Study on the Stability of Ascorbic acid in several Antacid Preparations

분말성제제(粉末性製劑)의 안정성(安定性)에 관(關)한 연구(硏究) -수종제산제중(數種制酸劑中)의 Ascorbic acid의 안정성(安定性)에 관(關)한 연구(硏究)-

There are many reports on the stability of drugs in powders and tablets. The stabilities of ascorbic acid in the antacid preparations, such as calcium carbonate, magnesium carbonate, magnesium trisilicate, magnesium alumino silicate, and dried aluminum hydroxide gel under various humidities were examined. From the result of the experiment, it was assumed that the concentration of ascorbic acid, the amount of water-vapor sorption, and the physical character of the antacid ingredients were the main factors, influencing the degradation of ascorbic acid. The ascorbic acid, mixed with carbonates, such as calcium carbonate, was degradaded rapidly, while the preparation with dried aluminum hydroxide gel was slightly degraded after 10 days. A 2% ascorbic acid in the prepation was rapidly degraded than 10% ascorbic acid in the preparation.