Journal of Biomedical Engineering Research (대한의용생체공학회:의공학회지)

The Korean Society of Medical and Biological Engineering (대한의용생체공학회)
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Development of Alginate-based Spray-type Hydrogel and Evaluation of Technical Compatibility for Container Application

알지네이트 기반 분사형 하이드로겔 개발 및 용기 적용에 대한 기술적합성 평가

  • 주용준 ((주)인코아) ;
  • 전희경 (한국생산기술연구원 에너지소재부품연구그룹) ;
  • 최정연 (한국생산기술연구원 첨단메카트로닉스연구그룹) ;
  • 홍경식 ((주)인코아)
  • Received : 2022.11.29
  • Accepted : 2023.02.15
  • Published : 2023.02.28
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Abstract

Initial burn wound care is one of the important factors in the outcome of burn treatment. In this study, we tried to develop spray-type alginate hydrogel dressing with advantages such as promoting wound healing, reducing pain, and increasing ease of use for emergency burn treatment. Spray implementation, physical properties, and cytotoxicity of the newly developed spray-type alginate hydrogel dressing were evaluated. As a result, a new functional spray-type hydrogel dressing with excellent physical properties and biocompatibility was developed along with the development of spray able containers, and it was confirmed that it could be applied as a treatment for skin regeneration in the future.

Keywords

Acknowledgement

본 연구는 한국생산기술연구원 지역혁신기반단기애로기술지원사업II(JF210026)와 지역특화산업육성사업(R&D, P0013693)의 지원을 받아 수행하였음.

References

  1. Demling RH. Burn injury. Acute Care. 1985;11:119-86.
  2. Tiwari VK. Burn wound: How it differs from other wounds?. Indian J Plast Surg. 2012;45(2):364-73. https://doi.org/10.4103/0970-0358.101319
  3. Madaghiele M, Demitri C, Sannino A, Ambrosio L. Polymeric hydrogels for burn wound care: Advanced skin wound dressings and regenerative templates. Burns Trauma. 2014;2:153-61. https://doi.org/10.4103/2321-3868.143616
  4. Daunton C, Kothari S, Smith L, Steele D. A history of materials and practices for wound management. Wound Pract Res. 2012;20:174-84.
  5. Coats TJ, Edwards C, Newton R, Staun E. The effect of gel burn dressings on skin temperature. Emerg Med J. 2002;19:224-25. https://doi.org/10.1136/emj.19.3.224
  6. Ashman H. Cooling of thermal burn injuries: A literature review. J Paramed Pract. 2018;10:200-04. https://doi.org/10.12968/jpar.2018.10.5.200
  7. Cuttle L, Kempf M, Liu PY, Kravchuk O, Kimble RM. The optimal duration and delay of first aid treatment for deep partial thickness burn injuries. Burns. 2010;36:673-79. https://doi.org/10.1016/j.burns.2009.08.002
  8. Goodwin NS. European Resuscitation Council 2015 burn 1st Aid recommendations concerns and issues for first responders. Burns. 2016;42:1148-50. https://doi.org/10.1016/j.burns.2016.01.033
  9. Zhao X, Wu H, Guo B, et al. Antibacterial anti-oxidant electroactive injectable hydrogel as self-healing wound dressing with hemostasis and adhesiveness for cutaneous wound healing. Biomaterials. 2017;122:34-47. https://doi.org/10.1016/j.biomaterials.2017.01.011
  10. Rongwei C, Luhang Z, Rongying O, et al. Polysaccharide-Based Hydrogels for Wound Dressing: Design Considerations and Clinical Applications. Bioeng Biotechnol. 2022; 10:845735.
  11. Liang Y, He J, Guo B. Functional Hydrogels as Wound Dressing to Enhance Wound Healing. ACS Nano. 2021;15(8):12687-722. https://doi.org/10.1021/acsnano.1c04206
  12. Dabrowska AK, Spano F, Derler S, et al. The relationship between skin function, barrier properties, and body-dependent factors. Skin Res Technol. 2018;24(2):165-74. https://doi.org/10.1111/srt.12424
  13. Martin P. Wound Healing-Aiming for Perfect Skin Regeneration. Science. 1997;276:75-81. https://doi.org/10.1126/science.276.5309.75
  14. Gurtner GC, Werner S, Barrandon Y, Longaker MT. Wound Repair and Regeneration. Nature. 2008;453(7193):314-21. https://doi.org/10.1038/nature07039
  15. Wasser SP, Weis AL. Therapeutic effects of substances occurring in higher Basidiomycetes mushrooms: a modern perspective. Crit Rev Immunol. 1999;19(1):65-96.
  16. Ohno N, Miura NN, Chiba N, Adachi Y. and Yadomae T. "Comparison of the Immunopharmacological Activities of Triple and Single-helical Schizophyllan in Mice". Biol Pharm Bull. 1995;18(9):1242-47. https://doi.org/10.1248/bpb.18.1242
  17. Kim MS, Park KM, Chang IS, Kang HH and Sim YC. "β-(1,6)-branched β-(1,3)-glucan in Skin Care". Allured's Cosmetics & Tolletries. 2000;115(7):79-86.
  18. Jacob GH, David SZ, Jennifer LR, Adam JM. Evaluating polymeric biomaterials to improve next generation wound dressing design. Biomaterials Research. 2022;26:50. https://doi.org/10.1186/s40824-022-00291-5
  19. Kim JT, Lim S, Kim BS, Lee DY, Choi JH. Fabrication and Characterization of 3-D Porous Collagen Scaffold. J Biomed Eng Res. 2014;35:192-96. https://doi.org/10.9718/JBER.2014.35.6.192
  20. Chin KB, Cordell B. The effect of tea tree oil (Melaleuca alternifolia) on wound healing using a dressing model. J Altern Complement Med. 2013;19(12):942-45. https://doi.org/10.1089/acm.2012.0787
  21. Pazyar N, Yaghoobi R, Bagherani N, Kazerouni A. A review of applications of tea tree oil in dermatology. Int J Dermatol. 2013;52(7):784-90. https://doi.org/10.1111/j.1365-4632.2012.05654.x
  22. Hhauflaire-Uhoda E, Paquet P, Pierard GE. Dew point effect of cooled hydrogel pads on human stratum conreum biosurface. Dermatology. 2008;216:37-9. https://doi.org/10.1159/000109356
  23. Soucy JR, Shirzaei Sani E, Portillo Lara R, Diaz D, Dias F, Weiss AS, Koppes AN, Koppes RA, Annabi N. Photocross-linkable Gelatin/Tropoelastin Hydrogel Adhesives for Peripheral Nerve Repair. Tissue Eng Part A. 2018;24(17-18):1393-1405. https://doi.org/10.1089/ten.tea.2017.0502
  24. Xiao S, Zhao T, Wang J, Wang C, Du J, Ying L, Lin J, Zhang C, Hu W, Wang L, Xu K. Gelatin Methacrylate (GelMA)-Based Hydrogels for Cell Transplantation: an Effective Strategy for Tissue Engineering. Stem Cell Rev Rep. 2019;15(5):664-79. https://doi.org/10.1007/s12015-019-09893-4
  25. Yue K, Trujillo-de Santiago G, Alvarez MM, Tamayol A, Annabi N, Khademhosseini A. Synthesis, properties, and biomedical applications of gelatin methacryloyl (GelMA) hydrogels. Biomaterials. 2015;73:254-71. https://doi.org/10.1016/j.biomaterials.2015.08.045
  26. Holbert MD, Kimble RM, Chatfield M, Griffin BR. Effectiveness of a hydrogel dressing as an analgesic adjunct to first aid for the treatment of acute paediatric burn injuries: A prospective randomised controlled trial. BMJ Open. 2021;11:e039981. https://doi.org/10.1136/bmjopen-2020-039981