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Effect of Alii Macrostemi Bulbus on Cultured Mouse Osteoblasts Damaged by Reactive Oxygen Species  

Son Il Hong (School of Medicine Wonkwang University, Institute of Wonkwang Science)
Yang Hyun Woong (School of Medicine Wonkwang University)
Lee Jai Kyoo (School of Medicine Wonkwang University)
Lee Kang Chang (Department of Graduate School of Oriental Medicine, Wonkwang University)
Publication Information
Journal of Physiology & Pathology in Korean Medicine / v.17, no.3, 2003 , pp. 787-790 More about this Journal
Abstract
It has been demonstrated that oxidative stress of reactive oxygen species(ROS) may be a causative factor in the pathogenesis of bony disorder. The purpose of this study was to evaluate the oxidative stress of glucose oxidase(GO) in the cultured mouse osteoblasts and the protective effect of Alii Macrostemi Bulbus(AMB) on ROS-induced osteotoxicity. Toxic effect of GO and protective effect of AMB were carried out by colorimetric assay. 20mU/mi GO decreased cell viability dose-dependently, and AMB increased cell viability against GO-induced cytotoxicity in these cultures. From above the results. GO has toxic effect, and AMB is very effective on GO-induced osteotoxicity in cultured osteoblasts of neonatal mouse.
Keywords
Cultured osteoblast; Alii Macrostemi Bulbus; Glucose oxidase;
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