• Journal of the Korean Applied Science and Technology
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• v.37 no.6
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• pp.1738-1751
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• 2020

The skin is divided into three parts: the epidermis, the dermis, and the subcutaneous fat, and the stratum corneum, which is located at the top of the epidermis, acts as a barrier that prevents drug delivery. Nanoemulsions are known to be effective in transdermal delivery of drugs through intercellular lipids because of their unique small particle size. In this study, phase inversion temperature (PIT) nanoemulsion containing α-bisabolol was optimized using response surface methodology (RSM) for effective skin absorption of α-bisabolol. As a preliminary experiment, the 25-2 fractional factorial design method and the 23 full factorial design method were performed. Box-Behnken design was performed based on the results of the factorial design method. The content of surfactant (6.3~12.6%), co-surfactant (5.2~7.8%) and α-bisabolol (0.5~5.0%) were used as factors, and the dependent variable was the particle size of the nanoemulsion. PIT nanoemulsion optimization was performed according to the RSM results, and as a result, the optimal nanoemulsion formulation conditions were predicted to be 10.4% surfactant content, 6.3% co-surfactant content, and 5.0% α-bisabolol content. As a result of the skin absorption test, the final skin absorption rate of the PIT nanoemulsion was 35.11±1.01%, and the final skin absorption rate of the general emulsion as a control was 28.25±1.69%, confirming that the skin absorption rate of the PIT nanoemulsion was better.

• Proceedings of the Membrane Society of Korea Conference
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• 2004.11a
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• pp.135-138
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• 2004

• Proceedings of the Korean Fiber Society Conference
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• 1998.10a
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• pp.469-472
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• 1998

상업적으로 유용한 대부분의 합성고분자막들은 상전환법(phase inversion process)이라는 방법에 의해서 제조된다. 이 제조공정에서는 단일 고분자(homogeneous polymer)용액에 존재하는 용매를 비용매와 교환함으로써 액체로부터 고체로 상이 전환된다. 그리고 pore의 크기나 pore의 크기분포와 같은 막의 구조를 결정하는 요인은 일반적으로 용질의 입자크기 또는 분자크기 및 화학적 성질에 기인한다[1-3]. (중략)

• Proceedings of the SCSK Conference
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• 2003.09b
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• pp.392-404
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• 2003

A new technology to achieve o/w microemulsions allows the formulation of transparent products with low surfactant content. The PIT Nanotechnology approach gives cosmetic/pharmaceutical o/w microemulsions in one step with a broad variety of surfactants, cosurfactants and oil phases.

• Proceedings of the Membrane Society of Korea Conference
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• 2005.11a
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• pp.87-91
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• 2005

• Proceedings of the Membrane Society of Korea Conference
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• 2005.11a
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• pp.92-95
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• 2005

• Proceedings of the Membrane Society of Korea Conference
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• 1998.10a
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• pp.91-92
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• 1998

1. 서론 : 고분자를 소재로 하는 중공사막의 제막은 일반적으로 상전환법(phase inversion method)에 의하여 제조된다. 이 방법에 의한 비대칭막의 생성은 용매가 고분자용액을 빠져나가는 속도와 응결액이 고분자쪽으로 침투되는 속도의 차이에 의해서 막의 1차구조가 형성된다. 그러므로 이 속도를 첨가제 등을 사용하여 조절하므로서 막의 특성을 변화시킬 수 있다. 본 연구에서는 polyetherimide(PEI) 중공사막의 첨가제로서 dioxane 등 9종류를 사용하여 중공사막의 생성 구조에 미치는 영향을 검토하였다.

• Journal of the Korean earth science society
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• v.28 no.7
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• pp.903-913
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• 2007

In this study, the researchers compared the S-wave velocity structures obtained by two kinds of dispersion curves: phase and group dispersions from a tidal flat located in the SW coast of the Korean peninsula. The ${\tau}-p$ stacking method was used for the phase velocity and two different methods (multiple filtering technique: MFT and continuous wavelet transform: CWT) for the phase velocity. It was difficult to separate higher modes from the fundamental mode phase velocities using the ${\tau}-p$ method, whereas the separation of different modes of group velocity were easily achieved by both MFT and CWT. Of the two methods, CWT was found to be more efficient than MFT. The spatial resolutions for the inversion results of the fundamental mode for both phase and group velocities were good for only a very shallow depth of ${\sim}1.5m$. On the other hand, the spatial resolutions were good up to ${\sim}4m$ when both the fundamental and the 1st higher mode poop velocities obtained by CWT were used for S-wave inversion. This implies that the 1st higher mode Rayleigh waves contain more information on the S-wave velocity in deeper subsurface. The researchers applied the CWT method to obtain the fundamental and the 1st higher mode poop velocities of the S-wave velocity structure of a tidal flat located in SW coast of the Korean peninsula. Thea the S-wave velocity structures were compared with the borehole description of the study area.

• Transactions of the Korean Society of Mechanical Engineers
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• v.18 no.5
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• pp.1192-1202
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• 1994

Fatigue behavior and life prediction were presented for thermal-mechanical and isothermal low cycle fatigue of 12Cr forged steel used for high temperature applications. In-phase and out-of-phase thermal-mechanical fatigue test at 350 to 600.deg. C and isothermal low cycle fatigue test at 600.deg. C were conducted using smooth cylindrical hollow specimen under strain-control with total strain ranges from 0.006 to 0.015. Cyclic softening behavior was observed regardless of thermal-mechanical and isothermal fatigue tests. The phase difference between temperature and strain in thermal-mechanical fatigue resulted in significantly shorter fatigue life for out-of-phase than for in-phase. The difference in fatigue lives was dependent upon the magnitudes of inelastic strain ranges and mean stresses. Increase in inelastic strain range showed a tendency of intergranular cracking and decrease in fatigue life, especially for out-of-phase thermal-mechanical fatigue. Thermal-mechanical fatigue life prediction was made by partitioning the strain ranges of the hysteresis loops and the results of isothermal low cycle fatigue tests which were performed under the combination of slow and fast strain rates. Predicted fatigue lives for out-of-phase using the strain range partitioning method showed an excellent agreement with the actual out-of-phase thermal-mechanical fatigue lives within a factor of 1.5. Conventional strain range partitioning method exhibited a poor accuracy in the prediction of in-phase thermal-mechanical fatigue lives, which was quite improved conservatively by a proposed strain range partitioning method.

• Journal of Advanced Navigation Technology
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• v.20 no.2
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• pp.161-166
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• 2016

In high capacity and long haul optical communication systems, signal distortion is induced by chromatic dispersion and nonlinear effects of optical fibers. Dispersion management (DM) combining with mid-spans spectral inversion (MSSI) is one of the various techniques for overcoming this drawback. The most simple configuration of DM link is obtained by uniformly distributing the lengths of single mode fiber (SMF) and residual dispersion per span (RDPS) over whole fiber spans consisted of optical link. In this paper, the system performances in the uniformly distributed DM link combined with MSSI are assessed as a function of the number of fiber spans, because the system performances in this configuration are used as the significant performance criterion in other link configurations, such as the artificial distribution or the random distribution of SMF lengths and RDPS.