Browse > Article
http://dx.doi.org/10.12925/jkocs.2020.37.6.1738

Study on Optimization and Skin Permeation of PIT Nanoemulsion Containing α-Bisabolol  

Kim, HuiJu (Department of Chemistry and Cosmetics, College of Natural Sciences Jeju National University)
Yoon, Kyung-Sup (Department of Chemistry and Cosmetics, College of Natural Sciences Jeju National University)
Publication Information
Journal of the Korean Applied Science and Technology / v.37, no.6, 2020 , pp. 1738-1751 More about this Journal
Abstract
The skin is divided into three parts: the epidermis, the dermis, and the subcutaneous fat, and the stratum corneum, which is located at the top of the epidermis, acts as a barrier that prevents drug delivery. Nanoemulsions are known to be effective in transdermal delivery of drugs through intercellular lipids because of their unique small particle size. In this study, phase inversion temperature (PIT) nanoemulsion containing α-bisabolol was optimized using response surface methodology (RSM) for effective skin absorption of α-bisabolol. As a preliminary experiment, the 25-2 fractional factorial design method and the 23 full factorial design method were performed. Box-Behnken design was performed based on the results of the factorial design method. The content of surfactant (6.3~12.6%), co-surfactant (5.2~7.8%) and α-bisabolol (0.5~5.0%) were used as factors, and the dependent variable was the particle size of the nanoemulsion. PIT nanoemulsion optimization was performed according to the RSM results, and as a result, the optimal nanoemulsion formulation conditions were predicted to be 10.4% surfactant content, 6.3% co-surfactant content, and 5.0% α-bisabolol content. As a result of the skin absorption test, the final skin absorption rate of the PIT nanoemulsion was 35.11±1.01%, and the final skin absorption rate of the general emulsion as a control was 28.25±1.69%, confirming that the skin absorption rate of the PIT nanoemulsion was better.
Keywords
Nanoemulsion; ${\alpha}$-Bisabolol; Skin absorption; Response Surface Methodology; Phase Inversion Temperature;
Citations & Related Records
Times Cited By KSCI : 2  (Citation Analysis)
연도 인용수 순위
1 S. B. Han, S. S. Kwon, Y. M. Jeong, B. J. Kong, E. R. Yu, S. N. Park, "Physical Characterizations and In vitro skin permeation of elastic liposomes for transdermal delivery of polygonum aviculare L. extract", Polymer (Korea), Vol.38 No.6, pp. 694-701, (2014).   DOI
2 S. K. Ahn, S. M. Hwang, E. H. Choi, W. S. Lee, "Morphologic characteristics of skin barrier and stratum corneum", The Journal of Skin Barrier Research, Vol.1, No.1, pp. 22-28, (1999).
3 G. Y. Noh, J. Y. Suh, S. N. Park, "Ceramide-based nanostructured lipid carriers for transdermal delivery of isoliquiritigenin: Development, physico-chemical characterization, and in vitro skin permeation studies", Korean Journal of Chemical Engineering, Vol.34, No.2, pp. 400-406, (2017).   DOI
4 S. P. Hong, "Bricks and mortar: Two compartment system", The Journal of Skin Barrier Research, Vol.12, No.1, pp. 35-40, (2010).
5 P. huesiang, U. Siripatrawan, R. Sanguandeekul, L. McLandsborough, D. J. McClements, "Optimization of cinnamon oil nanoemulsions using phase inversion temperature method: Impact of oil phase composition and surfactant concentration", Journal of Colloid and Interface Science, Vol.514, No.5, pp. 208-216, (2018).   DOI
6 Y. Chang, D. J. McClements, "Optimization of orange oil nanoemulsion formation by isothermal low-energy methods: influence of the oil phase, surfactant, and temperature", Journal of Agricultural and Food Chemistry, Vol.62, No.10, pp. 2306-2312, (2014).   DOI
7 Z. Jeirani, B. Mohamed Jan, B. Si Ali, I. Mohd Noor, S. Chun Hwa, W. Saphanuchart, "Prediction of phase-inversion temperature of a triglyceride microemulsion using design of experiments", Industrial and Engineering Chemistry Research, Vol.52, No.2, pp. 744-750, (2013).   DOI
8 J. Rao, D. J. McClements, "Stabilization of phase inversion temperature nanoemulsions by surfactant displacement", Journal of Agricultural and Food Chemistry, Vol.58, No.11, pp. 7059-7066, (2010).   DOI
9 R. Kadir, B. W. Barry, "α-Bisabolol, a possible safe penetration enhancer for dermal and transdermal therapeutics", International Journal of Pharmaceutics, Vol.70, No.1-2, pp. 87-94, (1991).   DOI
10 N. F. M. Rocha, E. R. V. Rios, A. M. R. Carvalho, G. S. Cerqueira, A. de Araujo Lopes, L. K. A. M. Leal, M. L. Dias, D. P. de Sousa, F. C. F. de Sousa, "Anti-nociceptive and anti-inflammatory activities of (-)-α-Bisabolol in rodents", Naunyn-Schmiedeberg's Archives of Pharmacology, Vol.384, No.6, pp. 525-533, (2011).   DOI
11 I. M. Yang, G. T. Oh, C. B. Yu, I. G. Hwang, "Design and analysis of experiments", Minyoungsa, pp. 83-264, (2015).
12 Y. B. Lim, S. H. Park, B. J. An, Y. I. Kim, "Practical design of experiments", Freeacademy, pp. 224-247, (2008).
13 C. H. Sim, "Optimization of process variables for insulation coating of conductive particles by response surface methodology", Korean Chemical Engineering Research, Vol.54, No.1, pp. 44-51, (2016).   DOI
14 S. Kim, D. H. Kwon, D. H. Lim, G. S. Kim, C. Y. Kang, "In vitro dtudy of transdermal delivery system for caffein in slim patch type" Journal of Korean Pharmaceutical Sciences, Vol.36, No.2, pp. 97-102, (2006).
15 L. Quanhong, F. Caili, "Application of response surface methodology for extraction optimization of germinant pumpkin seeds protein", Food Chemistry, Vol.92, No.4, pp. 701-706, (2005).   DOI