• Journal of Pharmacopuncture
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• v.12 no.1
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• pp.67-76
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• 2009

Objective : Following central nervous system(CNS) injury, inhibitory influences at the site of axonal damage occur. Glial cells become reactive and form a glial scar, gliosis. Also myelin debris such as MAG inhibits axonal regeneration. Astrocyte-rich gliosis relates with up-regulation of GFAP and CD81, and eventually becomes physical and mechanical barrier to axonal regeneration. MAG is one of several endogenous axon regeneration inhibitors that limit recovery from CNS injury and disease. It was reported that molecules that block such inhibitors enhanced axon regeneration and functional recovery. Recently it was reported that treatment with anti-CD81 antibodies enhanced functional recovery in the rat with spinal cord injury. So in this current study, the author investigated the effect of the water extract of Uncariae Ramulus et Uncus on the regulation of CD81, GFAP and MAG that increase when gliosis occurs. Methods : MTT assay was performed to examine cell viability, and cell-based ELISA, western blot and PCR were used to detect the expression of CD81, GFAP and MAG. Then also immunohistochemistry was performed to confirm in vivo. Results : Water extract of Uncariae Ramulus et Uncus showed relatively high cell viability at the concentration of 0.05%, 0.1% and 0.5%. The expression of CD81, GFAP and MAG in astrocytes was decreased after the administration of Uncariae Ramulus et Uncus water extract. These results was confirmed in the brain sections following cortical stab injury by immunohistochemistry. Conclusion : The authors observed that Uncariae Ramulus et Uncus significantly down-regulates the expression of CD81, GFAP and MAG. These results suggest that Uncariae Ramulus et Uncus can be a candidate to regenerate CNS injury.

• Transactions of the Korean hydrogen and new energy society
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• v.25 no.5
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• pp.482-490
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• 2014

Gaseous sulfur compound such as $H_2S$ or COS in coal- or biomass-derived hot syngas can be purified by solid sorbents at high temperatures. In this study, we investigated the physical properties and reactivity of solid regenerable desulfurization sorbents with 37.2, 41.9, and 46.5wt% ZnO to look into the ZnO content effect. The sorbents were produced by spray-drying method to apply to a fluidized-bed process. Sulfidation and regeneration reaction were carried out using a thermogravimetric analyzer. Sorbent prepared with 46.5wt% ZnO had physical properties suitable for a fluidized-bed process applications such as spherical shape, sufficient mechanical strength and density, high porosity and surface area. It showed high sulfur sorption capacity of 10.4wt% (ZnO utilization of 57%) at reaction temperatures of 500 and $650^{\circ}C$ for sulfidation and regeneration, respectively. However, the sulfur sorption capacity and ZnO utilization were significantly reduced and dimple shape appeared when the ZnO content decreased to 37.2 and 41.9wt%. Sulfur sorption capacity and regenerability were improved as reaction temperature increased within the experimental temperatures used in this work. The reaction temperature zones of $1500{\sim}550^{\circ}C$ and $650{\sim}700^{\circ}C$ are recommended for sulfidation and regeneration, respectively, to lead best reaction performances of the ZnO-based spray-dried sorbents developed in this work.

• The Journal of Korean Physical Therapy
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• v.15 no.3
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• pp.16-44
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• 2003

Skeletal muscle regeneration is a vital process for various muscle myopathies and muscular adaptation to physiological overload. Angiogenesis is the key event in the process of muscle regeneration, and vascular endothelial growth factor(VEGF) plays an important role in it. The purpose of this study was to evaluate the effect of GaAlAs(830nm) laser and immunoreactivity of VEGF on angiogenesis after muscle contusion injury. Muscle contusion injury was induced in the triceps surae muscle by dropping a metal bead(31.4g). GaAlAs laser irradiation(power 20 mW, frequency 2000 Hz, treatment time 15 min) was applied directly to the skin of injured muscle daily for seven days. The experimental group I was irradiated immediately by laser after injury, whereas the experimental group II was irradiated after 1 day of injury. The control group was non-irradiated. The results of this study were as follows. 1. In morphological observation, there were no significant changes in experimental and control groups for 7 days. At 3 days, however, the splited muscle fibers were observed in experimental groups, and the muscle atrophy and granular tissue viewed at 7 days in control group. 2. The VEGF was expressed in muscle fiber that located in the interspace between gastrocnemius and soleus muscles. As the time coursed, the immunoreactivity of VEGF also seemed to be strong in the individual muscle fibers. 3. The experimental group I & II showed higher immunoreactivity of VEGF than control group(p<0.05). Then, the experimental group I showed higher than group II especially(p<0.05). These data suggest GaAlAs semiconduct diode laser irradiation(830nm) enhanced angiogenesis in the skeletal muscle induced contusion injury, and immediate laser irradiation after injury promoted the angiogenesis greatly than after 1 day of injury.

• Journal of Biomedical Engineering Research
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• v.44 no.1
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• pp.64-72
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• 2023

Initial burn wound care is one of the important factors in the outcome of burn treatment. In this study, we tried to develop spray-type alginate hydrogel dressing with advantages such as promoting wound healing, reducing pain, and increasing ease of use for emergency burn treatment. Spray implementation, physical properties, and cytotoxicity of the newly developed spray-type alginate hydrogel dressing were evaluated. As a result, a new functional spray-type hydrogel dressing with excellent physical properties and biocompatibility was developed along with the development of spray able containers, and it was confirmed that it could be applied as a treatment for skin regeneration in the future.

• The Journal of the Korea Contents Association
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• v.22 no.5
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• pp.110-124
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• 2022

The purpose of this study is to develop community design evaluation factors for sustainable urban regeneration and to suggest considerations for sustainable community design by analyzing excellent community design cases. Through literature review, previous studies on the concept and core items of sustainable urban regeneration, and the concept and components of community design were considered. In addition, evaluation indicators for sustainable community design were developed in the socio-economic, physical, environmental, historical and cultural dimensions through the analysis of the linkage with the evaluation factors of community design through the analysis of previous studies. The evaluation index consists of 3 evaluation items and 9 items including social performance and participation at the social level, economic feasibility at the economic level, environmental characteristics at the physical and environmental level, accessibility, contextuality, locality at the historical and cultural level, identity, and artistry. Includes dog evaluation factors. Reliability and effectiveness are secured through the developed evaluation index and detailed description and expert verification. Exploratory factor analysis and expert interviews were conducted through the survey, and as a result of the analysis, the stability and Cronbach'α coefficients were verified, and the validity of the community design evaluation index considering sustainable urban regeneration was recognized through expert interview. The results of this study are considered meaningful in that they can provide basic data for the improvement of community design for sustainable urban regeneration in the future.

• The Journal of Korean Physical Therapy
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• v.13 no.3
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• pp.791-797
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• 2001

After brain injury, patients show a wide range in the degree of recovery. By a variety of mechanisms, the human brain is constantly undergoing plastic changes. Spontaneous recovery from brain injury in the chronic stage omes about because of plasticity. The brain regions are altered. resulting in functionally modified cortical network. This review cnsidered the neural plasticity from cellular and molecular mechanisms of synapse formation to behavioural recovery from brain injury in elderly humans. The stimuli required to elicit plasticity are thought to be activity-dependent elements. especially exercise and learning. Knowledge about the physiology of brain plasticity has led to the development of methods for rehabilitation.

• KIEAE Journal
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• v.8 no.6
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• pp.71-78
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• 2008

Necessity of paradigm change has been awared in urban redevelopment especially, in housing regeneration from uniform scratch without serious consideration about resident's lives to holistic approach based on local culture and residents' participation. The purpose of this research was to identify community places recognized and attached by residents of a housing improvement district which was scheduled to be changed for improvement of the area, in near future. This research itself was considered as an resident participation technique. Group interview at a field site was carried as the main research methodology. As results, valuable places cherished by residents were identified. Most of them could be explained in relation to religious leadership, traditional cultural heritage and democratic movement. In regeneration process those places which have a strong tie with residents needs to be deliberately considered as a target to be preserved rather than demolished. The places also play a role in diffusing a livable village making movement. The result is expected to be used to make a cognitive and emotional community map of residents which is meaningfully differentiated from just a physical and geographical map. The places, place recognition activities and diffusion movement for common appreciation can be a basic foundation for residents participation in improving their housing neighborhood environment, and in creating value added strategies for the area.

• Journal of the Korean housing association
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• v.27 no.3
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• pp.47-58
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• 2016

The new paradigm of urban regeneration, would promote the comprehensive communal view. Therefore, the community role has become an important and necessary for regeneration of communities. It is necessary for urban regeneration which should be matched with the regional characteristics, to develop an evaluation framework that can objectively and accurately diagnose the status of community; so it can be an integrated prescription. A new alternative, asset-based approach may be an alternative to build the community based on opportunities and strengths, which focuses on community inside and things that community have. In this study, a community asset is defined as the tangible and intangible components in the community. A community asset evaluation system is developed through the content analysis related to previous studies of several researchers who investigated the asset-based approaches. Community assets are classified into seven types: human, social, cultural, natural, physical, economic, and political property. Each type is classified into components and establish as a framework with 3 levels in order to set the indicators which can be measured concretely.

• KIEAE Journal
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• v.14 no.3
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• pp.111-120
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• 2014

In the late 20th century, Korea has accelerated urban sprawl and demolition based redevelopment without considering local characteristics. As a result, quantitative supplement of housing has been saturated and has pushed revitalization especially. The purpose of this research is to delineate the local asset based regeneration of Gamcheon Culture Village Busan. The research methods are field visit, site observation, in-depth interview, library and internet research, data were collected and analyzed with the contents analysis techniques. As results, elements of hardware, software and humanware resources and the dynamics of the whole process such as how the resources connected and utilized, and how the external resources have been converged into these to regenerate Gamcheon Culture Village in diverse dimensions, such as cultural, social, economical and physical one were analysed. This research is expected to share the wisdom of revitalizing with collaborations. Through enhancing negative resources of decayed area to positive ones, the case produced the synergy.

• The Journal of Korean Physical Therapy
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• v.16 no.2
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• pp.63-71
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• 2004

Denervated skeletal muscle produces muscle atrophy as well as changes at the neuromuscular junction which leads to terminal axonal sprouting and an ultrastructural remodeling. NT-3 is expressed in adult muscle and motoneurons. Normally NT-3 has a potential role in regulating adult neuromuscular jungtion and recovering following muscle atrophy. Also, it could influence synaptic neurotransmission between motoneurons and skeletal muscle cells. The purpose of this study was to investigate the effect of electrical stimulation therapy(EST) on NT-3 expression in neuromuscular junction following sciatic nerve transsection in rats. After EST application during 7 days, the immunoreactivity of NT-3 was increased in neuromuscular junction