• 대한전기학회:학술대회논문집
• /
• 대한전기학회 2005년도 제36회 하계학술대회 논문집 B
• /
• pp.960-962
• /
• 2005

In this paper, we investigated the quench characteristics of high-Tc superconducting(HTSC) elements in the integrated three-phase flux-lock type superconducting fault current limiter(SFCL) according to fault types such as the single-line-to-ground fault, the double-line-to-ground fault, the line-to-line fault and the triple-line-to-ground fault. The integrated three-phase flux-lock type SFCL is an upgrade version of single-phase flux-lock type SFCL. The structure of the integrated three-phase flux-lock type SFCL consisted of a three-phase flux-lock reactor wound on an iron core with the ratio of the same turn between coil 1 and coil 2 in each phase. When the SFCL is under the normal condition, the flux generated in the iron core is zero because the flux generated between two coils of each single phase is canceled out. Therefore, the SFCL's impedance is zero, and the SFCL has negligible influence on the power system. However, if a fault occurs in any single one of three phases, the flux generated in the iron core is not zero any more. The flux makes HTSC elements of all phases to quench irrespective of the fault type, which reduces the current in fault phase as well as the current of sound phase. It was obtained that the fault current limiting characteristics of the suggested SFCL were dependent on the quench characteristics of HTSC elements in all three phases.

• 방송공학회논문지
• /
• 제27권6호
• /
• pp.848-859
• /
• 2022

본 논문은 일반적으로 사용되는 2D 디스플레이 또는 HMD (Head-Mounted Display) 기반 VR (Virtual Reality, VR) 서비스에서 탈피하여, 대형 가상현실 공연장을 위한 360도 비디오 스트리밍 시스템을 제안한다. 제안된 시스템은 Phase 1, 2, 3의 연구개발 단계를 밟아 6DoF (Degrees of Freedom) 시점 자유도를 지원하는 360도 비디오 스트리밍 시스템을 개발하는 것을 최종목표로 하고 있으며, 현재는 Phase 1: 대형 가상현실 공연장을 위한 3DoF 360도 비디오 스트리밍 시스템 프로토타입의 개발까지 완료되었다. 구현된 스트리밍 시스템 프로토타입은 서브픽처 기반 Viewport-dependent 스트리밍 기술이 적용되어 있으며, 기존 방식과 비교하였을 때 약 80%의 비트율 감소, 약 543%의 영상 디코딩 속도 향상을 확인하였다. 또한, 단순 구현 및 성능평가에서 그치지 않고, 실제 미국 UCSB (University of California, Santa Barbara)에 위치한 대형 가상현실 공연장 AlloSphere에서의 시범방송을 수행하여, 향후 Phase 2, 3 연구단계를 위한 연구적 기반을 마련하였다.

• 동의생리병리학회지
• /
• 제17권1호
• /
• pp.183-189
• /
• 2003

Platycodi Radix, the root of Platycodon grandiflorum, commonly known as Doraji, is used as a traditional oriental medicine. Extracts from the roots of P. grandiflorum have been reported to have wide ranging health benefits. We investigated the effects of an aqueous extract from the roots of P. grandiflorum (AEPG) on the cell proliferation of human lung carcinoma A549 cells in order to understand its anti-proliferative mechanism. AEPG treatment resulted in the inhibition of cell proliferation in a concentration-dependent manner. This anti-proliferative effect of A549 cells by AEPG treatment was associated with morphological changes such as membrane shrinking, cell rounding up and inhibition of cell migration. DNA flow cytometric histograms showed that populations of both Sand G2/M phase of the cell cycle were increased by AEPG treatment in a concentration-dependent manner. AEPG treatment induced a marked accumulation of tumor suppressor p53 and a concomitant induction of cyclin-dependent kinase (Cdk) inhibitor p21 and p27. In addition, SSS treatment resulted in down-regulation of Cdk2 and Cdk4 expression. The present results indicated that AEPG-induced inhibition of lung cancer cell proliferation is associated with the blockage of S to G2/M phase progression the induction of apoptosis. Taken together, these findings suggest that P. grandiflorum has strong potential for development as an agent for prevention against human lung cancer.

• 동의생리병리학회지
• /
• 제18권4호
• /
• pp.1186-1191
• /
• 2004

The root of Saussurea lappa includes sesquiterpene lactones such as costunolide and dehydrocostus lactone, and has been shown to be anti-tumorigenic with being used in traditional medicinal therapy in the Eastern Asia. However, the molecular basis of the effects of Saussurea lappa on fate of gastric carcinoma, which incur very frequently in the area, has not been well identified. In this study, the cytostatic effects of Saussurea lappa were examined using gastric AGS cancer cells. Cell viability was dramatically reduced by Saussurea lappa, in a dose-dependent manner. As time passed after its treatment, apoptotic population was increased and clearly showed G2-arrest. Being consistent, its treatment resulted in maintaining of G1 and S-phase cyclins D1, E, and A even until a significant apoptotic population was observed, for example, at 24h after treatment. However, G2/M phase cyclin B1 was reduced even at 12 h after treatment. In addition, its treatment increased expression of p53, p21/sup Wafl / cyclin dependent kinase inhibitor (CKI), and Bax, resulted in cleavages of procaspase 3 and poly ADP-ribose polymerase(PARP), indicating that such G2 arrest- and apoptosis-related molecules are involved. Therefore, these suggest that extracts of Saussurea lappa root may be a safer and effective reagent to deal with gastric cancers either by traditional herbal therapy or combinational therapy with conventional chemotherapy.

• 대한한방부인과학회지
• /
• 제28권2호
• /
• pp.26-39
• /
• 2015

Objectives : Dendropanax morbifera is known as a tree that has been used in traditional medicine for various diseases. However, its biological activities in cancer have not yet been clearly elucidated. In this study, we investigated the anti-cancer effects of water extract of Dendropanax morbifera (DP) on 2 human breast cancer cell lines (estrogen dependent MCF-7 and estrogen independent MDA-MB-231). Methods : The MTT assay and flow cytometry were used to assess cell proliferation, along with cell cycle analysis. Nitric oxide production was detected by Griess assay. The expression of apoptosis related gene was assessed by quantitative real-time PCR. Results : Our data revealed that DP inhibits the cell growth in a dose dependent manner (0, 50, 100, 250, and 500 μg/ml) of both estrogen independent MDA-MB-231 and estrogen dependent MCF-7 breast cancer cells. Also, LPS induced nitric oxide production was significantly reduced by DP. Cell cycle analysis showed an increased G1 phase in the MCF-7 cell and G2/M phase in the MDA-MB-231 cell. DP decreased mRNA expression of apoptotic suppressor gene Bcl-xL, and increased mRNA expression of pro-apoptotic genes. DP increased mRNA expression of p21, and Rip1 in both cell. And DP decreased mRNA expression of survivin in the MCF-7 cell. Conclusions : Taken together, these results indicate that DP extract are source of anti-cancer potential and could be developed botanical drug.

• 한국연초학회지
• /
• 제32권1호
• /
• pp.19-27
• /
• 2010

The aim of this study is to compare the sensitivity of both two NCI-H292 and A549 cell types to acute inflammatory responses induced by cigarette smoke. For this, we treated two kinds of smoke fractions derived from 2R4F reference cigarettes: total particulate matter(TPM) collected onto a Cambridge filter pad and gas/vapor phase(GVP) prepared by bubbling through in buffer solution. When we measured cellular cytotoxicity by neutral red uptake assay after treatment for 24 hours, TPM and GVP induced cytotoxic effect in a dose-dependent manner in the range of 10-$100{\mu}g$/mL and 60-$300 {\mu}g$/mL., respectively, in both cell types without any cellular difference. Additionally, when we examined acute inflammatory responses by analyzing cytokines secreted into culture media including tumor necrosis factor-$\alpha$ (TNF-$\alpha$), interleukin-8(IL-8), and transforming growth factor-$\alpha$(TGF-$\alpha$) as well as matrix metalloproteinase-1(MMP-1), the treatment with smoke fractions increased those marker proteins in a dose-dependent manner in NCI-H292. Meanwhile, in A549 cells only MMP-1 was observed to be increased in a dose-dependent fashion. Collectively, our data indicate that NCI-H292 cell type is more sensitive to cigarette smoke-induced inflammatory response than A549 cells. This suggests that NCI-H292 could be useful as an in vitro evaluation tool to assess harmful effects of cigarette smoke.

• Korean Journal of Acupuncture
• /
• 제33권4호
• /
• pp.194-203
• /
• 2016

Objectives : The aim of this study was to observe the dose-dependent effects of bee venom (BV) pharmacopuncture on the serious ankle sprain in rats. Methods : The grade III ankle sprain was produced by surgically damaging the lateral ligaments complex of Sprague-Dawley rats. BV pharmacopuncture with the different doses($5{\mu}g/kg$, $10{\mu}g/kg$, $50{\mu}g/kg$) were treated on the different acupoints(GB34, GB39 and GB42) of the affected hind limb, respectively. By measuring foot weight bearing force ratio(FWBFR), the pain levels by ankle sprain and the pain recovery for 7 days were observed under BV pharmacopuncture on each acupoint. Results : In the normal and ankle sprained rat, the BV single administration decreased FWBFR in a dose - dependent pattern. The higher the BV dose, the higher the pain resulted in the normal and the sprained ankles. Especially, the dose - dependent effects of BV resulted in the most pronounced decrease in FWBFR in GB34. The recovery of FWBFR was shown at the low dose($5{\mu}g/kg$) BV and the effect was most remarkable in the BV of GB34, but the others showed no recovery effect compared with the control group. Conclusions : BV pharmacopuncture does not exhibit analgesic effects in acute phase of ankle sprain. However, the recovery of ankle sprain was more effective than the natural recovery in the case of low dose of BV repeated over time. Considering this, it is presumed that it would be important to select appropriate clinic guidelines for acute phase of ankle sprain.

• Journal of Magnetics
• /
• 제13권3호
• /
• pp.110-113
• /
• 2008

In this study, heavy rare earth garnet $Tb_2Bi_1Ga_1Fe_4O_{12}$ powders were fabricated by a sol-gel and vacuum annealing process. The crystal structure was found to be single-phase garnet with a space group of Ia3d. The lattice constant $a_0$ was determined to be 12.465 ${\AA}$. From the analysis of the vibrating sample magnetometer (VSM) hysteresis loop at room temperature, the saturation magnetization and coercivity of the sample are 7.64 emu/g and 229 Oe, respectively. The N$\acute{e}$el temperature($T_N$) was determined to be 525 K. The M$\ddot{o}$ssbauer spectrum of $Tb_2Bi_1Ga_1Fe_4O_{12}$ at room temperature consists of 2 sets of 6 Lorentzians, which is the pattern of single-phase garnet. From the results of the M$\ddot{o}$ssbauer spectrum at room temperature, the absorption area ratios of Fe ions on 24d and 16a sites are 74.7% and 25.3%(approximately 3:1), respectively. These results show that all of the non-magnetic Ga atoms occupy the 16a site by a vacuum annealing process. Absorption area ratios of Fe ions are dependent not only on a sintering condition but also on the temperature of the sample. It can then be interpreted that the Ga ion distribution is dependent on the temperature of the sample. The M$\ddot{o}$ssbauer measurement was carried out in order to investigate the atomic migration in $Tb_2Bi_1Ga_1Fe_4O_{12}$.

• 조명전기설비학회논문지
• /
• 제22권8호
• /
• pp.109-115
• /
• 2008

현재 우리나라의 접지시스템의 설계기준은 낮은 주파수에서 측정된 저항값을 기반으로 한다. 고주파 성분을 포함하는 뇌서지가 접지시스템에 인가되면, 접지임피던스는 정상상태의 저항과 매우 다르게 된다. 이 논문은 접지시스템의 고주파 성능에 대한 물의 저항률의 영향을 파악하기 위하여 대지를 모의하는 수조를 이용하여 물의 저항률에 따른 어드미턴스의 주파수 의존성을 기술하였다. 500[${\Omega}{\cdot}m$] 이상의 높은 물의 저항률에서 용량성 효과에 의해 주파수가 증가함에 따라 어드미턴스와 컨덕턴스가 증가하는 것으로 나타났다. 반면에, 500[${\Omega}{\cdot}m$] 미만의 낮은 저항률에서는 유도성 효과에 의해 주파수가 증가함에 따라 어드미턴스와 컨덕턴스가 감소하는 것으로 나타났다. 또한 200[kHz]에서 5[MHz]에 이르는 주파수 범위에서 전류와 전압의 위상차가 증가하는 것으로 나타났다. 결론적으로, 접지시스템의 주파수 의존성은 대지의 저항률과 밀접한 관계가 있으며, 주파수와 대지저항률이 접지시스템의 성능에 미치는 영향에 대한 고려가 필요하다.

• 전력전자학회논문지
• /
• 제17권3호
• /
• pp.238-245
• /
• 2012

This paper presents a sensorless speed control of a 2-phase switch reluctance motor(SRM). The proposed sensorless control scheme is based on the slide mode observer with parameter compensator to improve the estimation performance. In the stand still position, the initial rotor position is determined by pulse current responses of each phase windings and the current difference. In order to determine an accurate initial rotor position, the two initial rotor positions are estimated by the difference of the pulse currents. From the stand still to the operating region, a simple open loop control which determines the commutation sequence by the pulse current of the unexcited phase winding is used. When the motor speed is reached to the sensorless control region, the estimated rotor position and speed by the slide mode observer are used to control the SRM. The flux calculator used in the slide mode observer is designed by phase voltage and the voltage drops in the phase resistance of the winding. The accuracy of the flux calculator is dependent on the phase resistance. For the continuous update of the phase resistance, current gradient at the inductance break point is used in this paper. The error of the estimated rotor position at the current gradient position is used to update the phase resistance to improve the sensorless scheme. The proposed sensorless speed control scheme is verified with a practical compressor used in home appliances. And the results show the effectiveness of the proposed control scheme.