• KSBB Journal
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• v.23 no.3
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• pp.239-244
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• 2008

For physiological function of aloe concentrate by ultrafiltration (UF) process, jack bean urease inhibitory activity and bentonite flocculating activity of UF aloe concentrate was investigated and compared with fresh aloe gel. Urease inhibitory activity of UF aloe concentrate ranged from 87 to 90% in 1 mL sample. Also, urease inhibitory activity of UF aloe concentrate increased about 10% by heat treatment showing the heat stability. From Lineweaver-Burk plot for UF aloe concentrate, urease inhibition pattern indicated general non-competitive inhibition. From flocculation test of UF aloe concentrate about 1% (w/v) bentonite suspension, maximum flocclulating activity of 97% was obtained at 0.5 mL addition of UF aloe concentrate/ 5 ml bentonite suspension. However, flocculating activity of 81% was obtained at 1 mL addition of UF aloe concentrate/ 5 mL bentonite suspension, which was typical flocculating behavior of polymers with re-dispersion at overdose area. FT-IR spectra of UF aloe concentrate showed the characteristic patterns of $\beta$-binding polysaccharide and less deacetylation indicating higher level of bioactive polysaccharide content.

• Journal of Physiology & Pathology in Korean Medicine
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• v.18 no.4
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• pp.1159-1162
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• 2004

We studied on the production of the ceramic by the mineral-Oriental medicine and the property of the clean active water depositting on the ceramic stone. The results are as follows: We properly mixed of maifanshi, mica, ochre, and added to a small amount cinnabar, and therefore formed the ceramic stone. By the plasticity process and the irradiating magnetic force recovered the disappeared a part of constitutent elements. The recovered effects were become higher the freshness, maintenance, deodoriztion, clean water. As well as having the ability on capture of the notoxious heavy metal on human. The ceramic powder were mixed proper dose maifanshi, mica. And the powder had ionization, absorption, adhesion by the plasticity process and magnetic force. The clean active water of depositting on the ceramic stone during 24hours were observed significant the content of micro element, dissolved oxygen, abstraction on Herbs.

• Journal of Physiology & Pathology in Korean Medicine
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• v.33 no.6
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• pp.334-340
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• 2019

In order to promote scientification of Korean medicine, two hypothetical scenarios were proposed methodologically. Firstly, the scientification of Korean medicine requires a comprehensive understanding of the process and reality, and new logical procedures and the methods of observation and experiment. Secondly, transformation to revised Korean medicine is to replace traditional Korean medicine with biochemistry-based Western medicine, that is a method of reconstructing the recognition foundation describing symptoms and diseases using anatomical platforms and analytical tools. But there are areas of human training and practice that are not subject to scientification, and there are incommensurable parts as for the methodology between western medicine too. And additionally arbitrary rejection by uniform science with a political reason was done. So these various backgrounds and factors should be considered for the scientification of Korean medicine. And before that, reflection and agreement on the understanding and attitude of the method of scientification within the Korean medical community is necessary.

• Korean Journal of Soil Science and Fertilizer
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• v.2 no.1
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• pp.45-48
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• 1969

In an effort to determine the effect of the physiological function of phosphorus in higher plants, soybean have been used as samples in an attempt to compare them with rice on which there have been a number of reports of research. The absorptive and metabolic process phosphorus in each separate manuring period has been studied. It has iefluenced enhancement of vitality in the plants whether manuring is conducted earlier or later. These phenomena have greatly concerned with the absorption and transference of phosphorus in the process of growth are done more slowly than those of nitrogen and phosphorus from stems and leaves to pods.

• Journal of Microbiology and Biotechnology
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• v.4 no.3
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• pp.215-221
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• 1994

Two strains of yeast (RA-74-2 and RA-912) showing superior fermenting ability at a high temperature were isolated from soils and wastewaters by an enrichment culture method. Based on the morphological and physiological charateristics, the two strains were identified as Saccharomyces cerevisiae and Kluyveromyces marxianus, respectively. RA-74-2 was able to grow upto $43^{\circ}C$ and sustain similar fermenting ability in the temperatures range from 30 to $40^{\circ}C$. In addition, the sugar- and ethanol-tolerance of RA-74-2 were 30% (w/v) glucose and 10% (v/v) ethanol, which appeared to be higher than those of nine other industrial yeast strains currently being used in the alcohol factories. The thermotolerant ethanol fermenting yeast RA-912 showed identical growth in the temperatures range from 35 to $45^{\circ}C$ and was resistant to various heavy metals. The quality and quantity of byproducts of the isolated yeast strains in fermentation broth after fermentation at $40^{\circ}C$ and $45^{\circ}C$ were similiar with those obtained at $30^{\circ}C$. These results show that RA-74-2 can be adopted for the ethanol fermentation process where the expenses for cooling system is significant, and suggest that RA-912 may be applied in either SSF(simultaneous saccharification and fermentation) or Flash-fermentation process and RA-912 may be used as a gene donor for the development of thermotolerant ethanol-fermenting yeasts.

• Journal of Microbiology and Biotechnology
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• v.8 no.1
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• pp.81-88
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• 1998

The determination of appropriate parameters and parameter conditions is very important for the optimization of production of target materials. Taguchi's method has been used widely as the basis for development trials and optimization during industrial process design. Reaction variables which influence product yield are easily determined and their effects are revealed by just a few reactions, negating the need for extensive experimental investigation. There are usually some factors that are responsible for variations in process characteristics, so called noise factors. Controlling noise factors is very costly and difficult or impossible. Taguchi's experimental design method was examined to determine the control factor's level that is less sensitive to the changes in environmental conditions and other noise factors without control of noise factors. In this study, optimization of lipase-catalyzed production of lysophosphatidic acid (LPA) which has various physiological functions was performed by Taguchi's method. We obtained LPA yields ($66.5\%$) with low variance (5.32) at 400 RPM, molar ratio of 40 : 3 (mol) (fatty acid: G-3-P), 48 h, and $50^{\circ}C$. Thus, bioactive LPA with a desired fatty acid moiety could be produced with high yields and low variance despite various environmental noise factors.

• BMB Reports
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• v.49 no.8
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• pp.405-413
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• 2016

Tau proteins, which stabilize the structure and regulate the dynamics of microtubules, also play important roles in axonal transport and signal transduction. Tau proteins are missorted, aggregated, and found as tau inclusions under many pathological conditions associated with neurodegenerative disorders, which are collectively known as tauopathies. In the adult human brain, tau protein can be expressed in six isoforms due to alternative splicing. The aberrant splicing of tau pre-mRNA has been consistently identified in a variety of tauopathies but is not restricted to these types of disorders as it is also present in patients with non-tau proteinopathies and RNAopathies. Tau mis-splicing results in isoform-specific impairments in normal physiological function and enhanced recruitment of excessive tau isoforms into the pathological process. A variety of factors are involved in the complex set of mechanisms underlying tau mis-splicing, but variation in the cis-element, methylation of the MAPT gene, genetic polymorphisms, the quantity and activity of spliceosomal proteins, and the patency of other RNA-binding proteins, are related to aberrant splicing. Currently, there is a lack of appropriate therapeutic strategies aimed at correcting the tau mis-splicing process in patients with neurodegenerative disorders. Thus, a more comprehensive understanding of the relationship between tau mis-splicing and neurodegenerative disorders will aid in the development of efficient therapeutic strategies for patients with a tauopathy or other, related neurodegenerative disorders.

• Journal of Physiology & Pathology in Korean Medicine
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• v.17 no.3
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• pp.611-616
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• 2003

Through the whole period of the twentieth century, Chinese Traditional Medicine has been affected by the political and cultural changes of Chinese society. Before the 1949 Communist Revolution, Chinese Traditional Medicine was regarded as a dark past which should be cleared off. But Chinese Traditional Medicine has been reevaluated as a national medicine and spreaded quickly since the 1949 Communist Revolution. Moreover, 'the bare foot doctor' who received short term training appeared during the Cultural Revolution. It enhanced the status of Chinese Traditional Medicine. At the same time, it was estimated as a model of the self-reliant development of Third World countries. But the direction of development of Chinese Traditional Medicine was changed again recently. Chinese government has adapted the open-economy policy since the late 1970s. Accordingly Chinese Traditional Medicine also has been changed. Nowadays it pursues the professional development strategy. This paper inquired the following research questions. First, what kind of historical changes in the development strategy of Chinese Traditional Medicine has happened? Second, how much Chinese Traditional Medicine has accomplished the professionalization? Third, what kind of problems Chinese Traditional Medicine has met in the process of professionalization? Finally, why Chinese Traditional Medicine has adapted the professional development strategy?

• Journal of Physiology & Pathology in Korean Medicine
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• v.23 no.4
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• pp.745-750
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• 2009

The goal of this study is to examine on reasoning and search for construction of diagnosis ontology as a knowledge base of diagnosis expert system in oriental medicine. Expert system is a field of artificial intelligence. It is a system to acquire information with diverse reasoning methods after putting expert's knowledge in computer systematically. A typical model of expert system consists of knowledge base and reasoning & explanatory structure offering conclusion with the knowledge. To apply ontology as knowledge base to expert system practically, consideration on reasoning and search should be together. Therefore, this study compared and examined reasoning, search with diagnosis process in oriental medicine. Reasoning is divided into Rule-based reasoning and Case-based reasoning. The former is divided into Forward chaining and Backward chaining. Because of characteristics of diagnosis, sometimes Forward chaining or backward chaining are required. Therefore, there are a lot of cases that Hybrid chaining is effective. Case-based reasoning is a method to settle a problem in the present by comparing with the past cases. Therefore, it is suitable to diagnosis fields with abundant cases. Search is sorted into Breadth-first search, Depth-first search and Best-first search, which have respectively merits and demerits. To construct diagnosis ontology to be applied to practical expert system, reasoning and search to reflect diagnosis process and characteristics should be considered.

• Journal of Physiology & Pathology in Korean Medicine
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• v.16 no.3
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• pp.532-536
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• 2002

Jookrhyuk (Bambusae Caulis in Liqamen) was extracted at low temperature (100℃ - 160℃) and purified by adsorption and distillation and their physicochemical properties were compared. In case of colour among all Jookrhyuk samples the L value appeared to be higher in the purified Jookrhyuk,and the b value appeared to be higher in crude Jookrhyuk. Purified Jookrhyuk showed much lower level of total sugar and tar contents than crude Jookrhyuk. A considerable reduction in concentration of methanol and phenolic compounds was achieved by purification process, whereas the content of acetic acid was increased. Therefore it was suggested that adsoption and distillation could be used as one of effective purification methods of various Joockrhyuk samples.