• 한국의류학회지
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• 제32권11호
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• pp.1792-1801
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• 2008

This study was to develope the pesticide-proof clothes(PPC) for fruit-grower which has been well known over applied agricultural chemicals. The ergonomic evaluation of PPC were tested in two ways. Male adults volunteered the tests to evaluate the safety to pesticide in the field and the thermal comforts in the climate-chamber($30^{\circ}C$, 60%R.H.). PPC were made of 4 different fabrics. Two of them were on the market(coated non-woven and coated nylon). Others were water-repellent treatment and coated waterproof film by developed polyester. The field study was conducted for farmers growing apples to evaluate pesticide exposure. In this experiment, we collected data with patch test on the head, chest, back, right upperarm, right forearm, left thigh and left calf. From the results, the developed PPC showed the more excellent comfort than an existing PPC with nylon coated polyurethane. But the developed PPC of water-repellent fabric was penetrated into the PPC. Therefore, we designed the functional pesticide-proof clothes of 2 different developed polyester fabrics(water-repellent treatment in chest, abdomen, the lower of back, waist, and calf; coated waterproof film in head, shoulder, the upper of back, the crotch, hip, upper arm and thigh).

• 동의생리병리학회지
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• 제30권5호
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• pp.320-326
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• 2016

Tongue diagnosis is convenient and non-invasive method to examine the body's functional condition, and it has been frequently used in traditional Korean Medicine (KM). The aim of this study was to investigate the difference of the tongue color assessed by computerized tongue image analysis system (CTIS) between the common cold (CC) patients and healthy subjects. A total of 85 participants, including 45 CC patients without organic diseases and 40 healthy subjects, were asked to complete the CC symptom questionnaire. A tongue image was acquired by using CTIS. Color differences in Commission Internationale de l'Eclairage (CIE) L*, a* and b* between the CC patient group and the control group were analyzes by using paired t-test analysis. The variable CIE b* of the tongue body was significantly lower in CC than that in controls (P=0.019). The variable CIE L* of the tongue coating was significantly higher in CC than that in controls (P=0.032). In CC, the color of the tongue body seems to be changed to intense red color. The color of the tongue coating seems to be changed to thick fur. The present study demonstrated that the CTIS can be used as a diagnostic and monitoring tool for the objective and standardized evaluation of common cold in clinics.

• 약학회지
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• 제37권4호
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• pp.397-407
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• 1993

The muscarinic antagonist l-[benzilic-4,4'-$^3H$]quinuclidinyl benzilate([$^3H$]QNB) bound to a single class of muscarinic receptor with high affinity in guinea pig ileal membranes. The $K_{D}$ and B$_{max}$ values for [$^3H$]QNB calculated from analysis of saturation isotherms were 54 pM and 156fmol/mg, respectively. H$_{1}$-blockers inhibited [$^3H$]QNB binding to ileal membranes with $K_{i}$ values ranged from 0.008 $\mu{M}$ to 1.6 $\mu{M}$. The pseudo-Hill coefficients of H$_{1}$-blockers for inhibition of [$^3H$]QNB binding to the ileal membranes were close to unit. The $K_{i}$ values for H$_{1}$-blockers were similar to the $K_{M}$ values calculated by Schild plot of functional data obtained from inhibition of the carbachol-induced contraction in guinea-pig ileum, suggesting that binding of H$_{1}$-blockers vs [$^3H$]QNB in ileal membranes represents an interaction with a receptor of physiological relevance. The $K_{H}$ values of H$_{1}$-blockers for H$_{1}$-receptor estimated from inhibition of the histamine-induced contraction were the range of 0.15 nM to 56.5 nM. The $K_{M}$/K$_{H}$ ratio of H$_{1}$-blockers varied over a wide range of 3 to 2300. Thus, the antihistaminic potencies of H$_{1}$-blockers do not correlate with their antimuscarinic potencies, which suggest that antihistamines have different antimuscarinic potencies in therapeutic blood levels causing similar antiallergic effect. Among 13 traditional antihistaminics examined in this study, drug having the highest and the lowest $K_{M}$/K$_{H}$ ratio is triprolidine and diphenidol, respectively. The present results demonstrate that the antimuscarinic property of antihistamines is not necessary for their antiallergic effect, and data on the affinity of antihistamines for muscarinic and H$_{1}$-receptors can be an important parameter in the selection and evaluation of these drugs.

• 동의생리병리학회지
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• 제20권5호
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• pp.1180-1186
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• 2006

This research was planned and executed to evaluate how the composition of Yak-sun(oriental diet therapy) can effect health conditions of people who are suffering from diet-related diseases like obesity and hyperlipidemia by taking Yak-sun in a form of nutritional supplement with our daily meals. We produced Jangswucha with Koekac, Sansa, Heshouwu, Wulong and evaluated how this tea effects on serum lipids and oxidative stress by clinical practices. Also we examined physical characteristics of Jangswucha. Brix, pH and titratable acidity of Jangswucha were 1.4, 5.50 and 0.05%. With this observation, we found out that this tea has significant effect on increase of HDL-cholesterol, decrease of LDL-cholesterol concentration in serum. Also this tea significant effect on decrease oxidative stress and homocystein content. We think that scientific and objective evaluation was done on the components of Yak-sun tea prescription. We concluded that we could apply the components not only in a form of tea, but also in other forms of various food. The information we received from this conclusion will be a basic information on how we can apply oriental medicinal resources into other food and will also be a steppingstone for medicinal herbs to step foot in the field of functional food research, which already draws sizable attention world-wide.

• Pediatric Gastroenterology, Hepatology & Nutrition
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• 제26권5호
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• pp.249-265
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• 2023

Purpose: Infant regurgitation is associated with other functional gastrointestinal disorders and signs and symptoms that have a major impact on the quality of life of infants and their families. This study evaluated the safety, tolerance, and real-world effectiveness of an anti-regurgitation formula containing locust bean gum (LBG), prebiotics, and postbiotics to alleviate digestive symptoms beyond regurgitation. Methods: This 3-month study involved infants with regurgitation requiring the prescription of an anti-regurgitation formula according to usual clinical practice. Outcomes included evaluation of the evolution of stool consistency and frequency; occurrence of colic, constipation, and diarrhea; and assessment of regurgitation severity. Infant crying, parental assessment of infant well-being, and parental satisfaction with the stool consistency were also evaluated. Results: In total, 190 infants (average age: 1.9±1.1 months) were included. After three months, stool frequency and consistency remained within the normal physiological range, with 82.7% of infants passing one or two stools per day and 90.4% passing loose or formed stools. There was no significant increase in the number of infants with diarrhea, whereas a decrease was observed in the number of infants with constipation after 1 month (p=0.001) and with colic after both 1 and 3 months (p<0.001). Regurgitation severity and crying decreased and parental satisfaction with stool consistency, formula acceptability, infant well-being, and sleep quality increased. Monitoring of adverse events did not reveal any safety concerns. Conclusion: Formulas containing LBG, prebiotics, and postbiotics were well tolerated and provided an effective strategy for managing infant regurgitation and gastrointestinal discomfort.

• 한국지역사회생활과학회지
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• 제24권4호
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• pp.543-552
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• 2013

Physiological and subjective responses of the farmers and thermal environment during chili harvest in the open field were investigated to evaluate the thermal environments and farmers's workload. Eight career female farmers in their sixties participated as subjects both in morning work(MW, AM 9:00~10:30) and in afternoon work(AW, PM 15:00~16:30) with each lasting about 90 minutes. The results were as follows. 1) Air temperature, air humidity, globe temperature and WBGT of MW were mean $25.54^{\circ}C$, 81.82%RH, $37.72^{\circ}C$, $26.27^{\circ}C$ and AW were mean $30.63^{\circ}C$ 82.50%RH, $40.11^{\circ}C$, $30.02^{\circ}C$, respectively. By the WBGT, we evaluated that the thermal environment in the afternoon in the open field gave a thermal burden to farmers. 2) Mean skin temperature of AW($34.8{\pm}0.8^{\circ}C$) was higher than MW($33.5{\pm}1.2^{\circ}C$)(p<0.05). Clothing microclimate temperature on the chest of each work time were $31.3^{\circ}C$(MW) and $32.7^{\circ}C$(AW). Clothing microclimate humidity on the chest of each work time were over 80%RH. Heart rate were 88.5bpm(MW) and 91.7bpm(AW) respectively. 3) Farmers working in the afternoon felt uncomfortable after 45~60 min. of work and in the morning they felt uncomfortable after 90 min. of work. We evaluated that the harvesting of chilies in the open field was 'moderate work' by the physiological responses but the level of thermal burden increased over time especially in the afternoon work. It is suggested that farm workers should drink fluids between work to stay in homeostasis by sweating and to take frequent rests. Active clothing ventilation and wearing functional garments would help farm workers excrete sweat effectively.

• 생명과학회지
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• 제20권1호
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• pp.82-89
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• 2010

지금까지의 연구에 의하면 산야 발효액에 대한 보고가 미비하므로 본 연구에서는 산야의 기능성에 관한 연구를 위하여 산야 발효액으로 여러 가지 생리활성과 면역활성에 대하여 분석하였다. 우선, 산야의 항산화 활성을 측정하기 위하여 DPPH 활성과 플라보노이드 함량을 측정하였다. 그 결과 DPPH법을 통해 측정한 산야 발효액의 항산화력은 94.3%의 radical 소거능을 나타내었다. BHA와 비교 했을 때 유사한 항산화력이 측정되었는데, 이것은 항산화 활성이 높은 것으로 산야의 항산화력에 관한 높은 이용가치를 의미한다. 산야 발효액의 총 플라보이드 함량은 4.646 mg/g으로 높았으며, 이는 높은 항산화능과 연관성이 있는 것으로 나타났다. 산야 발효액과 면역활성과의 연관성은 NO 합성률과 LPS에 의해 유도되는 NO 합성 저해률 분석으로 조사되었다. 그 결과, 산야 발효액은 무려 11배의 높은 NO 합성율을 보였다. 또한 LPS에 의해 유도된 NO 합성 저해율은 56%로 나타나 산야의 높은 면역효과를 증명하고 있다. 혈전분해능에 대한 산야 발효액의 분석 결과는 혈전용해제로 알려져 있는 plasmin보다 높은 활성을 보이고 있다. SOD 유사활성은 42.2%로 비교적 높은 SOD 유사활성을 나타내었고, xanthine oxidase 저해활성은 75.6%로 높게 나타났다. 항고혈압 측정실험에서는 73.5%의 저해율을 나타내어 ACE 저해 활성이 뛰어난 것으로 나타났다. 이상의 결과는 산야의 우수한 생리활성을 증명하고 있고, 항산화력, 면역활성 및 항고혈압 효과가 높은 것으로 나타나 기능성 음료의 소재로서 그 활용도가 높을 것으로 판단된다.

• 동의생리병리학회지
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• 제21권1호
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• pp.171-180
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• 2007

The purpose of this study is to determine the possibility of using Flos Sophora japonica as natural health food source. To accomplish this purpose, the contents of general and antioxidative nutrients of Flos Sophora japonica a were measured. The contents of carbohydrate, crude protein, crude lipid and ash are 67.76%, 19.87%, 4.61% and 7.76%. And the calories of Flos Sophora japonica Linne was 318.32 Kcal. Total dietary fiber was 25.35% of total carbohydrates. The percentages of water soluble dietary fiber to insoluble dietary fiber were 1.80 % and 23.56 %, respectively. The protein were contained total 18 different kinds of amino acids. The contents of non-essential and essential amino acids were 4,898.78mg and 5,953.51mg. The K was the largest mineral followed by Ca, P and Mg, which means Flos Sophora japonica Linne is alkali material. The contents of saturated fatty acids, monounsaturated fatty acids and polyunsaturated fatty acids were 29.69%, 34.93% and 35.38%. Therefore, the amount of the total unsaturated fatty acid was higher than that of any other plant. The content of vitamin C in Flos Sophora japonica Linne was higher than that of any other plant, which suggest that it could increase blood elasticity. The content of rutin, which is responsible for capillary vessel permeability, was 22.60%. The contents of water soluble antioxidative materials in 1 mL of water-extracted Flos Sophora japonica Linne were 3.9 ${\mu}$g which is comparable to 1233.0 mmol of vitamin C in antioxidant effect. The general nutrients and other antioxidatant bioactive materials in Flos Sophora japonica Linne were also potential materials for good health food. It is expected that follow up study of Flos Sophora japonica Linne through developing processed food and evaluation of their functional properties would provide useful information as a source of medicinal foods.

• Journal of Plant Biotechnology
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• 제37권1호
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• pp.12-24
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• 2010

식물 대사체 (plant metabolomics) 연구는 식물 세포 및 조직에 존재하는 모든 대사산물의 시간적, 공간적 변화를 추적 조사함으로써 식물의 복잡한 생리 현상을 총체적으로 이해하는 연구이다. 이와 같은 식물 대사체 연구는 최근 개발이 이루어지고 있는 여러 오믹스 연구 분야의 하나로 시스템생물학의 한 분야이다. 식물 대사체 연구는 시료로부터 순수 화합물 또는 복합물을 정제하거나 또는 정제가 이루어지지 않은 혼합액으로부터 대사체 스펙트럼 정보를 확보하여 분석이 이루어지므로 추출액 제조 및 얻어진 대사체 데이터의 분석과정의 표준화가 필수적으로 이루어져야 한다. 이는 대사체 분석 결과의 해상도 및 재현성의 확보의 핵심 요소 이다. 식물 대사체 연구는 기능유전체학의 연구 수단은 물론 식물의 종, 품종, 더 나아가 GM 식물의 식별, 대사조절 기작 규명, 유용물질 생산, 식물의 외부 환경 스트레스 요인에 대한 다양한 생리적 반응 이해 등 다양한 연구 분야에서 활용이 이루어지고 있다. 최근 식물 대사체 연구는 모델식물(벼, 애기장대)의 유전체 정보와 연계하여 돌연변이주의 분석을 통해 유전자의 기능 정의 수단으로 활용되고 있다. 따라서 향후 유전체 정보와 대사체 정보의 연계를 통해 복잡한 대사경로 규명이나 다양한 생리 현상 해석 연구가 더욱 활발하게 진행될 것으로 전망된다.

• 한국식품영양학회지
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• 제34권5호
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• pp.477-486
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• 2021

To utilize Malus pruniforia Borkh. as a functional material, cold-water (CW), hot-water (HW), and 70% ethanol (EtOH) extracts were prepared, and their antioxidant and anti-inflammatory activities were compared. The antioxidant activity of the HW extract evaluated by ABTS and DPPH radical scavenging and FRAP activity was significantly effective. The total polyphenol content of the HW extract was also higher by 15.5±0.7 mg GAE/g extract compared to other extracts. The EtOH extract showed significantly decreased TNF-α (39.8%), IL-6 (65.5%), and NO (34.9%) levels in RAW 264.7 cells compared to the LPS-induced control group. The levels of IL-6 (21.1%) and IL-8 (19.3%) were significantly decreased by treatment of EtOH extract in HaCaT keratinocytes induced with TNF-α and IFN-γ. The UHPLC-MS results indicated that the EtOH extract might have chlorogenic acid and phlorizin as the major compounds. This was validated using HPLC-DAD, which showed that the EtOH extract had higher levels of chlorogenic acid and phlorizin (1,185±58 and 470±10 ㎍/g extract, respectively). In conclusion, the present study suggested that the anti-inflammatory activity of the EtOH extract was more effective than the CW and HW extracts, and chlorogenic acid and phlorizin could be used as indicator compounds and functional substances.