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DIAGNOSTIC EFFICACY OF MENTAL NERVE SEP(SOMATOSENSORY EVOKED POTENTIALS) FOR THE INJURED INFERIOR ALVEOLAR NERVE (하치조신경 손상시 턱끝신경 체성감각유발전위검사의 진단적 유용성에 관한 연구)

  • Jeong, Hyeon-Ju;Kim, Myung-Rae
    • Journal of the Korean Association of Oral and Maxillofacial Surgeons
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    • v.27 no.3
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    • pp.250-257
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    • 2001
  • Sensory dysfunction following the injury of the inferior alveolar nerve requires objective examination to get a reproducible data and to provide necessary treatment. This study was designed to evaluate if the SEP(somatosensory evoked potentials) of the mental nerve can be used as an objective method for the diagnosis of nerve injury and sensory disturbances. The subjects were nineteen patients ($37.4{\pm}11.3$ years old) who had been suffered from sensory disturbance of the unilateral lower lip and mental region for over 6 months after the inferior alveolar nerve injuries confirmed by the microsurgical explorations. The clinical neurosensory tests as SLTD(static light touch discrimination), MDD(moving direction discrimination), 2PD(two point discrimination), PPN(pin prick nociception) and accompanied pain were preceded to electro-physiologic examinations as SEP. The score of sensory dysfunction (sum score of all sensory tests) ranged from 0 to 8 were compared to the latency differences of the mental nerve SEPs. The correlation between clinical sensory scores and SEPs were tested by Spearman nonparametric rank correlation analysis, the differences in SEP latency by Kruskal-Wallis test and the latency differences according to PPN and accompanied pain by Mann-Whitney U test. This study resulted that the difference of the latencies between normal side and affected side was $2.22{\pm}2.46$ msec and correlated significantly with the neurosensory dysfunction scores (p=0.0001). Conclusively, the somatosensory evoked potentials of the mental nerve can be a useful diagnostic method to evaluate the inferior alveolar nerve injuries and the change of sensory dysfunction to be reproduced as an objective assessment.

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Development of a new brown button mushroom cultivar 'Hogam' (갈색 양송이 신품종 '호감' 육성)

  • Oh, Youn-Lee;Jang, Kab-Yeul;Kong, Won-Sik;Shin, Pyung-Gyun;Kim, Eun-Seon;Oh, Min ji;Choi, In-Geol
    • Journal of Mushroom
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    • v.13 no.3
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    • pp.237-242
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    • 2015
  • A new brown button mushroom cultivar, 'Hogam', C34 line, was made by crossing homokaryons, ASI1164-37 and ASI1175-66, selected by RAPD analysis and by cultivating three times. Mycelium of 'Hogam' on CDA (compost dextrose agar) media grew well at $25^{\circ}C$. The optimum pin-heading temperature of new variety and optimum growing temperature was $14-18^{\circ}C$. The thickness of the mature cap and stipe were thicker than a control, 'Dahyang' that developed in 2010. The color of pileus was light brown and lighter than 'Dahyang'. Days required from casing to first harvesting were three days longer than control strain, but the weight of harvested fruiting body increased by 1.35 times. 'Hogam' cultivar are expected to contribute to the diversification of domestic mushroom cultivars.

Effects of Alloying Elements on the High Pressure Wear Characteristics of Ductile Cast Iron I-Cu, Mn (구상흑연주철의 고압하 마멸특성에 미치는 합금원소의 영향 I-Cu, Mn)

  • Bang, Woong-Ho;Kang, Choon-Sik;Park, Jae-Hyun;Kweon, Young-Gak
    • Journal of Korea Foundry Society
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    • v.20 no.4
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    • pp.230-239
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    • 2000
  • High pressure wear characteristics of DCI(Ductile Cast Iron) were investigated through unlubricated pin-on-disc wear test. Wear test were carried out at speed of 23m/min, under pressure of 3MPa and 3.3 MPa. Cu and/or Mn were added to examine the effect of alloying elements on the high pressure wear characteristics of DCI. To investigate the relationship between wear characteristics and mechanical properties of DCI, Brinell hardness and V-notched Charpy impact energy were tested. Wear surface of each specimen was observed by SEM to determine the wear mechanism of DCI under high pressure wear condition. In the mild wear region, wear characteristics of alloyed DCI specimens were very similar to that of unalloyed DCI. But mild-severe wear transition was occurred at different wear distance and wear rate of DCI specimens were changed by alloying elements. In severe wear condition, wear rate of DCI was dramatically increased by the addition of Mn. Although the addition of Cu 0.46wt% did not decrease the wear rate of DCI in the severe wear region, but it delayed the mild-severe wear transition. Under high pressure wear condition, wear rate and mild-severe wear transition were not concerned with hardness of DCI specimens, but they were deeply associated with impact energy changed by alloying elements.

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Deficiency or activation of peroxisome proliferator-activated receptor α reduces the tissue concentrations of endogenously synthesized docosahexaenoic acid in C57BL/6J mice

  • Hsiao, Wen-Ting;Su, Hui-Min;Su, Kuan-Pin;Chen, Szu-Han;Wu, Hai-Ping;You, Yi-Ling;Fu, Ru-Huei;Chao, Pei-Min
    • Nutrition Research and Practice
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    • v.13 no.4
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    • pp.286-294
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    • 2019
  • BACKGROUND/OBJECTIVES: Docosahexaenoic acid (DHA), an n-3 long chain polyunsaturated fatty acid (LCPUFA), is acquired by dietary intake or the in vivo conversion of ${\alpha}$-linolenic acid. Many enzymes participating in LCPUFA synthesis are regulated by peroxisome proliferator-activated receptor alpha ($PPAR{\alpha}$). Therefore, it was hypothesized that the tissue accretion of endogenously synthesized DHA could be modified by $PPAR{\alpha}$. MATERIALS/METHODS: The tissue DHA concentrations and mRNA levels of genes participating in DHA biosynthesis were compared among $PPAR{\alpha}$ homozygous (KO), heterozygous (HZ), and wild type (WT) mice (Exp I), and between WT mice treated with clofibrate ($PPAR{\alpha}$ agonist) or those not treated (Exp II). In ExpII, the expression levels of the proteins associated with DHA function in the brain cortex and retina were also measured. An n3-PUFA depleted/replenished regimen was applied to mitigate the confounding effects of maternal DHA. RESULTS: $PPAR{\alpha}$ ablation reduced the hepatic Acox, Fads1, and Fads2 mRNA levels, as well as the DHA concentration in the liver, but not in the brain cortex. In contrast, $PPAR{\alpha}$ activation increased hepatic Acox, Fads1, Fads2, and Elovl5 mRNA levels, but reduced the DHA concentrations in the liver, retina, and phospholipid of brain cortex, and decreased mRNA and protein levels of the brain-derived neurotrophic factor in brain cortex. CONCLUSIONS: LCPUFA enzyme expression was altered by $PPAR{\alpha}$. Either $PPAR{\alpha}$ deficiency or activation-decreased tissue DHA concentration is a stimulus for further studies to determine the functional significance.

Bending characteristics of Prestressed High Strength Concrete (PHC) spun pile measured using distributed optical fibre strain sensor

  • Mohamad, Hisham;Tee, Bun Pin;Chong, Mun Fai;Lee, Siew Cheng;Chaiyasarn, Krisada
    • Smart Structures and Systems
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    • v.29 no.2
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    • pp.267-278
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    • 2022
  • Pre-stressed concrete circular spun piles are widely used in various infrastructure projects around the world and offer an economical deep foundation system with consistent and superior quality compared to cast in-situ and other concrete piles. Conventional methods for measuring the lateral response of piles have been limited to conventional instrumentation, such as electrical based gauges and pressure transducers. The problem with existing technology is that the sensors are not able to assist in recording the lateral stiffness changes of the pile which varies along the length depending on the distribution of the flexural moments and appearance of tensile cracks. This paper describes a full-scale bending test of a 1-m diameter spun pile of 30 m long and instrumented using advanced fibre optic distributed sensor, known as Brillouin Optical Time Domain Analysis (BOTDA). Optical fibre sensors were embedded inside the concrete during the manufacturing stage and attached on the concrete surface in order to measure the pile's full-length flexural behaviour under the prescribed serviceability and ultimate limit state. The relationship between moments-deflections and bending moments-curvatures are examined with respect to the lateral forces. Tensile cracks were measured and compared with the peak strains observed from BOTDA data which corroborated very well. By analysing the moment-curvature response of the pile, the structure can be represented by two bending stiffness parameters, namely the pre-yield (EI) and post-yield (EIcr), where the cracks reduce the stiffness property by 89%. The pile deflection profile can be attained from optical fibre data through closed-form solutions, which generally matched with the displacements recorded by Linear Voltage Displacement Transducers (LVDTs).

Standardization of machining process for progressive press die (순차이송형 프레스 금형의 가공표준화)

  • Lee, S.M.;Lee, S.J.
    • Journal of the Korean Society for Precision Engineering
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    • v.10 no.2
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    • pp.114-125
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    • 1993
  • In the present study the newly developed CAD/CAM system is applied to the process of the molding design, machining for mini-sized and precise processive die, and the production of press-stamped parts. When the design of a die was completed by means of CAD, wire cut NC data were generated with the aid of a design drawing in the CAD system and then inputed into the wire cut machine, and with the aid of a hole chart which had been made for this purpose, all the data were classified into the categories of CNC milling, jig boring, jig grinding, and machine center, and then developing a program of generating NC data, errors in process were reduced and programming time was shortened. The program was developed by using Autolisp language which was built-in the CAD, and realizing the intergation of designing a die, generating and processing NC data directly by a designer, designing time and machinery processing time were shorted. And the traditionally required working time for design. NC program required 6 days of work becomes 4 days of work by using the developed CAD/CAM system so that the efficiency shows 150% of the reduction working time. The prpgram of the design of the automation a progressive die mold was developed in the PC-Class Autocad system, therefore development expense could be reduced, and the integration of the CAD/CAM of the progressive die mold with the standard DB being built could be realized.

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Cloning of OLR1 Gene in Pig Adipose Tissue and Preliminary Study on Its Lipid-accumulating Effect

  • Sun, Chao;Liu, Chun-wei;Zhang, Zhong-pin
    • Asian-Australasian Journal of Animal Sciences
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    • v.22 no.10
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    • pp.1420-1428
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    • 2009
  • In this study we cloned and characterized a novel lipid-accumulating gene, the oxidized low-density lipoprotein receptor 1 (OLR1), which is associated with lipogenesis. We analyzed the gene structure and detected the mRNA transcriptional expression levels in pig adipose tissues at different months of age (MA) and in different economic types (lean type and obese type) using real-time fluorescence quantitative PCR. OLR1 expression profile in different tissues of pig was analyzed. Finally, we studied the correlation between OLR1 and lipid metabolism related genes including peroxisome proliferator-activated $receptor{\gamma}2$ ($PPAR{\gamma}2$), fatty acid synthetase (FAS), triacylglycerol hydrolase (TGH), CAAT/enhancer binding protein $\alpha$ ($C/EBP{\alpha}$) and sterol regulatory element binding protein-1c (SREBP-1c). Results indicated that the OLR1 gene of the pig exhibited the highest homology with the cattle (84%), and the lowest with the mouse (27%). The signal peptide located from amino acid 38 to 60 and the domain from amino acid 144 to 256 were shared by the C-type lectin family. The expression level of OLR1 in pig lung was exceedingly higher than other tested tissues (p<0.01). In pig adipose tissue, the expression level of OLR1 mRNA increased significantly with growth (p<0.01). The expression level of OLR1 mRNA in obese-type pigs was significantly higher than that of lean-type pigs of the same monthly age (p<0.05). In adipose tissue, the expression of OLR1 correlated with $PPAR{\gamma}2$, FAS and SREBP-1c, but not TGH or C/EBP${\alpha}$. In conclusion, OLR1 was highly associated with fat deposition and its transcription, as suggested by high correlations, was possibly regulated by $PPAR{\gamma}2$ and SREBP-1c.

Development of the Practical Garment Apparatus to Measure Vital Sign of ECG for U-Health Care (ECG 생체신호 측정을 위한 실용적 U-헬스케어 의복개발)

  • Park, Hye-Jun;Hong, Kyung-Hi;Kim, Seung-Hwan;Shin, Seung-Shul
    • Journal of the Korean Society of Clothing and Textiles
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    • v.31 no.2 s.161
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    • pp.292-299
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    • 2007
  • Development of portable device measuring the vital sign continuously with no limit of time and space is absolutely prerequisite for the U-health care that grafts the ubiquitous concept into medical system. Accordingly, it requires to develop a garment style apparatus for measuring vital-sign that is easy to wear on for a long time period. This study suggests a method to improve the insulation of electric cable and the skin adhesion of electrode by integrating the electric conductive material to garment, in order to develop a garment apparatus for measuring ECG for U-health care. Results of the research are as follows; In order to provide the adjacent conductive yarns with insulation, braid with narrow woven end was interlaced using polyester yarn. As a result, the direct contact between electric conductive yarns was restrained, which would be interposed into pin-tuck structured cable. Washable silicone gel applied around the electrode made of electric conductive fabric improved the adhesion, which prevents electrodes from dropping off from the skin surface during body movement. ECG signals on the human subject were tested using the garment apparatus developed by the above method. And the result was that the clear QRS wave formation in the typical form of ECG could be measured in both conditions of still and moving state as well. The result of this study is expected to contribute for the production of U-health care related medical apparatus by accelerating the practical uses of the garment measuring vital sign at a reasonable price.

Investigation of Structural and Optical Properties of III-Nitride LED grown on Patterned Substrate by MOCVD (Patterned substrate을 이용하여 MOCVD법으로 성장된 고효율 질화물 반도체의 광특성 및 구조 분석)

  • Kim, Sun-Woon;Kim, Je-Won
    • Korean Journal of Materials Research
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    • v.15 no.10
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    • pp.626-631
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    • 2005
  • GaN-related compound semiconductors were grown on the corrugated interface substrate using a metalorganic chemical vapor deposition system to increase the optical power of white LEDs. The patterning of substrate for enhancing the extraction efficiency was processed using an inductively coupled plasma reactive ion etching system and the surface morphology of the etched sapphire wafer and that of the non-etched surface were investigated using an atomic force microscope. The structural and optical properties of GaN grown on the corrugated interface substrate were characterized by a high-resolution x-ray diffraction, transmission electron microscopy, atomic force microscope and photoluminescence. The roughness of the etched sapphire wafer was higher than that of the non-etched one. The surface of III-nitride films grown on the hemispherically patterned wafer showed the nano-sized pin-holes that were not grown partially. In this case, the leakage current of the LED chip at the reverse bias was abruptly increased. The reason is that the hemispherically patterned region doesn't have (0001) plane that is favor for GaN growth. The lateral growth of the GaN layer grown on (0001) plane located in between the patterns was enhanced by raising the growth temperature ana lowering the reactor pressure resulting in the smooth surface over the patterned region. The crystal quality of GaN on the patterned substrate was also similar with that of GaN on the conventional substrate and no defect was detected in the interface. The optical power of the LED on the patterned substrate was $14\%$ higher than that on the conventional substrate due to the increased extraction efficiency.

Sliding Wear Properties of Carbon Fiber Reinforced $Si_3N_4$ Ceramics (탄소섬유강화 질화규소 세라믹스의 마찰마모 특성)

  • Park Yi-Hyun;Yoon Han-Ki;Kim Bu-Ahn;Park Won-Jo
    • Proceedings of the Korea Committee for Ocean Resources and Engineering Conference
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    • 2004.05a
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    • pp.347-351
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    • 2004
  • [ $Si_3N_4$ ] composites have been extensively studied for engineering ceramics, because it has excellent room and high temperature strength, wear resistance properties, good resistance to oxidation, and good thermal and chemical stability. In the present work, carbon short fiber reinforced $Si_3N_4$ ceramics were fabricated by hot press method in $N_2$ atmosphere at $1800^{\circ}C$ using $Al_2O_3\;and\;Y_2O_3$ as sintering additives. Content of carbon short fiber was $0\%,\;0.1\%\;and\;0.3\%$. The composites were evaluated in terms of density, flexural strength and elastic modulus through the 3-point bending test at room temperature. Also, The wear behavior was determined by the pin on disk wear tester using silicon nitride ball. Experimental density and flexural strength decreased with increasing content of carbon fiber. But specific modulus increased with increasing content of carbon fiber. In addition, friction coefficient and specific wear loss decreased with increasing content of carbon short fiber by reason of interfacial defects between matrix and fiber.

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