Asian Pacific Journal of Cancer Prevention

Asian Pacific Journal of Cancer Prevention (아시아태평양암예방학회)
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Equivocal Association of RAD51 Polymorphisms with Risk of Esophageal Squamous Cell Carcinoma in a Chinese Population

  • Zhang, Shu-Xiang (Nursing Department, Shandong Provincial Qianfoshan Hospital) ;
  • Yang, Shan (Department of Ultrasound, Shandong Provincial Qianfoshan Hospital) ;
  • Xu, Chang-Qing (Department of Gastroenterology, Shandong Provincial Qianfoshan Hospital) ;
  • Hou, Rui-Ping (Department of Gastroenterology, Shandong Provincial Qianfoshan Hospital) ;
  • Zhang, Chuan-Zhen (Department of Gastroenterology, Shandong Provincial Qianfoshan Hospital) ;
  • Xu, Cui-Ping (Department of Human Resources, Shandong Provincial Qianfoshan Hospital)
  • Published : 2014.01.30
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Abstract

Aim: To study the contribution of genetic variation in RAD51 to risk of esophageal squamous cell carcinoma (ESCC). Methods: Three single nucleotide polymorphisms (SNPs) in RAD51 (rs1801320, rs4144242 and rs4417527) were genotyped in 316 ESCC patients and 316 healthy controls in Anyang area of China using PCR-RFLP (polymerase chain reaction-restriction fragment length polymorphism). Demographic variables between cases and controls were statistically compared by T test and Chi-square test. Hardy-Weinberg equilibrium was evaluated by the Chi-square test. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated to measure any association with ESCC. Haplotype frequencies were estimated by Phase 2.1. Result: The genotype frequencies of rs1801320, rs4144242 and rs4417527 in patients with ESCC demonstrated no significant differences from those in control group (P>0.05). When the haplotypes of these three SNPs were constructed and their relationships with ESCC risk investigated, however, CGG was observed to increase the risk (P=0.020, OR=2.289). Conclusions: There was no association between the three SNPs of RAD51 and ESCC susceptibility in our Chinese population. However, the CGG haplotype might be a risk factor.

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