• Journal of Ginseng Research
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• 제14권2호
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• pp.221-227
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• 1990

The aqueous extract of fresh ginseng (Panax ginseng C.A. Meyer) contains a macromolecular fraction that showed mitogenic and co-mitogenic activities in human peripheral blood lymphocytes. Purification of the crude extract by size (ultrafiltration, Sephadex G-200) and charge (DEAE-cellulose, DEAE-Sepharose) yielded a semi.purified fraction (DS-3). This fraction contains at least three subgroups of anionic macromolecules with apparent molecular weight greater than 600 kilodaltons. It is a glycoprotein with a large amount of glucuronic acid. It acts as a mitogen in both T and B cells of human peripheral blood lymphocytes. It could also potentiate the mitogenic action of Concanavalin A in lymphocyte T cells. Such potentiation is not due to increased binding of Concanavalin A to the cell surface. Its mitogenic and co-mitogenic effects do depend on the presence of extracellular Ca2+.

• 한국임상수의학회지
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• 제16권2호
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• pp.417-421
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• 1999

To establish the electroacupuncture anesthesia for experimental animal, 5 adult rabbits (Newzealand-white species) and 6 rats (Spraque-dawley) were examined. The acupoints used for electroacupuncture anesthesia were Tian-ping and Bai-hui. After perpendicular insertion of needle to the acupoints, positive electrode was connected at Tian-ping and negative electrode was connected at Bai-hui using veterinary electroacupuncture anesthesia apparatus, respectively. Electric conditions were 2~3 V and 30 Hz in rabbits, and 1.5~2 V and 30 Hz in rats, respectively. To examine the effect of electroacupuncture anesthesia, laparotomy (2 heads), castration (2 heads) and ovariohysterectomy (1 head) were applied in rabbits, and laparotomy (5 heads) and castration (1 head) were peformed in rats, respectively. The induction time of electroacupuncture anesthesia was very rapid and approximately 1 minute, and pain of body surface including the extremities was not detected in rabbits and rats. As for the reactions with electroacupuncture anesthesia, consciousness was vivid, blepharoreaction was not observed and the tail was up at early stage but was down afterwards in rabbits. The same findings except cotinuous lifting of the tail were observed in rats. The pain was not observed during incision and suture, bleeding was comparatively small volume and the class of anesthesia effect was excellent.

• Asian Pacific Journal of Cancer Prevention
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• 제16권2호
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• pp.591-594
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• 2015

Background: Aberrations in gene methylation patterns play important roles in gliomagenesis. However, whether the ALDH1A3 promoter methylation is related to prognoses of primary glioblastomas (GBMs) in Western China remains unclear. Materials and Methods: Methylation levels of ALDH1A3 CpG island in 36 GBMs were identified by pyrophosphate sequencing, while ALDH1A3 expression was assessed with matched paraffin section immunohistochemistry. Survival curves were analysed by Kaplan-Meier. Results: The hypermethylation status of ALDH1A3 promoter predicted a better prognosis accompanied with low expression of ALDH1A3 protein. Conclusions: Our results indicate ALDH1A3 promoter methylation correlates with prognosis in primary GBMs.

• 한국군사과학기술학회지
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• 제13권2호
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• pp.196-203
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• 2010

The bistatic sonar operations using a spatially-separated source and receiver are classified into cooperative and non-cooperative operations. In the cooperative operation, an active signal of a friendly ship is used and the source information is known previously. In the non-cooperative operation, an active signal of the enemy is used and it is difficult to find out the source information. The source information consists of the range, speed, course and frequency of the source. It gives advantage to operating bistatic sonar. This paper suggests a method of estimating the source information with geographic information in the sea and the single-ping of the enemy. The source range is given using one geographic point. And the source speed, course and the frequency of the enemy's source signal are given using two geographic points. Finally, the validity of the scheme is confirmed through a simulation study.

• 한국정보디스플레이학회:학술대회논문집
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• 한국정보디스플레이학회 2005년도 International Meeting on Information Displayvol.II
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• pp.1534-1535
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• 2005

Highly luminescent efficiency phosphors have been successfully produced by surface modification and microwave irradiation treatment. The SEM image and XRD analysis reveal that the surface morphology of the white-light phosphors can be notably modified by microwave irradiation and exhibit with better crystalline property. The VUV PL spectra show that the microwave irradiation treatment can effectively enhance the luminescent efficiency by a factor of 1.5 times for intensity compared to that without microwave treatment. A further improvement in all visible emission can be made by modifying surface composition through MgO coating on the phosphor powder. These results demonstrate that such a simple approach can provide for improving luminescent efficiency of phosphors for the optoelectronic devices.

• Asian Pacific Journal of Cancer Prevention
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• 제14권7호
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• pp.4267-4271
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• 2013

Background: As natural medicines in Asia, curcumin and triptolide extracted from different drug plants have proven to possess anticancer potential and widely used for anti-cancer research. The present study attempted to clarify that curcumin and triptolide synergistically suppress ovarian cancer cell growth in vitro. Methods: To test synergic effects, cell viability and apoptosis were analyzed after curcumin and triptolide combination treatment on ovarian cancer cell lines. Synergistic effects on apoptosis induction were determined by lactate dehydrogenase (LDH) leakage assay, intracellular reactive oxygen species (ROS) assay, mitochondrial membrane potential (MMP) loss assay and flow cytometry analysis. Critical regulators of cell proliferation and apoptosis related were analyzed by qRT-PCR and Western blotting. Results: We showed that the combination of curcumin and triptolide could synergistically inhibit ovarian cancer cell growth, and induce apoptosis, which is accompanied by HSP27 and HSP70, indicating that HSP27 and HSP70 play the important role in the synergic effect. Conclusions: From the result present here, curcumin and triptolide combination with lower concentration have a synergistic anti-tumor effect on ovarian cancer and which will have a good potential in clinical applications.

• 대한전자공학회논문지TC
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• 제48권7호
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• pp.17-27
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• 2011

최근 들어 미래인터넷에 대한 관심과 연구가 활발히 진행 중에 있다. 국내에서도 미래인터넷 연구의 한 분야로서 이동성 및 무선 환경 위주의 네트워크 환경으로의 변화에 초점을 맞춘 미래인터넷 아키텍처로 MOFI 가 제안되었다. MOFI 는 Mobile Oriented Future Internet 의 약자로 name 기반의 통신을 제공하며 라우팅 scalability 가 보장되고 이동성이 제공되는 데이터 전달 구조이다. 본 논문에서는 MOFI 구조 연구의 일부분으로 HID 기반 통신을 지원하는 기본 MOFI 테스트베드를 구축하고, 기본적인 인터넷 서비스 (PING, WWW)의 실험을 통해 HID 기반의 통신 가능성을 검증하였다. 테스트베드를 구축함에 있어 VirtualBox 라는 가상 머신을 사용하였고, 또한 Click Modular Router를 사용하여 패킷 처리 및 HCP 헤더의 추가 및 변환을 구현하였다.

• Asian Pacific Journal of Cancer Prevention
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• 제13권5호
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• pp.1949-1952
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• 2012

Objective: The aim of this meta-analysis is to evaluate associations between LTA-252 A>G and breast cancer (BC). Methods: Electronic searches of several databases were conducted for all online publications. A total of 7 studies involving 4,625 BC patients and 4,373 controls were identified. Results: This meta-analysis showed no significant association between the LTA-252 A>G polymorphism and BC in overall or Caucasian populations. However, a positive association was found limited to Asian populations. Conclusion: Although there was no significant association found between the LTA-252 A>G polymorphism and BC overall, a positive association was found in Asian populations.

• Asian Pacific Journal of Cancer Prevention
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• 제15권2호
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• pp.763-767
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• 2014

Aim: To study the contribution of genetic variation in RAD51 to risk of esophageal squamous cell carcinoma (ESCC). Methods: Three single nucleotide polymorphisms (SNPs) in RAD51 (rs1801320, rs4144242 and rs4417527) were genotyped in 316 ESCC patients and 316 healthy controls in Anyang area of China using PCR-RFLP (polymerase chain reaction-restriction fragment length polymorphism). Demographic variables between cases and controls were statistically compared by T test and Chi-square test. Hardy-Weinberg equilibrium was evaluated by the Chi-square test. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated to measure any association with ESCC. Haplotype frequencies were estimated by Phase 2.1. Result: The genotype frequencies of rs1801320, rs4144242 and rs4417527 in patients with ESCC demonstrated no significant differences from those in control group (P>0.05). When the haplotypes of these three SNPs were constructed and their relationships with ESCC risk investigated, however, CGG was observed to increase the risk (P=0.020, OR=2.289). Conclusions: There was no association between the three SNPs of RAD51 and ESCC susceptibility in our Chinese population. However, the CGG haplotype might be a risk factor.

• ETRI Journal
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• 제37권6호
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• pp.1065-1076
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• 2015

Network densification is regarded as the dominant driver for wireless evolution into the era of 5G. However, in this context, interference-limited dense small cell deployments are facing technical challenges in mobility management. The recently announced results from an LTE field test conducted in a dense urban area show a handover failure (HOF) rate of over 21%. A major cause of HOFs is the transmission failure of handover command (HO CMD) messages. In this paper, we propose two enhancements to HO performance in LTE networks - radio link failure-proactive HO, which helps with the reliable transmission of HO CMD messages while the user equipment is under a poor radio link condition, and Early Handover Preparation with Ping-Pong Avoidance (EHOPPPA) HO, which assures reliable transmission of HO CMD under a good radio link condition. We analyze the HO performance of EHOPPPA HO theoretically, and perform simulations to compare the performance of the proposed schemes with that of standard LTE HO. We show that they can decrease the HOF rate to nearly zero through an analysis, and based on the simulation results, by over 70%, without increasing the ping-pong probability.