• Advances in nano research
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• 제13권3호
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• pp.217-231
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• 2022

This study investigates the geometrical impact on the nanomedicine drug delivery via nanodevices. A nanomotor made of the nanotube carrying the drug as the motor blade is considered in the blood flow. Physical activities change the blood flow, and sports training enhances the blood flow and plays a significant role in the stability of drug delivery devices. This paper studies the impact of geometrical parameters on the nanomotors carrying the nanomedicine. The effect of physical exercise on the dynamic response regarding the stability of drug delivery devices is discussed in detail.

• 한국산학기술학회논문지
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• 제17권2호
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• pp.45-57
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• 2016

본 연구에서는 중장년층을 대상으로 노후준비가 현재의 삶의 만족도에 미치는 영향요인을 파악하고자 하였다. 이를 위해 서울과 경기주변의 수도권에 거주하는 중장년층을 대상으로 설문조사를 실시하였고, 총 450부의 설문지를 회수하여 결측치가 많은 8부를 제외한 442부가 분석에 활용되었다. 연구의 결과를 요약하면 다음과 같다. 첫째, 정서적 만족도에 영향을 미치는 변수는 정서적 노후준비, 경제적 노후준비가 정서적 만족도에 긍정적인 영향을 미쳤다. 둘째, 신체적 만족도에 영향을 미치는 변수는 학력, 기술/노무직, 정서적 노후준비, 신체적 노후준비가 신체적 만족도에 긍정적인 영향을 미쳤다. 셋째, 경제적 만족도에 영향을 미치는 변수는 가계소득, 정서적 노후준비, 경제적 노후준비가 경제적 만족도에 긍정적인 영향을 미쳤다. 넷째, 사회관계 만족도에 영향을 미치는 변수는 성별, 정서적 노후준비가 사회관계 만족도에 긍정적인 영향을 미쳤다. 이러한 결과는 노년기 삶의 만족도는 노년기의 수준에서 향상되기는 매우 어렵기 때문에 중장년층 시절부터 노후준비가 잘되어 있어야 함을 시사해 주는 것이라 할 수 있다.

• 대한가정학회지
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• 제42권7호
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• pp.89-102
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• 2004

The purpose of this study is to examine the factors causing the attitudes and preparations toward retirement. Tow hundred eight employees participated in this study. The results of this study are as fellows: First, income, age, sex, self-esteem, attitudes toward job, family, and leisure affect the attitudes toward retirement. Second, income and attitudes toward leisure affect economic preparations. Third, age, attitudes toward family and leisure affect psychologic preparations. Fourth, age, self-esteem, locus of control, and attitudes toward leisure affect physical preparations.

• Journal of Ginseng Research
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• 제37권2호
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• pp.144-166
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• 2013

Actoprotectors are preparations that increase the mental performance and enhance body stability against physical loads without increasing oxygen consumption. Actoprotectors are regarded as a subclass of adaptogens that hold a significant capacity to increase physical performance. The focus of this article is studying adaptogen herbs of genus Panax (P. ginseng in particular) and their capabilities as actoprotectors. Some animal experiments and human studies about actoprotective properties of genus Panax attest that P. ginseng (administered as an extract) significantly increased the physical and intellectual work capacities, and the data provided suggests that ginseng is a natural source of actoprotectors. Preparations of ginseng can be regarded as potential actoprotectors which give way to further research of its influence on physical and mental work capacity, endurance and restoration after exhaustive physical loads while compared with reference actoprotectors.

• 응용통계연구
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• 제25권4호
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• pp.633-640
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• 2012

Biological methods are described for the assay of certain substances and preparations whose potency cannot be adequately assured by chemical or physical analysis. The principle applied through these assays is of a comparison with a standard preparation to determine how much of the examined substance produces the same biological effects as a given quantity (the Unit) of the standard preparation. In these dilution assays, to estimate the relative potencies of the unknown preparations to the standard preparations, it is necessary to compare dose-response relationships of standard and unknown preparations. The dose-response relationship in the dilution assay is non-linear and sigmoid when a wide range of doses is applied. The parallel line model (applied to the dose region with the steepest slope) is used to estimate the relative potency. In this paper, the statistical theory in the parallel line model is explained with an application to a dilution assay data. The parallel line method is implemented in a SAS program and is available at the author's homepage(http://cafe.daum.net/go.analysis).

• Biomolecules & Therapeutics
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• 제10권1호
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• pp.1-6
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• 2002

The particle size of medicinal materials is an Important physical property that affects the phar-maceutical behaviors such as dissolution, chemical stability, and bioavailability of solid dosage forms. The size reduction of raw medicinal powder is needed to formulate insoluble drugs or slightly soluble medicines and to improve the pharmaceutical properties such as the solubility, the pharmaceutical mixing, and the dispersion. The objective of the present study is to evaluate physiological activity of amorphous and nano-particle prep-arations of insoluble drug, ursodeoxycholic acid (UDCA), which were made by three types of fine grinding mills. The change of physical properties of ground UDCA was conformed by Mastersiger microplus and X-ray diffraction. We have investigated hepatoprotective effects of the nano-particle preparations of UDCA by plan-etary mill, vibration rod mill and jet mill in $CCI_4$-induced oxidatively injured mouse liver. The results showed that nano-particle preparations of UDCA all decreased reactive oxygen sepecies generation and lipid peroxi-dation in $CCI_4$-induced oxidative stress mice. Among them, nano-particle preparations by vibration rod mill and jet mill showed more significantly hepatoprotective effects compared to intact UDCA and planetary mill-ground UDCA. These results suggest that ground UDCA with vibration rod mill and jet mill shows a high amorphous state and the improved dissolution.

• Journal of Pharmaceutical Investigation
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• 제3권1_2호
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• pp.34-50
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• 1973

There are many reports on the stability of drugs in powders and tablets. The stabilities of ascorbic acid in the antacid preparations, such as calcium carbonate, magnesium carbonate, magnesium trisilicate, magnesium alumino silicate, and dried aluminum hydroxide gel under various humidities were examined. From the result of the experiment, it was assumed that the concentration of ascorbic acid, the amount of water-vapor sorption, and the physical character of the antacid ingredients were the main factors, influencing the degradation of ascorbic acid. The ascorbic acid, mixed with carbonates, such as calcium carbonate, was degradaded rapidly, while the preparation with dried aluminum hydroxide gel was slightly degraded after 10 days. A 2% ascorbic acid in the prepation was rapidly degraded than 10% ascorbic acid in the preparation.

• Biomolecules & Therapeutics
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• 제20권5호
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• pp.446-456
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• 2012

Actoprotectors are preparations that enhance body stability against physical loads without increasing oxygen consumption or heat production. Or, in short, actoprotectors are synthetic adaptogens with a significant capacity to improve physical performance. This paper explores the history of actoprotectors' development, their pharmacological properties, mechanism of action, and practical application to the improvement of mental and physical performance. A brief summary of the clinico-pharmacological characteristics of the main representatives of this class (bemitil and bromantane) is provided. Some other synthesized compounds, and even natural ones such as ginseng, also are regarded as potential actoprotectors, and these are treated herein as well. Actoprotectors, owing to their wide-ranging pharmacological activities, high efficiency and safety, can be applied under either normal or extreme conditions.

• 사회복지연구
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• 제48권4호
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• pp.157-185
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• 2017

본 연구는 지체장애인의 경제적 노후준비의 다양성과 변화성을 고려하여 시간의 경과에 따라 나타나는 경제적 노후준비의 변화궤적을 유형화하고, 그에 영향을 미치는 결정요인들의 영향력을 Andersen의 모형에 따라 검증하였다. 이를 위해 장애인고용패널 2차년도(2009)부터 8차년도(2015)까지 총 7개년의 자료를 활용하였으며, 분석에 사용된 대상자는 총 1847명이다. 장애인의 경제적 노후준비에 관한 종단적 변화유형을 파악하기 위해서는 잠재계층성장분석(LCGA)을 실시하였으며, 이후 분류된 유형에 대한 결정요인들의 영향력을 살펴보기 위해서는 다항로지스틱회귀분석을 실시하였다. 분석결과, 지체장애인의 경제적 노후준비 종단적 변화유형은 노후준비감소집단, 비노후준비지속집단, 노후준비증가집단, 노후준비유지집단으로 구분되었으며, 결정요인으로는 교육수준, 소득, 사회경제적 지위, 취업, 주택소유, 국민기초생활보장제도 수급여부, 일상생활능력정도가 각 유형의 분류에 유의미한 영향을 미치는 것으로 나타났다. 이러한 결과에 따라 지체장애인의 경제적 노후준비를 촉진할 수 있는 구체적이고 차별화된 대응방안과 실질적인 정책적 제언을 제시하였다.

• 산경연구논집
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• 제10권10호
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• pp.7-13
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• 2019

Purpose - This study is to verify the mediating effect of voluntariness in retirement and the moderating effects of leisure life to examine which parts of later life preparations have influence on the retired life. Research design, data, and methodology - In this study, the 6^th Korean Retirement and Income Study was conducted on 5,254 members of households with householders over the age of 50. To examine the relationship between later life preparation and retired life, this study used personal data based on the serial number of the household members. Results - First, physical preparation for later life had a positive influence on retired life satisfaction among retirement satisfaction. People showed higher retired life satisfaction. Secondly, physical preparation for later life had a positive influence on satisfaction over relationship after retirement among retirement satisfaction. People showed higher satisfaction over relationship after retirement when they were more physically prepared for later life. Conclusions - In particular, leisure life had a mediating effect for the influence of physical preparation for later life on the retired life. Also, leisure life and physical preparation for later life showed a close influencing relationship. People showed active leisure life and higher retired life satisfaction when they were more physically prepared for later life.