• 동의생리병리학회지
• /
• 제18권3호
• /
• pp.868-873
• /
• 2004

Renal dysfunction could be developed as the secondary disease of liver cirrhosis. Delayed or suppresed lipid peroxidation by the treatment with physiological active substances could be explained as the antioxidative and protective effect in tissue damage. In this study, we investigated an antioxidative effect and renal function improvement of Hovenia dulcis in liver fibrosis(cirrhosis) induced rats. The female Sprague-Dawley rats (180∼210 g) were divided into 3 groups (Normal, AC: CCl₄ mixture treated group, AC-HV: CCl₄ mixture+ Hovenia dulcis treated group) and renal damage was developed by CCl₄ mixture administration in 4 weeks (0.8 ㎖/rat). The tissue of kidney and liver and sera were used for quantitative measurement of enzyme activity, MDA and Hyp. The histological change and gene expression of collagen α1(III) mRNA and a1(IV) mRNA were observed by Masson's trichrome staining and RT-PCR. As a result, the clinical biochemical parameters of liver function (AST and ALT) in sera of AC-HV group showed significantly 46.4% and 104.8% lower (p<0.005), and the level of ALP and BUN as the parameter of protein urine and azotemia showed 17.8 % and 25.8 % lower than in AC group. In AC-HV group, the concentration of MDA in kidney and liver was decreased significantly 15.8% and 21.3% when compared with AC group (p<0.01 -0.005). The content of Hyp in kidney of AC-HV group is merely higher than in AC group, in contrast to liver tissue. The expression of collagen α1(III) mRNA and collagen α1(IV) mRNA was decreased in AC, but both of collagen mRNA in normal and AC-HV group expressed fast similar. More massive lipid droplets, thicker collagen fiber bundles in portal triads and more formation of portal central septum were observed in the liver of AC group than in AC-HV group. In conclusion, CCl₄ mixture intoxication could be developed not only liver fibrosis(cirrhosis) but also renal dysfunction by the massive lipid peroxidation and suppression of interstitial collagen and basement membrane collagen synthesis. And the water extract of Hovenia dulcis may be possessed the antioxidative and protective effect and improvement of kidney function in renal dysfunction induced rats.

• 전기학회논문지
• /
• 제60권8호
• /
• pp.1606-1616
• /
• 2011

The blood pressure measuring equipment, which is being supplied and used most widely by being recognized convenience and accuracy now generally, is oscillometric blood pressure monitor. However, a change in blood pressure is basically influenced by diverse elements such as each individual's physiological status and physical condition. Thus, the measurement of blood pressure, which used single element called oscillation in blood pressure of being conveyed to cuff, is not considered on physiological elements such as cardiovascular system status and blood vessel stiffness index, and on external elements, thereby being quite in error. Accordingly, this study detected diverse bio-signals and body informations in each individual as the measurement subject such as ECG, PPG, and Korotkoff Sound in order to enhance convenience and accuracy of measuring blood pressure in the complex measurement equipment, thereby having extracted regression method for compensation in error of oscillometric blood pressure measurement on the wrist, and having improved accuracy of measuring blood pressure. To verify a method of improving accuracy, the blood pressure value in each of SBP, DBP, MAP was acquired through 4-stage experimental procedure targeting totally 51 subjects. Prior to experiment, the subjects were divided into two groups such as the experimental group for extracting regression method and the control group for verifying regression method. Its error was analyzed by comparing the reference blood pressure value, which was obtained through the auscultatory method, and the oscillometric blood pressure value on the wrist. To reduce the detected error, the blood pressure compensation regression method was calculated through multiple linear regression analysis on elements of blood pressure, individual body information, PTT, HR, K-Sound PSD change. Verification was carried out on improving significance and accuracy by applying the regression method to the data of control group. In the experimental results, as a result of confirming error on the reference blood pressure value in SBP, DBP, and MAP, which were acquired through applying regression method, the results of $-0.47{\pm}7.45$ mmHg, $-0.23{\pm}7.13$ mmHg, $0.06{\pm}6.39$ mmHg could be obtained. This is not only the numerical value of satisfying the sphygmomanometer reference of AAMI, but also shows the lower result than the numerical value in SBP : $-2.5{\pm}12.2$ mmHg, DBP : $-7.5{\pm}8.4$ mmHg, which is the mean error in the experimental results of Brram's research for verifying accuracy of Omron RX-M, which shows relatively high accuracy among wrist sphygmomanometers. Thus, the blood pressure compensation could be confirmed to be made within significant level.

• 한국어병학회지
• /
• 제12권1호
• /
• pp.32-41
• /
• 1999

오존처리 해수중에 함유하는 잔류 옥시던트(TRO)가 양식 넙치의 생존, 혈액성상과 삼투질 농도, 산소소비 및 아가미 조직에 미치는 독성 영향을 조사하였다. TRO에 노출된 넙치의 48-hr 및 96-hr $LC_{50}$은 각각 26.4 와 22.3ppb이었고, 47ppb에서는 3시간 이내에 모두 치사하였으나 13ppb에서는 96시간 동안 폐사발생이 없었다. TRO 24~39ppb 농도범위에 노출된 넙치의 hematocrit, 헤모글로빈, 적혈구 수, 혈중 sodium과 chloride 이온 및 삼투압 농도는 TRO 농도가 높을수록 유의하게 증가하였고, 아가미 조직은 아가미 상피층이 모세혈관으로부터 박리되고, 괴사와 상피새포의 증생이 관찰되었다. 산소소비율은 TRO 농도가 높고, 노출이 계속될수록 감소하였다. 13ppb에서는 아가미 조직과 생리상태에 미치는 변화는 관찰되지 않았으나 혈당은 유의하게 증가하였다. 그러나 활성탄으로 TRO를 제거한 대조구에서는 오존의 독성 영향은 관찰되지 않았다. 잔류오존에 노출된 넙치는 삼투질 농도의 생리적 불균형 및 아가미 손상과 상피세포의 증생에 의한 산소섭취 부족이 치사를 유발하는 것으로 나타났다. 본 연구의 결과 해산어 양식장에서 오존을 사용할 경우에는 오존처리수중의 TRO는 제거하여야 하며, 비록 저농도라도 장기간 노출되면 양식어류의 생존과 생리상태에 미치는 영향은 현저할 것으로 평가되었다.

• Journal of Forest and Environmental Science
• /
• 제37권4호
• /
• pp.315-322
• /
• 2021

The aim of this study was to investigate the sensitivity to environmental stress, and changes in the photosynthesis capacity in Abies koreana seedlings by age and to suggest the most effective age for restoration. To identify these physiological characteristics of A. koreana, the chlorophyll fluorescence and photosynthetic capacity of 1-, 2-, 3-, 5- and 6-year-old A. koreana seedlings were observed from June 2020 to June 2021. The maximum quantum efficiency of Photosystem II (Fv/Fm), a chlorophyll fluorescence measurement parameter, was strongly positively correlated with the monthly average temperature (1-year-old seedling: r=0.8779, 2-year-old seedling: r=0.8605, 3-year-old seedling: r=0.8697, 5-year-old seedlings: r=0.8085, and 6-year-old seedlings: r=0.8316). The Fv/Fm values were the lowest in winter (November 2020-March 2021). In addition, the Fv/Fm values of 1-, 2-, and 3-year-old seedlings in winter were lower than that of 5- and 6-year-old seedlings, while the Fv/Fm values in summer were relatively higher than those in winter. Further, the Fv/Fm values of seedlings of all ages decreased in August 2020, when the monthly average temperature was the highest. In particular, 1-year-old to 3-year-old seedlings showed Fv/Fm values less than 0.8. Further, the photosynthetic capacity measured in August 2020 increased with increasing seedling age. The analysis of variance results for summer Fv/Fm values showed significant differences in age-specific averages (p<0.05), and Duncan's multiple range test showed significant differences between 5- and 6-year-old seedlings and 1-, 2-, and 3-year-old seedlings (p<0.05). These results suggested that the 5- and 6-year-old seedlings were less sensitive to environmental stress and showed better photosynthetic capacity than the 1-, 2-, and 3-year-old seedlings. Therefore, 5-year-old or older A. koreana seedlings can be used as restoration materials because they can show increased adaptability and stable growth during transplantation due to their relatively high environmental resistance and photosynthetic capacity.

• 생물환경조절학회지
• /
• 제31권1호
• /
• pp.1-7
• /
• 2022

서부 경남 지역 중 딸기재배로 유명한 지역 40개 농가를 대상으로 한 조사에 따르면 국산품종 중에서 "설향"이 65.0%으로서 가장 선호하고 있는 것으로 나타났다. 그리고 현재의 농업은 4차 산업혁명으로 스마트팜(Smart Farm)의 기술이 더욱 발전하고 있는 실정이다. 그러나 각 생육단계가 어떤 상황일 때 딸기의 생산량이 최적에 달하는지 대한 기준이 없으며, 이러한 판단기준은 아직까지 스마트팜에 경험이 있는 농업인의 의사에 달려있다는 문제점이 있다. 따라서 본 연구에서는 딸기의 생육상황에 대한 생산량 예측을 통해 선진화된 스마트팜 시스템을 구축하고자 한다. 실험 장소는 경상남도 사천시의 딸기 농가에서 수행하였으며, 총 3곳을 대상으로 데이터 수집을 진행하였다. 실험 대상의 모든 온실 내에서 재배하는 딸기의 품종은 '설향'이다. 작물 데이터의 수집 항목은 작물의 엽수, 꽃수, 과실수, 초장, 잎의 길이, 엽록소 함량이며, 환경 데이터의 수집 항목은 온도, 습도, 조도이다. 기존의 농가 단위의 스마트팜의 문제점 보완 및 개선을 통하여 고품질의 작물 생장 상태를 유지하기 위해 K-fold 교차검증, Lasso 회귀분석, MAPE 검증을 통해 예측모델을 도출하였으며, MAPE 검증 결과 값으로 0.511(꽃 예측)과 0.488(과일 예측)의 값이 나타났다. 본 연구는 스마트팜 데이터 구축을 위해서는 AI를 통해 성장상태별 수확량을 예측하였으며, 이를 농가 및 농업 관련 기업에 활용해 농업 서비스가 편리할 것으로 판단된다.

• 한국작물학회지
• /
• 제53권2호
• /
• pp.137-143
• /
• 2008

조기 초관폐쇄성(rapid canopy closure, RCC) 또한 벼의 유전적인 잠재수량성을 향상시킬 수 있는 생리적 특성 중 하나이다. EGV(early growth vigor)가 상이한 22개 품종을 선정하여 EGV와 초관의 조기폐쇄성(RCC)과의 관계, RCC와 생육 및 수량간의 관계를 평가하고자 포장실험(이앙재배)을 실시하였다. 초관이 폐쇄되기 전의 생장은 $y\;=\;{\alpha}{\cdot}{\exp}({\beta}{\cdot}t)$와 같은 지수생장함수로 표현되는데, y는 엽면적지수(LAI) 또는 지상부건물중(DW)이고, t는 적산온도이며, $\alpha$는 지수생장초기의 LAI나 DW 값이고, $\beta$는 지수생장이 일어나는 시기의 LAI 또는 DW의 상대생장률(relative growth rate, RGR; $^{\circ}C^{-1}$)이다. 1. 벼의 지수생장 초기단계에는 품종의 LAI나 DW가 $\alpha$와 높은 정의 상관이 있었고 또한 종자 무게(천립중)와 정의 상관이 있어 종자무게에 의하여 생육이 크게 영향을 받았으며, 그 후의 시기는 품종의 LAI 및 DW가 $\beta$와 높은 상관을 보였다. 2. $\alpha$와 $\beta$는 모두 품종간에 유의적인 차이가 있었다. 3. $\beta$는 단위면적당 영화수 및 수량과 높은 정의 상관을 보였다. 4. 결론적으로 EGV 및 RCC는 상호 밀접한 관련이 있고, EGV가 크면, RCC도 커서 수량에 정의 방향으로 영향을 하는 것으로 판단되었다.

• 대한의용생체공학회:학술대회논문집
• /
• 대한의용생체공학회 1996년도 춘계학술대회
• /
• pp.315-319
• /
• 1996

We have developed a prototype patient monitoring system including module-based bedside units, interbed network, and central stations. A bedside unit consists of a color monitor and a main CPU unit with peripherals including a module controller. It can also include up to 3 module cases and 21 different modules. In addition to the 3-channel recorder module, six different physiological parameters of ECG, respiration, invasive blood pressure, noninvasive blood pressure, body temperature, and arterial pulse oximetry with plethysmogaph are provided as parameter modules. Modules and a module controller communicate with up to 1Mbps data rate through an intrabed network based on RS-485 and HDLC protocol. Bedside units can display up to 12 channels of waveforms with any related numeric informations simultaneously. At the same time, it communicates with other bedside units and central stations through interbed network based on 10Mbps Ethernet and TCP/IP protocol. Software far bedside units and central stations fully utilizes gaphical user interface techniques and all functions are controlled by a rotate/push button on bedside unit and a mouse on central station. The entire system satisfies the requirements of AAMI and ANSI standards in terms of electrical safety and performances. In order to accommodate more advanced data management capabilities such as 24-hour full disclosure, we are developing a relational database server dedicated to the patient monitoring system. We are also developing a clinical workstation with which physicians can review and examine the data from patients through various kinds of computer networks far diagnosis and report generation. Portable bedside units with LCD display and wired or wireless data communication capability will be developed in the near future. New parameter modules including cardiac output, capnograph, and other gas analysis functions will be added.

• 동의생리병리학회지
• /
• 제16권1호
• /
• pp.201-208
• /
• 2002

The measurement parameter of QiguㆍInyoung pulse diagnosis distinguishes the excess, deficiency and quick-temper of pulse through relative comparison of Qigu and Inyoung. We have estimated the relationship between measurement of QiguㆍInyoung pulse wave detection system and measurement of manual pulse diagnosis by means of quantifying pulse peak and Inyoung/Qigu index. The results can be summarized as follows : When standardizing manual pulse diagnosis measurement was standardized, Inyoung index of machinery measurement was more significantly correlative with the index of manual pulse diagnosis than Qigu index of machinery measurement. The ratio of Inyoung/Qigu magnitude with machinery measurement was doser to manual pulse diagnosis than that of Qigu and Inyoung pulse magnitude measured separately. A linear proportion relationship was found between measurement of QiguㆍInyoung pulse wave detection system and measurement of manual pulse diagnosis. It was necessary to adjust the output signal of pulse in order to estimate the exact relationship between measurement of QiguㆍInyoung pulse wave detection system and measurement of manual pulse diagnosis.

• 대한의용생체공학회:의공학회지
• /
• 제37권1호
• /
• pp.21-30
• /
• 2016

Weibull distribution with two parameters, shape (k) and scale (s) parameters are used to model the fatigue failure analysis due to periodic vortex shedding of the synovial fluid in knee joints. In order to determine the later parameter, a suitable statistical model is required for velocity distribution of synovial fluid flow. Hence, wide applicability of Weibull distribution in life testing and reliability analysis can be applied to describe the probability distribution of synovial fluid flow velocity. In this work, comparisons of three most widely used methods for estimating Weibull parameters are carried out; i.e. the least square estimation method (LSEM), maximum likelihood estimator (MLE) and the method of moment (MOM), to study fatigue failure of bone joint due to periodic vortex shedding of synovial fluid. The performances of these methods are compared through the analysis of computer generated synovial fluidflow velocity distribution in the physiological range. Significant values for the (k) and (s) parameters are obtained by comparing these methods. The criterions such as root mean square error (RMSE), coefficient of determination ($R^2$), maximum error between the cumulative distribution functions (CDFs) or Kolmogorov-Smirnov (K-S) and the chi square tests are used for the comparison of the suitability of these methods. The results show that maximum likelihood method performs well for most of the cases studied and hence recommended.

• 동의생리병리학회지
• /
• 제31권2호
• /
• pp.138-144
• /
• 2017

The pharmacological rationale of Agastache rugosa (AR) or Pogostemon cablin (PC), which have been used in traditional Korean medicine to treat dampness pattern or syndrome in gastrointestinal tract, was investigated on the gastrointestinal disorders. In-vivo model studies that examined the effect on the gastrointestinal disorders of AR or PC were collected. They were classified into disease-induced in-vivo models or non-disease in vivo models. The target disease, animal species, induction method, administration, and outcomes (changes in morphological and histological parameter, or blood and fluid) of each study were analyzed. The therapeutic mechanism of AR or PC extract was evaluated by the induced diseases and the changes in outcomes. There were contradictory reports on gastrointestinal motility of AR or PC in disease non-disease in-vivo model. AR or PC inhibited gastrointestinal motility in disease model of increased gastrointestinal motility, while promoted motility in disease model of decreased gastrointestinal motility. AR or PC also inhibited inflammatory changes in gastrointestinal inflammation model. These results suggest that the bidirectional regulation of gastrointestinal motility and the improvement of gastrointestinal inflammatory disorders might underpin traditional therapeutic effect of AR or PC, that is effect to resolve dampness of gastrointestinal tract.