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http://dx.doi.org/10.7314/APJCP.2012.13.5.1949

The Lymphotoxin-α 252 A>G Polymorphism and Breast Cancer: A Meta-analysis  

Zhou, Ping (Department of General Surgery, the Third Affiliated Hospital to Nantong University)
Huang, Wei (Department of Intensive Care Unit, the Third Affiliated Hospital to Nantong University)
Chu, Xing (Department of Intensive Care Unit, the Third Affiliated Hospital to Nantong University)
Du, Liang-Feng (Department of Intensive Care Unit, the Third Affiliated Hospital to Nantong University)
Li, Jian-Ping (Department of General Surgery, the Third Affiliated Hospital to Nantong University)
Zhang, Chun (Department of General Surgery, the Third Affiliated Hospital to Nantong University)
Publication Information
Asian Pacific Journal of Cancer Prevention / v.13, no.5, 2012 , pp. 1949-1952 More about this Journal
Abstract
Objective: The aim of this meta-analysis is to evaluate associations between LTA-252 A>G and breast cancer (BC). Methods: Electronic searches of several databases were conducted for all online publications. A total of 7 studies involving 4,625 BC patients and 4,373 controls were identified. Results: This meta-analysis showed no significant association between the LTA-252 A>G polymorphism and BC in overall or Caucasian populations. However, a positive association was found limited to Asian populations. Conclusion: Although there was no significant association found between the LTA-252 A>G polymorphism and BC overall, a positive association was found in Asian populations.
Keywords
Meta-analysis; polymorphism; LTA; breast cancer;
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