress seems to be principally due to functional damage which is not caused by high temperature and Partly due to poor CO2 supply. Water potential of leaf appeared to be -16.8 bar suggesting weakness in draught tolerance. Ginseng leaves absorb water under high humidity. Water free space of leaf disc is %mailer than that of soybean leaf and water uptake appears to be more than two steps.

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Community Distribution on Mountain Forest Vegetation of the Gyebangsan Area in the Odaesan National Park, Korea (오대산 국립공원 계방산 일대 삼림식생의 군락분포에 관한 연구)

  • Kim, Chang-Hwan;Oh, Jang-Geun;Kang, Eun-Ok;Yun, Chil-Sun;Lim, Jin-Keun
    • Korean Journal of Ecology and Environment
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    • v.47 no.3
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    • pp.135-145
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    • 2014
  • The mountain forest vegetation of Gyebangsan (1,577 m) in Odaesan National Park is classified into deciduous broad-leaved forest, mountain valley forest, coniferous forest, subalpine coniferous forest, subalpine deciduous forest, plantation forest, and other vegetation which includes Actinidia argute community and agricultural land. As for the number of communities distributed in the each forest vegetation which were categorized by the physiognomy classification, deciduous broad-leaved forest had 33 communities, mountain valley forest 41 communities, coniferous forest 8 communities, subalpine coniferous forest 4 communities, subalpine deciduous forest 2 communities, plantation forest 6 communities and other vegetation 4 communities. Regarding the distribution rate of communities in the vegetation, in the deciduous broad-leaved forest. Quercus mongolica community accounted for 80.226% with $30,909,942.967m^2$, followed by Quercus variabilis community of 2.771% with $1,067,479.335m^2$. 55.463% of deciduous broad-leaved forest in the Gyebangsan had Quercus mongolica as a dominant or second dominant species. In the mountain valley forest, Fraxinus rhynchophylla - Juglans mandshurica community accounted for 10.955%. And there were ten mixed communities having Fraxinus rhynchophylla and upper layer at a similar level of coverage, taking up 32.776%. In the coniferous forest, Pinus densiflora and the community living with Pinus densiflora accounted for 100%, showing that the coniferous forest has the community with Pinus densiflora as a dominant species at upper layer. For other vegetation, subalpine coniferous forest had a total of four communities including Abies holophylla - Quercus mongolica community, and accounted for 4.980% of vegetation area of Odaesan National Park. Two communities including Betula ermani - Cornus controversa community were found in the subalpine deciduous forest, taking up 0.006% of total vegetation area of Odaesan National Park. Regarding plantation forest, Larix leptolepis was planted the most with 51.652%, followed by Betula platyphylla var. japonica with 38.975%, and Pinus koraiensis with 7.969%. These three species combined accounted for 98.565%. In conclusion, the forest vegetation found in the Gyebangsan of Odaesan National Park has Quercus mongolica as a dominant species at the top layer. A lot of other communities related with this species are expected to be quickly replaced due to vegetation succession and climatic causes. Therefore, Quercus mongolica is expected to become the main species in the deciduous broad-leaved forest, Fraxinus rhynchophylla, Juglans mandshurica and Fraxinus mandshurica in the mountain valley forest. Around the border line between deciduous broad-leaved forest and mountain valley forest, highly humid valley area is expected to be quickly taken up by Cornus controversa and Fraxinus mandshurica, and the slope area by Quercus mongolica. However, in the subalpine coniferous forest, the distribution rate of deciduous broad-leaved trees is expected to increase due to climate warming.

Artocarpus chaplasha: Establishment and Initial Growth Performance at Elevated Temperature and Saline Stresses

  • Rahman, Md. Siddiqur;Al-Amin, M.;Akter, Salena
    • Journal of Forest and Environmental Science
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    • v.28 no.1
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    • pp.12-18
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    • 2012
  • Like any other natural resources, forest flora may experience the extreme threat of elevated temperature and saline water submergence at different stages of their lives i.e. from germination to maturity due to climate change effects. The overall aim of the study was to measure the effect of higher temperatures along with saline water irrigation on survival and initial growth during seedling stage of Artocarpus chapalasha. The experiment was conducted in temperature- humidity-photoperiod regulated plant growth chamber during stipulated period to measure the growth performance of randomly selected seedlings. Within three different elevated temperatures viz. $30^{\circ}C$, $32^{\circ}C$ and $34^{\circ}C$, the seedlings were given three different saline conditions such as 0.5 g/L, 1.5 g/L and 2.5 g/L NaCl concentrations. Results found from the experiment was that, seedlings of Artocarpus chaplasha reared at different temperatures and saline water treatments showed stunted growth than reared at existing outdoor temperature ($26.31^{\circ}C$) irrigated with regular fresh water. Seedling growth at three different parameters such as height, collar diameter and number of leaves showed that with increasing temperature individuals respond negatively to increasing saline condition. The seedling's growth occurred at every day in height, collar diameter and leaf. However, growth rate reduced later during the observation. The combined effect of high salinity and higher elevated temperature results in seedling mortality. Therefore, Artocarpus chaplasha may not thrive at higher temperature and salinity intrusion at its early growing period in plantation and natural forest areas.

Estimation of Carbon Storage Using Mean Biomass Density in Korean Forests

  • Li, Xiaodong;Yi, Myong-Jong;Jeong, Mi-Jeong;Son, Yo-Whan;Jin, Guangze;Han, Sang-Sub
    • Journal of Korean Society of Forest Science
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    • v.99 no.5
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    • pp.673-681
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    • 2010
  • This study examined the biomass data estimated from different allometric models and calculated the mean aboveground biomass, mean belowground biomass and root/shoot ratio values according to the forest types and age classes. These mean values and the forest inventories in 2009 were used to estimate the aboveground and total biomass carbon storage in different forest types (coniferous, deciduous and mixed forests). The aboveground and total biomass carbon storage for all forest types in Korea were 350.201 Tg C and 436.724 Tg C. Over the past 36 years, plantations by reforestation programs have accounted for more than 70% of the observed carbon storage. The carbon storage in Korean forest biomass was 436.724 Tg C, of which 175.154 Tg C for coniferous forests, 126.772 Tg C for deciduous forests and 134.518 Tg C for mixed forests, comprising approximately 1/20 of the total carbon storage of the East Asian countries. The total carbon storage for the whole forest sector in Korea was 1213.122 Tg C, of which 436.724 Tg C is stored in forest biomass if using the ratio of carbon storage in different pools examined from the United States. Such large carbon storage in Korean forests is due mainly to active plantations growth and management practices.

Livestock Production under Coconut Plantations in Sri Lanka: 1. Social, Cultural and Economic Aspects of Buffalo Production

  • Jayatileka, T.N.;Weerakkody, P.R.;Ibrahim, M.N.M.
    • Asian-Australasian Journal of Animal Sciences
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    • v.11 no.5
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    • pp.586-596
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    • 1998
  • The relevance and importance of buffalo production under coconut plantations in the North Westen Province of Sri Lanka was studied in three districts (Bingiriya, Pannala, Kuliyapitiya). The objective of the study was to collect baseline information on socioeconomic and cultural aspects of buffalo production, with a view to promote and disseminate new technologies. The survey technique used consisted of a formal survey using a structured questionnaire (71 households) and rapid appraisal (55 households). The results indicate the existence of a wide stratification of dariy farmers which ranged from skilled dairy operators with high levels of production and management of efficiency to marginal subsistence farmers with low levels of productivity. The most frequent family size of households ranged from 4-5 members (58%), and the average family size was 4.7. The actual average land ownership accounts to 2.4 ha of upland and 0.5 ha of lowland, but when their accessibility to common property resources are taken into account, the land availability was assessed at 13 ha and 0.7 ha of upland and lowland, respectively. The highest average monthly income (Rs. 13,590) was received by farmers with off-farm employment (primary) who are also engaged in livestock production (secondary), and livestock contributed 43% of the total income. Livestock farmers who practised integrated crop farming as a secondary source of income received a monthly income of Rs. 10,843, and those involved in crop production as the primary source received the lowest average income (Rs. 7,295). The survey revealed a high investment cost on concentrate feeds (47%) for milk production. However some farmers obtained higher milk yields (11 litres/cow/day) at lower ration costs, and this could be attributed to the entrepreneurship skills and management efficiency. The study area had a well developed market infrastructure for fresh milk, principally due to the existence of the Nestle's company and the Coconut Triangle Milk Union. On an average the producer collected Rs. 10 per litre of milk marketed.

A Comparison of Lyophilized Amniotic Membrane with Cryopreserved Amniotic Membrane for the Reconstruction of Rabbit Corneal Epithelium

  • Ahn Jae-Il;Jang In-Keun;Lee Doo-Hoon;Seo Young-Kwon;Yoon Hee-Hoon;Shin Youn-Ho;Kim Jae-Chan;Song Kye-Yong;Lee Hee-Gu;Yang Eun-Kyung;Kim Ki-Ho;Park Jung-Keung
    • Biotechnology and Bioprocess Engineering:BBE
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    • v.10 no.3
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    • pp.262-269
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    • 2005
  • Many researchers have employed cryopreserved amniotic membrane (CAM) in the treatment of a severely damaged cornea, using corneal epithelial cells cultured on an amniotic membrane (AM). In this study, two Teflon rings were made for culturing the cells on the LAM and CAM, and were then used to support the AM, which is referred to in this paper as an Ahn's AM supporter. The primary corneal epithelial cells were obtained from the limbus, using an ex-plantation method. The corneal epithelium could be reconstructed by culturing the third­passage corneal epithelial cells on the AM. A lyophilized amniotic membrane (LAM) has a higher rate of graft take, a longer shelf life, is easier to store, and safer, due to gamma irradiation, than a (AM. The corneal epithelium reconstructed on the LAM and (AM, supported by the two­Teflon rings, was similar to normal corneal epithelium. However, the advantages of the LAM over that of the (AM make the former more useful. The reconstruction model of the corneal epithelium, using AM, is considered as a good in vitro model for transplantation of cornel epithelium into patients with a severely damaged cornea.

Derivation of Basal Area Projection Function for Forest Plantation Using Medium (3-5years) Measurement Cycles (중간(中間) 측정(測定) 주기(週期) (3-5년)를 이용(利用)한 인공림(人工林)의 흉고단면적(胸高斷面績) 추정(推定) 함수(函數)의 유도(誘導))

  • Lee, Sang-Hyun
    • Journal of Korean Society of Forest Science
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    • v.89 no.4
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    • pp.463-469
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    • 2000
  • Douglas-fir (Pseudotsuga menziesd Mirb. Franco) is highly regarded as a commercial timber species throughout the world in part due to its fast growth relative to many other species. In this study, basal area per hectare equation for Douglas-fir plantations in Southland of New Zealand has been developed based on medium measurement cycles of permanent sample plots data set. The function was developed using the algebraic difference equation method, and various sigmoid-shaped projection equations were used. Parameter estimation was obtained by non-linear routine of the SAS. As a result, of the functions tested a variant of the Schumacher polymorphic function including site index and thinning term as predictor variables showed the higher precision of the fitting. The results indicate that site index is positively correlated with basal area growth. And the thinning term was found to be useful to increase precision of the model.

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A Study on the Seeding Mixture Improvements for the Restoration and Revegetation of the Slopes by the Thin-Layer-Soil-Media Hydroseeding Revegetation Measures (생육보조재 취부 공법에 의한 비탈면 녹화 식생배합의 적정성에 관한 연구)

  • Kim, Jung-Hoon;Heo, Young-Jin;Kim, Nam-Choon;Cheong, Yong-Moon
    • Journal of the Korean Society of Environmental Restoration Technology
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    • v.8 no.2
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    • pp.90-97
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    • 2005
  • This study aimed to address problems and suggest solutions in applying seed mixture design criterior of slope revegetation works according to the "Slope revegetation design and guidelines(proposed)" proposed by the Ministry of Construction and Transportation. To do this, a proper thickness of attaching soil media was identified in April experiment where the thickness and slopes varied. The results were as follows. In the test, the coverage rate of plot where exotic grass was not sowed increased with time and was 79.3% after three months of seeding, which indicated less risk of soil erosion. When applying the provisional standards of the plant mix proposed by the Ministry of Construction and Transportation, tree seeds and native plants were found ill in the early stage in all test lands due to exotic grass. This was because exotic grass which grew well in the early stage, could grow densely, so it might hamper the growth of other plants. When slope revegetation were planted and goals were set for herb, shrub and tree dominant mixture types, it was required to shift focus toward nursing up native plants first rather than early plantation of exotic grass.