• Journal of Physiology & Pathology in Korean Medicine
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• v.17 no.3
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• pp.787-790
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• 2003

It has been demonstrated that oxidative stress of reactive oxygen species(ROS) may be a causative factor in the pathogenesis of bony disorder. The purpose of this study was to evaluate the oxidative stress of glucose oxidase(GO) in the cultured mouse osteoblasts and the protective effect of Alii Macrostemi Bulbus(AMB) on ROS-induced osteotoxicity. Toxic effect of GO and protective effect of AMB were carried out by colorimetric assay. 20mU/mi GO decreased cell viability dose-dependently, and AMB increased cell viability against GO-induced cytotoxicity in these cultures. From above the results. GO has toxic effect, and AMB is very effective on GO-induced osteotoxicity in cultured osteoblasts of neonatal mouse.

• Journal of Physiology & Pathology in Korean Medicine
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• v.16 no.6
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• pp.1302-1307
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• 2002

We experienced a case of patient of incomplete spinal cord injury following slipping off his clothes. He had complications : both leg paresisㆍboth arm weaknessㆍurine disturbanceㆍboth leg & arm sensory disorder . We could treat these complications with the methods of medical treatments ; acupunctureㆍmoxa therapyㆍherb-medicationㆍelectro-acupuncture & muscle exercises. We obtained results that motor grade and muscle atrophy were improved.

• Journal of Physiology & Pathology in Korean Medicine
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• v.23 no.4
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• pp.898-902
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• 2009

The aim of this study is to report the improvement after the Oriental medical treatment about a paraplegic patient caused by spinal cord injury. The paraplegia caused by spinal cord injury was the result of falling down. So we diagnosed it as Eohyeol(瘀血), Wei symptom(痿證), Urinary retention(癃閉) in Oriental medical system and applied herbal medicine, acupuncture, moxibustion, physical exercise to the patient for 42days. We evaluate the clinical effect of the treatment with VAS and motor/sensory function score of the body and lower extremities. After the Oriental medical treatment, we achieved the effective result on impairment in motor and sensory function of the paraplegic patient. And also we got the improvement of urinary disorder and pain. The more clinical study about paraplegic patient caused by spinal cord injury may be needed.

• Molecules and Cells
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• v.40 no.6
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• pp.379-385
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• 2017

Drug addiction is a severe psychiatric disorder characterized by the compulsive pursuit of drugs of abuse despite potential adverse consequences. Although several decades of studies have revealed that psychostimulant use can result in extensive alterations of neural circuits and physiology, no effective therapeutic strategies or medicines for drug addiction currently exist. Changes in neuronal connectivity and regulation occurring after repeated drug exposure contribute to addiction-like behaviors in animal models. Among the involved brain areas, including those of the reward system, the striatum is the major area of convergence for glutamate, GABA, and dopamine transmission, and this brain region potentially determines stereotyped behaviors. Although the physiological consequences of striatal neurons after drug exposure have been relatively well documented, it remains to be clarified how changes in striatal connectivity underlie and modulate the expression of addiction-like behaviors. Understanding how striatal circuits contribute to addiction-like behaviors may lead to the development of strategies that successfully attenuate drug-induced behavioral changes. In this review, we summarize the results of recent studies that have examined striatal circuitry and pathway-specific alterations leading to addiction-like behaviors to provide an updated framework for future investigations.

• Journal of Ginseng Research
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• v.6 no.1
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• pp.84-99
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• 1982

Water content and its seasonal change in reprodltctive organs were reviewed in relation to cultivation practice s. Precipitati on and humidity under shade roof were reviewed in relation to shading ,jystem and environmental factors. High water content of reproductive organs suggests vulnerability to water stress during reproductive growth stage. Watering during dehisconce treat menu seems to keep optimum temperature but cnoventional practice seems to be too often In watering. Information effe on water physiology of seeds is too rare to develop seed storing method and ctive seed use. Dehiscent mechanism was considered in terms of water absorption of embryo. Precipitation rate of conventional shade roof reaclled to 38% and at line level 50% and varied with shade patterns. Precipitation rate under shade has been investigated for itself but should be investigated in relation to light intensity and soil moisture content Relative humidity under shade depends mainly on air humidity and soil moisture, considerably on shade materials and lithe on pole height, bed width or plant density. Since relative humidity was lower in afternoon it was often less than 50% even in summer with high temperature suggesting possible disorder of phi biological function especially in photosynthesis. More information was needed on optimum humidity for productive physiological function of leaf.

• Journal of Physiology & Pathology in Korean Medicine
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• v.16 no.3
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• pp.567-571
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• 2002

In order to prove the sedative, anticonvulsive effects of Incenses and to identify the effect of this medicine to cerebral glutamic acid and GABA density in experimental animal. we used Incense which was made of traditional herb medicines. We also examined what kind of material is to be involved in biosynthesis of these elements. In addition we experimented to find out synthesis of active GABA-T. Incenses were inhaled 8 hours a day for 4 weeks to mice. Finally we have following results. On the convulsion induced by pentylenetetrazole(PTZ), Incenses showed significant anticonvulsive effect. Density of glutamic acid in brain was significantly decreased. On the contrary, density of GABA was significantly increased. The Activity of GABA- T in brain was significantly reduced. The quantity of lipid peroxide in the brain was significantly decreased. Activity of xanthine oxidase and aldehyde oxidase were significantly reduced in brain. From the above results, we confirmed that Incenses decreased the density of glutamic acid, increased GABA density and decreased the activity of GABA- T in brain. For the convulsion which was induced by PTZ, Incenses showed significant anticonvulsive effect. With this we can recognize that Incenses had ability to control the quantity of lipid peroxide in brain. In the conclusion, Incenses has significant anticonvulsive effect, so I strongly recommend to prescribe Incenses to treat convulsive disorder like epilepsy.

• Journal of Physiology & Pathology in Korean Medicine
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• v.17 no.2
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• pp.457-460
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• 2003

It has been suggested that oxidative stress of reactive oxygen species(ROS) may play an important role in the pathogenesis of neurological disorder. The aim of this study was to elucidate the oxidative stress of glucose oxidase(GO) in the cultured mouse spinal motor neurons and the preventing effect of Benincasae Semen(BS) on ROS-induced neurotoxicity. Cytotoxic effect of GO and protective effect of BS were performed by MTT assay. 30mU/ml GO decreased cell viability in dose-and time-dependent mannner, and BS diminished GO-induced neurotoxicity in these cultures. From above the results, ROS such as GO has toxic effect, and herb extract of BS is very effective against GO-induced neurotoxicity in cultured spinal motor neurons of neonatal mouse.

• Journal of the Korean Society for Nondestructive Testing
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• v.29 no.3
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• pp.214-218
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• 2009

The occlusal force of the tooth leads to loss of tooth tissue owing to attrition and abrasion, and may cause abfraction and pathological change of the dentin. Thus, we developed finite element models, examined them by applying ordinary occlusal force, and analyzed the stress distribution. Specimens used were mandibular first premolars from 15 Korean males and 13 females and were made into finite element models from medical images that were obtained using a Micro-CT. We have found that the irregular feature of the tooth is not only useful to masticating and pronouncing as well known, but it is also suitable for protecting inner tissue by dispersing stress and delivering proper pressure to periodontal tissue to continue a physiological action. Also, image analysis could let us know the factor that is the cause of a disorder due to stress concentration in the cervical line. These results are expected to support the field of dental treatment planning, operating procedure and clinical trial, and the advance of technical expertise to develop implants and dentures.

• Journal of Physiology & Pathology in Korean Medicine
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• v.22 no.1
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• pp.252-255
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• 2008

Phlegm-retention disease, which is called dameum(痰飮), is a kind of a pathologic secretion products, accumulated excessive water in a special part of a body. Urticaria is a common dermatopathy, coming under “eun-jin(隱疹)” in Korean herbal medicine. Headache and vertigo is a very common diseases in life. There are so many causes which induce uticaria, headache and vertigo. We experienced 31-year old woman case suffering from chronic urticaria, headache, vertigo with digestive disorder, nausea. We diagnosed those symptoms as dameum(痰飮). So we administered Jeongjeongamiyijintang-gamibang(正傳加味二陳湯加味方) to the urticaria, and Banhabaekchulcheonma-tang (半夏白朮天麻湯) to the headache, vertigo. They are both famous herbal medicines for treating dameum-related symptoms, because both of them contains Yijin-tang(二陳湯) which is the main Herbal medicine for dameum(痰飮). We suggest that dameun-related urticaria, headache, vertigo can be treated by preceding medicines.

• Journal of Physiology & Pathology in Korean Medicine
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• v.22 no.1
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• pp.246-251
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• 2008

Syringomyelia is a rare disorder that causes a cyst to form in spinal cord. This cyst, called a syrinx, can damage to the spinal cord and cause symptoms such as motor weakness, pain, sensory disturbance, etc. We experienced a case of tactile hypesthesia suspecting syringomyelia in 16 year old male patient. Syringomyelia in T2/3 level was diagnosed by magnetic resonance imaging. Hypesthesia was similar to mamokbulin in oriental medicine. And we assumed these symptoms induced by conditions called kiheo in analyzing patient's symptoms and signs. We treated the patient by acupuncture, herbal medicine improving kiheo, and other methods. In the result, the symptoms had withdrawn. This case suggested possibility to treat syringomyelia in oriental medicine, but single case is insufficient for evidence.