• Journal of Physiology & Pathology in Korean Medicine
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• v.30 no.5
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• pp.320-326
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• 2016

Tongue diagnosis is convenient and non-invasive method to examine the body's functional condition, and it has been frequently used in traditional Korean Medicine (KM). The aim of this study was to investigate the difference of the tongue color assessed by computerized tongue image analysis system (CTIS) between the common cold (CC) patients and healthy subjects. A total of 85 participants, including 45 CC patients without organic diseases and 40 healthy subjects, were asked to complete the CC symptom questionnaire. A tongue image was acquired by using CTIS. Color differences in Commission Internationale de l'Eclairage (CIE) L*, a* and b* between the CC patient group and the control group were analyzes by using paired t-test analysis. The variable CIE b* of the tongue body was significantly lower in CC than that in controls (P=0.019). The variable CIE L* of the tongue coating was significantly higher in CC than that in controls (P=0.032). In CC, the color of the tongue body seems to be changed to intense red color. The color of the tongue coating seems to be changed to thick fur. The present study demonstrated that the CTIS can be used as a diagnostic and monitoring tool for the objective and standardized evaluation of common cold in clinics.

• Journal of muscle and joint health
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• v.7 no.2
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• pp.227-240
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• 2000

The purpose of this article was to identify trend in Arthritis research and to provide ba an approach of Arthritis research. The results of analysis of 69 Arthritis articles public year of between 1970-1999 found that most articles(27.6%, n=19) were published since few(10.1%, n=7) were before 1994. Vast majority of articles(79.8%, n=55) were printed in The Journal of Rheumatology Health, and 79.8%(n=55) of those were quantitative research, 8.7%(n=6) were qualitative research, and 14%(n=1) was methodological research. 29.0%(n=20) of quantitative research were carried in experimental design and over half(50.8%, n=35) in nonexperimental design. Having concerned the types of treatment(or intervention) used in experimental study, the most common treatment was 'exercise' (45.0%, n=9), and other less common were 'self-help education(15.0%, n=3), home care(10.0%, n=2) supportive care(10.0%, n=2), flexibility exercise combined with local heat therapy(5.0%, n=1), relaxation training(5.0%, n=1). Of the types of exercise, aquatic exercise was 30.0%(n=6). The effect of exercise on outcome variable was found to be most strong among the other types of treatment. 18 articles of nonexperimental research were correlational research. From the analysis of correlational research, 29 concepts were identified, and the relationship between depression and other variable were strongly reported. In descriptive studies, most commonly physiological variables were examined in 5 articles(29.5%). Only one study(5.9%) explored patient's perception of the causal factors and those causality. In qualitative researches, two study were carried out by the means of grounded theory. Majority of those subjects were RA patients, and the largest number of sample were 23 and the smallest was 1 In two studies, patient's perceived causality of RA was identified as a research problems, and an experience of ADL, fatigue Phenomenon, an experience of having a total knee replacement with osteoarthritis were each found in one study. Methodological research was carried out to test validity and reliability of the RA Fatigue Scale.

• Journal of Veterinary Science
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• v.22 no.2
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• pp.24.1-24.16
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• 2021

Background: Bovine tuberculosis (TB) is caused by Mycobacterium bovis, a well-known cause of zoonotic tuberculosis in cattle and deer, and has been investigated in many physiological and molecular studies. However, detailed genome-level studies of M. bovis have not been performed in Korea. Objectives: To survey whole genome-wide single-nucleotide polymorphism (SNP) variants in Korean M. bovis field isolates and to define M. bovis groups in Korea by comparing SNP typing with spoligotyping and variable number tandem repeat typing. Methods: A total of 46 M. bovis field isolates, isolated from laryngopharyngeal lymph nodes and lungs of Korean cattle, wild boar, and Korean water deer, were used to identify SNPs by performing whole-genome sequencing. SNP sites were confirmed via polymerase chain reaction using 87 primer pairs. Results: We identified 34 SNP sites with different frequencies across M. bovis isolates, and performed SNP typing and epidemiological analysis, which divided the 46 field isolates into 16 subtypes. Conclusions: Through SNP analysis, detailed differences in samples with identical spoligotypes could be detected. SNP analysis is, therefore, a useful epidemiological tracing tool that could enable better management of bovine TB, thus preventing further outbreaks and reducing the impact of this disease.

• Physical Therapy Korea
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• v.7 no.2
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• pp.20-34
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• 2000

The purpose of this study was to establish modified physiological cost index (PCI) for predicting energy consumption by heart rate (HR) at isokinetic ergometer exercise testing. The subjects were twenty-eight healthy men in their twenties. All of them performed upper and lower extremity isokinetic ergometer exercise tests which had six loads (400, 500, 600, 700, 800, and 900 kg-m/min) and five loads (400, 500, 600, 700, and 800 kg-m/min) respectively. The exercise sessions were finished when HR was in plateau. HR and oxygen consumption were determined during the final minute. Resting heart rate and oxygen consumption were used for calculating heart rate, oxygen consumption changes and modified PCI. Regression analysis established the relationship between each variable to work load, HR and oxygen consumption. The results were as follows: 1) In the lower extremity ergometer exercise test, oxygen consumption increased continuously as work load increased, but in the upper extremity ergometer test, oxygen consumption only increased until work load was 700 kg-m/min. 2) HR increased as work load increased in both exercise tests, but in the upper extremity ergometer test, HR decreased from the 700 kg-m/min. 3) The modified PCI increased as work load mcreased until the 700 kg-m/min point in the lower extremity ergometer test and until the 500 kg-m/min point in the upper extremity ergometer test when it started to decrease in both tests. 4) In the lower extremity ergometer exercise test, regression analysis established the relation as $dVO_2$ = -.0215HR - .2141 where $dVO_2$ is given in l/min and HR in beat/min ($R^2$ = .2677, p = .000). ln the upper extremity ergometer exercise test. regression analysis established the relation as $dVO_2$ = -.0115HR + .2746 ($R^2$ = .1308, p = .000). The results of this study were similar to previous studies but were different under high work load conditions. So modified PCI should be used with only low intensity work load testing. Subjects for upper extremity ergometer exercise testing should complete a prescribed training course prior to testing, and only low intensity work load should be used for safety considerations.

• Journal of Korean Academy of Nursing
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• v.32 no.2
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• pp.265-276
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• 2002

This study was to identify the trends and contents of imagery interventions and to evaluate the effects of imagery interventions by using meta-analysis. Method: The materials used for this study were 15 imagery intervention studies carried out from Jan. 1995 to Dec. 2001. The studies were analyzed and evaluated in different categories: 1) types of dependent variables 2) types of imagery 3) interval of imagery 4) total duration of imagery 5) sample characteristics 6) intervention method. Result: 1) Behavioral imagery was more prevalent than dynamic imagery. There were wide variations in duration, and interval of interventions. Imagery intervention had moderate effects on psychological variables (state of anxiety, depression & and stress etc.) and had moderate to large effects on physiological variable(pulse rate, cortisol etc.). Behavioral imagery had larger effects than dynamic imagery. Imagery applied to the public had larger effect on decreasing the state of anxiety and stress than applied to the patients. But imagery applied to the patients had a larger effect on decreasing depression than applied to the public. The imagery intervention method by using the individual approach had greater effect than group approach method. Conclusion: These results of this study will be used to guide the development of imagery interventions to nursing practice. Also, various types of imagery interventions need to be developed based on the characteristics of nursing practice.

• Journal of Korean Biological Nursing Science
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• v.11 no.1
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• pp.68-76
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• 2009

Purpose: The purpose of this study was to evaluate the hemodynamic changes in degree and duration that occur during Valsalva maneuver (VM). Furthermore, we wanted to investigate the patterns and mechanisms of physiological hemodynamic control. Method: Thirty six healthy college students were recruited from Y university. Each participant was provided with written informed consent. Blood pressure (BP), heart rate (HR), cardiac output (CO) were continuously recorded using the Finometer. Result: During the phase I of VM, means of systolic and diastolic pressures were increased by 32.15% and 38.28%, respectively, compared with basal values. HR and CO were decreased by 9.91% and 13.01%, respectively. Immediately after the maneuver (phase III), systolic and diastolic pressures were decreased by 5.05% and 6.24%, respectively, compared with those obtained in the phase II. HR and CO were elevated by 13.33% and 11.93%, respectively, compared to the levels of earlier phases. BPs were represented with overshoot in the phase IV, and recovered by baseline values about 20 sec after VM. Conclusion: These results demonstrated that hemodynamic changes are variable in the event of VM even in healthy humans. It will be valuable to accumulate more quantitative hemodynamic information in special populations such as the elderly and the patients with cardiovascular problems.

• Progress in Medical Physics
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• v.5 no.2
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• pp.35-43
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• 1994

Electromagnetic wave may induce effect and damage on the bio-body, either by electric fields of magnetic fields. We measure electrophysiological changs in rabbit's brain exposed to 2.45GHz micro wave(power density 40mW/cm$^2$) which distance 30cm from the source. In order to process the bio-electrical signal (EEG), used pre-amplifier module with self-made and Digtal analyzer computer system. Spectal analysis of the EEG showed variable power in the frequency range(1～30Hz) through each exposure time(10min, 20min, 30min) before and after. In effectively measured by the bio-electrical signal processing and can found threshold of minmal permissible exposure and lethal exposure.

• Journal of Physiology & Pathology in Korean Medicine
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• v.18 no.6
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• pp.1938-1944
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• 2004

In this study, when we make a diagnosis of constitution using QSCC Ⅱ(Questionnaire of Sasang Constitution Classification). data mining techniques are applied to seek the classification function for improving the accuracy. Data used in the analysis are the questionnaires of 1051 patients who had been treated in Dong Eui Oriental Medical Hospital and Kyung Hee Oriental Medical Hospital. The criteria for data cleansing are the response pattern in the opposite questionnaires and the positive proportion of specific questionnaires in each constitution. And the criteria for variable selection are the test of homogeneity in frequency analysis and the coefficients in the linear discriminant function. Discriminant analysis model and decision tree model are applied to seek the classification function into Sasang constitution. The accuracy in learning sample is similar in two models, the higher accuracy in test sample is obtained in discriminant analysis model.

• Journal of Physiology & Pathology in Korean Medicine
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• v.27 no.3
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• pp.313-317
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• 2013

In order to standardize the pressure/depth against radial artery, the externally-applied-pressure measuring system was fabricated and evaluated. Based on the resistance-variable characteristic of the very thin($10{\mu}m$) film conductive tape along the pressure of a tip of a examiner's hand, this system was designed. The change of the pressure was processed through voltage regulator and Matlab S/W, then showed on computer monitor. The signal output through voltage regulator, and Matlab S/W was evaluated on various conditions. The evaluation was executed on these cases; an examiner slowly increases and decreases the pressure, rapidly increases and decreases the pressure, sequentially increases and decreases the pressure, sustains the pressure, micro-changes the pressure. As a pulse examiner varies the pressure on the radial artery of the examinee, the system's real-time output consistently varies according to the pressure. From the results, it is concluded that this system consistently shows the pressure of the tip of a examiner's hand in real time without interrupting the evaluation of the radial artery pulse. Therefore this system is expected to standardize the value of the pressure/depth externally applied by an examiner.

• Biomolecules & Therapeutics
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• v.25 no.5
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• pp.471-481
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• 2017

The canonical transient receptor potential channels (TRPCs) constitute a series of nonselective cation channels with variable degrees of $Ca^{2+}$ selectivity. TRPCs consist of seven mammalian members, TRPC1, TRPC2, TRPC3, TRPC4, TRPC5, TRPC6, and TRPC7, which are further divided into four subtypes, TRPC1, TRPC2, TRPC4/5, and TRPC3/6/7. These channels take charge of various essential cell functions such as contraction, relaxation, proliferation, and dysfunction. This review, organized into seven main sections, will provide an overview of current knowledge about the underlying pathogenesis of TRPCs in cardio/cerebro-vascular diseases, including hypertension, pulmonary arterial hypertension, cardiac hypertrophy, atherosclerosis, arrhythmia, and cerebrovascular ischemia reperfusion injury. Collectively, TRPCs could become a group of drug targets with important physiological functions for the therapy of human cardio/cerebro-vascular diseases.