• Journal of the Korean Data and Information Science Society
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• v.15 no.4
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• pp.973-980
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• 2004

Phase I clinical trials are often pharmacologically oriented and usually attempt to find the best dose of drug to employ. However, other purposes like determination of sizes and types of side effects and toxicity and organ system involved are equally important. Estimation of treatment effects or side effects is usually ignored since it is usually based on too small sample, even though Phase II clinical trials would be designed based on the Phase I studies. Statistical methods for constructing the approximate confidence interval for population median in case of small sample are considered and an improved method is proposed. The proposed estimator is compared with current methods through simulation studies.

• Journal of the Mineralogical Society of Korea
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• v.23 no.3
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• pp.267-272
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• 2010

High pressure x-ray diffraction patterns of ${\alpha}$-cristobalite gallium phosphate ($GaPO_4$) were acquired up to 8.9 GPa at room temperature using Mao-Bell type diamond anvil cell with high flux synchrotron radiation. Starting orthorhombic phase (phase-I) shows the splitting of peak which is possibly resulted from the pressure induced orientation disorder of the framework structure of tetrahedra. This is designated as phase-I'. This phase transforms to the orthorhombic high pressure phase-III between 2 and 3 GPa. Present phase transition sequence is not in accord with the recent high pressure X-ray diffraction results performed on the same starting sample (Ming et al., 2007). X-ray pattern of the unloaded sample to ambient pressure shows that the structure retains that of the high pressure phase prior to decompression.

• Communications for Statistical Applications and Methods
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• v.27 no.1
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• pp.65-77
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• 2020

Geometric charts are effective in monitoring the fraction nonconforming in high-quality processes. The in-control fraction nonconforming is unknown in most actual processes; therefore, it should be estimated using the Phase I sample. However, if the Phase I sample size is small the practitioner may not achieve the desired in-control performance because estimation errors can occur when the parameters are estimated. Therefore, in this paper, we adjust the control limits of geometric charts with the bootstrap algorithm to improve the in-control performance of charts with smaller sample sizes. The simulation results show that the adjustment with the bootstrap algorithm improves the in-control performance of geometric charts by controlling the probability that the in-control average run length has a value greater than the desired one. The out-of-control performance of geometric charts with adjusted limits is also discussed.

• Journal of the Korean Applied Science and Technology
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• v.10 no.2
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• pp.11-18
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• 1993

Contents of vitamin $D_3$ and 25-OH-vitamin $D_3$ in marine animal products(20 species) were determined by HPLC. The isomers of vitamin D, $D_2$ and $D_3$, were not clearly separated on a reversed phase, ${\mu}$ Bonda Pak, with 20% methanol-acetonitrile, and on a normal phase, Zorbax SIL. with 0.4% isopropanol-hexane, but 25-OH-vitamin $D_2$ and-$D_3$ were separated on either ${\mu}$ Bonda Pak with 10% methanol-acetonitrile, or on Zorbax SIL with 2.2% isopropanol-hexane, respectively. Although levels of vitamin $D_3$ and 25-OH-vitamin $D_3$ varied remarkably according to species, their average value(fish : $l,l87{sim}36,007$ I.U/sample 100g, mussel : $58{\sim}1,706$ I.U/sample 100g, pickle: $1,208{\sim}79,358$ I.U/sample 100g) was greatly higher than that of meat($80{\sim}100$ I.U/sample 100g) and dairy products($400{\sim}800$ I.U/sample 100g). Fatty tissues of fish and pickled fish intestines contained high level of vitamin $D_3$ and 25-OH-vitamin $D_3$, while the clam and mussel known to have various kinds of sterol including ${\Delta}^7$-sterol showed very low levels of vitamin $D_3$ and its derivative.

• Bulletin of the Korean Chemical Society
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• v.34 no.11
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• pp.3444-3450
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• 2013

Three phase hollow fiber-liquid phase microextraction (HF-LPME), which is faster, simpler and uses a more environmentally friendly sample-preparation technique, was developed for the analysis of Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) in human urine. For the effective simultaneous extraction/concentration of NSAIDs by three phase HF-LPME, parameters (such as extraction organic solvent, pH of donor/acceptor phase, stirring speed, salting-out effect, sample temperature, and extraction time) which influence the extraction efficiency were optimized. NSAIDs were extracted and concentrated from 4 mL of aqueous solution at pH 3 (donor phase) into dihexyl ether immobilized in the wall pores of a porous hollow fiber, and then extracted into the acceptor phase at pH 13 located in the lumen of the hollow fiber. After the extraction, 5 ${\mu}L$ of the acceptor phase was directly injected into the HPLC/UV system. Simultaneous chromatographic separation of seven NSAIDs was achieved on an Eclipse XDB-C18 (4.6 mm i.d. ${\times}$ 150 mm length, 5 ${\mu}m$ particle size) column using isocratic elution with 0.1% formic acid and methanol (30:70) at a HPLC-UV/Vis system. Under optimized conditions (extraction solvent, dihexyl ether; $pH_{donor}$, 3; $pH_{acceptor}$, 13; stirring speed, 1500 rpm; NaCl salt, 10%; sample temperature, $60^{\circ}C$; and extraction time, 45 min), enrichment factors (EF) were between 59 and 260. The limit of detection (LOD) and limit of quantitation (LOQ) in the spiked urine matrix were in the concentration range of 5-15 ng/mL and 15-45 ng/mL, respectively. The relative recovery and precision obtained were between 58 and 136% and below 15.7% RSD, respectively. The calibration curve was linear within the range of 0.015-0.96 ng/mL with the square of the correlation coefficient being more than 0.997. The established method can be used to analyse of NSAIDs of low concentration (ng/mL) in urine.

• Proceedings of the Korean Institute of Electrical and Electronic Material Engineers Conference
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• 2003.05e
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• pp.85-88
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• 2003

In this study, porcelain insulator samples which have a different alumina composition were manufactured in order to test electrical and mechanical properties and make an analysis of the propagation phenomena of micro cracks on porcelain body. From XRD quantitative analysis the crystalline phases were different with alumina composition, sample C and D which have about 17wt% Corundum phase without the Cristobalite phase shows better electrical and mechanical properties than sample A and 8 which have the Cristobalite phase. In dielectrics test on porcelain samples with below 17wt% alumina composition, it was found that the amount of glass phase$(SiO_2)$have an main effect to decrease the dielectric loss$(tan{\delta})$, and the dielectric breakdown voltage of aluminous porcelain insulators was largely affected by its relative density. As a micro cracks analysis, HRS were measured, then the intensity of HRS increased with the amount of alumina composition. On the other hand, the propagation behaviors of cracks was fairly influenced by the distribution of pores.

• Korean Journal of Adult Nursing
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• v.20 no.1
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• pp.1-9
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• 2008

Purposes: This study examined uncertainty and nursing need according to illness phases(phase I, II, III) in cancer patients, and investigated relationships between uncertainty and nursing need. Methods: A cross-sectional descriptive study was conducted with a sample of 121 adult cancer patients treated in two hospitals. Results: As for the total score, the uncertainty was not significantly different across the subgroups by illness phase. As for the subscale score, however, two sub-scales of the uncertainty were different across the subgroups. 'The unpredictability' was highest in illness phase I and II groups, while 'the lack of information' was highest in the illness phase III group. Nursing need as the total score was not significantly different across the subgroups by illness phase. However, all subscale scores of the nursing need were significantly different across the subgroups. Educational need was highest in the illness phase I group; physical and emotional needs were highest in the illness phase III group. Uncertainty and nursing need were not related to each other at any illness phase. Conclusion: The results suggest that nursing need and uncertainty may change across illness phases. Clinicians need to consider this pattern in caring for cancer patients.

• The Korean Journal of Applied Statistics
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• v.33 no.4
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• pp.451-466
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• 2020

CCC-r chart is effective for high-quality processes with a very low fraction nonconforming. The values of process parameters should be estimated from the Phase I sample since they are often not known. However, if the Phase I sample size is not sufficiently large, an estimation error may occur when the parameter is estimated and the practitioner may not achieve the desired in-control performance. Therefore, we adjust the control limits of CCC-r charts using the bootstrap algorithm to improve the in-control performance of charts with smaller sample sizes. The simulation results show that the adjustment with the bootstrap algorithm improves the in-control performance of CCC-r charts by controlling the probability that the in-control average number of observations to signal (ANOS) has a value greater than the desired one.

• Journal of Advanced Navigation Technology
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• v.9 no.2
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• pp.140-146
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• 2005

In this paper, we proposed the frequency offset compensation algorithm and tracking algorithm which could improve the accumulated phase error for HDR-WPAN system. The proposed frequency offset compensation technique estimated each sample phase error by autocorrelation characteristics of CAZAC sequence, estimated phase error multiple each sample in a symbol, and finally compensated for the frequency offset. After frequency offset compensation using two steps, coarse and fine frequency offset, tracking algorithm have to use to compensate for the accumulated phase error. Because there is no pilot symbol in payload, more phase rotation occurred in received signal constellations due to the accumulated phase error as the payload length increase. Tracking algorithm compensates for a cumulative phase error ${\theta}$ between payload data.

• Mass Spectrometry Letters
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• v.2 no.1
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• pp.12-15
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• 2011

The Korean government has regulated emission of polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/Fs) in waste water of manufacturing facilities producing chlorinated compounds since 2009. As this regulation is expected to be reinforced in 2013 to 50 pg I-TEQ/L, a large sample volume is required for the analysis of trace amounts of PCDD/Fs in waste water. Liquid-liquid extraction (LLE) is used to extract PCDD/Fs from aqueous samples; however, its low efficiency makes it inadequate for analyzing large sample volumes. Herein, we present a disk-type solid-phase extraction (SPE) method for the analysis of dioxin at a part per quadrillion level in waste water. This SPE system contains airtight glass covers with a decompression pump, which enables continuous semi-automated extraction. Small (0.5 L) and large (7 L) samples were extracted using LLE and SPE methods, respectively. The method detection limits (MDLs) were 0.001.0.25 and 0.015.4.1 pg I-TEQ/L for the SPE and LLE methods, respectively. The concentrations of detected congeners with both methods were similar. However, the concentrations of several congeners that were not detected with the LLE method were quantified using the SPE method.